In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease
Open accessAbstract
In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We focus on two pathological conditions for which neuropathological studies have shown the presence of neuroinflammation, which translates in opposite in vivo expression of TSPO. Alzheimer’s disease has been the most widely assessed with more than forty preclinical and clinical studies, showing overall that TSPO is upregulated in this condition, despite differences in the topography of this increase, its time-course and the associated cell types. In the case of schizophrenia, a reduction of TSPO has instead been observed, though the evidence remains scarce and contradictory. This review focuses on the key characteristics of TSPO as a biomarker of neuroinflammation in vivo, namely, on the cellular origin of the variations in its expression, on its possible biological/pathological role and on its variations across disease phases.
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Nanoparticles can make drugs more available, less toxic, and more efficient, and can be customized with different molecules for precise targeting.
“For example, nanoparticles can make drugs more available, less toxic, and more efficient. They can also be customized with different molecules for precise targeting [84].”
From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [84]
The Introduction and Conclusions and Perspectives discuss TSPO imaging and potential therapeutic targeting, not nanoparticle drug delivery. Searches for nanoparticles, drug bioavailability, toxicity, and molecule-based targeting found no passage supporting the attributed claims. (LLM, conf=0.76)
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The complexity of Alzheimer’s disease: an evolving puzzle
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“They can also be customized with different molecules for precise targeting [84].”
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- Authors
- Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Garibotto, V., & Millet, P.
- Affiliations
- University of Geneva (CH)
- University Hospital of Geneva (CH)
- Corresponding author
- Tournier, Benjamin B.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-08-21
- Volume
- 9
- Issue
- 9
- Pages
- 1941
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC7565089
- OpenAlex
- W3080813026
- Semantic Scholar
- 7ba579b63da858cc15a8a8be1dbceef0dc9fccae
- Cited by
- 79
- References
- 162
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 22 · 2021: 15 · 2020: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Fonds De La Recherche Scientifique - FNRS (320030-184713)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- translocator protein (TSPO), neuroinflammation, Alzheimer's disease, schizophrenia, TSPO PET imaging
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Humans, Signal Transduction, Receptors, GABA, Mice
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