Cited by 95Memory and Neural MechanismsNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

The study of active avoidance: a platform for discussion

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Diehl, Maria M., Bravo-Rivera, Christian, Quirk, Gregory J.·2019·Neuroscience & Biobehavioral Reviews

Abstract

Traditional active avoidance tasks have advanced the field of aversive learning and memory for decades and are useful for studying simple avoidance responses in isolation; however, these tasks have limited clinical relevance because they do not model several key features of clinical avoidance. In contrast, platform-mediated avoidance (PMA) more closely resembles clinical avoidance because the response i) is associated with an unambiguous safe location, ii) is not associated with an artificial termination of the warning signal, and iii) is associated with a decision-based appetitive cost. Recent findings on the neuronal circuits of PMA have confirmed that amygdala-striatal circuits are essential for avoidance. In PMA, however, the prelimbic cortex facilitates the avoidance response early during the warning signal, perhaps through disinhibition of the striatum. Future studies on avoidance should account for additional factors such as sex differences and social interactions that will advance our understanding of maladaptive avoidance contributing to neuropsychiatric disorders.

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Crossref · 10.1016/j.neubiorev.2019.09.010

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  • The balance between reward and threat perception can be assessed in approach-avoidance paradigms, some of which have shown good translation across species.

    “For example, the balance between reward and threat perception can be assessed in approach-avoidance paradigms, some of which have shown good translation across species (Sierra-Mercado et al. 2015, LeDoux et al. 2017, Diehl et al. 2019, Zorowitz et al. 2019).”

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Authors
Diehl, M. M., Bravo-Rivera, C., & Quirk, G. J.
Affiliations
  • Cold Spring Harbor Laboratory (US)
  • University of Puerto Rico, Medical Sciences Campus (PR)
Corresponding author
Quirk, Gregory J.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2019-12
Volume
107
Pages
229-237
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2971467915
Cited by
95
References
135
Citations by year
2026: 15 · 2025: 20 · 2024: 21 · 2023: 10 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 2 · 2017: 1
FWCI
0.89
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
active avoidance, aversive learning, prelimbic cortex, sex differences, social interaction, neuropsychiatric disorders
MeSH terms
Amygdala, Animals, Avoidance Learning, Corpus Striatum, Extinction, Psychological, Fear

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