Distinct Mechanisms for Processing Spatial Sequences and Pitch Sequences in the Human Auditory Brain
Open accessAbstract
Perception of the acoustic world requires the simultaneous processing of the acoustic patterns associated with sound objects and their location in space. In this functional magnetic resonance experiment, we investigated the human brain areas engaged in the analysis of pitch sequences and sequences of acoustic spatial locations in a paradigm in which both could be varied independently. Subjects were presented with sequences of sounds in which the individual sounds were regular interval noises with variable pitch. Positions of individual sounds were varied using a virtual acoustic space paradigm during scanning. Sound sequences with changing pitch specifically activated lateral Heschl's gyrus (HG), anterior planum temporale (PT), planum polare, and superior temporal gyrus anterior to HG. Sound sequences with changing spatial locations specifically activated posteromedial PT. These results demonstrate directly that distinct mechanisms for the analysis of pitch sequences and acoustic spatial sequences exist in the human brain. This functional differentiation is evident as early as PT: within PT, pitch pattern is processed anterolaterally and spatial location is processed posteromedially. These areas may represent human homologs of macaque lateral and medial belt, respectively.
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Lower-level auditory regions such as the auditory belt regions in the planum temporale exhibit a preference for rising sounds, which correspond to sounds approaching the boundaries of PPS.
“Notably, lower-level auditory regions such as the auditory belt regions located in the planum temporale (PT) exhibit a preference for rising sounds, which correspond to sounds approaching the boundaries of PPS (Warren et al. 2002; Seifritz et al. 2002; Warren and Griffiths 2003; Krumbholz et al. 2005).”
From Neuroanatomical correlates of peripersonal space: bridging the gap between perception, action, emotion and social cognition (2024) · cites this paper as Warren and Griffiths 2003
The Discussion reports that spatial information is processed in the posteromedial planum temporale, and discusses auditory belt areas. But the paper does not report a preference for rising sounds or relate such sounds to approaching the boundaries of peripersonal space; its Methods describe changes in azimuthal position, not approaching sounds. (LLM, conf=0.83)
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“…lower-level auditory regions such as the auditory belt regions located in the planum temporale (PT) exhibit a preference for rising sounds, which correspond to sounds approaching the boundaries of PPS (War-ren et al. 2002; Seifritz et al. 2002 ; Warren and Griffiths 2003 ; Krumbholz et al. 2005).”
Background
- Authors
- Warren, J. D., & Griffiths, T. D.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Newcastle University (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-07-02
- Volume
- 23
- Issue
- 13
- Pages
- 5799-5804
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741275
- OpenAlex
- W2125229781
- Cited by
- 247
- References
- 55
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 19 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 10 · 2018: 9 · 2017: 15 · 2016: 13 · 2015: 11 · 2014: 11 · 2013: 13 · 2012: 19
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- auditory cortex, planum temporale, planum polare, superior temporal gyrus, virtual acoustic space, sound localization
- MeSH terms
- Acoustic Stimulation, Adult, Auditory Cortex, Auditory Pathways, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Noise, Pitch Perception, Reference Values, Sound Localization
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