The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders
Open accessAbstract
Core pathologies of Alzheimer's disease (AD) are aggregated amyloid-β peptides (Aβ) and tau, and the latter is also characteristic of diverse neurodegenerative tauopathies. These amyloid lesions provoke microglial activation, and recent neuroimaging technologies have enabled visualization of this response in living brains using radioligands for the peripheral benzodiazepine receptor also known as the 18 kDa translocator protein (TSPO). Here, we elucidated contributions of Aβ and tau deposits to in vivo TSPO signals in pursuit of mechanistic and diagnostic significance of TSPO imaging in AD and other tauopathies. A new antibody to human TSPO revealed induction of TSPO-positive microgliosis by tau fibrils in tauopathy brains. Emergence of TSPO signals before occurrence of brain atrophy and thioflavin-S-positive tau amyloidosis was also demonstrated in living mice transgenic for mutant tau by positron emission tomography (PET) with two classes of TSPO radioligands, [11 C]AC-5216 and [18 F]fluoroethoxy-DAA1106. Meanwhile, only modest TSPO elevation was observed in aged mice modeling Aβ plaque deposition, despite the notably enhanced in vivo binding of amyloid radiotracer, [11 C]Pittsburgh Compound-B, to plaques. In these animals, [11 C]AC-5216 yielded better TSPO contrasts than [18 F]fluoroethoxy-DAA1106, supporting the possibility of capturing early neurotoxicity with high-performance TSPO probes. Furthermore, an additional line of mice modeling intraneuronal Aβ accumulation displayed elevated TSPO signals following noticeable neuronal loss, unlike TSPO upregulation heralding massive neuronal death in tauopathy model mice. Our data corroborate the utility of TSPO-PET imaging as a biomarker for tau-triggered toxicity, and as a complement to amyloid scans for diagnostic assessment of tauopathies with and without Aβ pathologies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“TPSO signal has been shown to increase with microglia activation in tauopathies including AD, PSP, PiD, and FTDP-17 [111–113] as well as several other neurodegenerative diseases and injury models such as other frontotemporal dementias (FTDs), Parkinson’s disease, stroke and TBI [114].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [111]
In the citing paper
“Importantly, TPSO signaling preceded thioflavin-S-positive tangles and MRI-measureable regional atrophy in the mice implying TPSO PET may be more adept at detecting neuroinflammation induced by tau aggregation [111].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [111]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Self-citationUbiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576
Self-citationImaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208
Self-citationTau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., et al. (2005) · Science · doi:10.1126/science.1113694 · Cited by 2,014
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Logan, J., Fowler, J. S., Volkow, N. D., Wang, G., Ding, Y., & Alexoff, D. L. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00008 · Cited by 1,515
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Self-citationMCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287 · cited 1×
“It is well known that amyloid deposition triggers microglial and astroglial activation in AD brains (McGeer and McGeer, 1995).”
BackgroundJack, C. R., Lowe, V. J., Weigand, S. D., Wiste, H. J., Senjem, M. L., Knopman, D. S., Shiung, M. M., Gunter, J. L., Boeve, B. F., Kemp, B. J., et al. (2009) · Brain · doi:10.1093/brain/awp062 · Cited by 1,099
Research works printed but not linked: 1
- Takeuchi, 2009, Development of therapies and monitoring for tauopathies with dementia, Soc Neurosci Abstr, 35, 236
Cited by
Sorted by citations
Maruyama, M., Shimada, H., Suhara, T., Shinotoh, H., Ji, B., Maeda, J., Zhang, M.-R., Trojanowski, J. Q., Lee, V. M.-Y., Ono, M., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.037 · Cited by 760
Self-citationNeuroinflammation as a common feature of neurodegenerative disorders
Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702
Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer’s Disease
Serrano-Pozo, A., Mielke, M. L., Gómez-Isla, T., Betensky, R. A., Growdon, J. H., Frosch, M. P., & Hyman, B. T. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.05.047 · Cited by 488
Stancu, I.-C., Cremers, N., Vanrusselt, H., Couturier, J., Vanoosthuyse, A., Kessels, S., Lodder, C., Brône, B., Huaux, F., Octave, J.-N., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-01957-y · Cited by 447
Bloomfield, P. S., Selvaraj, S., Veronese, M., Rizzo, G., Bertoldo, A., Owen, D. R., Bloomfield, M., Bonoldi, I., Kalk, N. J., Turkheimer, F., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101358 · Cited by 446
Glial contributions to neurodegeneration in tauopathies
Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409
Tau-targeting therapies for Alzheimer disease: Current status and future directions
Congdon, E. E., Ji, C., Tetlow, A. M., Jiang, Y., & Sigurdsson, E. M. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00883-2 · Cited by 371
Microglia Function in Alzheimer’s Disease
Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 361
Neuroinflammation in Neurodegenerative Disorders-a Review
Schain, M., & Kreisl, W. C. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0733-2 · Cited by 301
Tagai, K., Ono, M., Kubota, M., Kitamura, S., Takahata, K., Seki, C., Takado, Y., Shinotoh, H., Sano, Y., Yamamoto, Y., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.042 · Cited by 276
Self-citationPET imaging of neuroinflammation in neurological disorders
Kreisl, W. C., Kim, M.-J., Coughlin, J. M., Henter, I. D., Owen, D. R., & Innis, R. B. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30346-x · Cited by 254
PET Imaging of Inflammation Biomarkers
Wu, C., Li, F., Niu, G., & Chen, X. S. (2013) · Theranostics · doi:10.7150/thno.6592 · Cited by 204
Cellular sources of TSPO expression in healthy and diseased brain
Nutma, E., Ceyzériat, K., Amor, S., Tsartsalis, S., Millet, P., Owen, D. R., Papadopoulos, V., & Tournier, B. B. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-05166-2 · Cited by 192
Molecular imaging of microglia/macrophages in the brain
Venneti, S., Lopresti, B. J., & Wiley, C. A. (2012) · Glia · doi:10.1002/glia.22357 · Cited by 194
TSPO in diverse CNS pathologies and psychiatric disease: a critical review and a way forward
Guilarte, T. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.09.003 · Cited by 173
A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease
Serrano-Pozo, A., Gómez-Isla, T., Growdon, J. H., Frosch, M. P., & Hyman, B. T. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.02.031 · Cited by 169
Bosco, A., Romero, C. O., Breen, K., Chagovetz, A. A., Steele, M. R., Ambati, B. K., & Vetter, M. L. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.018788 · Cited by 160
PET Imaging of Neuroinflammation in Alzheimer’s Disease
Zhou, R., Ji, B., Kong, Y., Qin, L., Ren, W., Guan, Y., & Ni, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.739130 · Cited by 157
Self-citationRodriguez‐Vieitez, E., Ni, R., Gulyás, B. Z., Tóth, M., Häggkvist, J., Halldin, C., Voytenko, L. P., Marutle, A., & Nordberg, A. K. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3047-0 · Cited by 149
Yasuno, F., Kosaka, J., Ota, M., Higuchi, M., Ito, H., Fujimura, Y., Nozaki, S., Takahashi, S., Mizukami, K., Asada, T., et al. (2012) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.08.013 · Cited by 148
Self-citationA quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
Nutma, E., Stephenson, J. A., Gorter, R. P., de Bruin, J., Boucherie, D. M., Donat, C. K., Breur, M., van der Valk, P., Matthews, P. M., Owen, D. R., et al. (2019) · Brain · doi:10.1093/brain/awz287 · Cited by 138
“…Domene et al., 2016; Israel et al., 2016; Nguyen et al., 2018), only a few have examined astrocytic expression of TSPO in the human CNS (Kaunzner et al., 2019), and these descriptions have been qualitative rather than quantitative (CosenzaNashat et al., 2009; Maeda et al., 2011; Liu et al., 2015).”
BackgroundSuridjan, I., Pollock, B. G., Verhoeff, N. P. L. G., Voineskos, A. N., Chow, T., Rusjan, P. M., Lobaugh, N. J., Houle, S., Mulsant, B. H., & Mizrahi, R. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.1 · Cited by 132
Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging
Zimmer, E. R., Leuzy, A., Benedet, A. L., Breitner, J., Gauthier, S., & Rosa-Neto, P. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-120 · Cited by 121
Modulation of inflammation in transgenic models of Alzheimer’s disease
Birch, A. M., Katsouri, L., & Sastre, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-25 · Cited by 121
Neuroinflammation in mouse models of Alzheimer's disease
Saito, T., & Saido, T. C. (2018) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12475 · Cited by 118
Self-citationLiu, B., Le, K. X., Park, M.-A., Wang, S., Belanger, A. P., Dubey, S., Frost, J. L., Holton, P., Reiser, V., Jones, P. A., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0996-15.2015 · Cited by 114
Morawski, M., Schilling, S., Kreuzberger, M., Waniek, A., Jäger, C., Koch, B. M., Cynis, H., Kehlen, A., Arendt, T., Hartlage‐Rübsamen, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131535 · Cited by 114
Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
Iwata, N., Sekiguchi, M., Hattori, Y., Takahashi, A., Asai, M., Ji, B., Higuchi, M., Staufenbiel, M., Muramatsu, S., & Saido, T. C. (2013) · Scientific Reports · doi:10.1038/srep01472 · Cited by 109
Self-citationHuperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?
Qian, Z., & Ke, Y. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00216 · Cited by 103
Sillerud, L. O., Solberg, N. O., Chamberlain, R., Orlando, R. A., Heidrich, J. E., Brown, D. C., Brady, C. I., Jagt, T. A. V., Garwood, M., & Jagt, D. L. V. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121171 · Cited by 106
Molecular imaging of inflammation - Current and emerging technologies for diagnosis and treatment
MacRitchie, N. A., Frleta‐Gilchrist, M., Sugiyama, A., Lawton, T., McInnes, I. B., & Maffia, P. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107550 · Cited by 106
A review of β-amyloid neuroimaging in Alzheimer's disease
Adlard, P. A., Tran, B. A., Finkelstein, D. I., Desmond, P. M., Johnston, L. A., Bush, A. I., & Egan, G. F. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00327 · Cited by 93
Lü, L., Qian, Z., Wu, K.-C., Yung, W., & Ke, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0067-0 · Cited by 92
In vivo Imaging of Glial Activation in Alzheimer's Disease
Edison, P., Donat, C. K., & Sastre, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00625 · Cited by 88
Rominger, A., Brendel, M., Burgold, S., Keppler, K., Baumann, K., Xiong, G., Mille, E., Gildehaus, F., Carlsen, J., Schlichtiger, J., et al. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.114660 · Cited by 83
Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
Klohs, J., Rudin, M., Shimshek, D. R., & Beckmann, N. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00032 · Cited by 82
Mirzaei, N., Tang, S. P., Ashworth, S., Coello, C., Plisson, C., Passchier, J., Selvaraj, V., Tyacke, R. J., Nutt, D. J., & Sastre, M. (2016) · Glia · doi:10.1002/glia.22978 · Cited by 82
Maeda, J., Minamihisamatsu, T., Shimojo, M., Zhou, X., Ono, M., Matsuba, Y., Ji, B., Ishii, H., Ogawa, M., Akatsu, H., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab011 · Cited by 80
Self-citationIn Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Garibotto, V., & Millet, P. (2020) · Cells · doi:10.3390/cells9091941 · Cited by 79
Ni, R., Ji, B., Ono, M., Sahara, N., Zhang, M.-R., Aoki, I., Nordberg, A., Suhara, T., & Higuchi, M. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.201632 · Cited by 72
Self-citationJames, M. L., Belichenko, N. P., Shuhendler, A. J., Höhne, A., Andrews, L., Condon, C., Nguyen, T. V., Reiser, V., Jones, P. A., Trigg, W., et al. (2017) · Theranostics · doi:10.7150/thno.17666 · Cited by 77
Ishikawa, A., Tokunaga, M., Maeda, J., Minamihisamatsu, T., Shimojo, M., Takuwa, H., Ono, M., Ni, R., Hirano, S., Kuwabara, S., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170509 · Cited by 69
Self-citationXie, L., Yui, J., Hatori, A., Yamasaki, T., Kumata, K., Wakizaka, H., Yoshida, Y., Fujinaga, M., Kawamura, K., & Zhang, M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.002 · Cited by 68
Self-citationAstrocytic TSPO upregulation appears before microglial TSPO in Alzheimer’s disease
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Fraser, B. H., Grégoire, M.-C., Kövari, E., & Millet, P. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-200136 · Cited by 65
Zhou, X., Ji, B., Seki, C., Nagai, Y., Minamimoto, T., Fujinaga, M., Zhang, M., Saito, T., Saido, T. C., Suhara, T., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211004146 · Cited by 62
Self-citationTrapani, A., Palazzo, C., de Candia, M., Lasorsa, F. M., & Trapani, G. (2013) · Bioconjugate Chemistry · doi:10.1021/bc300666f · Cited by 65
Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease
Hartlage‐Rübsamen, M., Waniek, A., Meißner, J., Morawski, M., Schilling, S., Jäger, C., Kleinschmidt, M., Cynis, H., Kehlen, A., Arendt, T., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1395-2 · Cited by 62
Tournier, B. B., Tsartsalis, S., Rigaud, D., Fossey, C., Cailly, T., Fabis, F., Pham, T., Grégoire, M.-C., Kövari, E., Moulin-Sallanon, M., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.022 · Cited by 62
Virdee, K., Cumming, P. D., Caprioli, D., Jupp, B., Rominger, A., Aigbirhio, F. I., Fryer, T. D., Riss, P. J., & Dalley, J. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.01.009 · Cited by 61
Tomiyama, T., & Shimada, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041413 · Cited by 62
Self-citationNerella, S. G., Bhattacharya, A., Joshi, R. K., Nagaraj, C., Bharath, R. D., & Kumar, P. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01053 · Cited by 59
Brendel, M., Jaworska, A. M., Grießinger, E., Rötzer, C., Burgold, S., Gildehaus, F., Carlsen, J., Cumming, P. D., Baumann, K., Haass, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116678 · Cited by 53
James, M. L., Belichenko, N. P., Nguyen, T. V., Andrews, L., Ding, Z., Liu, H., Bodapati, D., Arksey, N., Shen, B., Cheng, Z., et al. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.141648 · Cited by 52
Imaging Alzheimer's disease pathophysiology with PET
Schilling, L. P., Zimmer, E. R., Shin, M., Leuzy, A., Pascoal, T. A., Benedet, A. L., Borelli, W. V., Palmini, A., Gauthier, S. G., & Rosa‐Neto, P. (2016) · Dementia & Neuropsychologia · doi:10.1590/s1980-5764-2016dn1002003 · Cited by 57
Wu, C., Yue, X., Lang, L., Kiesewetter, D. O., Li, F., Zhu, Z., Niu, G., & Chen, X. S. (2014) · Theranostics · doi:10.7150/thno.8159 · Cited by 49
Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Medina, Z., Fraser, B., Grégoire, M., Kövari, E., & Millet, P. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19860408 · Cited by 52
Chen, L., van Zijl, P. C. M., Wei, Z., Lu, H., Duan, W., Wong, P. C., Li, T., & Xu, J. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118071 · Cited by 48
Lopez‐Picon, F. R., Snellman, A., Eskola, O., Helin, S., Solin, O. H., Haaparanta‐Solin, M., & Rinne, J. O. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.197608 · Cited by 49
Bales, K. R. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.666234 · Cited by 46
Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque
Holland, J. P., Liang, S. H., Rotstein, B. H., Collier, T. L., Stephenson, N. A., Greguric, I. D., & Vasdev, N. (2013) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3158 · Cited by 43
Barron, A. M., Higuchi, M., Hattori, S., Kito, S., Suhara, T., & Ji, B. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02136-5 · Cited by 44
Self-citationSahara, N., & Yanai, R. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1149761 · Cited by 46
Saito, T., Hisahara, S., Iwahara, N., Emoto, M. C., Yokokawa, K., Suzuki, H., Manabe, T., Matsumura, A., Suzuki, S., Matsushita, T., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.014 · Cited by 42
Glial cells and adaptive immunity in frontotemporal dementia with tau pathology
Hartnell, I. J., Blum, D. L., Nicoll, J. A. R., Dorothée, G., & Boche, D. (2020) · Brain · doi:10.1093/brain/awaa457 · Cited by 41
Ejaz, S., Emmrich, J., Sitnikov, S., Hong, Y. T., Sawiak, S. J., Fryer, T. D., Aigbirhio, F. I., Williamson, D. J., & Baron, J. (2016) · Brain · doi:10.1093/brain/awv391 · Cited by 40
TSPO Radioligands for Neuroinflammation: An Overview
Salerno, S., Viviano, M., Baglini, E., Poggetti, V., Giorgini, D., Castagnoli, J., Barresi, E., Castellano, S., Settimo, F. D., & Taliani, S. (2024) · Molecules · doi:10.3390/molecules29174212 · Cited by 41
MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research
Zimmer, E. R., Parent, M. J., Cuello, A. C., Gauthier, S. G., & Rosa‐Neto, P. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.002 · Cited by 41
Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia
Kreisl, W. C., Henter, I. D., & Innis, R. B. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.004 · Cited by 41
Aging and the neurovascular unit
del Zoppo, G. J. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06686.x · Cited by 35
The neurobiology of Alzheimer disease defined by neuroimaging
Masdeu, J. C., Kreisl, W. C., & Berman, K. F. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283557b36 · Cited by 39
Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy
Fairley, L. H., Sahara, N., Aoki, I., Ji, B., Suhara, T., Higuchi, M., & Barron, A. M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02122-1 · Cited by 37
Self-citationThe penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disorders
Ginsberg, S. D., Joshi, S., Sharma, S., Guzman, G., Wang, T., Arancio, O., & Chiosis, G. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15525 · Cited by 38
Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET
Barron, A. M., Tokunaga, M., Zhang, M., Ji, B., Suhara, T., & Higuchi, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0700-x · Cited by 37
Self-citationSantin, M. D., Debeir, T., Bridal, S. L., Rooney, T., & Dhénain, M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.106 · Cited by 34
Viviano, M., Barresi, E., Siméon, F. G., Costa, B., Taliani, S., Settimo, F. D., Pike, V. W., & Castellano, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220329204054 · Cited by 35
Eckenweber, F., Medina-Luque, J., Blume, T., Sacher, C., Biechele, G., Wind, K., Deussing, M., Briel, N., Lindner, S., Boening, G., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01883-5 · Cited by 32
Mori, T., Maeda, J., Shimada, H., Higuchi, M., Shinotoh, H., Ueno, S., & Suhara, T. (2012) · Psychogeriatrics · doi:10.1111/j.1479-8301.2012.00409.x · Cited by 31
Self-citationWu, G., Miller, R. A., Connolly, B., Marcus, J., Renger, J. J., & Savage, M. J. (2013) · Neurodegenerative Diseases · doi:10.1159/000353634 · Cited by 31
Meng, T., Cao, Q. C., Lei, P., Bush, A. I., Xiang, Q., Su, Z., He, X., Rogers, J. T., Chiu, I., Zhang, Q., et al. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.05.004 · Cited by 31
Yang, J., Shi, X., Wang, Y., Ma, M., Liu, H., Wang, J., & Xu, Z. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230593 · Cited by 33
Bosco, A., Romero, C. O., Ambati, B. K., & Vetter, M. L. (2015) · Journal of Visualized Experiments · doi:10.3791/52731 · Cited by 28
Alzheimer's disease biomarkers: correspondence between human studies and animal models
Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.010 · Cited by 27
Huang, Y.-Y., Fang, N., Luo, H., Gao, F., Zou, Y., Zhou, L., Zeng, Q.-P., Fang, S.-S., Xiao, F., & Zheng, Q. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108304 · Cited by 26
Ji, B., Ono, M., Yamasaki, T., Fujinaga, M., Zhang, M., Seki, C., Aoki, I., Kito, S., Sawada, M., Suhara, T., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x21992457 · Cited by 25
Self-citationAlzheimer's disease biomarkers in animal models: closing the translational gap.
Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Europe PMC (PubMed Central) · Cited by 24
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice
Takeuchi, H., Imamura, K., Ji, B., Tsukita, K., Enami, T., Takao, K., Miyakawa, T., Hasegawa, M., Sahara, N., Iwata, N., et al. (2020) · npj Vaccines · doi:10.1038/s41541-020-0172-y · Cited by 22
Self-citationFuture Directions in Imaging Neurodegeneration
Masdeu, J. C. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0718-1 · Cited by 22
The translocator protein as a drug target in Alzheimer’s disease
Chua, S. W., Kassiou, M., & Ittner, L. M. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.896201 · Cited by 20
Mouse strain and brain region‐specific expression of the glutaminyl cyclases QC and isoQC
Höfling, C., Indrischek, H., Höpcke, T., Waniek, A., Cynis, H., Koch, B. M., Schilling, S., Morawski, M., Demuth, H., Roßner, S., et al. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.05.008 · Cited by 20
Gallagher, R. L., Koscik, R. L., Moody, J. F., Vogt, N. M., Adluru, N., Kecskemeti, S., Hulle, C. A. V., Chin, N. A., Asthana, S., Kollmorgen, G., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01281-y · Cited by 22
Pandolfo, G., Iannuzzo, F., Genovese, G., Bruno, A., Pioggia, G., Baldari, S., & Gangemi, S. (2021) · Brain Sciences · doi:10.3390/brainsci11101352 · Cited by 18
Zheng, J., Winkeler, A., Peyronneau, M., Dollé, F., & Boisgard, R. (2015) · Molecular Imaging and Biology · doi:10.1007/s11307-015-0877-x · Cited by 22
Yamasaki, T., Fujinaga, M., Yui, J., Ikoma, Y., Hatori, A., Xie, L., Wakizaka, H., Kumata, K., Nengaki, N., Kawamura, K., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.243 · Cited by 18
Self-citationJi, B., Chen, C.-J., Bando, K., Ashino, H., Shiraishi, H., Sano, H., Kasahara, H., Minamizawa, T., YAMADA, K., Ono, M., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13293 · Cited by 17
Self-citationA genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains
Shimojo, M., Ono, M., Takuwa, H., Mimura, K., Nagai, Y., Fujinaga, M., Kikuchi, T., Okada, M., Seki, C., Tokunaga, M., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021107757 · Cited by 18
Self-citationLopez‐Picon, F. R., Keller, T., Bocancea, D. I., Helin, J. S., Krzyczmonik, A., Helin, S., Damont, A., Dollé, F., Rinne, J. O., Haaparanta‐Solin, M., et al. (2021) · Molecular Imaging and Biology · doi:10.1007/s11307-021-01646-5 · Cited by 16
Positron Emission Tomography in Animal Models of Tauopathies
Cao, L., Kong, Y., Ji, B., Ren, Y., Guan, Y., & Ni, R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.761913 · Cited by 14
Self-citationNeuroimaging of Diseases Causing Dementia
Masdeu, J. C. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.08.003 · Cited by 16
Stamenković, S., Li, Y., Waters, J., & Shih, A. Y. (2023) · Stroke · doi:10.1161/strokeaha.122.037156 · Cited by 14
Song, H., Chang, Y. J., Moon, M., Park, S. K., Tran, P., Hoang, V.-H., Lee, J., & Mook‐Jung, I. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141356 · Cited by 13
Metadata
- Authors
- Maeda, J., Zhang, M.-R., Okauchi, T., Ji, B., Ono, M., Hattori, S., Kumata, K., Iwata, N., Saido, T. C., Trojanowski, J. Q., Lee, V. M.-Y., Staufenbiel, M., Tomiyama, T., Mori, H., Fukumura, T., Suhara, T., & Higuchi, M.
- Affiliations
- National Institute of Radiological Sciences (JP)
- RIKEN Center for Brain Science (JP)
- University of Pennsylvania (US)
- Novartis (Switzerland) (CH)
- Osaka City University (JP)
- Corresponding author
- Higuchi, Makoto
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-03-23
- Volume
- 31
- Issue
- 12
- Pages
- 4720-4730
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3251921
- OpenAlex
- W2160881303
- Cited by
- 136
- References
- 53
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 14 · 2020: 14 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 17 · 2013: 14 · 2012: 9
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- National Institutes of Health (AG 10 124, AG 17586)
- Japan Society for the Promotion of Science (20790047, 23390235, 20023036, 22790835)
- National Institute on Aging (P30AG010124, P01AG017586, AG17586, AG-10124)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, tauopathy, translocator protein (TSPO), microglial activation, amyloid plaques, tau fibrils, TSPO PET imaging, Pittsburgh compound B, intraneuronal amyloid-beta, neurodegeneration biomarkers, neuroinflammation
- MeSH terms
- Acetamides, Alzheimer Disease, Aniline Compounds, Animals, Autoradiography, Brain, Humans, Immunohistochemistry, Isotope Labeling, Magnetic Resonance Imaging, Mice, Inbred C57BL, Neuritis, Neuroglia, Purines, Supranuclear Palsy, Progressive, Thiazoles, Amyloid beta-Protein Precursor, tau Proteins, Receptors, GABA, Radiopharmaceuticals, Pick Disease of the Brain, Positron-Emission Tomography, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
