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Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research
Open accessAbstract
The recently implemented National Institutes of Health policy requiring that grant applicants consider sex as a biological variable in the design of basic and preclinical animal research studies has prompted considerable discussion within the neuroscience community. Here, we present reasons to be optimistic that this new policy will be valuable for neuroscience, and we suggest some ways for neuroscientists to think about incorporating sex as a variable in their research.
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“Finally, there is considerable evidence that sex is an important factor to consider in neuroscience research,92–95”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [95]
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Metadata
- Authors
- Shansky, R. M., & Woolley, C. S.
- Affiliations
- Northeastern University (US)
- Northwestern University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2016-11-23
- Volume
- 36
- Issue
- 47
- Pages
- 11817-11822
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC5125240
- OpenAlex
- W2556063377
- Cited by
- 191
- References
- 59
- Citations by year
- 2026: 23 · 2025: 12 · 2024: 27 · 2023: 16 · 2022: 16 · 2021: 17 · 2020: 27 · 2019: 19 · 2018: 18 · 2017: 16
- FWCI
- 17.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH095248)
- National Institute of Neurological Disorders and Stroke (R29NS037324, R01NS037324)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- sex as a biological variable, NIH policy, sex differences, preclinical research, brain research, sex-inclusive research
- MeSH terms
- Animals, Female, Humans, Male, National Institutes of Health (U.S.), Neurosciences, Research Design, Research Support as Topic, Sex Characteristics, Sex Factors, United States, Biomedical Research
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