The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats
Open accessAbstract
NMDA receptor antagonists block conditioned fear extinction when injected systemically and also when infused directly into the amygdala. Here we evaluate the ability of d-cycloserine (DCS), a partial agonist at the strychnine-insensitive glycine-recognition site on the NMDA receptor complex, to facilitate conditioned fear extinction after systemic administration or intra-amygdala infusions. Rats received 10 pairings of a 3.7 sec light and a 0.4 mA footshock (fear conditioning). Fear-potentiated startle (increased startle in the presence vs the absence of the light) was subsequently measured before and after 30, 60, or 90 presentations of the light without shock (extinction training). Thirty non-reinforced light presentations produced modest extinction, and 60 or 90 presentations produced nearly complete extinction (experiment 1). DCS injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhanced extinction (experiment 2) but did not influence fear-potentiated startle in rats that did not receive extinction training (experiment 3). These effects were blocked by HA-966, an antagonist at the glycine-recognition site (experiment 4). Neither DCS nor HA-966 altered fear-potentiated startle when injected before testing (experiment 5). The effect of systemic administration was mimicked by intra-amygdala DCS (10 μg/side) infusions (experiment 6). These results indicate that treatments that promote NMDA receptor activity after either systemic or intra-amygdala administration promote the extinction of conditioned fear.
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“Walker et al. (64) found that d-cycloserine (DCS), an NMDA receptor partial agonist, facilitated extinction learning in rats; a finding that was later replicated by several other groups employing multiple types of fear learning paradigms in rodents [e.g., Ref. (65)] but not replicated using skin conductance and expectancy ratings in humans (66).”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [64]
In the citing paper
“Preclinical research has demonstrated that DCS facilitates extinction learning and memory in rodent models (Davis et al, 2006; Ledgerwood et al, 2003; Walker et al, 2002).”
From D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial (2014) · cites this paper as Walker et al, 2002
In the citing paper
“We chose weekly dosing, administered 90 min before exposure sessions, as this regimen has been effective in multiple animal and human fear extinction studies (Ledgerwood et al, 2003; Ressler et al, 2004; Walker et al, 2002)”
From D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial (2014) · cites this paper as Walker et al, 2002
In the citing paper
“administration of D-cycloserine (DCS), a partial agonist of the NMDA receptor involved in long-term potentiation (a cellular model of learning), facilitates extinction (e.g., Walker, Ressler, Lu, & Davis, 2002; Ledgerwood, Richardson, & Cranney, 2003).”
From D-cycloserine facilitates context-specific fear extinction learning (2008) · cites this paper as Walker, Ressler, Lu, & Davis, 2002
In the citing paper
“The DCS dose (15 mg/kg per rat) was chosen on the basis of the results of other behavioral studies (Ledgerwood et al, 2003(Ledgerwood et al, , 2005;;Walker et al, 2002).”
From Effects of Single Prolonged Stress and D-Cycloserine on Contextual Fear Extinction and Hippocampal NMDA Receptor Expression in a Rat Model of PTSD (2008) · cites this paper as Walker et al, 2002
In the citing paper
“Our results are generally in agreement with the results of Walker et al (2002) and Ledgerwood et al (2003), in which DCS systemic administration enhanced the extinction of conditioned fear.”
From Effects of Single Prolonged Stress and D-Cycloserine on Contextual Fear Extinction and Hippocampal NMDA Receptor Expression in a Rat Model of PTSD (2008) · cites this paper as Walker et al (2002)
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Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,514
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,878
A modern learning theory perspective on the etiology of panic disorder.
Bouton, M. E., Mineka, S., & Barlow, D. H. (2001) · Psychological Review · doi:10.1037/0033-295x.108.1.4 · Cited by 1,017
Neuroanatomical Hypothesis of Panic Disorder, Revised
Gorman, J. M., KENT, J. M., Sullivan, G. M., & Coplan, J. D. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.493 · Cited by 998
Why We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala
Fanselow, M. S., & LeDoux, J. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80775-8 · Cited by 933
From normal fear to pathological anxiety.
Rosen, J. B., & Schulkin, J. A. (1998) · Psychological Review · doi:10.1037/0033-295x.105.2.325 · Cited by 914
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824
Self-citationSchafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08177.2000 · Cited by 678
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673
Self-citation
Research works printed but not linked: 2
- Falls WA Davis M (1995) Behavioral and physiological analysis of fear inhibition. in Neurobiological and clinical consequences of stress: from normal adaptation to PTSD, eds Friedman MJ Charney DS Deutch AY (Lippincott-Raven, Philadelphia), pp 177–202.
- Pavlov IP (1927) Conditioned reflexes. (Oxford UP, Oxford).
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“administration of DCS before or after extinction learning results in better extinction memory recall when tested 24 h later (Richardson et al., 2004; Walker et al., 2002).”
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“DCS is an NMDA partial agonist that has been shown to enhance fear extinction learning in both animals and humans [51-53].”
Background
Metadata
- Authors
- Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M.
- Affiliations
- Emory University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-03-15
- Volume
- 22
- Issue
- 6
- Pages
- 2343-2351
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758267
- OpenAlex
- W1946000001
- Cited by
- 815
- References
- 58
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 8 · 2023: 18 · 2022: 18 · 2021: 22 · 2020: 15 · 2019: 28 · 2018: 29 · 2017: 37 · 2016: 23 · 2015: 47 · 2014: 48 · 2013: 53 · 2012: 54
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9876754)
- Woodruff Foundation
- Pfizer
- National Institute of Mental Health (MH59906, MH-57250, R01MH057250, P50MH052384, R01MH059906, P50MH058922, MH58922, MH 47840, MH-52384, R37MH047840, R01MH047840)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- D-cycloserine, fear-potentiated startle, NMDA receptor, glycine site, HA-966, amygdala, fear conditioning, footshock, strychnine-insensitive glycine receptor, NMDA receptor antagonists
- MeSH terms
- Acoustic Stimulation, Amygdala, Animals, Behavior, Animal, Catheterization, Conditioning, Classical, Cycloserine, Dose-Response Relationship, Drug, Electroshock, Extinction, Psychological, Fear, Infusions, Parenteral, Male, Photic Stimulation, Pyrrolidinones, Reflex, Startle, Stereoisomerism, Rats, Sprague-Dawley, Excitatory Amino Acid Agonists, Rats
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