The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus In Vitro
Open accessAbstract
This study evaluated the effects of acute psychological stress (cat exposure) in adult male rats on electrophysiological plasticity subsequently assessed in the hippocampus in vitro. Two physiological models of memory were studied in CA1 in each recording session: (1) primed burst potentiation (PBP), a low-threshold form of plasticity produced by a total of five physiologically patterned pulses; and (2) long-term potentiation (LTP), a suprathreshold form of plasticity produced by a train of 100 pulses. Three groups of rats were studied: (1) undisturbed rats in their home cage (home cage); (2) rats placed in a chamber for 75 min (chamber); and (3) rats placed in a chamber for 75 min in close proximity to a cat (chamber/stress). At the end of the chamber exposure period, blood samples were obtained, and the hippocampus was prepared for in vitro recordings. Only the chamber/stress group had elevated (stress) levels of corticosterone. The major finding was that PBP, but not LTP, was blocked in the chamber/stress group. Thus, the psychological stress experienced by the rats in response to cat exposure resulted in an inhibition of plasticity, which was localized to the intrinsic circuitry of the hippocampus. This work provides novel observations on the effects of an ethologically relevant stressor on PBP in vitro and of the relative insensitivity of LTP to being modulated by psychological stress. We discuss the relevance of these electrophysiological findings to our behavioral work showing that predator stress impairs spatial memory.
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“Moreover, in electrophysiological studies, stress or stress-related neuromodulators have been shown to block LTP produced by relatively weak (primed burst or theta burst) tetanizing stimulation, but stress has been shown to have no effect on LTP produced by stronger forms of tetanizing stimulation (Corradetti et al. [283]; Mesches et al. [51]; Diamond et al. [139]; Alfarez et al. [152]; Vouimba et”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Mesches et al. [51]
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“and blocked the induction of PB potentiation in vivo (Diamond et al. [139]; Vouimba et al. [140]) and in vitro (Mesches et al. [51]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Mesches et al. [51]
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“animal studies have shown that stress exposure can lead to a suppression of synaptic and structural plasticity underlying information storage in the hippocampus (Mesches et al. 1999;Diamond et al. 2005).”
From Stress administered prior to encoding impairs neutral but enhances emotional long-term episodic memories. (2007) · cites this paper as Mesches et al. 1999
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Cites
Stress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182 · cited 3×
“…learning and memory are impaired by acute and chronic stress in rats (Luine et al., 1994; Bodnoff et al., 1995; Conrad et al., 1996; Diamond et al., 1996b; Healy and Drugan, 1996; Krugers et al., 1997; de Quervain et al., 1998) and in people (Kirschbaum et al., 1996; Lupien et al., 1997).”
BackgroundThe acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024
Kirschbaum, C., Wolf, O. T., May, M., Wippich, W., & Hellhammer, D. H. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00118-x · Cited by 815
Repeated stress causes reversible impairments of spatial memory performance.
Luine, V., Villegas, M., Martinez, C., & McEwen, B. (1994) · Brain Research · doi:10.1016/0006-8993(94)91778-7 · Cited by 813
Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1321 · Cited by 805
Diamond, D. M., Bennett, M. C., Fleshner, M., & Rose, G. M. (1992) · Hippocampus · doi:10.1002/hipo.450020409 · Cited by 688
Self-citationBodnoff, S., Humphreys, A., Lehman, J., Diamond, D. M., Rose, G., & Meaney, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00061.1995 · Cited by 529
Self-citationBehavioural stress facilitates the induction of long-term depression in the hippocampus
Xu, L., Anwyl, R., & Rowan, M. J. (1997) · Nature · doi:10.1038/387497a0 · Cited by 521
Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus
Shors, T. J., Seib, T. B., Levine, S., & Thompson, R. F. (1989) · Science · doi:10.1126/science.2704997 · Cited by 458
Glucocorticoid-induced impairment in declarative memory performance in adult humans
Newcomer, J., Craft, S., Hershey, T., Askins, K., & Bardgett, M. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02047.1994 · Cited by 441
Research works printed but not linked: 2
- Diamond DM, Park CR, Heman K L, Rose GM (1999b) Exposure to a predator impairs spatial working memory in the radial arm water maze. Hippocampus, in press.
- Mesches M H, Rose GM, Fleshner M, Heman K L, Diamond DM (1998) E xposing rats to a predator blocks hippocampal primed burst potenti- ation in vitro. Proceedings of the 27th Annual Meeting of the Society for Neuroscience, pp 1420 -1420. Washington, DC: Society for Neuroscience.
Cited by
Sorted by citations
Morris water maze: procedures for assessing spatial and related forms of learning and memory
Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Self-citationBiological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529
Time zones: a comparative genetics of circadian clocks
Young, M. W., & Kay, S. A. (2001) · Nature Reviews Genetics · doi:10.1038/35088576 · Cited by 1,159
Metadata
- Authors
- Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M.
- Affiliations
- University of Colorado Health (US)
- University of Colorado Boulder (US)
- United States Department of Veterans Affairs (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-07-15
- Volume
- 19
- Issue
- 14
- Pages
- RC18-RC18
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6783102
- OpenAlex
- W1599181452
- Cited by
- 276
- References
- 48
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 9 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Funders
- Office of Naval Research (N00014)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- predator stress, cat exposure, long-term potentiation, hippocampal plasticity, CA1, corticosterone, acute psychological stress, spatial memory
- MeSH terms
- Action Potentials, Animals, Cats, Corticosterone, Fear, Hippocampus, Male, Memory, Stress, Psychological, Rats, Sprague-Dawley, Long-Term Potentiation, Rats
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