The Human Parietal Operculum. II. Stereotaxic Maps and Correlation with Functional Imaging Results
Abstract
In this study we describe the localization of the cytoarchitectonic subdivisions of the human parietal operculum in stereotaxic space and relate these anatomically defined cortical areas to the location of the functionally defined secondary somatosensory cortex (SII cortex) using a meta-analysis of functional imaging results. The human parietal operculum consists of four distinct cytoarchitectonic areas (OP 1-4) as shown in the preceding publication. The 10 cytoarchitectonically examined brains were 3-D-reconstructed and spatially normalized to the T1-weighted single-subject template of the Montreal Neurological Institute (MNI). A probabilistic map was calculated for each area in this standard stereotaxic space. A cytoarchitectonic summary map of the four cortical areas on the human parietal operculum which combines these probabilistic maps was subsequently computed for the comparison with a meta-analysis of functional locations of SII. The meta-analysis used the results from 57 fMRI and PET studies and allowed the comparison of the functionally defined SII region to the cytoarchitectonic map of the parietal operculum. The functional localization of SII showed a good match to the cytoarchitectonically defined region. Therefore the cytoarchitectonic maps of OP 1-4 of the human parietal operculum can be interpreted as an anatomical correlate of the (functionally defined) human SII region. Our results also suggest that the SII foci reported in functional imaging studies may actually reflect activations in either of its architectonic subregions.
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Prior research identified OP1 and dpINS as two regions in the operculoinsular region specifically involved in pain-related somatosensory processing.
“Prior research has identi fi ed two regions in the operculoinsular region that are speci fi cally involved in pain-related somatosensory processing: OP1, the most caudal area of the parietal operculum, and dpINS (19 -23).”
From Social rejection shares somatosensory representations with physical pain (2011) · cites this paper as [21]
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- Authors
- Eickhoff, S. B., Amunts, K., Mohlberg, H., & Zilles, K.
- Affiliations
- Forschungszentrum Jülich (DE)
- Corresponding author
- Eickhoff, Simon B.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-11
- Volume
- 16
- Issue
- 2
- Pages
- 268-279
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2005197503
- Cited by
- 411
- References
- 87
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 11 · 2021: 15 · 2020: 12 · 2019: 25 · 2018: 18 · 2017: 17 · 2016: 19 · 2015: 31 · 2014: 19 · 2013: 33 · 2012: 28
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- parietal operculum, secondary somatosensory cortex, cytoarchitecture, stereotactic localization
- MeSH terms
- Brain Mapping, Cadaver, Female, Humans, Magnetic Resonance Imaging, Male, Movement, Nerve Net, Neural Pathways, Neurons, Parietal Lobe, Somatosensory Cortex, Statistics as Topic, Subtraction Technique, Evoked Potentials, Motor, Imaging, Three-Dimensional, In Vitro Techniques
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