Elevated Correlations in Neuronal Ensembles of Mouse Auditory Cortex Following Parturition
Open accessAbstract
The auditory cortex is malleable by experience. Previous studies of auditory plasticity have described experience-dependent changes in response profiles of single neurons or changes in global tonotopic organization. However, experience-dependent changes in the dynamics of local neural populations have remained unexplored. In this study, we examined the influence of a dramatic yet natural experience in the life of female mice, giving birth and becoming a mother on single neurons and neuronal ensembles in the primary auditory cortex (A1). Using in vivo two-photon calcium imaging and electrophysiological recordings from layer 2/3 in A1 of mothers and age-matched virgin mice, we monitored changes in the responses to a set of artificial and natural sounds. Population dynamics underwent large changes as measured by pairwise and higher-order correlations, with noise correlations increasing as much as twofold in lactating mothers. Concomitantly, changes in response properties of single neurons were modest and selective. Remarkably, despite the large changes in correlations, information about stimulus identity remained essentially the same in the two groups. Our results demonstrate changes in the correlation structure of neuronal activity as a result of a natural life event.
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Pup distress calls are overrepresented in dams compared to virgins, leading to a stronger activation of the deep layers and increased noise correlation in layer II/III of auditory cortex in lactating females.
“Pup distress calls are overrepresented in dams compared to virgins, leading to a stronger activation of the deep layers and increased noise correlation in layer II/III of auditory cortex in lactating females”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Rothschild et al., 2013
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- Authors
- Rothschild, G., Cohen, L., Mizrahi, A., & Nelken, I.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-07-31
- Volume
- 33
- Issue
- 31
- Pages
- 12851-12861
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618552
- OpenAlex
- W2063074401
- Cited by
- 46
- References
- 70
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 3 · 2013: 3
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gatsby Charitable Foundation
- United States-Israel Binational Science Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- auditory cortex, childbirth, motherhood, experience-dependent plasticity, neuronal ensembles, noise correlation, two-particle correlations, higher-order correlations, primary auditory cortex, layer 2/3, single neuron responses, population dynamics, lactation
- MeSH terms
- Acoustic Stimulation, Action Potentials, Analysis of Variance, Aniline Compounds, Animals, Animals, Newborn, Auditory Cortex, Calcium, Female, Neurons, Psychoacoustics, Reaction Time, Statistics as Topic, Xanthenes, Parturition, Mice, Optics and Photonics
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