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Chronic Stress Induces Contrasting Patterns of Dendritic Remodeling in Hippocampal and Amygdaloid Neurons
Open accessAbstract
The hippocampus and the amygdala are essential components of the neural circuitry mediating stress responses. The hippocampus, which provides negative feedback regulation of the stress response, is particularly vulnerable to degenerative changes caused by chronic stress. Unlike the hippocampus, relatively little is known about how stress affects the amygdala and the nature of its role in the stress response. Hence, we examined the effects of two different models of chronic stress on hippocampal and amygdaloid neuronal morphology in rats. In agreement with previous reports, chronic immobilization stress (CIS) induced dendritic atrophy and debranching in CA3 pyramidal neurons of the hippocampus. In striking contrast, pyramidal and stellate neurons in the basolateral complex of the amygdala exhibited enhanced dendritic arborization in response to the same CIS. Chronic unpredictable stress (CUS), however, had little effect on CA3 pyramidal neurons and induced atrophy only in BLA bipolar neurons. These results indicate that chronic stress can cause contrasting patterns of dendritic remodeling in neurons of the amygdala and hippocampus. Moreover, CIS, but not CUS, reduced open-arm activity in the elevated plus-maze. These findings raise the possibility that certain forms of chronic stress, by affecting specific neuronal elements in the amygdala, may lead to behavioral manifestations of enhanced emotionality. Thus, stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress.
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“In the basolateral amygdala (BLA) chronic unpredictable stress also produced dendritic atrophy but chronic immobilization stress instead increased dendritic branching (Banasr and Duman, 2007;Vyas et al, 2002Vyas et al, , 2003)).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Vyas et al, 2002
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In animals, chronic stress results in the prolonged release of glucocorticoids and leads to hypertrophy of the amygdala and nucleus accumbens, atrophy of the hippocampus and prefrontal cortex (PFC), and functional impairment of the PFC (44–55).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [47]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“enhanced BDNF/TrkB signaling in the amygdala leads to maladaptive plasticity resulting in overactivation of this brain region and exacerbated anxiety and fear responses (47, 198–200)”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [47]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“By contrast to the PFC and hippocampus, dendrites in the amygdala expand in response to chronic stress exposure112.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [112]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In contrast to the PFC, chronic stress exposure increases dendritic growth in the amygdala77, thus accentuating the imbalance of amygdala over PFC function.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [77]
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In the citing paper
“In the basolateral amygdala (BLA) chronic unpredictable stress also produced dendritic atrophy but chronic immobilization stress instead increased dendritic branching (Banasr and Duman, 2007;Vyas et al, 2002Vyas et al, , 2003)).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Vyas et al, 2002
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In the citing paper
“The authors revealed that chronic immobilisation stress in rats resulted in significant dendritic atrophy of apical and basal dendrites of CA3 pyramidal neurons, with a more pronounced loss in apical dendrites.”
From Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus—A Mini Review (2025) · cites this paper as [95]
The cited source says what the claim attributes to it.
In the citing paper
“Animal studies revealed that chronic stress causes atrophy of apical dendrites of pyramidal neurons in the CA3 region of the hippocampus (Magarinos et al. 1996; Vyas et al. 2002; Watanabe et al. 1992).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Vyas et al. 2002
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In the citing paper
“This view is supported by recent evidence that individual brain regions are affected by stress in very different ways.”
From Episodic memory, perceptual memory, and their interaction: Foundations for a theory of posttraumatic stress disorder. (2014) · cites this paper as Vyas, Mitra, Rao, & Chattarji, 2002
The cited source says what the claim attributes to it.
In the citing paper
“a study of neuronal morphology showed that the same stress experience produced dendritic atrophy and debranching in the hippocampus at the same time as producing enhanced dendritic arborization in the amygdala”
From Episodic memory, perceptual memory, and their interaction: Foundations for a theory of posttraumatic stress disorder. (2014) · cites this paper as Vyas, Mitra, Rao, & Chattarji, 2002
In the citing paper
“In rodents, repeated stress results in dendritic atrophy and reduced glial cell counts in hippocampal regions (McEwen and Magarinos, 2001) as well as increased dendritic branching in the basolateral amygdala (Vyas et al., 2002).”
From Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk (2012) · cites this paper as Vyas et al., 2002
In the citing paper
“Specifically, studies of rodents show that stress increases dendritic arborization and spine density of the amygdala, with concomitant increases in anxiety-like behaviors (Vyas et al., 2002; Vyas et al., 2003, Mitra et al., 2005).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Vyas et al., 2002
In the citing paper
“In contrast, stress-induced amygdala morphology and volume changes seem to persist (Vyas et al., 2002, Adamec et al., 2005, Tottenham et al., 2010).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Vyas et al., 2002
In the citing paper
“By contrast, stress results in atrophy of the hippocampus and medial PFC (mPFC) (Magariños et al., 1997, Vyas et al., 2002, Radley et al., 2006).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Vyas et al., 2002
In the citing paper
“Neuronal and synaptic remodeling in BLA PNs, along with enhanced glutamatergic transmission, has been repeatedly associated with the negative consequence of stress (14,33,34,40), and prevention of these changes is paralleled by a protection against stress-induced increases in anxiety-like behavior (26,41).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [14]
In the citing paper
“Repeated stress causes dendritic shortening in medial prefrontal cortex (Sousa et al., 2000; Wellman, 2001; Vyas et al., 2002; Kreibich and Blendy, 2004; Cook and Wellman, 2004; Radley et al., 2004; Brown et al., 2005; Radley et al., 2005)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Vyas et al., 2002
In the citing paper
“but produces dendritic growth in neurons in amygdala (Vyas et al., 2002)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Vyas et al., 2002
In the citing paper
“both acute and chronic stress also increases spine synapse formation in amygdala (Vyas et al., 2002)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Vyas et al., 2002
In the citing paper
“Acute stress induces spine synapses in the CA1 region of hippocampus98 and both acute and chronic stress also increases spine synapse formation in amygdala,95-99 but chronic stress decreases it in hippocampus.77”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [95]
In the citing paper
“Repeated stress causes dendritic shortening in medial prefrontal cortex.89-95 but produces dendritic growth in neurons in amygdala,95 as well as in orbitofrontal cortex.96”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [95]
In the citing paper
“Behavioral correlates of remodeling in the prefrontal cortex include impairment in attention set shifting, possibly reflecting structural remodeling in the medial prefrontal cortex.95”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [95]
In the citing paper
“Additionally, multiple studies have found that chronic stress results in an increase in dendritic arborization and spinogenesis on BLA pyramidal neurons, increasing their intrinsic excitability and afferent stimulation in a manner that correlates with heightened anxiety-like behavior [70–72].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [70]
In the citing paper
“Acute traumatic stressors were found to cause increased spine density on basolateral amygdale (BlA) neurons and chronic stress leads to the expansion of BlA dendrites.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [18]
In the citing paper
“Chronic stress causes dendritic shrinkage not only in CA3 and dentate gyrus neurons of hippocampus but also in medial amygdala and mPFC, while dendrites in BlA and orbitofrontal cortex expand with chronic stress.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [18]
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Citations
Cites
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351
Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00162-x · Cited by 1,283
Research works printed but not linked: 1
- [28]28. McDonald AJ (1992) Cell types and intrinsic connections of the amyg- dala. In: The amygdala (Aggleton JP, ed), pp 67-96. New York: Wiley.
Cited by
Sorted by citations
Items 301–400 of 1,000
McEwen, B. S., & Olié, J. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001648 · Cited by 136
Lateral amygdaloid nucleus expansion in adult rats is associated with exposure to prenatal stress
Salm, A. K., Pavelko, M., Krouse, E. M., Webster, W., Kraszpulski, M., & Birkle, D. L. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.11.005 · Cited by 125
Henningsen, K., Andreasen, J. T., Bouzinova, E. V., Jayatissa, M. N., Jensen, M. S., Redrobe, J. P., & Wiborg, O. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.039 · Cited by 130
Neurocognitive effects of stress: a metaparadigm perspective
Kim, E. J., & Kim, J. J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01986-4 · Cited by 154
Sex Differences in Synaptic Plasticity: Hormones and Beyond
Hyer, M. M., Phillips, L. L., & Neigh, G. N. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00266 · Cited by 121
Impact of Early Life Stress on Reward Circuit Function and Regulation
Hanson, J. L., Williams, A. V., Bangasser, D. A., & Peña, C. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.744690 · Cited by 133
The neural addiction of cancer
Magnon, C., & Hondermarck, H. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00556-8 · Cited by 128
The impact of stress in decision making in the context of uncertainty
Morgado, P. F., Sousa, N., & Cerqueira, J. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23521 · Cited by 134
Physician Distress and Burnout: The Neurobiological Perspective
Arnsten, A. F. T., & Shanafelt, T. D. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.12.027 · Cited by 152
Yang, R. J., Mozhui, K., Karlsson, R.-M., Cameron, H. A., Williams, R. W., & Holmes, A. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301665 · Cited by 143
Nácher, J., Pham, K., Gil, V., & McEwen, B. S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.038 · Cited by 121
From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants
Pecoraro, N. C., Dallman, M. F., Warne, J. P., Ginsberg, A. B., Laugero, K. D., la Fleur, S. E., Houshyar, H., Gómez-Oliver, F., Bhargava, A., & Akana, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.004 · Cited by 125
Neural plasticity and stress coping in teleost fishes
Sørensen, C., Johansen, I. B., & Øverli, Ø. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.12.003 · Cited by 124
Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress
Xu, Y., Lin, D., Li, S., Li, G., Shyamala, S. G., Barish, P. A., Vernon, M. M., Pan, J., & Ogle, W. O. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.010 · Cited by 119
O’Mahony, C. M., Clarke, G. A., Gibney, S. M., Dinan, T. G., & Cryan, J. F. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.11.012 · Cited by 121
Crestani, C. C. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00251 · Cited by 126
Shilpa, B. A., Bhagya, V. R., Harish, G., Bharath, M. S., & Rao, B. S. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.025 · Cited by 122
Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction
Wilber, A. A., Walker, A. G., Southwood, C. J., Farrell, M. R., Lin, G. L., Rebec, G. V., & Wellman, C. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.070 · Cited by 115
van Noordt, S. J. R., & Segalowitz, S. J. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00197 · Cited by 128
Munshi, S., Loh, M. K., Ferrara, N., DeJoseph, M. R., Ritger, A., Padival, M., Record, M. J., Urban, J. H., & Rosenkranz, J. A. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.023 · Cited by 117
Attachment trauma and the developing right brain: Origins of pathological dissociation.
Schore, A. N. (2009) · Cited by 117
Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder
Golub, Y., Kaltwasser, S. F., Mauch, C. P., Herrmann, L., Schmidt, U., Holsboer, F., Czisch, M., & Wotjak, C. T. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.10.014 · Cited by 120
Stress, the cortisol awakening response and cognitive function
Law, R. J., & Clow, A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.01.001 · Cited by 125
Bonett, R. M., Hu, F., Bagamasbad, P., & Denver, R. J. (2008) · Endocrinology · doi:10.1210/en.2008-1441 · Cited by 119
Hill, M. N., & Gorzalka, B. B. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.06.069 · Cited by 119
Delgado y Palacios, R., Campo, A., Henningsen, K., Verhoye, M., Poot, D., Dijkstra, J., Van Audekerke, J., Benveniste, H., Sijbers, J., Wiborg, O., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.014 · Cited by 113
Wingenfeld, K., & Wolf, O. T. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00207.x · Cited by 118
Stress-induced alterations in large-scale functional networks of the rodent brain
Henckens, M. J. A. G., van der Marel, K., van der Toorn, A., Pillai, A. G., Fernández, G., Dijkhuizen, R. M., & Joëls, M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.10.037 · Cited by 119
Stress, glucocorticoids and glutamate release: Effects of antidepressant drugs
Musazzi, L., Racagni, G., & Popoli, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.05.002 · Cited by 118
McLaughlin, K. J., Baran, S. E., Wright, R. L., & Conrad, C. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.083 · Cited by 113
Liu, Z., Qi, Y., Cheng, Z., Zhu, X., Fan, C., & Yu, S. Y. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.050 · Cited by 112
Song, C., Liu, B.-P., Zhang, Y., Peng, Z., Wang, J., Collier, A. D., Echevarria, D. J., Savelieva, K. V., Lawrence, R. F., Rex, C. S., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.021 · Cited by 119
Dong, H., Yuede, C. M., Yoo, H.-S., Martin, M. V., Deal, C., Mace, A. G., & Csernansky, J. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.017 · Cited by 112
Central role of glucocorticoid receptors in Alzheimer's disease and depression
Canet, G., Chevallier, N., Zussy, C., Desrumaux, C., & Givalois, L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00739 · Cited by 106
Cisler, J. M., Scott Steele, J., Smitherman, S., Lenow, J. K., & Kilts, C. D. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.06.003 · Cited by 107
Morales-Medina, J. C., Sanchez, F., Flores, G., Dumont, Y., & Quirion, R. (2009) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2009.05.009 · Cited by 111
Synaptic regulation of affective behaviors; role of BDNF
Ninan, I. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.011 · Cited by 114
Koe, A. S., Ashokan, A., & Mitra, R. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.217 · Cited by 109
Self-citationZhang, L., Luo, J., Zhang, M., Yao, W., Ma, X., & Yu, S. Y. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001661 · Cited by 116
Bhagya, V. R., Srikumar, B. N., Veena, J., & Rao, B. S. S. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23992 · Cited by 110
Suvrathan, A., Bennur, S., Ghosh, S., Tomar, A., Anilkumar, S., & Chattarji, S. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0151 · Cited by 115
Self-citationFunctional Connectivity from the Amygdala to the Hippocampus Grows Stronger after Stress
Ghosh, S., Laxmi, T. R., & Chattarji, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0638-13.2013 · Cited by 115
Self-citationFan, C., Song, Q., Wang, P., Li, Y., Yang, M., & Yu, S. Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02889 · Cited by 109
RetractedMetabolic Mechanisms of Stress Hyperglycemia
Mechanick, J. I. (2006) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607106030002157 · Cited by 110
Which clinical and experimental data link temporal lobe epilepsy with depression?
Kondziella, D., Alvestad, S., Vaaler, A., & Sonnewald, U. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04926.x · Cited by 114
Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients
Varea, E., Guirado, R., Gilabert‐Juan, J., Martí, U., Castillo-Gómez, E., Blasco‐Ibáñez, J. M., Crespo, C., & Nácher, J. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.10.011 · Cited by 111
Savitz, J. B., Nugent, A. C., Bogers, W., Liu, A., Sills, R., Luckenbaugh, D. A., Bain, E., Price, J. L., Zarate, C. A., Manji, H. K., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.025 · Cited by 109
Guadagno, A., Wong, T. P., & Walker, C. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.025 · Cited by 112
Stress, Anxiety, and Immunomodulation
Ray, A., Gulati, K., & Rai, N. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.09.007 · Cited by 111
Song, M., Ruan, J., Zhang, R., Deng, J., Ma, Z., & Ma, S. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.208 · Cited by 108
Keilhoff, G., Becker, A., Grecksch, G., Bernstein, H., & Wolf, G. L. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300924 · Cited by 109
Chronic immobilization stress alters aspects of emotionality and associative learning in the rat.
Wood, G. E., Norris, E. H., Waters, E. M., Stoldt, J. T., & McEwen, B. S. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.282 · Cited by 109
The dynamics of the stress neuromatrix
Sousa, N. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.196 · Cited by 111
Synaptic Mechanisms Regulating Mood State Transitions in Depression
Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101
Stress-induced remodeling of hippocampal CA3 pyramidal neurons
McEwen, B. S. (2016) · Brain Research · doi:10.1016/j.brainres.2015.12.043 · Cited by 105
Cullen, C. L., Burne, T. H. J., Lavidis, N. A., & Moritz, K. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054924 · Cited by 105
Brain structural basis of cognitive reappraisal and expressive suppression
Hermann, A., Bieber, A., Keck, T., Vaitl, D., & Stark, R. M. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst130 · Cited by 109
Out of my real body: cognitive neuroscience meets eating disorders
Riva, G. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00236 · Cited by 110
Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders
Patel, D., Kas, M. J., Chattarji, S., & Buwalda, B. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111900 · Cited by 111
Self-citationMechanisms of neuroplasticity linking early adversity to depression: developmental considerations
Ho, T. C., & King, L. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01639-6 · Cited by 117
Stress and the Neuroendocrinology of Anxiety Disorders
Pêgo, J. M., Sousa, J. C., Almeida, O., & Sousa, N. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_13 · Cited by 104
Conrad, C. D., MacMillan, D. D., Tsekhanov, S., Wright, R. L., Baran, S. E., & Fuchs, R. A. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.01.002 · Cited by 104
Ulrich‐Lai, Y. M., & Ryan, K. K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.020 · Cited by 113
Daskalakis, N. P., Cohen, H., Nievergelt, C. M., Baker, D. G., Buxbaum, J. D., Russo, S. J., & Yehuda, R. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.024 · Cited by 105
Madalena, K. M., & Lerch, J. K. (2017) · Neural Plasticity · doi:10.1155/2017/8640970 · Cited by 108
Krugers (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00024 · Cited by 102
Neuroplasticity and major depression, the role of modern antidepressant drugs
Serafini, G. (2012) · World Journal of Psychiatry · doi:10.5498/wjp.v2.i3.49 · Cited by 105
Wang, Y., Ho, U., Ko, M., Liao, C., & Lee, L. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0355-4 · Cited by 106
Dauer-Specific Dendrite Arborization in C. elegans Is Regulated by KPC-1/Furin
Schroeder, N. E., Androwski, R. J., Rashid, A., Lee, H., Lee, J., & Barr, M. M. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.058 · Cited by 103
HPA Axis Interactions with Behavioral Systems
Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150042 · Cited by 138
Veerakumar, A., Challis, C., Gupta, P., Da, J., Upadhyay, A., Beck, S. G., & Berton, O. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.009 · Cited by 106
Diabetes as a chronic metabolic stressor: Causes, consequences and clinical complications
Reagan, L. P. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.004 · Cited by 104
Camp, M., MacPherson, K. P., Lederle, L. I., Graybeal, C., Gaburro, S., DeBrouse, L., Ihne, J. L., Bravo, J. A., O’Connor, R. M., Ciocchi, S., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.340 · Cited by 103
Toward understanding the impact of trauma on the early developing human brain
Thomason, M. E., & Marusak, H. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.022 · Cited by 101
Polman, J. A. E., Hunter, R. G., Speksnijder, N., van den Oever, J. M. E., Korobko, O. B., McEwen, B. S., de Kloet, E. R., & Datson, N. A. (2012) · Endocrinology · doi:10.1210/en.2012-1255 · Cited by 104
Zimmermann, K. S., Richardson, R., & Baker, K. (2019) · Brain Sciences · doi:10.3390/brainsci9030065 · Cited by 111
Establishing an Agenda for Translational Research on PTSD
MILLER, M. M., & McEWEN, B. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.023 · Cited by 101
Liu, Z.-P., Song, C., Wang, M., He, Y., Xu, X.-B., Pan, H.-Q., Chen, W.-B., Peng, W.-J., & Pan, B.-X. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-32 · Cited by 99
Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner
Bollinger, J. L., Collins, K. E., Patel, R., & Wellman, C. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187631 · Cited by 105
Maroun, M. (2012) · The Neuroscientist · doi:10.1177/1073858412464527 · Cited by 107
Suicidal attempts and increased right amygdala volume in schizophrenia
Spoletini, I., Piras, F., Fagioli, S., Rubino, I. A., Martinotti, G., Siracusano, A., Caltagirone, C., & Spalletta, G. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.08.023 · Cited by 98
Gilabert‐Juan, J., Castillo-Gómez, E., Pérez-Rando, M., Moltó, M. D., & Nácher, J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.07.009 · Cited by 102
Emotional Modulation of Learning and Memory: Pharmacological Implications
LaLumiere, R. T., McGaugh, J. L., & McIntyre, C. K. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013474 · Cited by 103
Liu, N., Wang, Y., An, A. Y., Banker, C., Qian, Y., & O’Donnell, J. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14565 · Cited by 102
Stress-Induced Chronic Visceral Pain of Gastrointestinal Origin
Meerveld, B. G., & Johnson, A. C. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00086 · Cited by 102
Effect of the environment on the dendritic morphology of the rat auditory cortex
Bose, M., Muñoz-LLancao, P., Roychowdhury, S., Nichols, J., Jakkamsetti, V., Porter, B. A., Byrapureddy, R., Salgado, H., Kilgard, M. P., Aboitiz, F., et al. (2009) · Synapse · doi:10.1002/syn.20710 · Cited by 97
Jett, J. D., Bulin, S. E., Hatherall, L. C., McCartney, C. M., & Morilak, D. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.01.017 · Cited by 92
Sex-selective effects of neonatal isolation on fear conditioning and foot shock sensitivity
Kosten, T. A., Miserendino, M. J. D., Bombace, J. C., Lee, H. J., & Kim, J. J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.07.001 · Cited by 97
Corticolimbic regulation of cardiovascular responses to stress
Myers, B. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.10.015 · Cited by 98
Chronic stress and hippocampal dendritic complexity: Methodological and functional considerations
Conrad, C. D., Ortiz, J. B., & Judd, J. M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.017 · Cited by 101
Social stress-related behavior affects hippocampal cell proliferation in mice
Mitra, R., Sundlass, K., Parker, K. J., Schatzberg, A. F., & Lyons, D. M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.047 · Cited by 95
Self-citationCastro, J. E., Diessler, S., Varea, E., Márquez, C., Larsen, M. H., Cordero, M. I., & Sandi, C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.014 · Cited by 99
Suzuki, H., Luby, J. L., Botteron, K. N., Dietrich, R., McAvoy, M. P., & Barch, D. M. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.04.013 · Cited by 92
Touyarot, K., Venero, C., & Sandi, C. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00031-3 · Cited by 94
Patel, D., Anilkumar, S., Chattarji, S., & Buwalda, B. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.034 · Cited by 93
Self-citationLau, T., Bigio, B., Zelli, D., McEwen, B. S., & Nasca, C. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.68 · Cited by 93
Transformation of cortical and hippocampal neural circuit by environmental enrichment
Hirase, H., & Shinohara, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.031 · Cited by 96
Amygdala Volume in Patients Receiving Chronic Corticosteroid Therapy
Brown, E. S., Woolston, D. J., & Frol, A. B. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.014 · Cited by 93
Xu, Y., Pan, J., Sun, J., Ding, L., Ruan, L., Reed, M. N., Yu, X., Klabnik, J., Lin, D., Li, J., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.028 · Cited by 92
Neuroplasticity and the next wave of antidepressant strategies
Hayley, S., & Litteljohn, D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00218 · Cited by 92
Metadata
- Authors
- Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S.
- Affiliations
- Tata Institute of Fundamental Research (IN)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-08-01
- Volume
- 22
- Issue
- 15
- Pages
- 6810-6818
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758130
- OpenAlex
- W2136403062
- Semantic Scholar
- 587bd6bf61952d2c4d4fa8f4155737d79006655e
- Cited by
- 1,662
- References
- 51
- Citations by year
- 2026: 42 · 2025: 36 · 2024: 47 · 2023: 50 · 2022: 51 · 2021: 83 · 2020: 94 · 2019: 89 · 2018: 111 · 2017: 87 · 2016: 99 · 2015: 83 · 2014: 90 · 2013: 112 · 2012: 86
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Directorate for Biological Sciences
- National Centre for Biological Sciences
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chronic stress, dendritic remodeling, hippocampus, amygdala, restraint stress, chronic unpredictable mild stress, CA3 pyramidal cells, basolateral amygdala, stellate neurons, dendritic atrophy, dendritic branching, stress response, structural plasticity, anxiety-like behavior, emotionality, mood disorders
- MeSH terms
- Adrenal Glands, Amygdala, Animals, Anxiety, Body Weight, Chronic Disease, Dendrites, Disease Models, Animal, Hippocampus, Male, Neuronal Plasticity, Neurons, Organ Size, Restraint, Physical, Stress, Physiological, Rats, Wistar, Pyramidal Cells, Rats
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