Reduction of Stress-Induced Behavior by Antagonism of Corticotropin-Releasing Hormone 2 (CRH2) Receptors in Lateral Septum or CRH1Receptors in Amygdala
Open accessAbstract
Although corticotropin-releasing hormone (CRH), a regulator of stress responses, acts through two receptors (CRH1 and CRH2), the role of CRH2 in stress responses remains unclear. Knock-out mice without the CRH2 gene exhibit increased stress-like behaviors. This profile could result either directly from the absence of CRH2 receptors or indirectly from developmental adaptations. In the present study, CRH2 receptors were acutely blocked by alpha-helical CRH (alpha(h)CRH, CRH1/CRH2 antagonist; 0, 30, 100, and 300 ng) infusion into the lateral septum (LS), which abundantly expresses CRH2 but not CRH1 receptors. Freezing, locomotor activity, and analgesia were tested after infusion. Intra-LS alpha(h)CRH blocked shock-induced freezing without affecting activity or pain responses; infusions into lateral ventricle or nucleus of the diagonal band had no effects. The same behavioral profile was obtained with d-Phe-CRH((12-41)) (100 ng), another CRH1/CRH2 antagonist. A selective CRH1 antagonist (NBI27914), in doses that reduced freezing on intra-amygdala (central nucleus) infusion (0, 0.2, and 1.0 microg), did not affect freezing when infused into the LS. Ex vivo autoradiography revealed that binding of [125I]sauvagine, a mixed CRH1/CRH2 agonist, was prevented in the LS by previous intra-LS infusion of alpha(h)CRH but not NBI27914. In vitro studies demonstrated that [125I]sauvagine binding in the LS could be inhibited by a CRH1/CRH2 antagonist but not by the selective CRH1 receptor antagonist, confirming that in the LS, alpha(h)CRH antagonized exclusively CRH2 receptors. Acute antagonism of CRH2 receptors in the LS thus produces a behaviorally, anatomically, and pharmacologically specific reduction in stress-induced behavior, in contrast to results of recent knock-out studies, which induced congenital and permanent CRH2 removal. CRH2 receptors may thus represent a potential target for the development of novel CRH system anxiolytics.
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LS injections of agonists of the type 2 corticotropin-releasing factor receptor (Crfr2) have resulted in increased anxiety.
“For example, LS injections of agonists of the type 2 corticotropin-releasing factor receptor (Crfr2) have resulted in increased anxiety (Radulovic et al., 1999; Bakshi et al., 2002; Henry et al., 2006).”
From Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit (2014) · cites this paper as Bakshi et al., 2002
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Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501 · see citing works
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953 · see citing works
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485 · see citing works
Chalmers, D., Lovenberg, T. W., & Souza, E. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06340.1995 · Cited by 925 · see citing works
Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121165198 · Cited by 925 · see citing works
Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics · doi:10.1038/520 · Cited by 919 · see citing works
Smith, G. W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80491-2 · Cited by 892 · see citing works
Reyes, T. M., Lewis, K., Perrin, M. H., Kunitake, K. S., Vaughan, J., Arias, C. A., Hogenesch, J. B., Gulyas, J., Rivier, J., Vale, W. W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051626398 · Cited by 887 · see citing works
Functional characteristics of the midbrain periaqueductal gray.
Behbehani, M. M. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00009-k · Cited by 879 · see citing works
Bale, T. L., Contarino, A., Smith, G. W., Chan, R. K. W., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. (2000) · Nature Genetics · doi:10.1038/74263 · Cited by 850 · see citing works
Zobel, A. W., Nickel, T., Künzel, H. E., Ackl, N., Sonntag, A., Ising, M., & Holsboer, F. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00016-9 · Cited by 705 · see citing works
Connections of the rat lateral septal complex 1Published on the World Wide Web on 2 June 1997. 1
Risold, P. Y., & Swanson, L. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00009-x · Cited by 671 · see citing works
Hsu, S. Y., & Hsueh, A. J. W. (2001) · Nature Medicine · doi:10.1038/87936 · Cited by 651 · see citing works
Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S., Hill, J. K., Pantely, G. A., Hohimer, A. R., et al. (2000) · Nature Genetics · doi:10.1038/74255 · Cited by 588 · see citing works
Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide
Spina, M. G., Merlo‐Pich, E., Chan, R. K. W., Basso, A. M., Rivier, J., Vale, W., & Koob, G. F. (1996) · Science · doi:10.1126/science.273.5281.1561 · Cited by 564 · see citing works
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
Koob, G. F., & Heinrichs, S. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01991-5 · Cited by 530 · see citing works
Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
Kishimoto, T., Radulović, J., Radulović, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G., & Spiess, J. (2000) · Nature Genetics · doi:10.1038/74271 · Cited by 502 · see citing works
Rizvi, T. A., Ennis, M., Behbehani, M. M., & Shipley, M. T. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903030111 · Cited by 500 · see citing works
Corticotropin Releasing Factor Receptors and Their Ligand Family
Perrin, M. H., & Vale, W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08687.x · Cited by 431 · see citing works
Rassnick, S., Heinrichs, S. C., Britton, K. T., & Koob, G. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91352-s · Cited by 407 · see citing works
Habib, K. E., Weld, K. P., Rice, K. C., Pushkas, J., Champoux, M., Listwak, S. J., WEBSTER, E. L., Atkinson, A. J., Schulkin, J. A., Contoreggi, C. S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6079 · Cited by 404 · see citing works
Radulovic, J., Rühmann, A., Liepold, T., & Spiess, J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05016.1999 · Cited by 402 · see citing works
Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals.
Graeff, F. G. (1994) · PubMed · Cited by 337 · see citing works
Heinrichs, S. C., Pich, E. M., Miczek, K. A., Britton, K. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)90708-h · Cited by 329 · see citing works
DAVIS, M., & SHI, C. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09273.x · Cited by 328 · see citing works
Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior
Heinrichs, S. C., Lapsansky, J., Lovenberg, T. W., Souza, E. B. D., & Chalmers, D. T. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(97)01005-7 · Cited by 235 · see citing works
Contarino, A., Dellu-Hagedorn, F., Koob, G. F., Smith, G. W., Lee, K., Vale, W., & Gold, L. H. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01158-5 · Cited by 228 · see citing works
Swiergiel, A. H., Takahashi, L. K., & Kalin, N. H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91432-r · Cited by 199 · see citing works
Self-citationLiebsch, G., Landgraf, R., Engelmann, M., Lörscher, P., & Holsboer, F. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)80047-2 · Cited by 191 · see citing works
Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior
Picciotto, M. R., & Wickman, K. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1131 · Cited by 185 · see citing works
Bandler, R. J., Depaulis, A., & Vergnes, M. (1985) · Behavioural Brain Research · doi:10.1016/0166-4328(85)90058-0 · Cited by 181 · see citing works
Characterization of a novel and potent corticotropin-releasing factor antagonist in rats.
Menzaghi, F., Howard, R. L., Heinrichs, S. C., Vale, W., Rivier, J., & Koob, G. F. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38740-9 · Cited by 181 · see citing works
Urocortin, a novel neuropeptide with anxiogenic-like properties
Moreau, J., Kilpatrick, G. J., & Jenck, F. (1997) · Neuroreport · doi:10.1097/00001756-199705060-00027 · Cited by 170 · see citing works
Rühmann, A., Bonk, I., Lin, C. R., Rosenfeld, M. G., & Spiess, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15264 · Cited by 170 · see citing works
Autoradiographic Localization of CRF1 and CRF2 Binding Sites in Adult Rat Brain
Primus, R. J. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00071-7 · Cited by 159 · see citing works
Okuyama, S., Chaki, S., Kawashima, N., Suzuki, Y., Ogawa, S., Nakazato, A., Kumagai, T., Okubo, T., & Tomisawa, K. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38220-5 · Cited by 152 · see citing works
Chen, Dagnino, R., Souza, E. B. D., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm960149e · Cited by 137 · see citing works
Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety
Takahashi, L. K., Ho, S. P., Livanov, V., Graciani, N., & Arneric, S. P. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02405-2 · Cited by 132 · see citing works
Antagonism of endogenous CRH systems attenuates stress-induced freezing behavior in rats.
Kalin, N., Sherman, J. E., & Takahashi, L. (1988) · Brain Research · doi:10.1016/0006-8993(88)90064-9 · Cited by 125 · see citing works
Self-citationAlbert, D., & Walsh, M. (1984) · Neuroscience and Biobehavioral Reviews · doi:10.1016/0149-7634(84)90017-4 · Cited by 124 · see citing works
Gingrich, J. A., & Hen, R. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00061-6 · Cited by 123 · see citing works
McCarthy, J. R., Heinrichs, S. C., & Grigoriadis, D. E. (1999) · Current Pharmaceutical Design · doi:10.2174/138161280505230110095255 · Cited by 120 · see citing works
Self-citationSkelton, K. H., Nemeroff, C. B., Knight, D. L., & Owens, M. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01240.2000 · Cited by 119 · see citing works
The behavioural effects of corticotropin-releasing factor-related peptides in rats
Jones, D. N. C., Kortekaas, R., Slade, P. D., Middlemiss, D. N., & Hagan, J. J. (1998) · Psychopharmacology · doi:10.1007/s002130050654 · Cited by 115 · see citing works
The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review
Mitchell, A. J. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00059-6 · Cited by 115 · see citing works
Glazner, G. W., Mu, X., & Springer, J. E. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980202)391:1 · Cited by 110 · see citing works
Urocortin, Corticotropin Releasing Factor-2 Receptors and Energy Balance
Cullen, M. J., Ling, N., Foster, A. C., & Pelleymounter, M. A. (2001) · Endocrinology · doi:10.1210/endo.142.3.7989 · Cited by 100 · see citing works
Electrophysiological actions of corticotropin-releasing factor in the central nervous system.
Siggins, G. R., Gruol, D. L., Aldenhoff, J. B., & Pittman, Q. J. (1985) · PubMed · Cited by 100 · see citing works
The inhibitory modulation of agonistic behavior in the rat brain: A review
Albert, D. J., & Walsh, M. L. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90051-3 · Cited by 96 · see citing works
Swiergiel, A. H., Takahashi, L. K., Rubin, W. W., & Kalin, N. H. (1992) · Brain Research · doi:10.1016/0006-8993(92)91006-z · Cited by 74 · see citing works
Self-citationHigelin, J., Py-Lang, G., Paternoster, C., et al. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00105-2 · Cited by 68 · see citing works
Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors
Simonato, M., Manservigi, R., Marconi, P., & Glorioso, J. C. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01539-8 · Cited by 64 · see citing works
Chan, R. K. W., Vale, W. W., & Sawchenko, P. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00322-5 · Cited by 63 · see citing works
Corticotropin releasing factor‐containing afferents to the lateral septum of the rat brain
Sakanaka, M., Magari, S., Shibasaki, T., & Lederis, K. P. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902700309 · Cited by 43 · see citing works
GABAergic organization of the cat medial geniculate body
Huang, C. L., Larue, D. T., & Winer, J. A. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991220)415:3 · Cited by 39 · see citing works
Inducible Knockout Strategies to Probe the Functions of 5‐HT Receptorsa
Stark, K. L., Oosting, R. S., & Hen, R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10173.x · Cited by 11 · see citing works
McCarthy, J. R., Heinrichs, S. C., & Grigoriadis, D. E. (1999) · ChemInform · doi:10.1002/chin.199929277 · Cited by 7 · see citing works
Self-citationCorticotropin-releasing factor injected into the lateral septum improves memory function in rats.
Lee, E. H. Y. (1995) · PubMed · Cited by 7 · see citing works
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- Bakshi VP, Kalin NH (2002) Animal models and endophenotypes of anxiety and stress disorders. In: Neuropsychopharmacology: the 5th generation of progress (Davis KL, Charney D, Coyle JT, Nemeroff C, eds), pp 883-900. New York: Lippincott Williams & Wilkins.
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Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
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Anthony, T. E., Dee, N., Bernard, A., Lerchner, W., Heintz, N., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2013.12.040 · Cited by 310 · see citing works
Bosch, O. J., Nair, H. P., Ahern, T. H., Neumann, I. D., & Young, L. J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.154 · Cited by 216 · see citing works
Sahuque, L. L., Kullberg, E. F., Mcgeehan, A. J., Kinder, J. R., Hicks, M. P., Blanton, M. G., Janak, P. H., & Olive, M. F. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0362-y · Cited by 207 · see citing works
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Henry, B., Vale, W., & Markou, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1494-06.2006 · Cited by 147 · see citing works
Ladd, C. O., Thrivikraman, K. V., Huot, R. L., & Plotsky, P. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.12.004 · Cited by 145 · see citing works
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Lim, M. M., Nair, H. P., & Young, L. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20532 · Cited by 95 · see citing works
Deussing, J. M., Breu, J., Kuhne, C., Kallnik, M., Bunck, M., Glasl, L., Yen, Y.-C., Schmidt, M. V., Zurmuhlen, R., Vogl, A. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1049-10.2010 · Cited by 86 · see citing works
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Liu, X., Wellman, L. L., Yang, L., Ambrozewicz, M. A., Tang, X., & Sanford, L. D. (2011) · Sleep · doi:10.5665/sleep.1394 · Cited by 35 · see citing works
- Authors
- Bakshi, V. P., Smith-Roe, S., Newman, S. M., Grigoriadis, D. E., & Kalin, N. H.
- Affiliations
- University of Wisconsin–Madison (US)
- Neurocrine Biosciences (United States) (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-04-01
- Volume
- 22
- Issue
- 7
- Pages
- 2926-2935
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758335
- OpenAlex
- W1659705459
- Cited by
- 171
- References
- 61
- Citations by year
- 2025: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f32mh012360-01)
- National Institute of Mental Health (R01MH040855)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- lateral septum, amygdala, stress response, freezing behavior, analgesia, locomotor activity
- MeSH terms
- CRF Receptor, Type 1, Amygdala, Animals, Autoradiography, Behavior, Animal, Binding, Competitive, Corticotropin-Releasing Hormone, Drug Administration Routes, Hormone Antagonists, Male, Motor Activity, Pain Measurement, Peptides, Stress, Physiological, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Septum of Brain, Amphibian Proteins, Peptide Hormones, Rats
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