The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Role of the Dorsal Hippocampus in the Acquisition and Retrieval of Context Memory Representations
Open accessAbstract
It is argued that the hippocampus contributes to contextual fear conditioning by supporting the acquisition of a conjunctive memory representation of context, which associates with shock. This function was examined by studying the context pre-exposure facilitation effect (CPFE). A rat that is shocked immediately after being placed into a context subsequently displays almost no fear of that context. However, if it is pre-exposed to the context the day before immediate shock, it displays significant freezing to that context. By using 5-aminomethyl-3-hydroxysoxazole to temporarily inactivate the dorsal hippocampus (DH) at three different phases of the procedure, which produces the CPFE, we show that the hippocampus is necessary for the following: (1) acquisition of the context memory, (2) retrieval of this memory at the time of immediate shock, and (3) retrieval of the context-shock memory at the time of testing. In contrast, inactivating the DH before a standard contextual shock experience had no effect on contextual fear conditioning. These results support the view that two processes can support contextual fear conditioning: (1) conditioning to the conjunctive representation, which depends on the hippocampus, and (2) conditioning to the features that make up the context, which does not.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Simple memory: a theory for archicortex
Marr, D. (1971) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1971.0078 · Cited by 2,771
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Hippocampal synaptic enhancement and information storage within a distributed memory system
McNaughton, B. L., & Morris, R. G. M. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90011-7 · Cited by 1,304
Phillips, R. G., & LeDoux, J. E. (1994) · Learning & Memory · doi:10.1101/lm.1.1.34 · Cited by 528
Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction
Corcoran, K. A., & Maren, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01720.2001 · Cited by 455 · cited 2×
“This dose has been successfully used in other recent experiments to inactivate the DH (Holt and Maren, 1999a; Corcoran and Maren, 2001).”
BackgroundMethodThe place of the hippocampus in fear conditioning
Sanders, M. J., Wiltgen, B. J., & Fanselow, M. S. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01283-4 · Cited by 316
Conjunctive representations, the hippocampus, and contextual fear conditioning
RUDY, J. W., & O'REILLY, R. C. (2001) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.1.1.66 · Cited by 247
Self-citationKiernan, M. J., & Westbrook, R. F. (1993) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640749308401089 · Cited by 132 · cited 1×
“In fact, if the rat is not pre-exposed to the context, immediate shock will produce almost no conditioning (Fanselow, 1990; Kiernan and Westbrook, 1993).”
Background
Cited by
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547
Levin, R., & Nielsen, T. A. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.3.482 · Cited by 554
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429
The hippocampal indexing theory and episodic memory: Updating the index
Teyler, T. J., & Rudy, J. W. (2007) · Hippocampus · doi:10.1002/hipo.20350 · Cited by 373
Self-citationRoozendaal, B., Hahn, E. L., Nathan, S. V., de Quervain, D. J.-F., & McGaugh, J. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2574-04.2004 · Cited by 301
Context representations, context functions, and the parahippocampal–hippocampal system
Rudy, J. W. (2009) · Learning & Memory · doi:10.1101/lm.1494409 · Cited by 296
Self-citationLocus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context
Wagatsuma, A., Okuyama, T., Sun, C., Smith, L. M., Abe, K., & Tonegawa, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714082115 · Cited by 283
Knapska, E., & Maren, S. (2009) · Learning & Memory · doi:10.1101/lm.1463909 · Cited by 264
McGaugh, J. L. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-014954 · Cited by 271
Bilbo, S. D., Biedenkapp, J. C., Der-Avakian, A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1748-05.2005 · Cited by 251
“First, each stage of the procedure critically depends on the hippocampus, and the hippocampus may be particularly vulnerable to immune-related alterations (Barrientos et al., 2002; Rudy et al., 2002; Matus-Amat et al., 2004).”
BackgroundBarrett, R. M., Malvaez, M., Kramar, E., Matheos, D. P., Arrizon, A., Cabrera, S. M., Lynch, G., Greene, R. W., & Wood, M. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.61 · Cited by 243
From contextual fear to a dynamic view of memory systems
Fanselow, M. S. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.10.008 · Cited by 227
BERLAU, D., & MCGAUGH, J. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.12.008 · Cited by 220
Gafford, G. M., Parsons, R. G., & Helmstetter, F. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.023 · Cited by 110
Bilbo, S. D., Newsum, N. J., Sprunger, D. B., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.005 · Cited by 88
Self-citationZhao, Y., Fung, C., Shin, D., Shin, B.-C., Thamotharan, S., Sankar, R., Ehninger, D., Silva, A., & Devaskar, S. U. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.51 · Cited by 88
Williamson, L. L., McKenney, E. A., Holzknecht, Z. E., Belliveau, C., Rawls, J. F., Poulton, S., Parker, W., & Bilbo, S. D. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.006 · Cited by 84
Separating subjective emotion from the perception of emotion-inducing stimuli: An fMRI study
Garrett, A. S., & Maddock, R. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.024 · Cited by 82
Fear conditioning increases NREM sleep.
Hellman, K., & Abel, T. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.310 · Cited by 62
Design of a Neurally Plausible Model of Fear Learning
Krasne, F. B., Fanselow, M. S., & Zelikowsky, M. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00041 · Cited by 51
Sauerhöfer, E., Pamplona, F. A., Bedenk, B., Moll, G. H., Dawirs, R. R., von Hörsten, S., Wotjak, C. T., & Golub, Y. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.016 · Cited by 46
Metadata
- Authors
- Matus-Amat, P., Higgins, E. A., Barrientos, R. M., & Rudy, J. W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-03-10
- Volume
- 24
- Issue
- 10
- Pages
- 2431-2439
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2033606943
- Cited by
- 349
- References
- 9
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
