Cited by 346Pain Management and Placebo EffectPain Mechanisms and TreatmentsPain Management and Treatment

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Isolating the Modulatory Effect of Expectation on Pain Transmission: A Functional Magnetic Resonance Imaging Study

Open access

Keltner, John R., Furst, Ansgar, Fan, Catherine, Redfern, Rick, Inglis, Ben, Fields, Howard L.·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.4463-05.2006PMC PMC6674009

Open this paper in CoChat — free account Open PDF

Abstract

We use a novel balanced experimental design to specifically investigate brain mechanisms underlying the modulating effect of expected pain intensity on afferent nociceptive processing and pain perception. We used two visual cues, each conditioned to one of two noxious thermal stimuli [∼48°C (high) or 47°C (low)]. The visual cues were presented just before and during application of the noxious thermal stimulus. Subjects reported significantly higher pain when the noxious stimulus was preceded by the high-intensity visual cue. To control for expectancy effects, for one-half of the runs, the noxious thermal stimuli were accompanied by the cue conditioned to the other stimulus. Comparing functional magnetic resonance imaging blood oxygenation level-dependent activations produced by the high and low thermal stimulus intensities presented with the high-intensity visual cue showed significant activations in nociceptive regions of the thalamus, second somatosensory cortex, and insular cortex. To isolate the effect of expectancy, we compared activations produced by the two visual cues presented with the high-intensity noxious thermal stimulus; this showed significant differences in the ipsilateral caudal anterior cingulate cortex, the head of the caudate, cerebellum, and the contralateral nucleus cuneiformis (nCF). We propose that pain intensity expectancy modulates activations produced by noxious stimuli through a distinct modulatory network that converges with afferent nociceptive input in the nCF.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.4463-05.2006

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151
Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?
Bandler, R., & Shipley, M. T. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90047-7 · Cited by 1,051
A new view of pain as a homeostatic emotion
Craig, A. D. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00123-1 · Cited by 1,024
State-dependent opioid control of pain
Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946 · cited 3×
“One possible mechanism for the modulatory effect of expectancy on pain is that it activates descending modulatory systems (Fields, 2004; Fields et al., 2006).”
BackgroundSelf-citation
Neuroanatomy of the pain system and of the pathways that modulate pain
Willis, W. D., & Westlund, K. N. (1997) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199701000-00002 · Cited by 924
Imaging how attention modulates pain in humans using functional MRI
Bantick, S. J., Wise, R. G., Ploghaus, A., Clare, S., Smith, S. M., & Tracey, I. (2002) · Brain · doi:10.1093/brain/awf022 · Cited by 888
Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network
Ploghaus, A., Narain, C., Beckmann, C. F., Clare, S., Bantick, S., Wise, R., Matthews, P. M., Rawlins, J. N. P., & Tracey, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09896.2001 · Cited by 822
Central nervous system mechanisms of pain modulation
Fields, H. L., Basbaum, A. I., & Heinricher, M. M. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50012-6 · Cited by 761
Self-citation

Show all 48 references

Research works printed but not linked: 1

Talairach J, Tournoux P (1988) In: A coplanar stereotactic atlas of the human brain Stuttgart: Thieme.

Sorted by citations

The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392
Central modulation of pain
Ossipov, M. H., Dussor, G. O., & Porreca, F. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43766 · Cited by 1,234
A Comprehensive Review of the Placebo Effect: Recent Advances and Current Thought
Price, D. D., Finniss, D. G., & Benedetti, F. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.113006.095941 · Cited by 1,146
Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain
Noseda, R., & Burstein, R. (2013) · Pain · doi:10.1016/j.pain.2013.07.021 · Cited by 892
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844
Neurocognitive aspects of pain perception
Wiech, K., Ploner, M., & Tracey, I. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.05.005 · Cited by 737
Chronic Stress, Cortisol Dysfunction, and Pain: A Psychoneuroendocrine Rationale for Stress Management in Pain Rehabilitation
Hannibal, K. E., & Bishop, M. D. (2014) · Physical Therapy · doi:10.2522/ptj.20130597 · Cited by 729
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
The placebo response in medicine: minimize, maximize or personalize?
Enck, P., Bingel, U., Schedlowski, M., & Rief, W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3923 · Cited by 671
Significance of the insula for the evolution of human awareness of feelings from the body
(Bud) Craig, A. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05990.x · Cited by 646
When words are painful: unraveling the mechanisms of the nocebo effect
Benedetti, F., Lanotte, M., Lopiano, L., & Colloca, L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.020 · Cited by 636
Placebo effects on human μ-opioid activity during pain
Wager, T. D., Scott, D. J., & Zubieta, J.-K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702413104 · Cited by 562
A multisensory investigation of the functional significance of the “pain matrix”
Mouraux, A., Diukova, A., Lee, M., Wise, R. G., & Iannetti, G. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.084 · Cited by 581
Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
Tracey, I. (2010) · Nature Medicine · doi:10.1038/nm.2229 · Cited by 553
Virtual Reality and Pain Management: Current Trends and Future Directions
Li, A., Montaño, Z., Chen, V. J., & Gold, J. I. (2011) · Pain Management · doi:10.2217/pmt.10.15 · Cited by 572
New Insights into the Placebo and Nocebo Responses
Enck, P., Benedetti, F., & Schedlowski, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.030 · Cited by 547
Placebo Analgesia: A Predictive Coding Perspective
Büchel, C., Geuter, S., Sprenger, C., & Eippert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.042 · Cited by 505
Emotional moments across time: a possible neural basis for time perception in the anterior insula
Craig, A. D. (. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0008 · Cited by 499
Placebo and the New Physiology of the Doctor-Patient Relationship
Benedetti, F. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2012 · Cited by 492
Deconstructing the sensation of pain: The influence of cognitive processes on pain perception
Wiech, K. (2016) · Science · doi:10.1126/science.aaf8934 · Cited by 503
Individual differences in reward responding explain placebo-induced expectations and effects
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.028 · Cited by 466
How expectations shape pain
Atlas, L. Y., & Wager, T. D. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.039 · Cited by 463
How Placebos Change the Patient's Brain
Benedetti, F., Carlino, E., & Pollo, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.81 · Cited by 446
The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect
Benedetti, F., Amanzio, M., Vighetti, S., & Asteggiano, G. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2947-06.2006 · Cited by 419
Brain mediators of predictive cue effects on perceived pain
Atlas, L. Y., Bolger, N., Lindquist, M. A., & Wager, T. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0057-10.2010 · Cited by 389
Quantitative Meta-analysis Identifies Brain Regions Activated During Rectal Distension in Irritable Bowel Syndrome
Tillisch, K., Mayer, E. A., & Labus, J. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.07.053 · Cited by 412
The role of learning in nocebo and placebo effects
Colloca, L., Sigaudo, M., & Benedetti, F. (2008) · Pain · doi:10.1016/j.pain.2008.02.006 · Cited by 411
Mechanisms of Placebo and Placebo-Related Effects Across Diseases and Treatments
Benedetti, F. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094711 · Cited by 398
Nocebo hyperalgesia: how anxiety is turned into pain
Colloca, L., & Benedetti, F. (2007) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3282b972fb · Cited by 350
Localization of pain-related brain activation: A meta-analysis of neuroimaging data
Duerden, E. G., & Albanese, M. (2013) · Human Brain Mapping · doi:10.1002/hbm.21416 · Cited by 342
Reconceptualising pain according to modern pain science
Moseley, G. L. (2007) · Physical Therapy Reviews · doi:10.1179/108331907x223010 · Cited by 334
Predicting Individual Differences in Placebo Analgesia: Contributions of Brain Activity during Anticipation and Pain Experience
Wager, T. D., Atlas, L. Y., Leotti, L. A., & Rilling, J. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3420-10.2011 · Cited by 328
A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging
Borsook, D., Upadhyay, J., Chudler, E. H., & Becerra, L. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-27 · Cited by 326
Neuro-bio-behavioral mechanisms of placebo and nocebo responses: implications for clinical trials and clinical practice
Schedlowski, M., Enck, P., Rief, W., & Bingel, U. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009423 · Cited by 323
Imaging CNS Modulation of Pain in Humans
Bingel, U., & Tracey, I. (2008) · Physiology · doi:10.1152/physiol.00024.2008 · Cited by 318
Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain
Rossettini, G., Carlino, E., & Testa, M. (2018) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-018-1943-8 · Cited by 337
Psychosocial versus physiological stress — Meta-analyses on deactivations and activations of the neural correlates of stress reactions
Kogler, L., Müller, V. I., Chang, A., Eickhoff, S. B., Fox, P. T., Gur, R. C., & Derntl, B. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.059 · Cited by 310
A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
Kong, J., Gollub, R. L., Polich, G., Kirsch, I., LaViolette, P., Vangel, M., Rosen, B., & Kaptchuk, T. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2944-08.2008 · Cited by 263
“Previous brain imaging studies have indicated that expectation can significantly modulate subsequent noxious stimuli perception (Sawamoto et al., 2000; Koyama et al., 2005; Keltner et al., 2006).”
The placebo effect: From concepts to genes
Colagiuri, B., Schenk, L. A., Keßler, M., Dorsey, S. G., & Colloca, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.017 · Cited by 278
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism
Malchow, R. J., & Black, I. H. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31817e2fc9 · Cited by 248
The Organization of the Primate Insular Cortex
Evrard, H. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00043 · Cited by 242
Interictal Dysfunction of a Brainstem Descending Modulatory Center in Migraine Patients
Moulton, E. A., Burstein, R., Tully, S., Hargreaves, R. J., Becerra, L. R., & Borsook, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003799 · Cited by 218
Relief as a reward: hedonic and neural responses to safety from pain
Leknes, S., Lee, M., Berna, C., Andersson, J., & Tracey, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017870 · Cited by 207
Optimism lowers pain: Evidence of the causal status and underlying mechanisms
Hanssen, M. M., Peters, M. L., Vlaeyen, J. W. S., Meevissen, Y. M. C., & Vancleef, L. M. G. (2013) · Pain · doi:10.1016/j.pain.2012.08.006 · Cited by 202
The importance of context: When relative relief renders pain pleasant
Leknes, S., Berna, C., Lee, M., Snyder, G. D., Biele, G., & Tracey, I. (2012) · Pain · doi:10.1016/j.pain.2012.11.018 · Cited by 187
Different circuits for different pain: Patterns of functional connectivity reveal distinct networks for processing pain in self and others
Zaki, J., Ochsner, K. N., Hanelin, J., Wager, T. D., & Mackey, S. (2007) · Social Neuroscience · doi:10.1080/17470910701401973 · Cited by 193
Functional connectivity of the frontoparietal network predicts cognitive modulation of pain
Kong, J., Jensen, K. B., Loiotile, R. E., Cheetham, A., Wey, H., Tan, Y. H. V., Rosen, B. R., Smoller, J. W., Kaptchuk, T. J., & Gollub, R. L. (2012) · Pain · doi:10.1016/j.pain.2012.12.004 · Cited by 191
Treating pain with pain: Supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation
Sprenger, C., Bingel, U., & Büchel, C. (2011) · Pain · doi:10.1016/j.pain.2010.11.018 · Cited by 192
How expectations influence pain
Fields, H. L. (2018) · Pain · doi:10.1097/j.pain.0000000000001272 · Cited by 175
Self-citation
Uncertainty increases pain: evidence for a novel mechanism of pain modulation involving the periaqueductal gray
Yoshida, W., Seymour, B., Koltzenburg, M., & Dolan, R. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4984-12.2013 · Cited by 165
Can neuroimaging studies identify pain endophenotypes in humans?
Tracey, I. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.4 · Cited by 170
The context of a noxious stimulus affects the pain it evokes
Moseley, G. L., & Arntz, A. R. (2007) · Pain · doi:10.1016/j.pain.2007.03.002 · Cited by 166
Challenges and opportunities for brainstem neuroimaging with ultrahigh field MRI
Sclocco, R., Beißner, F., Bianciardi, M., Polimeni, J. R., & Napadow, V. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.052 · Cited by 163
A meta-analysis of brain mechanisms of placebo analgesia: consistent findings and unanswered questions
Atlas, L. Y., & Wager, T. D. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-662-44519-8_3 · Cited by 162
Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine
Schwedt, T. J., Chong, C. D., Chiang, C., Baxter, L. C., Schlaggar, B. L., & Dodick, D. W. (2014) · Cephalalgia · doi:10.1177/0333102414526069 · Cited by 160
Context matters: the psychoneurobiological determinants of placebo, nocebo and context-related effects in physiotherapy
Rossettini, G., Camerone, E. M., Carlino, E., Benedetti, F., & Testa, M. (2020) · Archives of Physiotherapy · doi:10.1186/s40945-020-00082-y · Cited by 173
A Neural Circuit Framework for Somatosensory Amplification in Somatoform Disorders
Perez, D. L., BARSKY, A. J., Vago, D. R., Baslet, G. C., & Silbersweig, D. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13070170 · Cited by 151
Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain
Friebel, U., Eickhoff, S. B., & Lotze, M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.022 · Cited by 142
Beyond Neurovascular: Migraine as a Dysfunctional Neurolimbic Pain Network
Maizels, M., Aurora, S. K., & Heinricher, M. M. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2012.02209.x · Cited by 142
Expectancy and the Treatment of Depression: A Review of Experimental Methodology and Effects on Patient Outcome
Rutherford, B. R., Wager, T. D., & Roose, S. P. (2010) · Current Psychiatry Reviews · doi:10.2174/157340010790596571 · Cited by 144
Nocebo and pain: an overview of the psychoneurobiological mechanisms
Blasini, M., Corsi, N., Klinger, R., & Colloca, L. (2017) · PAIN Reports · doi:10.1097/pr9.0000000000000585 · Cited by 139
“creating an augmentation of pain experience and processing.(52,58,63) For example, the mere expectation to feel more pain after the administration of an inert medication affects a laserinduced pain experience and related laser-evoked potential amplitude in the treated hand.”
Background
The contribution of psychosocial factors to the development of chronic pain: The key to better outcomes for patients?
Blyth, F., Macfarlane, G. J., & Nicholas, M. K. (2007) · Pain · doi:10.1016/j.pain.2007.03.009 · Cited by 140
Do words hurt? Brain activation during the processing of pain-related words
Richter, M., Eck, J., Straube, T., Miltner, W. H. R., & Weiß, T. (2009) · Pain · doi:10.1016/j.pain.2009.08.009 · Cited by 132
Topographically organized projection to posterior insular cortex from the posterior portion of the ventral medial nucleus in the long‐tailed macaque monkey
Craig, A. D. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23425 · Cited by 128
Neural Correlates of Altered Pain Response in Women with Posttraumatic Stress Disorder from Intimate Partner Violence
Strigo, I. A., Simmons, A. N., Matthews, S. C., Grimes, E. M., Allard, C. B., Reinhardt, L. E., Paulus, M. P., & Stein, M. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.034 · Cited by 124
Role of 5-HT receptors in neuropathic pain: potential therapeutic implications
Liu, Q. Q., Yao, X. X., Gao, S. H., Li, R., Li, B. J., Yang, W., & Cui, R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104949 · Cited by 124
Pain and the context
Carlino, E., Frisaldi, E., & Benedetti, F. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.17 · Cited by 112
Pain-Related Expectation and Prediction Error Signals in the Anterior Insula Are Not Related to Aversiveness
Fazeli, S., & Büchel, C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0671-18.2018 · Cited by 105
Breaking down the Barriers: fMRI Applications in Pain, Analgesia and Analgesics
Borsook, D., & Becerra, L. R. (2006) · Molecular Pain · doi:10.1186/1744-8069-2-30 · Cited by 108
Lessons learned from placebo groups in antidepressant trials
Mora, M. C. S., Nestoriuc, Y., & Rief, W. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0394 · Cited by 111
Bogus Visual Feedback Alters Onset of Movement-Evoked Pain in People With Neck Pain
Harvie, D. S., Broecker, M., Smith, R., Meulders, A., Madden, V. J., & Moseley, G. L. (2015) · Psychological Science · doi:10.1177/0956797614563339 · Cited by 106
Effects of trauma-related cues on pain processing in posttraumatic stress disorder: an fMRI investigation
Mickleborough, M. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.080188 · Cited by 110
Emotional and Cognitive Influences on Pain Experience
Peters, M. L. (2015) · Modern trends in psychiatry · doi:10.1159/000435938 · Cited by 110
Different contexts, different pains, different experiences
Carlino, E., & Benedetti, F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.053 · Cited by 115
Brain correlates of stress-induced analgesia
Yilmaz, P., Diers, M., Diener, S. J., Rance, M., Wessa, M., & Flor, H. (2010) · Pain · doi:10.1016/j.pain.2010.08.016 · Cited by 104
Cutaneous C-fiber pain abnormalities of fibromyalgia patients are specifically related to temporal summation
Staud, R. M., Bovee, C. E., Robinson, M. E., & Price, D. D. (2008) · Pain · doi:10.1016/j.pain.2008.04.024 · Cited by 100
Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala: An fMRI study
Yoshino, A., Okamoto, Y., Onoda, K., Yoshimura, S., Kunisato, Y., Demoto, Y., Okada, G., & Yamawaki, S. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.079 · Cited by 105
Psychobiological Correlates of Improved Mental Health in Patients With Musculoskeletal Pain After a Mindfulness-based Pain Management Program
Brown, C. A., & Jones, A. K. P. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31824c5d9f · Cited by 106
Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects
Borsook, D., Moulton, E. A., Tully, S., Schmahmann, J. D., & Becerra, L. R. (2008) · The Cerebellum · doi:10.1007/s12311-008-0011-6 · Cited by 96
Revisiting the Cognitive Model of Depression: The Role of Expectations
Rief, W., & Joormann, J. (2019) · Clinical Psychology in Europe · doi:10.32872/cpe.v1i1.32605 · Cited by 100
Instructed knowledge shapes feedback-driven aversive learning in striatum and orbitofrontal cortex, but not the amygdala
Atlas, L. Y., Doll, B. B., Li, J., Daw, N. D., & Phelps, E. A. (2016) · eLife · doi:10.7554/elife.15192 · Cited by 87
Neurobiology of Stress-Induced Hyperalgesia
Olango, W. M., & Finn, D. P. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_302 · Cited by 90
Insular Cortex Activity Is Associated with Effects of Negative Expectation on Nociceptive Long-Term Habituation
Rodriguez‐Raecke, R., Doganci, B., Breimhorst, M., Stankewitz, A., Büchel, C., Birklein, F., & May, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2197-10.2010 · Cited by 89
Tracing neural connections to pain pathways with relevance to primary headaches
Edvinsson, L. I. (2011) · Cephalalgia · doi:10.1177/0333102411398152 · Cited by 88
The ACTTION–APS–AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions
Kent, M. L., Tighe, P. J., Belfer, I., Brennan, T. J., Bruehl, S. P., Brummett, C. M., Buckenmaier, C. C., Buvanendran, A., Cohen, R. I., Desjardins, P. J., et al. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.02.421 · Cited by 91
Placebo and Nocebo Effects: A Complex Interplay Between Psychological Factors and Neurochemical Networks
Frisaldi, E., Piedimonte, A., & Benedetti, F. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2014.976785 · Cited by 93
How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions
Manaï, M., van Middendorp, H., Veldhuijzen, D. S., Huizinga, T. W. J., & Evers, A. W. M. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000699 · Cited by 84
Confidence in beliefs about pain predicts expectancy effects on pain perception and anticipatory processing in right anterior insula
Brown, C. A., Seymour, B., El-Deredy, W., & Jones, A. K. P. (2008) · Pain · doi:10.1016/j.pain.2008.04.028 · Cited by 83
The Nocebo Effect
Colloca, L. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-022723-112425 · Cited by 98
The Perception and Endogenous Modulation of Pain
Ossipov, M. H. (2012) · Scientifica · doi:10.6064/2012/561761 · Cited by 90
Neurocognitive evidence for mental imagery-driven hypoalgesic and hyperalgesic pain regulation
Fardo, F., Allen, M., Jegindø, E.-M. E., Angrilli, A., & Roepstorff, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.07.008 · Cited by 81
The enigma of the dorsolateral pons as a migraine generator
Borsook, D., & Burstein, R. (2012) · Cephalalgia · doi:10.1177/0333102412453952 · Cited by 78
Placebo analgesia and reward processing: Integrating genetics, personality, and intrinsic brain activity
Yu, R., Gollub, R. L., Vangel, M. G., Kaptchuk, T. J., Smoller, J. W., & Kong, J. (2014) · Human Brain Mapping · doi:10.1002/hbm.22496 · Cited by 80
The power of imagination — How anticipatory mental imagery alters perceptual processing of fearful facial expressions
Diekhof, E. K., Kipshagen, H. E., Falkai, P., Dechent, P., Baudewig, J., & Gruber, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.034 · Cited by 76
Caregiver placebo effect in analgesic clinical trials for cats with naturally occurring degenerative joint disease‐associated pain
Gruen, M. E., Dorman, D. C., & Lascelles, B. D. X. (2017) · Veterinary Record · doi:10.1136/vr.104168 · Cited by 76
The ACTTION–APS–AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions
Kent, M. L., Tighe, P. J., Belfer, I., Brennan, T. J., Bruehl, S. P., Brummett, C. M., Buckenmaier, C. C., Buvanendran, A., Cohen, R., Desjardins, P. J., et al. (2017) · Pain Medicine · doi:10.1093/pm/pnx019 · Cited by 82
Brainstem and Thalamic Projections from a Craniovascular Sensory Nervous Centre in the Rostral Cervical Spinal Dorsal Horn of Rats
Liu, Y., Broman, J., Zhang, M., & Edvinsson, L. I. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01829.x · Cited by 73
Imaging pain modulation in health and disease
Bingel, U., Schoell, E., & B??chel, C. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328259c34d · Cited by 70
Cerebral Activation and Catastrophizing During Pain Anticipation in Patients With Fibromyalgia
Burgmer, M., Petzke, F. W., Giesecke, T., Gaubitz, M., Heuft, G., & Pfleiderer, B. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318236588a · Cited by 71

Authors: Keltner, J. R., Furst, A., Fan, C., Redfern, R., Inglis, B., & Fields, H. L.
Affiliations: University of California, San Francisco (US)
University of California, Berkeley (US)
ORCID: Keltner, John R.
Furst, Ansgar
Fan, Catherine
Inglis, Ben
Fields, Howard L.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-04-19
Volume: 26
Issue: 16
Pages: 4437-4443
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4463-05.2006
PMC: PMC6674009
OpenAlex: W2160938249
Cited by: 346
References: 48
Citations by year: 2026: 4 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 12 · 2021: 10 · 2020: 14 · 2019: 22 · 2018: 24 · 2017: 19 · 2016: 14 · 2015: 23 · 2014: 20 · 2013: 16 · 2012: 22
FWCI: 8.90
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
International Anesthesia Research Society
U.S. Public Health Service (NS 21445)
National Institute of Neurological Disorders and Stroke (NS21445)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: pain anticipation, pain transmission, nociceptive processing, thermal pain, visual cues, thalamus, secondary somatosensory cortex, insula, caudal anterior cingulate cortex, caudate nucleus, nucleus cuneiformis, pain perception, expectancy effects
MeSH terms: Adult, Cues, Hot Temperature, Humans, Magnetic Resonance Imaging, Male, Pain, Pain Measurement, Perception, Photic Stimulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Isolating the Modulatory Effect of Expectation on Pain Transmission: A Functional Magnetic Resonance Imaging Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks