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Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin
Open accessAbstract
At the postsynaptic membrane of glutamatergic synapses, the cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and calcineurin (CaN) anchoring protein AKAP79/150 is recruited to NMDA and AMPA glutamate receptors by postsynaptic density (PSD)-95 family membrane-associated guanylate kinase (MAGUK) scaffold proteins. These signaling scaffold complexes may function to regulate receptor phosphorylation in synaptic plasticity. Thus, it is important to understand regulation of AKAP79/150 targeting to synapses and recruitment to PSD-MAGUK complexes. AKAP79 is targeted to the plasma membrane by an N-terminal basic domain that binds phosphatidylinositol-4,5-bisphosphate (PI-4,5-P(2)) and is regulated by PKC phosphorylation and calmodulin binding. Here we demonstrate that this same domain also binds F-actin in a calmodulin- and PKC-regulated manner, targets to membrane ruffles enriched in F-actin and PI-4,5-P(2) in COS7 cells, and localizes to dendritic spines with F-actin and PSD-MAGUKs in hippocampal neurons. Inhibition of actin polymerization disrupted AKAP79 targeting of PKA and CaN to ruffles in COS7 cells and endogenous AKAP79/150 dendritic spine localization with PKA, CaN, and PSD-MAGUKs in neurons. AKAP79/150 postsynaptic localization was rapidly regulated by NMDA receptors through CaN activation and F-actin remodeling, further suggesting that AKAP79/150 signaling scaffold targeting depends on actin dynamics. NMDA receptor activation also regulated dendritic spine localization of PKA and CaN and association of the AKAP79/150-PKA complex with PSD-MAGUKs. Because AMPA receptor PKA phosphorylation and synaptic localization are regulated by similar NMDA receptor-CaN signaling pathways linked to hippocampal long-term depression, this regulation of AKAP79/150 postsynaptic targeting might be important for synaptic plasticity.
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“AKAP79/150 is targeted to dendritic spines and the PSD by an N-terminal basic region that is palmitoylated on two Cys residues and binds directly to the membrane lipid phosphatidylinositol-4,5-bisphosphate (PIP2), the actin cytoskeleton, and cadherin adhesion molecules”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors (2012) · cites this paper as Gomez et al., 2002
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“This AKAP removal from synapses is caused by inhibition of N-terminal targeting interactions through depalmitoylation, phospholipase C cleavage of PIP2, and CaN-dependent actin depolymerization”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors (2012) · cites this paper as Gomez et al., 2002
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“LTD leads to loss of AKAP79/150 binding to PSD-95 and cadherins and removal of the AKAP and PKA from synapses”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors (2012) · cites this paper as Gomez et al., 2002
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“CaN activity is also required for cLTD-induced F-actin depolymerization and subsequent disruption of AKAP150 binding to PSD-95 and membranes (Gomez et al., 2002); this uncoupling of AKAP150 from PSD-95 and membranes may prevent PKA re-phosphorylation of GluA1 that would promote recycling after LTD”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors (2012) · cites this paper as Gomez et al., 2002
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Citations
Cites
Tsien, R. Y. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.509 · Cited by 6,178
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
PDZ Domains and the Organization of Supramolecular Complexes
Sheng, M., & Sala, C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1 · Cited by 1,211
Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 711
Lee, H.-K., Kameyama, K., Huganir, R. L., & Bear, M. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80632-7 · Cited by 668
Synaptic plasticity and dynamic modulation of the postsynaptic membrane
Lüscher, C., Nicoll, R. A., Malenka, R. C., & Müller, D. (2000) · Nature Neuroscience · doi:10.1038/75714 · Cited by 662
Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
Passafaro, M., Piëch, V., & Sheng, M. (2001) · Nature Neuroscience · doi:10.1038/nn0901-917 · Cited by 655
Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein
Coghlan, V. M., Perrino, B. A., Howard, M. L., Langeberg, L. K., Hicks, J. B., Gallatin, W. M., & Scott, J. D. (1995) · Science · doi:10.1126/science.7528941 · Cited by 617
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 562
Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X., & Huganir, R. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07258.2000 · Cited by 558
Allison, D. W., Gelfand, V. I., Spector, I., & Craig, A. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02423.1998 · Cited by 556
The postsynaptic density at glutamatergic synapses
Kennedy, M. B. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01033-8 · Cited by 475
Carroll, R. C., Lissin, D., von Zastrow, M., Nicoll, R. A., & Malenka, R. C. (1999) · Nature Neuroscience · doi:10.1038/8123 · Cited by 472
Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00013-1 · Cited by 467
The Marcks brothers: A family of protein kinase C substrates
Aderem, A. A. (1992) · Cell · doi:10.1016/0092-8674(92)90546-o · Cited by 465
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
Gating of CaMKII by cAMP-Regulated Protein Phosphatase Activity During LTP
Blitzer, R. D., Connor, J. H., Brown, G. P., Wong, T., Shenolikar, S., Iyengar, R., & Landau, E. M. (1998) · Science · doi:10.1126/science.280.5371.1940 · Cited by 445
Dynamin-dependent endocytosis of ionotropic glutamate receptors
Carroll, R. C., Beattie, E. C., Xia, H., Lüscher, C., Altschuler, Y., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14112 · Cited by 423
Leonard, A. S., Davare, M. A., Horne, M. C., Garner, C. C., & Hell, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19518 · Cited by 421
Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin
Halpain, S., Hipolito, A., & Saffer, L. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09835.1998 · Cited by 408 · cited 9×
“To test whether reorganization of F-actin is in fact necessary for NMDA receptorregulated redistribution of AKAP79/150, we pretreated neurons with jasplakinolide, a drug that stabilizes F-actin filaments and prevents NMDA-induced reorganization of dendritic spine F-actin (Halpain et al., 1998).”
BackgroundResultInfluentialRao, A., Kim, E., Sheng, M., & Craig, A. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01217.1998 · Cited by 399
A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation
Kim, C.-H., & Lisman, J. E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04314.1999 · Cited by 386
Enlightening the Postsynaptic Density
Ziff, E. B. (1997) · Neuron · doi:10.1016/s0896-6273(00)80409-2 · Cited by 384
Krucker, T., Siggins, G. R., & Halpain, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100139797 · Cited by 374
Rosenmund, C., Carr, D. W., Bergeson, S. E., Nilaver, G., Scott, J. D., & Westbrook, G. L. (1994) · Nature · doi:10.1038/368853a0 · Cited by 371
Lue, R. A., Marfatia, S. M., Branton, D., & Chishti, A. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9818 · Cited by 367
Carr, D. W., Stofko, R. E., Fraser, I. D. C., Cone, R. D., & Scott, J. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41856-x · Cited by 331
Daw, M. I., Chittajallu, R., Bortolotto, Z. A., Dev, K. K., Duprat, F., Henley, J. M., Collingridge, G. L., & Isaac, J. T. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00160-4 · Cited by 323
Shen, L., Liang, F., Walensky, L. D., & Huganir, R. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07932.2000 · Cited by 305
Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Lüthi, A., Chittajallu, R., Duprat, F., Palmer, M. J., Benke, T. A., Kidd, F. L., Henley, J. M., Isaac, J. T. R., & Collingridge, G. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80852-1 · Cited by 298
Osten, P., Khatri, L., Perez, J. L., Köhr, G., Giese, G., Daly, C., Schulz, T. W., Wensky, A. K., Lee, L. M., & Ziff, E. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)00039-8 · Cited by 295
Spine Formation and Correlated Assembly of Presynaptic and Postsynaptic Molecules
Okabe, S., Miwa, A., & Okado, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06105.2001 · Cited by 291
El-Husseini, A., Craven, S. E., Chetkovich, D. M., Firestein, B. L., Schnell, E., Aoki, C. J., & Bredt, D. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.1.159 · Cited by 272
Sans, N., Racca, C., Petralia, R. S., Wang, Y., McCallum, J. D., & Wenthold, R. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07506.2001 · Cited by 269
Stages of Synapse Development Defined by Dependence on F-Actin
Zhang, W., & Benson, D. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05169.2001 · Cited by 262
Pickard, L., Noël, J., Henley, J. M., Collingridge, G. L., & Molnár, E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07922.2000 · Cited by 250
Allison, D. W., Chervin, A. S., Gelfand, V. I., & Craig, A. M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04545.2000 · Cited by 245
Contribution of cytoskeleton to the internalization of AMPA receptors
Zhou, Q., Xiao, M., & Nicoll, R. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1261 · Cited by 233
Membrane‐targeting sequences on AKAP79 bind phosphatidylinositol‐4,5‐bisphosphate
Dell’Acqua, M. L., Faux, M. C., Thorburn, J., Thorburn, A., & Scott, J. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2246 · Cited by 229
Self-citationRegulation of Synaptic Strength by Protein Phosphatase 1
Morishita, W., Connor, J. H., Xia, H., Quinlan, E. M., Shenolikar, S., & Malenka, R. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00554-2 · Cited by 227
Tavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03044.2002 · Cited by 222
Lissin, D., Carroll, R. C., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01263.1999 · Cited by 207
AMPA Receptor Trafficking and the Control of Synaptic Transmission
Sheng, M., & Lee, S. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00406-8 · Cited by 196
High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B
Bregman, D. B., Bhattacharyya, N. P., & Rubin, C. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83792-9 · Cited by 182
Wang, J., Arbuzova, A., Hangyás-Mihályné, G., & McLaughlin, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008355200 · Cited by 176
PDZ Protein Interactions Regulating Glutamate Receptor Function and Plasticity
Tomita, S., Nicoll, R. A., & Bredt, D. S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.f19 · Cited by 154
The Calcineurin-Dynamin 1 Complex as a Calcium Sensor for Synaptic Vesicle Endocytosis
Lai, M. M.-S., Hong, J. J., Ruggiero, A. M., Burnett, P. E., Slepnev, V. I., Camilli, P. V. D., & Snyder, S. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.25963 · Cited by 145
Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane
Wu, H., Reuver, S. M., Kuhlendahl, S., Chung, W. J., & Garner, C. C. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.16.2365 · Cited by 134
Regulation of the AKAP79-Protein Kinase C Interaction by Ca2+/Calmodulin
Faux, M. C., & Scott, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17038 · Cited by 120
Lue, R. A., Brandin, E., Chan, E. P., & Branton, D. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.4.1125 · Cited by 120
Dynamics of phosphatidylinositol 4,5-bisphosphate in actin-rich structures
Tall, E. G., Spector, I., Pentyala, S., Bitter, I., & Rebecchi, M. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00541-8 · Cited by 120
AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region
Kashishian, A., Howard, M. L., Loh, C., Gallatin, W. M., Hoekstra, M. F., & Lai, Y. Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27412 · Cited by 93
Mutational Analysis of the A-Kinase Anchoring Protein (AKAP)-binding Site on RII
Hausken, Z. E., Dell’Acqua, M. L., Coghlan, V. M., & Scott, J. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29016 · Cited by 81
Self-citationLi, Y., Ndubuka, C., & Rubin, C. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16862 · Cited by 79
Bubb, M., Lenox, R. H., & Edison, A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36472 · Cited by 43
Craven, S. E., & Bredt, D. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910153199 · Cited by 36
Research works printed but not linked: 1
- Goslin K, Asmussen H, Banker G (1998) Rat hippocampal neurons in low density culture In: Culturing nerve cells, Ed 2 (Banker G, Goslin K, eds), pp 339 -370. Cambridge, MA: MIT.
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Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A
Taskén, K., & Aandahl, E. M. (2004) · Physiological Reviews · doi:10.1152/physrev.00021.2003 · Cited by 807
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695
Peng, J., Kim, M. J., Cheng, D., Duong, D. M., Gygi, S. P., & Sheng, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400103200 · Cited by 473
Metadata
- Authors
- Gomez, L. L., Alam, S., Smith, K. E., Horne, E., & Dell'Acqua, M. L.
- ORCID
- Horne, Eric
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-08-15
- Volume
- 22
- Issue
- 16
- Pages
- 7027-7044
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757891
- OpenAlex
- W2101875004
- Cited by
- 170
- References
- 68
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 8 · 2012: 11
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health (NS40701)
- National Institute of Neurological Disorders and Stroke (R56NS040701, R01NS040701)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- AKAP79/150, protein kinase A, calcineurin, NMDA receptor signaling, F-actin binding, phosphatidylinositol 4,5-bisphosphate, calmodulin, protein kinase C, dendritic spines, ruffles, synaptic plasticity, hippocampal neurons, AMPA receptor phosphorylation
- MeSH terms
- Disks Large Homolog 4 Protein, Actins, Animals, Carrier Proteins, Cells, Cultured, Dendrites, Membrane Proteins, Nerve Tissue Proteins, Neurons, Peptide Fragments, Protein Binding, Synapses, Transfection, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Protein Structure, Tertiary, Cyclic AMP-Dependent Protein Kinases, Receptors, AMPA, COS Cells, Calcineurin, Protein Transport, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Rats, A Kinase Anchor Proteins
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