NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo

Reversible middle cerebral artery occlusion without craniectomy in rats.

Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989) · Stroke · doi:10.1161/01.str.20.1.84 · Cited by 7,463

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

Benveniste, H., Drejer, J., Schousboe, A., & Diemer, N. H. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05396.x · Cited by 2,863

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,676

Regulation of neuronal survival by the serine-threonine protein kinase Akt

Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., & Lipton, S. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7162 · Cited by 1,958

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686

Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells

Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 1,385

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

Paoletti, P., Bellone, C., & Zhou, Q. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3504 · Cited by 2,523

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644

Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells

Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 1,385

Apoptotic Mechanisms After Cerebral Ischemia

Broughton, B. R. S., Reutens, D. C., & Sobey, C. G. (2009) · Stroke · doi:10.1161/strokeaha.108.531632 · Cited by 1,269

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

Lai, T. W., Zhang, S., & Wang, Y. T. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.006 · Cited by 1,106

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

Ng, S. Y., & Lee, A. Y. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00528 · Cited by 906

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Tuo, Q., Zhang, S., & Lei, P. (2021) · Medicinal Research Reviews · doi:10.1002/med.21817 · Cited by 758

Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

Li, S., Jin, M., Koeglsperger, T., Shepardson, N. E., Shankar, G. M., & Selkoe, D. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0203-11.2011 · Cited by 703

Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)

Zhao, Y., Zhang, X., Chen, X., & Wei, Y. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5070 · Cited by 648

Pathogenic mechanisms following ischemic stroke

Khoshnam, S. E., Winlow, W., Farzaneh, M., Farbood, Y., & Moghaddam, H. F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2938-1 · Cited by 636

Astrocyte metabolism and signaling during brain ischemia

Rossi, D. J., Brady, J. D., & Mohr, C. (2007) · Nature Neuroscience · doi:10.1038/nn2004 · Cited by 558

Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses

Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538

The Role of NMDA Receptors in Alzheimer’s Disease

Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00043 · Cited by 535

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

Tu, W., Xu, X., Peng, L., Zhong, X., Zhang, W., Soundarapandian, M. M., Belal, C., Wang, M., Jia, N., Zhang, W., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.055 · Cited by 493

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489

Synapses and Alzheimer's Disease

Sheng, M., Sabatini, B. L., & Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005777 · Cited by 436

NMDA receptors in clinical neurology: excitatory times ahead

Kalia, L. V., Kalia, S. K., & Salter, M. W. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70165-0 · Cited by 421

Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential

Mony, L., Kew, J. N. C., Gunthorpe, M. J., & Paoletti, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00304.x · Cited by 420

Calcium‐dependent mitochondrial function and dysfunction in neurons

Pivovarova, N. B., & Andrews, S. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07754.x · Cited by 389

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

Raymond, L. A., André, V. M., Cepeda, C., Gladding, C. M., Milnerwood, A. J., & Levine, M. S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.052 · Cited by 336

Mechanism of differential control of NMDA receptor activity by NR2 subunits

Gielen, M. C., Retchless, B. S., Mony, L., Johnson, J. W., & Paoletti, P. (2009) · Nature · doi:10.1038/nature07993 · Cited by 344

Targeting NMDA receptors in stroke: new hope in neuroprotection

Wu, Q. J., & Tymianski, M. (2018) · Molecular Brain · doi:10.1186/s13041-018-0357-8 · Cited by 338

In Vivo Voltage-Sensitive Dye Imaging in Adult Mice Reveals That Somatosensory Maps Lost to Stroke Are Replaced over Weeks by New Structural and Functional Circuits with Prolonged Modes of Activation within Both the Peri-Infarct Zone and Distant Sites

Brown, C. E., Aminoltejari, K., Erb, H., Winship, I. R., & Murphy, T. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4249-08.2009 · Cited by 319

NMDA receptors in nervous system diseases

Zhou, Q., & Sheng, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.030 · Cited by 304

Dysfunction of NMDA receptors in Alzheimer’s disease

Zhang, Y., Li, P., Feng, J., & Wu, M. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2546-5 · Cited by 282

Triheteromeric NR1/NR2A/NR2B Receptors Constitute the Major N-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses

Rauner, C., & Köhr, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.182600 · Cited by 287

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Hardingham, G. E. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371147 · Cited by 268

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

Léveillé, F., Gaamouch, F. E., Gouix, E., Lecocq, M., Lobner, D., Nicole, O., & Buisson, A. (2008) · The FASEB Journal · doi:10.1096/fj.08-107268 · Cited by 280

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

Rönicke, R., Mikhaylova, M., Rönicke, S., Meinhardt, J., Schröder, U. H., Fändrich, M., Reiser, G., Kreutz, M. R., & Reymann, K. G. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.01.011 · Cited by 262

Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

Chen, M., Lu, T., Chen, X., Zhou, Y., Chen, Q., Feng, X., Xu, L., Duan, W., & Xiong, Z. (2008) · Stroke · doi:10.1161/strokeaha.108.521898 · Cited by 244

Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke

Shen, Z., Xiang, M., Chen, C., Ding, F., Wang, Y., Shang, C., Xin, L., Zhang, Y., & Cui, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113125 · Cited by 241

Activation of microglial N‐methyl‐D‐aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

Kaindl, A. M., Degos, V., Peineau, S., Gouadon, E., Chhor, V., Loron, G., Charpentier, T. L., Josserand, J., Ali, C., Vivien, D., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23626 · Cited by 246

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

Rizzo, F. R., Musella, A., Vito, F. D., Fresegna, D., Bullitta, S., Vanni, V., Guadalupi, L., Bassi, M. S., Buttari, F., Mandolesi, G., et al. (2018) · Neural Plasticity · doi:10.1155/2018/8430123 · Cited by 221

Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation

Fan, X., Wu, J., Lu, J., Wang, J., & Wang, Y. T. (2014) · Nature Neuroscience · doi:10.1038/nn.3637 · Cited by 222

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

Mota, S. I., Ferreira, I. L., & Rego, A. C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.013 · Cited by 215

Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices

Harris, A. Z., & Pettit, D. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.137679 · Cited by 202

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

Choi, D. W. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.579953 · Cited by 204

Zinc and cortical plasticity

Nakashima, A. S., & Dyck, R. H. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.10.003 · Cited by 203

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

Gladding, C. M., & Raymond, L. A. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.05.001 · Cited by 214

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

Stanika, R. I., Pivovarova, N. B., Brantner, C. A., Watts, C. A., Winters, C. A., & Andrews, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903546106 · Cited by 191

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

Ferreira, I. L., Bajouco, M., Mota, S. I., Auberson, Y. P., Oliveira, C. R., & Rego, A. C. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.11.008 · Cited by 196

Non‐synaptic receptors and transporters involved in brain functions and targets of drug treatment

Vizi, E. S., Fekete, Á., Károly, R., & Mike, Á. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00624.x · Cited by 193

Stroke intervention pathways: NMDA receptors and beyond

Lai, T. W., Shyu, W., & Wang, Y. T. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.12.008 · Cited by 183

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

Hackos, D. H., Lupardus, P. J., Grand, T., Chen, Y., Wang, T.-M., Reynen, P., Gustafson, A. E., Wallweber, H. J. A., Volgraf, M., Sellers, B. D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.016 · Cited by 174

The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

Martel, M., Ryan, T. J., Bell, K. F. S., Fowler, J. H., McMahon, A., Al-Mubarak, B. R., Komiyama, N. H., Horsburgh, K. J., Kind, P. C., Grant, S. G. N., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.021 · Cited by 183

Multiple Defects in Energy Metabolism in Alzheimers Disease

Ferreira, I. L., Resende, R., Ferreiro, E. B., Rego, A. C., & Pereira, C. (2010) · Current Drug Targets · doi:10.2174/1389450111007011193 · Cited by 185

The Dichotomy of NMDA Receptor Signaling

Papadia, S., & Hardingham, G. E. (2007) · The Neuroscientist · doi:10.1177/10738584070130060401 · Cited by 180

Organization, control and function of extrasynaptic NMDA receptors

Papouin, T., & Oliet, S. H. R. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0601 · Cited by 189

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology of Alzheimer’s Disease

Rudy, C. C., Hunsberger, H. C., Weitzner, D. S., & Reed, M. N. (2015) · Aging and Disease · doi:10.14336/ad.2014.0423 · Cited by 187

Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice

Fitting, S., Ignatowska-Jankowska, B. M., Bull, C., Skoff, R. P., Lichtman, A. H., Wise, L. E., Fox, M. A., Su, J., Medina, A. E., Krahe, T. E., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.026 · Cited by 168

Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease

Yu, S. P., Jiang, M. Q., Shim, S. S., Pourkhodadad, S., & Wei, L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00636-1 · Cited by 178

G-Protein-Coupled Receptor 30 Mediates Rapid Neuroprotective Effects of Estrogen via Depression of NR2B-Containing NMDA Receptors

Liu, S.-B., Zhang, N., Guo, Y.-Y., Zhao, R., Shi, T.-R., Feng, S.-F., Wang, S.-Q., Yang, Q., Li, X.-Q., Wu, Y.-M., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5828-11.2012 · Cited by 154

Safety and Efficacy of Transcranial Direct Current Stimulation in Acute Experimental Ischemic Stroke

Peruzzotti‐Jametti, L., Cambiaghi, M., Bacigaluppi, M., Gallizioli, M., Gaude, E., Mari, S., Sandrone, S., Cursi, M., Teneud, L., Comı, G., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.001687 · Cited by 169

Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

Soriano, F. X., Martel, M., Papadia, S., Vaslin, A., Baxter, P. S., Rickman, C., Forder, J. P., Tymianski, M., Duncan, R. R., Aarts, M. M., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1207-08.2008 · Cited by 162

Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents

Khoshnam, S. E., Winlow, W., Farbood, Y., Moghaddam, H. F., & Farzaneh, M. (2017) · Journal of Stroke · doi:10.5853/jos.2016.01368 · Cited by 156

Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers

Ferreiro, E. B., Baldeiras, I., Ferreira, I. L., Costa, R. O., Rego, A. C., Pereira, C., & Oliveira, C. R. (2012) · International Journal of Cell Biology · doi:10.1155/2012/735206 · Cited by 156

Regulation of NMDA glutamate receptor functions by the GluN2 subunits

Vieira, M., Yong, X. L. H., Roche, K. W., & Anggono, V. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14970 · Cited by 151

SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB

Sasaki, T., Takemori, H., Yagita, Y., Terasaki, Y., Uebi, T., Horike, N., Takagi, H., Susumu, T., Teraoka, H., Kusano, K.-I., et al. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.004 · Cited by 153

Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies

Carvajal, F. J., Mattison, H. A., & Cerpa, W. F. (2016) · Neural Plasticity · doi:10.1155/2016/2701526 · Cited by 154

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

Zhou, X., Ding, Q., Chen, Z., Yun, H., & Wang, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482000 · Cited by 154

In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death

Martel, M., Wyllie, D. J. A., & Hardingham, G. E. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.080 · Cited by 149

NMDA and AMPA receptors dysregulation in Alzheimer's disease

Babaei, P. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174310 · Cited by 154

Plasticity and repair in the post-ischemic brain

Filippo, M. D., Tozzi, A., Costa, C., Belcastro, V., Tantucci, M., Picconi, B., & Calabresi, P. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.01.012 · Cited by 151

Distinct Roles for μ-Calpain and m-Calpain in Synaptic NMDAR-Mediated Neuroprotection and Extrasynaptic NMDAR-Mediated Neurodegeneration

Wang, Y., Briz, V., Chishti, A. H., Bi, X., & Baudry, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3293-13.2013 · Cited by 145

Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death

Wroge, C. M., Hogins, J., Eisenman, L., & Mennerick, S. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6371-11.2012 · Cited by 148

Calcium Signaling in Synapse-to-Nucleus CommunicationPreprint

Hagenston, A. M., & Bading, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004564 · Cited by 147

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

Sebastião, A. M., Colino-Oliveira, M., Assaife‐Lopes, N., Dias, R. B., & Ribeiro, J. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.053 · Cited by 138

Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries

Taghibiglou, C., Martin, H. G. S., Lai, T. W., Cho, T., Prasad, S. S., Kojic, L., Lu, J., Liu, Y., Lo, E., Zhang, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2064 · Cited by 135

Emerging mechanisms of disrupted cellular signaling in brain ischemia

Tymianski, M. (2011) · Nature Neuroscience · doi:10.1038/nn.2951 · Cited by 131

Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

Kaufman, A. M., Milnerwood, A. J., Sepers, M. D., Coquinco, A., She, K., Wang, L., Lee, H., Craig, A. M., Cynader, M. S., & Raymond, L. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4129-11.2012 · Cited by 135

TRPM2 channel-mediated cell death: An important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions

Malko, P., & Jiang, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101755 · Cited by 128

Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease

Sepers, M. D., & Raymond, L. A. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.02.006 · Cited by 126

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model

Lozovaya, N., Gataullina, S., Tsintsadze, T. S., Tsintsadze, V., Pallesi‐Pocachard, E., Minlebaev, M., Goriounova, N. A., Buhler, E., Watrin, F., Shityakov, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5563 · Cited by 123

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity

Franchini, L., Carrano, N., Luca, M. D., & Gardoni, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041538 · Cited by 127

Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

Vizi, E. S., Kisfali, M., & Lőrincz, T. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.10.005 · Cited by 125

Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules

Forder, J. P., & Tymianski, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.021 · Cited by 123

In VivoEvidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington DiseasePreprint

Heng, M. Y., Detloff, P. J., Wang, P. L., Tsien, J. Z., & Albin, R. L. (2008) · Nature Precedings · doi:10.1523/jneurosci.5599-08.2009 · Cited by 130

Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance

Varela, E. V., Etter, G., & Williams, S. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.04.010 · Cited by 122

NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition

Báez, M. V., Cercato, M. C., & Jerusalinsky, D. A. (2018) · Neural Plasticity · doi:10.1155/2018/5093048 · Cited by 125

Copper‐dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

Stys, P. K., You, H., & Zamponi, G. W. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.225276 · Cited by 115

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

Ren, Z., Pribiag, H., Jefferson, S. J., Shorey, M., Fuchs, T., Stellwagen, D., & Luscher, B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.009 · Cited by 114

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington’s disease

Zádori, D., Nyíri, G., Szőnyi, A., Szatmári, I., Fülöp, F., Toldi, J., Freund, T. F., Vécsei, L., & Klivènyi, P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0573-6 · Cited by 112

Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress.

Tian, Z., Wang, Y., Zhang, N., Guo, Y.-Y., Feng, B., Liu, S.-B., & Zhao, M.-G. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.011 · Cited by 109

Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia

Kim, H. J., Hwang, I. K., & Won, M. H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.066 · Cited by 110

Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death

Alim, I., Teves, L. M., Li, R., Mori, Y., & Tymianski, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1729-13.2013 · Cited by 107

Alzheimer’s Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines

Zádori, D., Veres, G., Szalárdy, L., Klivènyi, P., & Vécsei, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170929 · Cited by 108

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

Huang, K., Kang, M. H., Askew, C. E., Kang, R., Sanders, S. S., Wan, J., Davis, N. G., & Hayden, M. R. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.027 · Cited by 107

A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus

Zhang, X.-L., Sullivan, J. A., Moskal, J. R., & Stanton, P. K. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.018 · Cited by 107

Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

Ryan, T. J., Emes, R. D., Grant, S. G. N., & Komiyama, N. H. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-6 · Cited by 109

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

Esteras, N., & Abramov, A. Y. (2020) · Cells · doi:10.3390/cells9092135 · Cited by 106

Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

Brassai, A., Suvanjeiev, R.-G., Bán, E.-G., & Lakatos, M. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.12.007 · Cited by 104

Neurotransmitters in the mediation of cerebral ischemic injury

Mayor, D., & Tymianski, M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.050 · Cited by 102

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects

Li, S.-X., Han, Y., Xu, L., Yuan, K., Zhang, R.-X., Sun, C.-Y., Xu, D.-F., Yuan, M., Deng, J.-H., Meng, S.-Q., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.85 · Cited by 100

Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus

Echeverry, R., Wu, J., Haile, W. B., Guzman, J., & Yepes, M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41722 · Cited by 100

Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

Zádori, D., Klivènyi, P., Szalárdy, L., Fülöp, F., Toldi, J., & Vécsei, L. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.06.004 · Cited by 98

Ca 2+ homeostasis dysregulation in Alzheimer's disease: a focus on plasma membrane and cell organelles

Wang, X., & Zheng, W. (2019) · The FASEB Journal · doi:10.1096/fj.201801751r · Cited by 97

Hippocampal NMDA receptor subunits differentially regulate fear memory formation and neuronal signal propagation

Gao, C., Gill, M. B., Tronson, N. C., Guedea, A. L., Guzmán, Y. F., Huh, K. H., Corcoran, K. A., Swanson, G. T., & Radulović, J. (2009) · Hippocampus · doi:10.1002/hipo.20705 · Cited by 96

Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury

Curcio, M., Salazar, I. L., Mele, M., Canzoniero, L. M. T., & Duarte, C. B. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.001 · Cited by 99

Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors

Olmo, I. G., Carvalho, T. G., Costa, V. V., Alves‐Silva, J., Ferrari, C. Z., Izidoro‐Toledo, T. C., da Silva, J., Teixeira, A. L., Souza, D. G., Marques, J. T., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01016 · Cited by 98

Subunit-specific effects of NMDA receptor signaling: Implications for stroke

Liu, Y., Wong, T. P., Aarts, M. M., Liu, L., Wu, D., Lu, J., Tymianski, M., & Wang, Y.-T. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9591524.0431

Opposing roles of NMDA receptor subtypes in neuronal fate and novel treatments for ischemic brain injury

Liu, Y. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0092964

Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors

von Engelhardt, J., Coserea, I., Pawlak, V., Fuchs, E. C., Köhr, G., Seeburg, P. H., & Monyer, H. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.015 · Cited by 151

Molecular mechanisms of NMDA receptor-mediated excitotoxicity: Implications for neuroprotective therapeutics for stroke

Wang, Y., & Li, V. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.194713 · Cited by 55

Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

Vizi, E. S., Kisfali, M., & Lőrincz, T. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.10.005 · Cited by 125