The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms
Open accessAbstract
Synapse loss occurs normally during development and pathologically during neurodegenerative disease. Long-term depression, a proposed physiological correlate of synapse elimination, requires caspase-3 and the mitochondrial pathway of apoptosis. Here, we show that caspase-3 activity is essential—and can act locally within neurons—for regulation of spine density and dendrite morphology. By photostimulation of Mito-KillerRed, we induced caspase-3 activity in defined dendritic regions of cultured neurons. Within the photostimulated region, local elimination of dendritic spines and dendrite retraction occurred in a caspase-3-dependent manner without inducing cell death. However, pharmacological inhibition of inhibitor of apoptosis proteins or proteasome function led to neuronal death, suggesting that caspase activation is spatially restricted by these “molecular brakes” on apoptosis. Caspase-3 knock-out mice have increased spine density and altered miniature EPSCs, confirming a physiological involvement of caspase-3 in the regulation of spines in vivo.
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Cites
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Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
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Actin in dendritic spines: connecting dynamics to function
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Caspase signalling controls microglia activation and neurotoxicity
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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
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Cited by
Old, new and emerging functions of caspases
Shalini, S., Dorstyn, L., Dawar, S., & Kumar, S. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.216 · Cited by 1,267
Fricker, M., Tolkovsky, A. M., Borutaite, V., Coleman, M., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,108
Mitochondria at the neuronal presynapse in health and disease
Devine, M. J., & Kittler, J. T. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.170 · Cited by 615
Dejanovic, B., Huntley, M. A., De Mazière, A., Meilandt, W. J., Wu, T., Srinivasan, K., Jiang, Z., Gandham, V., Friedman, B. A., Ngu, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.014 · Cited by 517
Self-citationThe Coming Decade of Cell Death Research: Five Riddles
Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.04.024 · Cited by 566
Metadata
- Authors
- Ertürk, A., Wang, Y., & Sheng, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-01-29
- Volume
- 34
- Issue
- 5
- Pages
- 1672-1688
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2022755347
- Cited by
- 231
- References
- 17
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ertürk, A., Wang, Y., & Sheng, M. (2014). Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3121-13.2014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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