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Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain
Open accessAbstract
How human beings integrate information from external sources and internal cognition to produce a coherent experience is still not well understood. During the past decades, anatomical, neurophysiological and neuroimaging research in multimodal integration have stood out in the effort to understand the perceptual binding properties of the brain. Areas in the human lateral occipitotemporal, prefrontal, and posterior parietal cortices have been associated with sensory multimodal processing. Even though this, rather patchy, organization of brain regions gives us a glimpse of the perceptual convergence, the articulation of the flow of information from modality-related to the more parallel cognitive processing systems remains elusive. Using a method called stepwise functional connectivity analysis, the present study analyzes the functional connectome and transitions from primary sensory cortices to higher-order brain systems. We identify the large-scale multimodal integration network and essential connectivity axes for perceptual integration in the human brain.
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“Additionally, it has been demonstrated that aMCC is as a key region in a multimodal network that integrates information originating from primary sensory regions (e.g., visual, auditory, and somatosensory) (Sepulcre et al., 2012).”
From Motivation in the Service of Allostasis: The Role of Anterior Mid-Cingulate Cortex (2019) · cites this paper as Sepulcre et al., 2012
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“Moreover, the inverse correlation between the dorsal attention network and the default-mode network, interpreted by most as a sign of ‘competition’ between the processing of external and internal events in the mature brain106, also emerges during the first year of life112.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [112]
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Metadata
- Authors
- Sepulcre, J., Sabuncu, M. R., Yeo, T. B., Liu, H., & Johnson, K. A.
- Affiliations
- Harvard University (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Brigham and Women's Hospital (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-08-01
- Volume
- 32
- Issue
- 31
- Pages
- 10649-10661
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3483645
- OpenAlex
- W2054260111
- Cited by
- 323
- References
- 72
- Citations by year
- 2026: 18 · 2025: 29 · 2024: 30 · 2023: 36 · 2022: 25 · 2021: 36 · 2020: 22 · 2019: 22 · 2018: 18 · 2017: 19 · 2016: 26 · 2015: 15 · 2014: 9 · 2013: 16 · 2012: 2
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- Alzheimer's Association (NIRG-11-205690)
- National Institutes of Health
- National Institute on Aging (R01AG036694, R01AG037497, P01AG036694)
- National Institute of Neurological Disorders and Stroke (K25NS069805)
- National Institute of Biomedical Imaging and Bioengineering (K25EB013649)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- multimodal integration, functional connectivity, functional connectome, perceptual binding, sensory modalities, primary sensory cortex, lateral occipitotemporal cortex, prefrontal cortex, posterior parietal cortex
- MeSH terms
- Brain Mapping, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Mental Processes, Models, Neurological, Neural Pathways, Oxygen, Sensation, Linear Models, Young Adult
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