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Widespread Modulation of Cerebral Perfusion Induced during and after Transcranial Direct Current Stimulation Applied to the Left Dorsolateral Prefrontal Cortex
Open accessAbstract
Noninvasive neuromodulatory techniques such as transcranial direct current stimulation (tDCS) are attracting increasing interest as potential therapies for a wide range of neurological and psychiatric conditions. When targeted to the dorsolateral prefrontal cortex (DLPFC), anodal, facilitatory tDCS has been shown to improve symptoms in a range of domains including working memory, mood, and pain perception (Boggio et al., 2008a; Dockery et al., 2009; Kalu et al., 2012). However, the mechanisms underlying these promising behavioral effects are not well understood. Here, we investigated brain perfusion changes, as assessed using whole-brain arterial spin labeling (ASL), during tDCS applied to the left DLPFC in healthy humans. We demonstrated increased perfusion in regions closely anatomically connected to the DLPFC during anodal tDCS in conjunction with a decreased functional coupling between the left DLPFC and the thalami bilaterally. Despite highly similar effects on cortical excitability during and after stimulation (Nitsche and Paulus, 2000, 2001), cortical perfusion changes were markedly different during these two time periods, with widespread decreases in cortical perfusion being demonstrated after both anodal and cathodal tDCS compared to the period during stimulation. These findings may at least partially explain the different effects on behavior in these time periods described previously in the motor system (Stagg et al., 2011). In addition, the data presented here provide mechanistic explanations for the behavioral effects of anodal tDCS applied to the left DLPFC in terms of modulating functional connectivity between the DLPFC and thalami, as has been hypothesized previously (Lorenz et al., 2003).
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“Importantly, changes in cortical excitability and improvements in behavior induced by tDCS have been reported to persist long after the stimulation period [25–28].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [26]
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Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656
Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859
Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617
Bayesian analysis of neuroimaging data in FSL
Woolrich, M. W., Jbabdi, S., Patenaude, B., Chappell, M., Makni, S., Behrens, T., Beckmann, C., Jenkinson, M., & Smith, S. M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.055 · Cited by 2,385
Physiological basis of transcranial direct current stimulation
Stagg, C. J., & Nitsche, M. A. (2011) · The Neuroscientist · doi:10.1177/1073858410386614 · Cited by 1,719
Self-citationReis, J., Schambra, H. M., Cohen, L. G., Buch, E. R., Fritsch, B., Zarahn, E., Celnik, P. A., & Krakauer, J. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805413106 · Cited by 1,401
Datta, A., Bansal, V., Diaz, J., Patel, J., Reato, D., & Bikson, M. (2009) · Brain stimulation · doi:10.1016/j.brs.2009.03.005 · Cited by 1,317
Lateral prefrontal cortex: architectonic and functional organization
Petrides, M. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1631 · Cited by 1,212
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke
Hummel, F. C. (2005) · Brain · doi:10.1093/brain/awh369 · Cited by 1,141
Petrides, M., & Pandya, D. N. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00518.x · Cited by 1,068 · cited 2×
“The L-DLPFC was based on cytoarchitectonic features that included Brodmann areas 8A, 46, and 9/46, which have a well-developed layer IV (Petrides and Pandya, 1999; Petrides, 2005).”
BackgroundMethodNitsche, M. A., Schauenburg, A., Lang, N., Liebetanz, D., Exner, C., Paulus, W., & Tergau, F. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903321662994 · Cited by 1,032
Keeping pain out of mind: The role of the dorsolateral prefrontal cortex in pain modulation
Lorenz, J., Minoshima, S., & Casey, K. L. (2003) · Brain · doi:10.1093/brain/awg102 · Cited by 952
Monte-Silva, K. K., Kuo, M., Hessenthaler, S., Fresnoza, S. M., Liebetanz, D., Paulus, W., & Nitsche, M. A. (2012) · Brain stimulation · doi:10.1016/j.brs.2012.04.011 · Cited by 914
Lang, N., Siebner, H. R., Ward, N., Lee, L., Nitsche, M. A., Paulus, W., Rothwell, J. C., Lemon, R., & Frackowiak, R. S. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04233.x · Cited by 767
Nitsche, M. A., Seeber, A., Frommann, K., Klein, C. C., Rochford, C., Nitsche, M. S., Fricke, K., Liebetanz, D., Lang, N., Antal, A., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.092429 · Cited by 744
Kalina Christoff, A., & Gabrieli, J. D. E. (2000) · Psychobiology · doi:10.3758/bf03331976 · Cited by 697
Fregni, F., Boggio, P. S., Lima, M. C., Ferreira, M. J. L., Wagner, T., Rigonatti, S. P., de Castro, A. W., de Souza, D. R., Riberto, M., Freedman, S. D., et al. (2006) · Pain · doi:10.1016/j.pain.2006.02.023 · Cited by 694
Keeser, D., Meindl, T., Bor, J., Palm, U., Pogarell, O. M., Mulert, C., Brunelin, J., Möller, H., Reiser, M. F., & Padberg, F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0542-11.2011 · Cited by 615
Boggio, P. S., Rigonatti, S. P., Ribeiro, R. B., Myczkowski, M. L., Nitsche, M. A., Pascual‐Leone, Á., & Fregni, F. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007833 · Cited by 577
Fregni, F., Gimenes, R. O., Valle, A. C., Ferreira, M. J. L., Rocha, R. R., Natalle, L., Bravo, R., Rigonatti, S. P., Freedman, S. D., Nitsche, M. A., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22195 · Cited by 568
Fecteau, S., Knoch, D., Fregni, F., Sultani, N., Boggio, P., & Pascual-Leone, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3283-07.2007 · Cited by 470
Stagg, C. J., Jayaram, G., Pastor, D., Kincses, Z. T., Matthews, P. M., & Johansen‐Berg, H. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.02.009 · Cited by 446
Self-citationExperimental design and the relative sensitivity of BOLD and perfusion fMRI
Aguirre, G. K., Detre, J. A., Zarahn, E., & Alsop, D. C. (2002) · NeuroImage · doi:10.1006/nimg.2001.0990 · Cited by 403
Enhancement of Planning Ability by Transcranial Direct Current Stimulation
Dockery, C. A., Hueckel-Weng, R., Birbaumer, N., & Plewnia, C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0065-09.2009 · Cited by 380
Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow
Zheng, X., Alsop, D. C., & Schlaug, G. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.018 · Cited by 368
Transcranial direct current stimulation in the treatment of major depression: a meta-analysis
Kalu, U. G., Sexton, C. E., Loo, C. K. A., & Ebmeier, K. P. (2012) · Psychological Medicine · doi:10.1017/s0033291711003059 · Cited by 293
Boggio, P. S., Zaghi, S., Lopes, M. P., & Fregni, F. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02270.x · Cited by 275
Fricke, K., Seeber, A. A., Thirugnanasambandam, N., Paulus, W., Nitsche, M. A., & Rothwell, J. C. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00608.2009 · Cited by 266
Polanía, R. H., Paulus, W., Antal, A., & Nitsche, M. A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.085 · Cited by 257
Apparent diffusion tensor measurements in myelin-deficient rat spinal cords
Gulani, V., WEBB, A. G., Duncan, I. D., & Lauterbur, P. C. (2001) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200102)45:2 · Cited by 250
Brain polarization enhances the formation and retention of motor memories.
Galea, J., & Celnik, P. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00184.2009 · Cited by 202
Modulation of movement‐associated cortical activation by transcranial direct current stimulation
Stagg, C. J., O’Shea, J., Kincses, Z. T., Woolrich, M. W., Matthews, P. M., & Johansen‐Berg, H. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06937.x · Cited by 179
Self-citationLimited impact of homeostatic plasticity on motor learning in humans
Kuo, M., Unger, M., Liebetanz, D., Lang, N., Tergau, F., Paulus, W., & Nitsche, M. A. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.02.023 · Cited by 176
Short, B., Borckardt, J. J., Anderson, B. S., Frohman, H. A., Beam, W., Reeves, S. T., & George, M. S. (2011) · Pain · doi:10.1016/j.pain.2011.05.033 · Cited by 148
Wachter, D., Wrede, A., Schulz‐Schaeffer, W., Taghizadeh‐Waghefi, A., Nitsche, M. A., Kutschenko, A., Rohde, V., & Liebetanz, D. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.12.005 · Cited by 129
Mapping resting-state functional connectivity using perfusion MRI
Chuang, K., van Gelderen, P., Merkle, H., Bodurka, J., Ikonomidou, V. N., Koretsky, A. P., Duyn, J. H., & Talagala, S. L. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.006 · Cited by 120
Durand, S., Fromy, B., Bouyé, P., Saumet, J., & Abraham, P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013364 · Cited by 97
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Self-citationAntal, A., Alekseichuk, I., Bikson, M., Brockmöller, J., Brunoni, A. R., Chen, R. E., Cohen, L. G., Dowthwaite, G., Ellrich, J., Flöel, A., et al. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.06.001 · Cited by 1,380
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Ong, W., Stohler, C. S., & Herr, D. R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1130-9 · Cited by 824
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Metadata
- Authors
- Stagg, C. J., Lin, R. L., Mezue, M., Segerdahl, A., Kong, Y., Xie, J., & Tracey, I.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-07-10
- Volume
- 33
- Issue
- 28
- Pages
- 11425-11431
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3724554
- OpenAlex
- W2077726842
- Cited by
- 279
- References
- 41
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 20 · 2022: 18 · 2021: 22 · 2020: 18 · 2019: 28 · 2018: 35 · 2017: 33 · 2016: 29 · 2015: 18 · 2014: 16 · 2013: 7
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (83259)
- Marshall Aid Commemoration Commission
- National Institute for Health and Care Research
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- transcranial direct current stimulation, dorsolateral prefrontal cortex, cerebral perfusion, arterial spin labeling, functional connectivity, thalamus, anodal stimulation, cathodal stimulation, cortical excitability, neuromodulation mechanisms
- MeSH terms
- Adult, Cerebrovascular Circulation, Electric Stimulation, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Prefrontal Cortex, Transcranial Magnetic Stimulation, Young Adult
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