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Cited by 750

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Growing Together and Growing Apart: Regional and Sex Differences in the Lifespan Developmental Trajectories of Functional Homotopy

Open access
Zuo, Xi-Nian, Kelly, Clare, Di Martino, Adriana, Mennes, Maarten, Margulies, Daniel S., Bangaru, Saroja, Grzadzinski, Rebecca, Evans, Alan C., Zang, Yu-Feng, Castellanos, F. Xavier, Milham, Michael P.·2010·The Journal of Neuroscience
DOI 10.1523/jneurosci.2612-10.2010
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Abstract

Functional homotopy, the high degree of synchrony in spontaneous activity between geometrically corresponding interhemispheric (i.e., homotopic) regions, is a fundamental characteristic of the intrinsic functional architecture of the brain. However, despite its prominence, the lifespan development of the homotopic resting-state functional connectivity (RSFC) of the human brain is rarely directly examined in functional magnetic resonance imaging studies. Here, we systematically investigated age-related changes in homotopic RSFC in 214 healthy individuals ranging in age from 7 to 85 years. We observed marked age-related changes in homotopic RSFC with regionally specific developmental trajectories of varying levels of complexity. Sensorimotor regions tended to show increasing homotopic RSFC, whereas higher-order processing regions showed decreasing connectivity (i.e., increasing segregation) with age. More complex maturational curves were also detected, with regions such as the insula and lingual gyrus exhibiting quadratic trajectories and the superior frontal gyrus and putamen exhibiting cubic trajectories. Sex-related differences in the developmental trajectory of functional homotopy were detected within dorsolateral prefrontal cortex (Brodmann areas 9 and 46) and amygdala. Evidence of robust developmental effects in homotopic RSFC across the lifespan should serve to motivate studies of the physiological mechanisms underlying functional homotopy in neurodegenerative and psychiatric disorders.

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Metadata

Authors
Zuo, X.-N., Kelly, C., Di Martino, A., Mennes, M., Margulies, D. S., Bangaru, S., Grzadzinski, R., Evans, A. C., Zang, Y.-F., Castellanos, F. X., & Milham, M. P.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2010-11-10
Volume
30
Issue
45
Pages
15034-15043
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.2612-10.2010
OpenAlex
W2015895869
Cited by
750
References
32
FWCI
11.22
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)

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CoChat. (2026). Citation check: Growing Together and Growing Apart: Regional and Sex Differences in the Lifespan Developmental Trajectories of Functional Homotopy. https://app.cochat.ai/papers/10.1523/jneurosci.2612-10.2010
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Zuo, X.-N., Kelly, C., Di Martino, A., Mennes, M., Margulies, D. S., Bangaru, S., Grzadzinski, R., Evans, A. C., Zang, Y.-F., Castellanos, F. X., & Milham, M. P. (2010). Growing Together and Growing Apart: Regional and Sex Differences in the Lifespan Developmental Trajectories of Functional Homotopy. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2612-10.2010

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