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Active Avoidance Requires a Serial Basal Amygdala to Nucleus Accumbens Shell Circuit
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Freezing is a species-typical defensive reaction to conditioned threats. While the neural circuitry of aversive Pavlovian behavior has been extensively studied, less is known about the circuitry underlying more active responses to danger. Here we show that the flow of information between the basal amygdala (BA) and the nucleus accumbens (NAcc) is necessary for signaled active avoidance behavior. Rats trained to avoid shock by shuttling during an auditory conditioned stimulus showed increased expression of the activity-dependent protein c-Fos in the NAcc, specifically the shell subregion (NAccSh). Silencing neural activity in the NAccSh, but not in the adjacent NAcc core, disrupted avoidance behavior. Disconnection of the BA and the NAccSh was just as effective at disrupting avoidance behavior as bilateral NAccSh inactivations, suggesting learned avoidance behavior requires an intact BA-NAccSh circuit. Together, these data highlight an essential role for the amygdalar projection to the ventral striatum in aversively motivated actions.
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“The vmPFC is proposed to toggle between these different output paths of the amygdala, shifting the flow of information to promote aversively motivated action instead of Pavlovian freezing responses (Moscarello and LeDoux, 2013; Ramirez et al., 2015).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Ramirez et al., 2015
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“The lateral nucleus also projects to the basal nucleus of the amygdala, which projects to the striatum. These connections are essential for avoidance learning (Amorapanth et al., 2000; Ramirez et al., 2015).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Ramirez et al., 2015
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“Instrumental control over threat has been shown to involve the amygdala, striatum, and ventromedial prefrontal cortex (vmPFC) in rodents.”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Ramirez et al., 2015
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“However, the basal nucleus of the amygdala is engaged during avoidance learning and may transfer information about CS-US association to the striatum (Amorapanth et al., 2000; Ramirez et al., 2015).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Ramirez et al., 2015
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Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Self-citationNeurobiology of Pavlovian fear conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,543
Handbook of Approach and Avoidance Motivation
(2013) · Psychology Press eBooks · doi:10.4324/9780203888148 · Cited by 1,325
Graybiel, A. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00593-5 · Cited by 1,051
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012
Self-citationNeural organization of the defensive behavior system responsible for fear
Fanselow, M. S. (1994) · Psychonomic Bulletin & Review · doi:10.3758/bf03210947 · Cited by 1,000
Research works printed but not linked: 1
- Paxinos G Watson C (2007) The rat brain in sterotaxic coordinates (Elsevier, Amsterdam), Ed 3.
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Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework
LeDoux, J. E., & Pine, D. S. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16030353 · Cited by 1,035
Self-citationAdult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Fenster, R. J., Lebois, L. A. M., Ressler, K. J., & Suh, J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0039-7 · Cited by 456
An amygdalar neural ensemble that encodes the unpleasantness of pain
Corder, G. F., Ahanonu, B., Grewe, B. F., Wang, D., Schnitzer, M. J., & Scherrer, G. (2019) · Science · doi:10.1126/science.aap8586 · Cited by 418
LeDoux, J. E., & Daw, N. D. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.22 · Cited by 405
Self-citationThe birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm
LeDoux, J. E., Moscarello, J., Sears, R., & Campese, V (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.166 · Cited by 348
Self-citationThe prefrontal cortex, pathological anxiety, and anxiety disorders
Kenwood, M. M., Kalin, N. H., & Barbas, H. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01109-z · Cited by 379
Rethinking avoidance: Toward a balanced approach to avoidance in treating anxiety disorders
Hofmann, S. G., & Hay, A. C. (2018) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2018.03.004 · Cited by 361
Space, Time, and Fear: Survival Computations along Defensive Circuits
Mobbs, D., Headley, D. B., Ding, W., & Dayan, P. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.12.016 · Cited by 281
Neuroanatomic differences associated with stress susceptibility and resilience
Anacker, C., Scholz, J., O’Donnell, K. J., Allemang-Grand, R., Diorio, J., Bagot, R. C., Nestler, E. J., Hen, R., Lerch, J. P., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.009 · Cited by 167
Sangha, S., Diehl, M. M., Bergstrom, H. C., & Drew, M. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.006 · Cited by 151
Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding
Boeke, E. A., Moscarello, J. M., LeDoux, J. E., Phelps, E. A., & Hartley, C. A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3261-16.2017 · Cited by 131
“The vmPFC is proposed to toggle between these different output paths of the amygdala, shifting the flow of information to promote aversively motivated action instead of Pavlovian freezing responses (Moscarello and LeDoux, 2013; Ramirez et al., 2015).”
BackgroundInfluentialSelf-citationKirouac, G. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.627633 · Cited by 140
Agency and the Calibration of Motivated Behavior
Moscarello, J. M., & Hartley, C. A. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.06.008 · Cited by 137
Self-citationAoki, S., Smith, J. B., Li, H., Yan, X., Igarashi, M., Coulon, P., Wickens, J. R., Ruigrok, T. J. H., & Jin, X. (2019) · eLife · doi:10.7554/elife.49995 · Cited by 134
Cohodes, E. M., Kitt, E. R., Baskin-sommers, A. R., & Gee, D. G. (2020) · Developmental Psychobiology · doi:10.1002/dev.21969 · Cited by 133
Capuzzo, G., & Floresco, S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0414-20.2020 · Cited by 127
Genetically identified amygdala–striatal circuits for valence-specific behaviors
Zhang, X., Guan, W., Yang, T., Furlan, A., Xiao, X., Yu, K., An, X., Galbavy, W., Ramakrishnan, C., Deisseroth, K., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00927-0 · Cited by 126
Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
Bravo-Rivera, C., Roman-Ortiz, C., Montesinos-Cartagena, M., & Quirk, G. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00184 · Cited by 124
The study of active avoidance: a platform for discussion
Diehl, M. M., Bravo-Rivera, C., & Quirk, G. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.010 · Cited by 95
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Ressler, K. J. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20010055 · Cited by 104
Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice
Zhou, K., Xu, H. Z., Lu, S., Jiang, S., Hou, G., Deng, X., He, M., & Zhu, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33843-3 · Cited by 118
Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex
Diehl, M. M., Bravo-Rivera, C., Rodríguez-Romaguera, J., Pagan-Rivera, P. A., Burgos-Robles, A., Roman-Ortiz, C., & Quirk, G. J. (2018) · eLife · doi:10.7554/elife.34657 · Cited by 108
Avoidance Problems Reconsidered
Cain, C. K. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.09.002 · Cited by 87
Measuring maladaptive avoidance: from animal models to clinical anxiety
Ball, T. M., & Gunaydin, L. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01263-4 · Cited by 96
Ma, J., du Hoffmann, J., Kindel, M., Beas, B. S., Chudasama, Y., & Penzo, M. A. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00912-7 · Cited by 86
Dynamical prefrontal population coding during defensive behaviours
Jercog, D., Winke, N., Sung, K., Martín‐Fernández, M., Francioni, C., Rajot, D., Courtin, J., Chaudun, F., Jercog, P. E., Valério, S., et al. (2021) · Nature · doi:10.1038/s41586-021-03726-6 · Cited by 85
Striatal structure and function predict individual biases in learning to avoid pain
Eldar, E., Hauser, T. U., Dayan, P., & Dolan, R. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519829113 · Cited by 79
Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
Diehl, M. M., Iravedra-García, J. M., Morán-Sierra, J., Rojas-Bowe, G., Gonzalez-Diaz, F. N., Valentín-Valentín, V. P., & Quirk, G. J. (2020) · eLife · doi:10.7554/elife.59281 · Cited by 80
Systems Neuroscience of Psychosis: Mapping Schizophrenia Symptoms onto Brain Systems
Strik, W. K., Stegmayer, K., Walther, S., & Dierks, T. (2017) · Neuropsychobiology · doi:10.1159/000485221 · Cited by 82
When scientific paradigms lead to tunnel vision: lessons from the study of fear
Paré, D., & Quirk, G. J. (2017) · npj Science of Learning · doi:10.1038/s41539-017-0007-4 · Cited by 83
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Orsini, C. A., Heshmati, S. C., Garman, T. S., Wall, S. C., Bizon, J. L., & Setlow, B. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.018 · Cited by 71
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McNally, G. P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.021 · Cited by 78
Flexibility in the face of fear: hippocampal–prefrontal regulation of fear and avoidance
Moscarello, J. M., & Maren, S. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.09.010 · Cited by 77
Self-citationLinking Social Cognition to Learning and Memory
Leblanc, H., & Ramirez, S. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1280-20.2020 · Cited by 69
Piantadosi, P. T., Yeates, D. C. M., Wilkins, M., & Floresco, S. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.02.017 · Cited by 68
Dopfel, D., Pérez, P. D., Verbitsky, A., Bravo-Rivera, H., Ma, Y., Quirk, G. J., & Zhang, N. (2019) · Nature Communications · doi:10.1038/s41467-019-09926-z · Cited by 68
Walther, S., Lefebvre, S., Conring, F., Gangl, N., Nadesalingam, N., Alexaki, D., Wüthrich, F., Rüter, M., Viher, P. V., Federspiel, A., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01337-w · Cited by 61
Orsini, C. A., Hernandez, C. M., Singhal, S. M., Kelly, K. B., Frazier, C. J., Bizon, J. L., & Setlow, B. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2344-17.2017 · Cited by 61
Post-traumatic stress disorder: a psychiatric disorder requiring urgent attention
Du, J., Diao, H., Zhou, X., Zhang, C., Chen, Y., Gao, Y. F., & Wang, Y. (2022) · Medical Review · doi:10.1515/mr-2022-0012 · Cited by 69
Embracing Complexity in Defensive Networks
Headley, D. B., Kanta, V., Kyriazi, P., & Paré, D. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.024 · Cited by 61
Emotion, motivation and function
Fanselow, M. S. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.12.013 · Cited by 69
Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems
Kaplan, G. B., Lakis, G. A., & Zhoba, H. B. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.05.006 · Cited by 54
Hormigo, S., Shanmugasundaram, B., Zhou, J. H., & Castro‐Alamancos, M. A. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-21.2021 · Cited by 51
Keep at bay! – Abnormal personal space regulation as marker of paranoia in schizophrenia
Schoretsanitis, G., Kutynia, A., Stegmayer, K., Strik, W. K., & Walther, S. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.10.001 · Cited by 49
Zona Incerta GABAergic Output Controls a Signaled Locomotor Action in the Midbrain Tegmentum
Hormigo, S., Zhou, J. H., & Castro‐Alamancos, M. A. (2020) · eNeuro · doi:10.1523/eneuro.0390-19.2020 · Cited by 45
Prefrontal cortex development and its implications in mental illness
Goodpaster, C. M., Christensen, C. R., Alturki, M.-B., & DeNardo, L. A. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02154-8 · Cited by 58
Prefrontal circuits signaling active avoidance retrieval and extinction
Martínez-Rivera, F. J., Bravo-Rivera, C., Velázquez-Díaz, C. D., Montesinos-Cartagena, M., & Quirk, G. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5012-7 · Cited by 51
Neural circuits for coping with social defeat
Diaz, V. E., & Lin, D. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.016 · Cited by 48
Specific cerebral perfusion patterns in three schizophrenia symptom dimensions
Stegmayer, K., Strik, W. K., Federspiel, A., Wiest, R., Bohlhalter, S., & Walther, S. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.018 · Cited by 44
Fernández‐Teruel, A., & Tobeña, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.08.014 · Cited by 43
McCullough, K. M., Missig, G., Robble, M. A., Foilb, A. R., Wells, A. M., Hartmann, J., Anderson, K. J., Neve, R. L., Nestler, E. J., Ressler, K. J., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.030 · Cited by 44
Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats
Oleksiak, C. R., Ramanathan, K. R., Miles, O. W., Perry, S. J., Maren, S., & Moscarello, J. M. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107458 · Cited by 42
Self-citationRoss, E. K., Kim, J. P., Settell, M. L., Han, S. R., Blaha, C. D., Min, H.-K. P., & Lee, K. H. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.12.056 · Cited by 45
Avoidance of learnt fear: Models, potential mechanisms, and future directions
Wong, A. H. K., Wirth, F. M., & Pittig, A. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104056 · Cited by 43
PTSD: Past, present and future implications for China
Zhou, Y., Shang, Z., Zhang, F., Wu, L., Sun, L., Jia, Y., Yu, H., & Liu, W. (2021) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2021.04.011 · Cited by 43
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Piantadosi, P. T., Halladay, L. R., Radke, A. K., & Holmes, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15342 · Cited by 45
Hormigo, S., Vega‐Flores, G., Rovira, V., & Castro‐Alamancos, M. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0049-19.2019 · Cited by 40
Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress
Cabib, S., Campus, P., Conversi, D., Orsini, C., & Puglisi‐Allegra, S. (2020) · Brain Sciences · doi:10.3390/brainsci10020127 · Cited by 39
Dutta, S., Beaver, J. N., Halcomb, C. J., & Jasnow, A. M. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100365 · Cited by 39
Wang, J., Bast, T., Wang, Y.-C., & Zhang, W. (2015) · Hippocampus · doi:10.1002/hipo.22471 · Cited by 38
Piantadosi, P. T., Yeates, D. C. M., & Floresco, S. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.028 · Cited by 40
Günther, V., Ihme, K. A., Kersting, A., Hoffmann, K., Lobsien, D., & Suslow, T. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.034 · Cited by 39
Limoges, A., Yarur, H. E., & Tejeda, H. A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.963691 · Cited by 35
Yao, Y., Gao, G., Liu, K., Shi, X., Cheng, M., Xiong, Y., & Song, S. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00632-9 · Cited by 31
Characterizing Different Strategies for Resolving Approach-Avoidance Conflict
Bravo-Rivera, H., Arzola, P. R., Caban, A. J., Vélez-Avilés, A. N., Ayala-Rosario, S. N., & Quirk, G. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.608922 · Cited by 32
Headley, D. B., Kyriazi, P., Feng, F., Nair, S. S., & Paré, D. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3159-20.2021 · Cited by 37
Buades‐Rotger, M., Beyer, F., & Krämer, U. M. (2017) · eNeuro · doi:10.1523/eneuro.0337-16.2017 · Cited by 33
Manassero, E., Renna, A., Milano, L., & Sacchetti, B. (2018) · Scientific Reports · doi:10.1038/s41598-017-19074-3 · Cited by 33
Engaging endogenous opioid circuits in pain affective processes
Kimmey, B. A., McCall, N. M., Wooldridge, L. M., Satterthwaite, T. D., & Corder, G. F. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24762 · Cited by 31
Jiao, X., Beck, K. D., Myers, C. E., Servatius, R. J., & Pang, K. C. H. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00249 · Cited by 34
The Neural Foundations of Reaction and Action in Aversive Motivation
Campese, V. D., Sears, R. M., Moscarello, J. M., Díaz-Mataix, L., Cain, C. K., & LeDoux, J. E. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_401 · Cited by 33
Self-citationAmygdala subnucleus volumes in psychosis high-risk state and first-episode psychosis
Armio, R.-L., Laurikainen, H., Ilonen, T., Walta, M., Salokangas, R. K. R., Koutsouleris, N., Hietala, J. A., & Tuominen, L. J. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.10.014 · Cited by 32
Román-Albasini, L., Díaz‐Véliz, G., Olave, F. A., Aguayo, F. I., García‐Rojo, G., Corrales, W. A., Silva, J. P., Avalos, A. M., Rojas, P. S., Aliaga, E., et al. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100234 · Cited by 27
Neural correlates of the mother‐to‐infant social transmission of fear
Chang, D.-J., & Dębiec, J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23739 · Cited by 31
Noradrenergic Regulation of Central Amygdala in Aversive Pavlovian-to-Instrumental Transfer
Campese, V. D., Soroeta, J. M., Vazey, E. M., Aston‐Jones, G., LeDoux, J. E., & Sears, R. M. (2017) · eNeuro · doi:10.1523/eneuro.0224-17.2017 · Cited by 30
Self-citationBasolateral amygdala neurons are activated during threat expectation
Amir, A., Kyriazi, P., Lee, S.-C., Headley, D. B., & Paré, D. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00807.2018 · Cited by 25
A human subcortical network underlying social avoidance revealed by risky economic choices
Schultz, J., Willems, T., Gädeke, M., Chakkour, G., Franke, A., Weber, B., & Hurlemann, R. (2019) · eLife · doi:10.7554/elife.45249 · Cited by 27
Al-Amin, M. M., Sullivan, R., Kurniawan, N. D., & Burne, T. H. J. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01840-w · Cited by 27
Baker, A. E., & Galván, A. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100841 · Cited by 28
Antunes, G. F., Gouveia, F. V., Rezende, F. S., Seno, M. D. D. J., de Carvalho, M. C., de Oliveira, C. C., dos Santos, L. C. T., de Castro, M. C., Kuroki, M. A., Teixeira, M. J., et al. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100219 · Cited by 26
Halladay, L. R., & Blair, H. T. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23736 · Cited by 27
Hormigo, S., Zhou, J. H., Chabbert, D., Shanmugasundaram, B., & Castro‐Alamancos, M. A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1067-20.2020 · Cited by 22
Issa, H. A., Staes, N., Diggs-Galligan, S., Stimpson, C. D., Gendron‐Fitzpatrick, A., Taglialatela, J. P., Hof, P. R., Hopkins, W. D., & Sherwood, C. C. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1751-9 · Cited by 24
de Oliveira, J. C., Drabowski, B. M. B., Rodrigues, S. M. A. F., Maciel, R. M., Moraes, M. F. D., & Cota, V. R. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.05.009 · Cited by 21
Population-level coding of avoidance learning in medial prefrontal cortex
Ehret, B., Boehringer, R., Amadei, E. A., Cervera, M. R., Henning, C., Galgali, A. R., Mante, V., & Grewe, B. F. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01704-5 · Cited by 22
Cigarroa, I., Lalanza, J. F., Caimari, A., Bas-Prior, J. M. D., Capdevila, L., Arola, L., & Escorihuela, R. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153687 · Cited by 20
Ausas, M. S., Mazzitelli-Fuentes, L., Román, F. R., Crichigno, S. A., Vincenti, A. P. D., & Mongiat, L. A. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.10.006 · Cited by 20
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Guo, X., Yuan, Y., Su, X., Cao, Z., Chu, C., Lei, C., Wang, Y., Yang, L., Pan, Y., Sheng, H., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02371-x · Cited by 20
Abend, R., Ruiz, S. G., Bajaj, M. A., Harrewijn, A., Linke, J. O., Atlas, L. Y., Winkler, A. M., & Pine, D. S. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100428 · Cited by 18
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Self-citationProlonged avoidance training exacerbates OCD-like behaviors in a rodent model
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Self-citationCohodes, E. M., Sisk, L. M., Keding, T. J., Mandell, J. D., Notti, M. E., & Gee, D. G. (2023) · Development and Psychopathology · doi:10.1017/s0954579423000822 · Cited by 21
Metadata
- Authors
- Ramirez, F., Moscarello, J. M., LeDoux, J. E., & Sears, R. M.
- Affiliations
- New York University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-02-25
- Volume
- 35
- Issue
- 8
- Pages
- 3470-3477
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4339356
- OpenAlex
- W2091209465
- Cited by
- 198
- References
- 58
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 16 · 2023: 18 · 2022: 15 · 2021: 25 · 2020: 21 · 2019: 25 · 2018: 17 · 2017: 14 · 2016: 11 · 2015: 8
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Science Foundation (0920153)
- National Institute of Mental Health (R01 MH38774, R01MH038774, MH38774)
- National Institute on Drug Abuse (R01DA029053, R56DA029053)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- active avoidance, basal amygdala, nucleus accumbens shell, freezing behavior, auditory conditioned stimulus, shock avoidance, neural circuits, Fos expression, ventral striatum, neural silencing, circuit disconnection
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Conditioning, Classical, Fear, Male, Neural Pathways, Nucleus Accumbens, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Rats
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