Lost in translation: How to upgrade fear memory research
Abstract
We address some of the current limitations of translational research in fear memory and suggest alternatives that might help to overcome them. Appropriate fear responses are adaptive, but disruption of healthy fear memory circuits can lead to anxiety and fear-based disorders. Stress is one of the main environmental factors that can disrupt memory circuits and constitutes as a key factor in the etiopathology of these psychiatric conditions. Current therapies for anxiety and fear-based disorders have limited success rate, revealing a clear need for an improved understanding of their neurobiological basis. Although animal models are excellent for dissecting fear memory circuits and have driven tremendous advances in the field, translation of these findings into the clinic has been limited so far. Animal models of stress-induced pathological fear combined with powerful cutting-edge techniques would help to improve the translational value of preclinical studies. We also encourage combining animal and human research, including psychiatric patients in order to find new pharmacological targets with real therapeutic potential that will improve the extrapolation of the findings. Finally, we highlight novel neuroimaging approaches that improve our understanding of anxiety and fear-based disorders.
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There are important constraints in translation from animal models to humans such as uniqueness of human endophenotypes, cognitive traits, processes and brain structures.
“However, there are important constraints in this translation such as the uniqueness of human endophenotypes, cognitive traits, processes and brain structures that have been highlighted in various reviews [see e.g.: (Andrews, Papakosta, & Barnes, 2014;Cryan & Sweeney, 2011;Flores et al., 2018;Freudenberg, O'Leary, Aguiar, & Slattery, 2018;Haller, Aliczki, & Gyimesine Pelczer, 2013;Harro, 2018;Ste”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Flores et al., 2018
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Self-citationReviewer #2 (Public Review): Network-Level Changes in the Brain Underlie Fear Memory Strength
Haubrich, J., & Nader, K. (2023) · eLife · doi:10.7554/elife.88172.2.sa0
Author Response: Network-Level Changes in the Brain Underlie Fear Memory Strength
Haubrich, J., & Nader, K. (2023) · eLife · doi:10.7554/elife.88172.2.sa3
eLife Assessment: Network-Level Changes in the Brain Underlie Fear Memory Strength
Iordanova, M. D. (2023) · eLife · doi:10.7554/elife.88172.2.sa2
Network-Level Changes in the Brain Underlie Fear Memory StrengthPreprint
Haubrich, J., & Nader, K. (2023) · eLife · doi:10.7554/elife.88172.2
Reviewer #1 (Public Review): Network-Level Changes in the Brain Underlie Fear Memory Strength
Haubrich, J., & Nader, K. (2023) · eLife · doi:10.7554/elife.88172.2.sa1
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- Authors
- Flores, Á., Fullana, M. À., Soriano-Mas, C., & Andero, R.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Andero, Raül
- Venue
- Molecular Psychiatry
- Published
- 2018-01-03
- Volume
- 23
- Issue
- 11
- Pages
- 2122-2132
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2781845107
- Cited by
- 59
- References
- 105
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 3 · 2023: 15 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 1
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- fear memory, translational research, anxiety disorders, stress, therapeutic target, neuroimaging
- MeSH terms
- Animals, Anxiety, Anxiety Disorders, Extinction, Psychological, Fear, Humans, Memory, Stress, Psychological, Models, Animal, Translational Research, Biomedical
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