The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Chronic Stress Induces Contrasting Patterns of Dendritic Remodeling in Hippocampal and Amygdaloid Neurons
Open accessAbstract
The hippocampus and the amygdala are essential components of the neural circuitry mediating stress responses. The hippocampus, which provides negative feedback regulation of the stress response, is particularly vulnerable to degenerative changes caused by chronic stress. Unlike the hippocampus, relatively little is known about how stress affects the amygdala and the nature of its role in the stress response. Hence, we examined the effects of two different models of chronic stress on hippocampal and amygdaloid neuronal morphology in rats. In agreement with previous reports, chronic immobilization stress (CIS) induced dendritic atrophy and debranching in CA3 pyramidal neurons of the hippocampus. In striking contrast, pyramidal and stellate neurons in the basolateral complex of the amygdala exhibited enhanced dendritic arborization in response to the same CIS. Chronic unpredictable stress (CUS), however, had little effect on CA3 pyramidal neurons and induced atrophy only in BLA bipolar neurons. These results indicate that chronic stress can cause contrasting patterns of dendritic remodeling in neurons of the amygdala and hippocampus. Moreover, CIS, but not CUS, reduced open-arm activity in the elevated plus-maze. These findings raise the possibility that certain forms of chronic stress, by affecting specific neuronal elements in the amygdala, may lead to behavioral manifestations of enhanced emotionality. Thus, stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In the basolateral amygdala (BLA) chronic unpredictable stress also produced dendritic atrophy but chronic immobilization stress instead increased dendritic branching (Banasr and Duman, 2007;Vyas et al, 2002Vyas et al, , 2003)).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Vyas et al, 2002
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In animals, chronic stress results in the prolonged release of glucocorticoids and leads to hypertrophy of the amygdala and nucleus accumbens, atrophy of the hippocampus and prefrontal cortex (PFC), and functional impairment of the PFC (44–55).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [47]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“enhanced BDNF/TrkB signaling in the amygdala leads to maladaptive plasticity resulting in overactivation of this brain region and exacerbated anxiety and fear responses (47, 198–200)”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [47]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“By contrast to the PFC and hippocampus, dendrites in the amygdala expand in response to chronic stress exposure112.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [112]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In contrast to the PFC, chronic stress exposure increases dendritic growth in the amygdala77, thus accentuating the imbalance of amygdala over PFC function.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [77]
Experimental — accuracy not yet measured
The cited source says what the claim attributes to it.
In the citing paper
“In the basolateral amygdala (BLA) chronic unpredictable stress also produced dendritic atrophy but chronic immobilization stress instead increased dendritic branching (Banasr and Duman, 2007;Vyas et al, 2002Vyas et al, , 2003)).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Vyas et al, 2002
The cited source says what the claim attributes to it.
In the citing paper
“The authors revealed that chronic immobilisation stress in rats resulted in significant dendritic atrophy of apical and basal dendrites of CA3 pyramidal neurons, with a more pronounced loss in apical dendrites.”
From Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus—A Mini Review (2025) · cites this paper as [95]
The cited source says what the claim attributes to it.
In the citing paper
“Animal studies revealed that chronic stress causes atrophy of apical dendrites of pyramidal neurons in the CA3 region of the hippocampus (Magarinos et al. 1996; Vyas et al. 2002; Watanabe et al. 1992).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Vyas et al. 2002
The cited source says what the claim attributes to it.
In the citing paper
“This view is supported by recent evidence that individual brain regions are affected by stress in very different ways.”
From Episodic memory, perceptual memory, and their interaction: Foundations for a theory of posttraumatic stress disorder. (2014) · cites this paper as Vyas, Mitra, Rao, & Chattarji, 2002
The cited source says what the claim attributes to it.
In the citing paper
“a study of neuronal morphology showed that the same stress experience produced dendritic atrophy and debranching in the hippocampus at the same time as producing enhanced dendritic arborization in the amygdala”
From Episodic memory, perceptual memory, and their interaction: Foundations for a theory of posttraumatic stress disorder. (2014) · cites this paper as Vyas, Mitra, Rao, & Chattarji, 2002
In the citing paper
“In rodents, repeated stress results in dendritic atrophy and reduced glial cell counts in hippocampal regions (McEwen and Magarinos, 2001) as well as increased dendritic branching in the basolateral amygdala (Vyas et al., 2002).”
From Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk (2012) · cites this paper as Vyas et al., 2002
In the citing paper
“Specifically, studies of rodents show that stress increases dendritic arborization and spine density of the amygdala, with concomitant increases in anxiety-like behaviors (Vyas et al., 2002; Vyas et al., 2003, Mitra et al., 2005).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Vyas et al., 2002
In the citing paper
“In contrast, stress-induced amygdala morphology and volume changes seem to persist (Vyas et al., 2002, Adamec et al., 2005, Tottenham et al., 2010).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Vyas et al., 2002
In the citing paper
“By contrast, stress results in atrophy of the hippocampus and medial PFC (mPFC) (Magariños et al., 1997, Vyas et al., 2002, Radley et al., 2006).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Vyas et al., 2002
In the citing paper
“Neuronal and synaptic remodeling in BLA PNs, along with enhanced glutamatergic transmission, has been repeatedly associated with the negative consequence of stress (14,33,34,40), and prevention of these changes is paralleled by a protection against stress-induced increases in anxiety-like behavior (26,41).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [14]
In the citing paper
“Repeated stress causes dendritic shortening in medial prefrontal cortex (Sousa et al., 2000; Wellman, 2001; Vyas et al., 2002; Kreibich and Blendy, 2004; Cook and Wellman, 2004; Radley et al., 2004; Brown et al., 2005; Radley et al., 2005)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Vyas et al., 2002
In the citing paper
“but produces dendritic growth in neurons in amygdala (Vyas et al., 2002)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Vyas et al., 2002
In the citing paper
“both acute and chronic stress also increases spine synapse formation in amygdala (Vyas et al., 2002)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Vyas et al., 2002
In the citing paper
“Acute stress induces spine synapses in the CA1 region of hippocampus98 and both acute and chronic stress also increases spine synapse formation in amygdala,95-99 but chronic stress decreases it in hippocampus.77”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [95]
In the citing paper
“Repeated stress causes dendritic shortening in medial prefrontal cortex.89-95 but produces dendritic growth in neurons in amygdala,95 as well as in orbitofrontal cortex.96”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [95]
In the citing paper
“Behavioral correlates of remodeling in the prefrontal cortex include impairment in attention set shifting, possibly reflecting structural remodeling in the medial prefrontal cortex.95”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [95]
In the citing paper
“Additionally, multiple studies have found that chronic stress results in an increase in dendritic arborization and spinogenesis on BLA pyramidal neurons, increasing their intrinsic excitability and afferent stimulation in a manner that correlates with heightened anxiety-like behavior [70–72].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [70]
In the citing paper
“Acute traumatic stressors were found to cause increased spine density on basolateral amygdale (BlA) neurons and chronic stress leads to the expansion of BlA dendrites.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [18]
In the citing paper
“Chronic stress causes dendritic shrinkage not only in CA3 and dentate gyrus neurons of hippocampus but also in medial amygdala and mPFC, while dendrites in BlA and orbitofrontal cortex expand with chronic stress.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351
Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00162-x · Cited by 1,283
Research works printed but not linked: 1
- [28]28. McDonald AJ (1992) Cell types and intrinsic connections of the amyg- dala. In: The amygdala (Aggleton JP, ed), pp 67-96. New York: Wiley.
Cited by
Sorted by citations
Items 401–500 of 1,000
O'Sullivan, E., Barrett, E., Grenham, S., Fitzgerald, P., Stanton, C., Ross, R., Quigley, E., Cryan, J., & Dinan, T. (2011) · Beneficial Microbes · doi:10.3920/bm2011.0015 · Cited by 92
The Role of Chronic Stress in Anxious Depression
Ross, R. A., Foster, S. L., & Ionescu, D. F. (2017) · Chronic Stress · doi:10.1177/2470547016689472 · Cited by 92
The effects of chronic unpredictable stress on male rats in the water maze
Gouirand, A. M., & Matuszewich, L. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.06.027 · Cited by 92
Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex
Codeluppi-Arrowsmith, S. A., Chatterjee, D., Prévot, T. D., Bansal, Y., Misquitta, K. A., Sibille, E. L., & Banasr, M. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab052 · Cited by 98
Guadagno, A., Belliveau, C., Mechawar, N., & Walker, C. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.669120 · Cited by 98
Neural plasticity: consequences of stress and actions of antidepressant treatment
Duman, R. S. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.2/rduman · Cited by 95
Perez‐Cruz, C., Keuker, J. I. H., Heilbronner, U., Fuchs, E., & Flügge, G. (2007) · Neural Plasticity · doi:10.1155/2007/46276 · Cited by 91
Clauss, J. A., Avery, S. N., & Blackford, J. U. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.001 · Cited by 93
Sullivan, E. C., Hinde, K., Mendoza, S. P., & Capitanio, J. P. (2010) · Developmental Psychobiology · doi:10.1002/dev.20483 · Cited by 89
Hall, B. S., Moda, R. N., & Liston, C. M. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.008 · Cited by 94
Longden, T. A., Dabertrand, F., Hill‐Eubanks, D. C., Hammack, S. E., & Nelson, M. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401811111 · Cited by 91
Veer, I. M., Oei, N. Y. L., van Buchem, M. A., Spinhoven, P., Elzinga, B. M., & Rombouts, S. A. R. B. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.07.016 · Cited by 95
Allostasis and the developing human brain: Explicit consideration of implicit models
Ganzel, B. L., & Morris, P. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000447 · Cited by 93
Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Luft, T., Abelaira, H. M., Fries, G. R., Aguiar, B. W., Kapczinski, F., Hallak, J. E., Zuardi, A. W., et al. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00579.x · Cited by 86
Ashokan, A., Hegde, A., & Mitra, R. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.009 · Cited by 88
Self-citationHippocampus and amygdala volume in relation to migraine frequency and prognosis
Liu, H., Chou, K., Lee, P., Fuh, J., Niddam, D. M., Lai, K., Hsiao, F., Lin, Y., Chen, W., Wang, S., et al. (2016) · Cephalalgia · doi:10.1177/0333102416678624 · Cited by 88
Weir, R. K., Bauman, M. D., Jacobs, B., & Schumann, C. M. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24332 · Cited by 87
Maroun, M., Ioannides, P. J., Bergman, K. L., Kavushansky, A., Holmes, A., & Wellman, C. L. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12259 · Cited by 86
The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking
Butler, T. R., Ariwodola, O. J., & Weiner, J. L. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00102 · Cited by 85
Endocannabinoids, cannabinoids and the regulation of anxiety
Petrie, G. N., Nastase, A. S., Aukema, R. J., & Hill, M. N. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108626 · Cited by 91
Differential Adaptive Responses to Chronic Stress of Maternally Stressed Male Mice Offspring
Chung, S., Son, G. H., Park, S. H., Park, E., Lee, K. H., Geum, D., & Kim, K. (2005) · Endocrinology · doi:10.1210/en.2004-1458 · Cited by 85
Neuroimaging Revolutionizes Therapeutic Approaches to Chronic Pain
Borsook, D., Moulton, E. A., Schmidt, K. F., & Becerra, L. R. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-25 · Cited by 85
Lussier, A. L., Caruncho, H. J., & Kalynchuk, L. E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.05.050 · Cited by 83
An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress
Lu, J., Tjia, M., Mullen, B., Cao, B., Lukasiewicz, K., Shah-Morales, S., Weiser, S., Cameron, L. P., Olson, D. E., Chen, L., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01159-1 · Cited by 84
Structural and functional neuroimaging correlates of depression in temporal lobe epilepsy
Richardson, E. J., Griffith, H. R., Martin, R. C., Paige, A. L., Stewart, C. C., Jones, J. E., Hermann, B. P., & Seidenberg, M. (2007) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2006.11.013 · Cited by 87
Wu, T.-C., Chen, H.-T., Chang, H.-Y., Yang, C., Hsiao, M., Cheng, M., & Chen, J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.011 · Cited by 87
Prenatal stress affects the developmental trajectory of the rat amygdala
Kraszpulski, M., Dickerson, P. A., & Salm, A. K. (2006) · Stress · doi:10.1080/10253890600798109 · Cited by 93
Iidaka, T., Matsumoto, A., Ozaki, N., Suzuki, T., Iwata, N., Yamamoto, Y., Okada, T., & Sadato, N. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.015 · Cited by 84
Effects of single-prolonged stress on neurons and their afferent inputs in the amygdala
Cui, H., Sakamoto, H., Higashi, S., & Kawata, M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.12.028 · Cited by 88
Qin, M., Xia, Z., Huang, T., & Smith, C. B. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.047 · Cited by 87
The Neuroscience of Adolescence
Galván, A. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316106143 · Cited by 82
Joyce, M. K. P., Uchendu, S., & Arnsten, A. F. T. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.06.016 · Cited by 86
Cohen, M. M., Tottenham, N., & Casey, B. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.023 · Cited by 89
Hoffman, A. N., Lorson, N. G., Sanabria, F., Olive, M. F., & Conrad, C. D. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.01.018 · Cited by 89
Pollandt, S., Liu, J., Orozco-Cabal, L. F., Grigoriadis, D. E., Vale, W., Gallagher, J. P., & Shinnick‐Gallagher, P. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05049.x · Cited by 82
Localization of Mineralocorticoid Receptors at Mammalian Synapses
Prager, E. M., Brielmaier, J., Bergstrom, H. C., McGuire, J., & Johnson, L. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014344 · Cited by 81
Fear relief—toward a new conceptual frame work and what endocannabinoids gotta do with it
Riebe, C. J. N., Pamplona, F. A., Kamprath, K., & Wotjak, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.057 · Cited by 84
Smoller, J. W., Gallagher, P., Duncan, L. E., McGrath, L. M., Haddad, S. A., Holmes, A. J., Wolf, A. B., Hilker, S., Block, S. R., Weill, S. R., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.018 · Cited by 81
Neuronal and brain morphological changes in animal models of schizophrenia
Flores, G., Morales‐Medina, J. C., & Díaz, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.034 · Cited by 82
Sarne, Y., Toledano, R., Rachmany, L., Sasson, E., & Doron, R. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.025 · Cited by 83
VanTieghem, M., Korom, M., Flannery, J., Choy, T., Caldera, C., Humphreys, K. L., Gabard-Durnam, L. J., Goff, B., Gee, D. G., Telzer, E. H., et al. (2021) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2021.100916 · Cited by 88
The delayed effects of chronic unpredictable stress on anxiety measures
Matuszewich, L., Karney, J. J., Carter, S., Janasik, S. P., O'Brien, J. L., & Friedman, R. D. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.12.006 · Cited by 81
Effects of stressors in adolescence on learning and memory in rodent models
Green, M. R., & McCormick, C. M. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.09.012 · Cited by 86
Davis, E., Humphreys, K. L., McEwen, L. M., Sacchet, M. D., Camacho, M. C., MacIsaac, J. L., Lin, D., Kobor, M. S., & Gotlib, I. H. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.188 · Cited by 83
Datta, D., & Arnsten, A. (2019) · Brain Sciences · doi:10.3390/brainsci9050113 · Cited by 78
Resilience against predator stress and dendritic morphology of amygdala neurons
Mitra, R., Adamec, R., & Sapolsky, R. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.014 · Cited by 80
Self-citationAcosta, H., Tuulari, J. J., Scheinin, N. M., Hashempour, N., Rajasilta, O., Lavonius, T. I., Pelto, J., Saunavaara, V., Parkkola, R., Lähdesmäki, T., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00175 · Cited by 80
de Carvalho-Netto, E. F., Myers, B., Jones, K., Solomon, M. B., & Herman, J. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.024 · Cited by 77
The interplay between rapid and slow corticosteroid actions in brain
Joëls, M., Pasricha, N., & Karst, H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.015 · Cited by 82
Srikumar, B. N., Raju, T. R., & Rao, B. S. S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.041 · Cited by 80
Differential impact of stress and environmental enrichment on corticolimbic circuits
Smail, M. A., Smith, B. L., Nawreen, N., & Herman, J. P. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172993 · Cited by 80
Zhang, W., & Rosenkranz, J. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.051 · Cited by 77
Impact of glucocorticoids on brain function: Relevance for mood disorders
Joëls, M. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.004 · Cited by 83
Taylor, S. B., Anglin, J. M., Paode, P. R., Riggert, A. G., Olive, M. F., & Conrad, C. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.029 · Cited by 78
Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice
Elliott, E., Manashirov, S., Zwang, R., Gil, S., Tsoory, M., Shemesh, Y., & Chen, A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0971-15.2016 · Cited by 78
Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin
Corrigan, M., O’Rourke, A. M., Moran, B., Fletcher, J. M., & Harkin, A. (2023) · Neuronal Signaling · doi:10.1042/ns20220054 · Cited by 81
Siegmund, A., & Wotjak, C. T. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.032 · Cited by 76
Ding, J., Han, F., & Shi, Y. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.06.001 · Cited by 78
McLaughlin, K. J., Wilson, J. O., Harman, J. S., Wright, R. L., Wieczorek, L., Gomez, J. L., Korol, D. L., & Conrad, C. D. (2009) · Hippocampus · doi:10.1002/hipo.20678 · Cited by 77
Vieira, J. O., Duarte, J. O., Ferreira, W. C., Morais‐Silva, G., Marin, M. T., & Crestani, C. C. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.014 · Cited by 76
Circadian Rhythms of Perineuronal Net Composition
Pantazopoulos, H., Gisabella, B., Rexrode, L., Benefield, D., Yıldız, E., Seltzer, P., Valeri, J., Chelini, G., Reich, A., Ardelt, M., et al. (2020) · eNeuro · doi:10.1523/eneuro.0034-19.2020 · Cited by 77
Kopp, B., Wick, D., & Herman, J. P. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.05.030 · Cited by 84
Effects of repeated stress on excitatory drive of basal amygdala neurons in vivo
Padival, M., Quinette, D., & Rosenkranz, J. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.74 · Cited by 75
Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107327 · Cited by 75
Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress
Maeng, L. Y., & Milad, M. R. (2017) · Chronic Stress · doi:10.1177/2470547017713297 · Cited by 92
de Kloet, E. R. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.053 · Cited by 83
Amygdala substructure volumes in Major Depressive Disorder
Roddy, D. W., Kelly, J. R., Farrell, C. M., Doolin, K., Román, E., Nasa, A., Frodl, T., Harkin, A., O’Mara, S. M., O’Hanlon, E., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102781 · Cited by 79
Conrad, C. D., & Bimonte‐Nelson, H. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82002-3 · Cited by 81
A Model for the Involvement of Neural Cell Adhesion Molecules in Stress-Related Mood Disorders
Sandi, C., & Bisaz, R. (2007) · Neuroendocrinology · doi:10.1159/000101535 · Cited by 76
Morrissey, M. D., Zovkic, I. B., & McCormick, C. M. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.10.007 · Cited by 78
Nácher, J., Guirado, R., & Castillo-Gómez, E. (2013) · Neurochemical Research · doi:10.1007/s11064-013-0977-4 · Cited by 76
Pillai, A. G., de Jong-Bolm, D., Kanatsou, S., Krugers, H. J., Knapman, A., Heinzmann, J.-M., Holsboer, F., Landgraf, R., Joëls, M., & Touma, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038971 · Cited by 75
Shirayama, Y., Takahashi, M., Osone, F., Hara, A., & Okubo, T. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.11.006 · Cited by 84
Alquicer, G., Morales‐Medina, J. C., Quirion, R., & Flores, G. (2007) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2007.10.001 · Cited by 74
Mahati, K., Bhagya, V. R., Christofer, T., Sneha, A., & Rao, B. S. S. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.017 · Cited by 80
Adamec, R., Hebert, M., Blundell, J., & Mervis, R. F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.09.009 · Cited by 74
Behavioral correlates of differences in neural metabolic capacity
Sakata, J. T., Crews, D., & Gonzalez-Lima, F. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.017 · Cited by 73
Zhang, Y., Liu, W., Zhou, Y., Ma, C., Li, S., & Cong, B. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.014 · Cited by 73
Cordero, M. I., Rodríguez, J. J., Davies, H. A., Peddie, C. J., Sandi, C., & Stewart, M. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.046 · Cited by 73
PSA-NCAM expression in the rat medial prefrontal cortex
Varea, E., Nácher, J., Blasco‐Ibáñez, J. M., Gómez‐Climent, M. Á., Castillo-Gómez, E., Crespo, C., & Martinez-Guijarro, F. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.009 · Cited by 74
Neuroplasticity in mood disorders
Drevets, W. C. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.2/wdrevets · Cited by 75
The antidepressant mechanism of action of vagus nerve stimulation: Evidence from preclinical studies
Grimonprez, A., Raedt, R., Baeken, C., Boon, P., & Vonck, K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.019 · Cited by 81
Zhang, W., Liu, W.-Z., He, Y., You, W.-J., Zhang, J., Xu, H. A., Tian, X.-L., Li, B., Mei, L., Holmes, A., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.12.010 · Cited by 75
Rubinow, M. J., Mahajan, G., May, W., Overholser, J. C., Jurjus, G., Dieter, L., Herbst, N. P., Steffens, D. C., Miguel-Hidalgo, J. J., Rajkowska, G., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0900-z · Cited by 76
Changed Synaptic Plasticity in Neural Circuits of Depressive-Like and Escitalopram-Treated Rats
Li, X., Yuan, Y., Xu, H., Wu, D., Gong, W.-G., Geng, L., Wu, F., Tang, H., Xu, L., & Zhang, Z. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv046 · Cited by 72
The aftermath of 9/11: Effect of intensity and recency of trauma on outcome.
Ganzel, B., Casey, B. J., Glover, G., Voss, H. U., & Temple, E. (2007) · Emotion · doi:10.1037/1528-3542.7.2.227 · Cited by 72
Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder
Chen, L. W., Sun, D., Davis, S. L., Haswell, C. C., Dennis, E. L., Swanson, C. A., Whelan, C. D., Gutman, B. A., Jahanshad, N., Iglesias, J. E., et al. (2018) · Depression and Anxiety · doi:10.1002/da.22833 · Cited by 75
Blume, S. R., Padival, M., Urban, J. H., & Rosenkranz, J. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-48683-3 · Cited by 71
Seeding Stress Resilience through Inoculation
Ashokan, A., Sivasubramanian, M., & Mitra, R. (2016) · Neural Plasticity · doi:10.1155/2016/4928081 · Cited by 71
Self-citationHypothalamic-pituitary-adrenocortical axis dysfunction in epilepsy
Wulsin, A. C., Solomon, M. B., Privitera, M., Danzer, S. C., & Herman, J. P. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.015 · Cited by 72
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Liao, C., Dua, A. N., Wojtasiewicz, C., Liston, C. M., & Kwan, A. C. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00876-0 · Cited by 81
Park, S. W., Phuong, V. T., Lee, C. H., Lee, J. G., Seo, M. K., Cho, H. Y., Fang, Z., Lee, B. J., & Kim, Y. H. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.08.010 · Cited by 71
Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala
Reagan, L. P., Hendry, R. M., Reznikov, L. R., Piroli, G. G., Wood, G. E., McEwen, B. S., & Grillo, C. A. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.02.023 · Cited by 70
de Castro, O. W., Santos, V. R., Pun, R. Y. K., McKlveen, J. M., Batie, M. R., Holland, K. D., Gardner, M., Garcia‐Cairasco, N., Herman, J. P., & Danzer, S. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046044 · Cited by 71
Neeley, E. W., Berger, R., Koenig, J. I., & Leonard, S. S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.065 · Cited by 71
Early life stress as an influence on limbic epilepsy: a hypothesis whose time has come?
Koe, A. S. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.024.2009 · Cited by 74
Adamec, R. E., Blundell, J. J., & Burton, P. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.017 · Cited by 71
Grabe, H. J., Wittfeld, K., Van der Auwera, S., Janowitz, D., Hegenscheid, K., Habes, M., Homuth, G., Barnow, S., John, U., Nauck, M., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23123 · Cited by 67
Conrad, K. L., Louderback, K. M., Gessner, C. P., & Winder, D. G. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.001 · Cited by 71
Bridging Intimate Partner Violence and the Human Brain: A Literature Review
Wong, J. Y.-H., Fong, D. Y.-T., Lai, V., & Tiwari, A. (2014) · Trauma, Violence, & Abuse · doi:10.1177/1524838013496333 · Cited by 69
Metadata
- Authors
- Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S.
- Affiliations
- Tata Institute of Fundamental Research (IN)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-08-01
- Volume
- 22
- Issue
- 15
- Pages
- 6810-6818
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758130
- OpenAlex
- W2136403062
- Semantic Scholar
- 587bd6bf61952d2c4d4fa8f4155737d79006655e
- Cited by
- 1,662
- References
- 51
- Citations by year
- 2026: 42 · 2025: 36 · 2024: 47 · 2023: 50 · 2022: 51 · 2021: 83 · 2020: 94 · 2019: 89 · 2018: 111 · 2017: 87 · 2016: 99 · 2015: 83 · 2014: 90 · 2013: 112 · 2012: 86
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Directorate for Biological Sciences
- National Centre for Biological Sciences
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chronic stress, dendritic remodeling, hippocampus, amygdala, restraint stress, chronic unpredictable mild stress, CA3 pyramidal cells, basolateral amygdala, stellate neurons, dendritic atrophy, dendritic branching, stress response, structural plasticity, anxiety-like behavior, emotionality, mood disorders
- MeSH terms
- Adrenal Glands, Amygdala, Animals, Anxiety, Body Weight, Chronic Disease, Dendrites, Disease Models, Animal, Hippocampus, Male, Neuronal Plasticity, Neurons, Organ Size, Restraint, Physical, Stress, Physiological, Rats, Wistar, Pyramidal Cells, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
