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Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
Open accessAbstract
The subjective experience of one's environment is constructed by interactions among sensory, cognitive, and affective processes. For centuries, meditation has been thought to influence such processes by enabling a nonevaluative representation of sensory events. To better understand how meditation influences the sensory experience, we used arterial spin labeling functional magnetic resonance imaging to assess the neural mechanisms by which mindfulness meditation influences pain in healthy human participants. After 4 d of mindfulness meditation training, meditating in the presence of noxious stimulation significantly reduced pain unpleasantness by 57% and pain intensity ratings by 40% when compared to rest. A two-factor repeated-measures ANOVA was used to identify interactions between meditation and pain-related brain activation. Meditation reduced pain-related activation of the contralateral primary somatosensory cortex. Multiple regression analysis was used to identify brain regions associated with individual differences in the magnitude of meditation-related pain reductions. Meditation-induced reductions in pain intensity ratings were associated with increased activity in the anterior cingulate cortex and anterior insula, areas involved in the cognitive regulation of nociceptive processing. Reductions in pain unpleasantness ratings were associated with orbitofrontal cortex activation, an area implicated in reframing the contextual evaluation of sensory events. Moreover, reductions in pain unpleasantness also were associated with thalamic deactivation, which may reflect a limbic gating mechanism involved in modifying interactions between afferent input and executive-order brain areas. Together, these data indicate that meditation engages multiple brain mechanisms that alter the construction of the subjectively available pain experience from afferent information.
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In the citing paper
“The neural mechanisms of mindfulness-based pain relief have demonstrated that reductions of pain intensity are associated with heightened activity of the anterior cingulate cortex, the anterior insula, and the orbitofrontal cortex, while reductions in pain unpleasantness are associated with attenuated activity of the thalamus.32”
From Mechanisms of mindfulness in patients with migraine: Results of a qualitative study. (2023) · cites this paper as [32]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Brain imaging has shown that mindfulnessmeditation-related pain reductions are associated with activation of the perigenual ACC, OFC, and anterior insula (Zeidan et al., 2011;Zeidan et al., 2015).”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Based on our previous studies (Zeidan et al., 2010a;Zeidan et al., 2011;Zeidan et al., 2015) and sample size determination software (G*power, 3.1), 16 subjects per group were considered sufficient to detect a signifi-cant difference (large effect size ϭ p 2 ϭ.14) between groups on a twosided, 0.05 test of proportions [repeated-measures (RM)”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Specifically, mindfulness meditation significantly deactivates the thalamus (Zeidan et al., 2011;Zeidan et al., 2015), potentially reflecting cognitive gating of the transmission of sensory information to the cortex (Zeidan et al., 2011;Zeidan et al., 2012).”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“While mindfulness meditation has been shown to attenuate the subjective pain experience in healthy controls,31, 32”
From Mechanisms of mindfulness in patients with migraine: Results of a qualitative study. (2023) · cites this paper as [32]
The cited source says what the claim attributes to it.
In the citing paper
“Though these mindfulness interventions are too truncated to expect any long-term effects, studies indicate that they can have immediate effects on psychological and neuroendocrine responses to social stress,60 and perceived pain severity in response to noxious heat stimulation.61”
From Mindfulness-Based Interventions for Anxiety and Depression (2017) · cites this paper as [61]
The cited source says what the claim attributes to it.
In the citing paper
“some impact on pain intensity may be reached because mindfulness skills have been found to influence brain mechanisms that may alter the pain experience (Zeidan et al., 2011).”
From Acceptance- and mindfulness-based interventions for the treatment of chronic pain: a meta-analytic review (2016) · cites this paper as Zeidan et al., 2011
The cited source says what the claim attributes to it.
In the citing paper
“Importantly, mindfulness-meditation-induced pain relief is also associated with reduced thalamic activity, which may be related to significantly attenuated low-level sensory processing (Zeidan et al., 2011).”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
The cited source says what the claim attributes to it.
In the citing paper
“Brief mindfulness interventions have been reported to reduce experimentally-induced pain in the laboratory, 15, 16”
From Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. (2017) · cites this paper as [15]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“So, decreased functional connectivity in these regions may contribute to enhanced quality of life that is reported post-ACT [21,40].”
From Graph theory analysis of induced neural plasticity post-Acceptance and Commitment Therapy for chronic pain (2020) · cites this paper as [40]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Activation of these regions has been linked to thoughts of helplessness, pessimism, and rumination in the instance of CMP [40].”
From Graph theory analysis of induced neural plasticity post-Acceptance and Commitment Therapy for chronic pain (2020) · cites this paper as [40]
Experimental — accuracy not yet measuredIn the citing paper
“A number of studies have found that meditation-related activation or volume increases are lateralized to the right hemisphere and correspond to tonic alertness–related brain areas (lateral PFC, inferior parietal, and anterior insula).65–70”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Buddhist meditation practices have been found to be associated with increases in activation in the dACC both during meditation45,65,76,78,86 and during tasks.70,80,81,87–89”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Converging evidence suggests that meditation training may be associated with decreased DMN activity,67, 70, 87, 94, 97–99”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Buddhist meditation practices have been found to be associated with increased activity in the DLPFC, both during meditation45,65,76–79 and during tasks,67,70,80,81 as well as larger frontal gray matter volumes.66,82,83”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Vipassana meditation has been described as a state of nonappraisal and/or a nonelaborative mental stance.45,137”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [137]
In the citing paper
“Regression analyses revealed that greater pain relief was directly associated with greater activation of the pgACC, right anterior insula, and bilateral OFC.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Focusing on the breath before the intervention reduced pain unpleasantness ratings but not pain intensity ratings when compared with rest.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“To this extent, it is now well established that mindfulness meditation significantly reduces pain after brief mental training (4 days > 4 weeks).62,134–136,141”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“In the presence of noxious heat, mindfulness significantly reduced SI activation corresponding to the stimulation site (right leg), suggesting that mindfulness reduces ascending nociceptive inputs to somatosensory cortical regions.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“In the presence of noxious heat, mindfulness significantly reduced SI activation corresponding to the stimulation site (right leg), suggesting that mindfulness reduces ascending nociceptive inputs to somatosensory cortical regions.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“After training, mindful attention to the breath significantly reduced pain intensity (↓40%) and pain unpleasantness (↓57%) ratings when compared with rest.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Mindfulness meditation produced widespread activation of the (1) ACC extending from the dACC to the perigenual ACC (pgACC), (2) bilateral orbitofrontal cortex (OFC), (3) the primary somatosensory cortices (SI) corresponding to the face region, (4) bilateral ventral striatum, and (5) deactivation of the default mode network.141”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Greater mindfulness-based pain relief was also associated with significant extensive, bilateral deactivation of the thalamus, a critical node of ascending nociceptive information from the spinal cord (Fig. 1).49”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“There was also significant deactivation of the PAG and thalamus, replicating and extending on the findings described in the previous ASL study.141”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Furthermore, when compared with BOLD, ASL fMRI can reliably assess rostral neural regions, such as the OFC,126 a brain area repeatedly implicated in mindfulness meditation,135,141 but suffering from substantial susceptibility artifacts.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“For instance, we found that mindfulness significantly increases on average by 13% after only three to four, 20 minutes sessions of mindfulness–based mental training [83; 84; 86–88].”
From Neural mechanisms supporting the relationship between dispositional mindfulness and pain (2018) · cites this paper as [88]
In the citing paper
“demonstrating that mindfulness meditation significantly attenuates pain through multiple, unique mechanisms”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“We postulated that mindfulness meditation attenuates pain through engagement of top-down (OFC to thalamus) inhibition of ascending nociceptive information.15, 20, 21, 23”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Meditation, after the four-session intervention, during noxious heat produced a mean 40% reduction in pain intensity and 57% reduction in pain unpleasantness ratings.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Greater activation of the subgenual ACC (sgACC), OFC, and right anterior insula (Fig. 1) was associated with mindfulness meditation–based analgesia.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“We also found that mindfulness meditation–based pain relief was associated with greater bilateral thalamic deactivation (Fig. 1) 21.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Activation of the OFC may facilitate inhibitory connections of the thalamic reticular nuclei (TRN) to further reduce the elaboration of nociceptive information throughout the cortex (evidenced by reductions in thalamic, PAG, and SI activation).21, 23”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“While meditation after brief training (less than 1 week) produces significant reductions in pain intensity and unpleasantness ratings,20, 21, 23, 122, 142”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Novice meditators recruit higher-order brain regions (OFC, sgACC, anterior insula) to downregulate ascending nociceptive input at the level of the thalamus through shifts in executive attention.21,23”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Mindfulness meditation–based pain relief was associated with similar brain activation as in our previous neuroimaging study,21 including greater activation of the OFC, pregenual ACC (pgACC), and right anterior insula.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Furthermore, across almost all mindfulness/pain–focused experiments, the unpleasantness dimension of pain was significantly more attenuated with respect to pain intensity,16–21, 23, 121, 122”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Mindfulness training decreases the suffering that accompanies painful stimuli,48,50 an effect that seems in part to be orthogonal to opioid-dependent pain processing.47”
From Randomized, wait-list–controlled pilot study of app-delivered mindfulness for patients reporting chronic pain (2021) · cites this paper as [50]
In the citing paper
“These promising results at the end of the proposed mindfulness program may indicate reduced subjective pain and changes in the brain [25-27].”
From A Cloud-Based Virtual Reality App for a Novel Telemindfulness Service: Rationale, Design and Feasibility Evaluation (2017) · cites this paper as [27]
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Citations
Cites
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
PENFIELD, W., & BOLDREY, E. (1937) · Brain · doi:10.1093/brain/60.4.389 · Cited by 4,188
Mindfulness-based stress reduction and health benefits
Grossman, P., Niemann, L., Schmidt, S., & Walach, H. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00573-7 · Cited by 3,958
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 2×
“, 2010), and interoceptive awareness (right AI) (Critchley et al., 2004) (Fig.”
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859
Attention regulation and monitoring in meditation
Lutz, A., Slagter, H. A., Dunne, J. D., & Davidson, R. J. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.01.005 · Cited by 2,659
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Research works printed but not linked: 1
- Allison PD (2002) Missing data (Sage Publications, Thousand Oaks, CA).
Cited by
Sorted by citations
Items 201–300 of 640
Reiner, K., Granot, M., Soffer, E., & Lipsitz, J. D. (2016) · Pain Medicine · doi:10.1111/pme.12883 · Cited by 34
Attention to breath sensations does not engage endogenous opioids to reduce pain
Wells, R. E., Collier, J., Posey, G., Morgan, A., Auman, T., Strittmatter, B., Magalhaes, R., Adler-Neal, A. L., McHaffie, J. G., & Zeidan, F. Z. (2020) · Pain · doi:10.1097/j.pain.0000000000001865 · Cited by 36
Self-citationKajimura, S., Masuda, N., Lau, J. K. L., & Murayama, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-75396-9 · Cited by 31
Mindfulness‐based stress reduction training modulates striatal and cerebellar connectivity
Santarnecchi, E., Egiziano, E., D’Arista, S., Gardi, C., Romanella, S. M., Mencarelli, L., Rossi, S., Reda, M. A., & Rossi, A. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24798 · Cited by 37
A Bibliometric and Visualization Analysis of Mindfulness and Meditation Research from 1900 to 2021
Wang, Y., Liao, L., Lin, X., Sun, Y., Wang, N., Wang, J., & Luo, F. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182413150 · Cited by 37
Effects of progressive muscle relaxation on cerebral activity: An fMRI investigation
Kobayashi, S., & Koitabashi, K. (2016) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2016.02.010 · Cited by 32
Joseph, A., Moman, R. N., Barman, R. A., Kleppel, D. J., Eberhart, N. D., Gerberi, D., Murad, M. H., & Hooten, W. M. (2022) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x221078006 · Cited by 44
Fossati, A., Porro, F. V., Maffei, C., & Borroni, S. (2012) · Journal of Clinical Psychology · doi:10.1002/jclp.21848 · Cited by 33
Mindfulness and Sustainability: Utilizing the Tourism Context
Lengyel, A. (2015) · Journal of Sustainable Development · doi:10.5539/jsd.v8n9p35 · Cited by 31
Greenwald, J. D., & Shafritz, K. M. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00018 · Cited by 35
Lutz, J. G., Berry, M. P., Napadow, V., Germer, C. K., Pollak, S. M., Gardiner, P. M., Edwards, R. R., Desbordes, G., & Schuman‐Olivier, Z. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111155 · Cited by 34
Lopes, S. A., Vannucchi, B., Demarzo, M., Cunha, Â. G. J., & Nunes, M. D. P. T. (2018) · Pain Management Nursing · doi:10.1016/j.pmn.2018.02.065 · Cited by 30
Cunningham, N. R., Kashikar‐Zuck, S., & Coghill, R. C. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000767 · Cited by 30
Self-citationBottaccioli, A. G., Bottaccioli, F., Carosella, A., Cofini, V., Muzi, P., & Bologna, M. (2019) · EXPLORE · doi:10.1016/j.explore.2019.10.006 · Cited by 32
Interpersonal touch suppresses visual processing of aversive stimuli
Kawamichi, H., Kitada, R., Yoshihara, K., Takahashi, H. K., & Sadato, N. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00164 · Cited by 30
Esch, T., Winkler, J., Auwärter, V., Gnann, H., Huber, R., & Schmidt, S. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00674 · Cited by 29
Neural Mechanisms of Hypnosis and Meditation-Induced Analgesia: A Narrative Review
Benedittis, G. D. (2021) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2021.1917294 · Cited by 38
Nicolardi, V., Simione, L., Scaringi, D., Malinowski, P., Yordanova, J., Kolev, V., Mauro, F., Giommi, F., Barendregt, H. P., Aglioti, S. M., et al. (2022) · Mindfulness · doi:10.1007/s12671-021-01797-0 · Cited by 29
Pain response measured with arterial spin labeling
Maleki, N., Brawn, J., Barmettler, G., Borsook, D., & Becerra, L. R. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2911 · Cited by 29
Baumgartner, J. N., Quintana, D., Leija, L., Schuster, N. M., Bruno, K. A., Castellanos, J. P., & Case, L. K. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.07.009 · Cited by 33
Facing the experience of pain: A neuropsychological perspective
Fabbro, F., & Crescentini, C. (2013) · Physics of Life Reviews · doi:10.1016/j.plrev.2013.12.010 · Cited by 31
Khusid, M. A., & Vythilingam, M. (2016) · Military Medicine · doi:10.7205/milmed-d-14-00678 · Cited by 31
Riquino, M. R., Priddy, S. E., Howard, M. O., & Garland, E. L. (2018) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-018-0088-6 · Cited by 28
Ahmed, M., Modak, S. I., & Sequeira, S. M. (2013) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000024 · Cited by 29
The neurobiology of mindfulness meditation.
Zeidan, F. Z. (2014) · Cited by 27
Self-citationHo, N. S. P., Sun, D., Ting, K. H., Chan, C. C. H., & Lee, T. M. C. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/212368 · Cited by 28
Neuroimaging of Itch as a Tool of Assessment of Chronic Itch and Its Management
Yosipovitch, G., & Mochizuki, H. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-44605-8_4 · Cited by 27
Mechanisms of mindfulness in patients with migraine: Results of a qualitative study.
Estave, P. M., Margol, C., Beeghly, S., Anderson, R., Shakir, M., Coffield, A., Byrnes, J., O'Connell, N., Seng, E., Gardiner, P., et al. (2023) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14481 · Cited by 26
“Current use of prophylactic treatment 8 (80) 12 (32) 20 (43) Current use of acute medicationb 10 (100) 33 (89) 43 (92)”
BackgroundWells, R. E., Smitherman, T. A., Seng, E. K., Houle, T. T., & Loder, E. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12362 · Cited by 26
Cingulate-mediated approaches to treating chronic pain
Peyron, R., Quesada, C., & Fauchon, C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00017-0 · Cited by 26
Mindfulness meditation alters neural activity underpinning working memory during tactile distraction
Wang, M. Y., Freedman, G., Raj, K., Fitzgibbon, B. M., Sullivan, C. M., Tan, W.-L., Dam, N. T. V., Fitzgerald, P. B., & Bailey, N. W. (2020) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-020-00828-y · Cited by 27
Faraj, M. M., Lipanski, N. M., Morales, A., Goldberg, E., Bluth, M. H., Marusak, H. A., & Greenwald, M. K. (2021) · Pain Medicine · doi:10.1093/pm/pnab162 · Cited by 29
Kemper, K. J., Powell, D. S., Helms, C. C., & Kim‐Shapiro, D. B. (2014) · EXPLORE · doi:10.1016/j.explore.2014.10.002 · Cited by 26
Does meditation reduce pain through a unique neural mechanism?
Salomons, T. V., & Kucyi, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2843-11.2011 · Cited by 25
Felsch, C. L., & Kuypers, K. P. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104724 · Cited by 25
What Mindfulness, and for Whom? And Why Might it Work?
Sedlmeier, P. (2023) · Mindfulness · doi:10.1007/s12671-023-02218-0 · Cited by 26
Marchand, W. R. (2011) · Depression Research and Treatment · doi:10.1155/2012/246725 · Cited by 28
Mechanism of Action of Mindfulness-Based Interventions for Pain Relief—A Systematic Review
Ploesser, M., & Martin, D. D. (2024) · Journal of Integrative and Complementary Medicine · doi:10.1089/jicm.2023.0328 · Cited by 32
Midcingulate somatomotor and autonomic functions
Amiez, C., & Procyk, E. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00004-2 · Cited by 28
Hu, X., Beard, K., Sherbel, M. C., Nascimento, T. D., Petty, S., Pantzlaff, E., Schwitzer, D., Kaciroti, N., Maslowski, E., Ashman, L. M., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/27298 · Cited by 29
Mindfulness Meditation in the Treatment of Chronic Pain
Brandel, M. G., Lin, C., Hennel, D., Khazen, O., Pilitsis, J. G., & Ben‐Haim, S. (2022) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2022.02.005 · Cited by 25
Behavioral therapy: emotion and pain, a common anatomical background
Schenck, L. A. ‐., Sable, J. J., & Andrasik, F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2928-3 · Cited by 27
Tung, K.-M., Su, Y., Kang, Y., Hou, W., Hoang, K. D., Chen, K., & Chen, C. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111666 · Cited by 26
Rod, K. (2016) · Pain Research and Management · doi:10.1155/2016/8714785 · Cited by 24
Bilevicius, E., Kolesar, T., & Kornelsen, J. (2016) · Brain Sciences · doi:10.3390/brainsci6020014 · Cited by 22
Smernoff, E., Mitnik, I., Kolodner, K., & Lev-ari, S. (2015) · EXPLORE · doi:10.1016/j.explore.2014.10.003 · Cited by 22
Garland, E. L., & Howard, M. O. (2018) · Journal of the Society for Social Work and Research · doi:10.1086/697685 · Cited by 22
Howarth, A., Riaz, M. A., Perkins-Porras, L., Smith, J. G., Subramaniam, J., Copland, C., Hurley, M. V., Beith, I. D., & USSHER, M. H. (2019) · Journal of Behavioral Medicine · doi:10.1007/s10865-019-00040-5 · Cited by 22
Meditation as a Potential Therapy for Autism: A Review
Sequeira, S. M., & Ahmed, M. (2012) · Autism Research and Treatment · doi:10.1155/2012/835847 · Cited by 27
Meier, S. K., Ray, K. L., Waller, N. C., Gendron, B. C., Aytur, S. A., & Robin, D. A. (2020) · doi:10.1101/2020.10.19.20212605 · Cited by 21
“…these regions have been linked to thoughts of helplessness, pessimism, and rumination in the instance of CMP, as previously stated, so decreased functional connectivity in these regions may contribute to enhanced quality of life that is reported post-ACT (Zeidan et al., 2011; Aytur et al., 2020).”
BackgroundMind-body practices, interoception and pain: a scoping review of behavioral and neural correlates
Voss, S., Boachie, D. A., Nieves, N., & Gothe, N. P. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2275661 · Cited by 25
Employing pain and mindfulness to understand consciousness: a symbiotic relationship
Grant, J. A., & Zeidan, F. Z. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.12.025 · Cited by 24
Self-citationImaging clinically relevant pain states using arterial spin labeling
Loggia, M. L., Segerdahl, A. R., Howard, M. A., & Tracey, I. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000750 · Cited by 23
Nakamura, Y., Lipschitz, D. L., Kanarowski, E., McCormick, T., Sutherland, D., & Melow-Murchie, M. (2015) · Sage Open · doi:10.1177/2158244015572489 · Cited by 18
“…that even a brief training in mindful attention (Westbrook et al., 2013) or mindfulness meditation (Zeidan, Gordon, Merchant, & Goolkasian, 2010; Zeidan et al., 2011) can significantly reduce self-reported and neural reactivity to cue-induced craving or painful stimulation, respectively.”
BackgroundMindfulness, rejection, and recovery of positive mood and friendliness: A Cyberball study.
Clear, S. J., Zimmer‐Gembeck, M. J., Hawes, T., Duffy, A. L., & Barber, B. L. (2021) · Emotion · doi:10.1037/emo0000987 · Cited by 22
Meditation as an Adjunct to the Management of Acute Pain
Wipplinger, F., Holthof, N., Andereggen, L., Urman, R. D., Luedi, M. M., & Bello, C. (2023) · Current Pain and Headache Reports · doi:10.1007/s11916-023-01119-0 · Cited by 20
Gardner‐Nix, J., Barbati, J., Grummitt, J., Pukal, S., & Newton, R. R. (2012) · Mindfulness · doi:10.1007/s12671-012-0169-3 · Cited by 20
Burning Issues in Dispositional Mindfulness Research
Goodman, R. J., Quaglia, J. T., & Brown, K. W. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2263-5_6 · Cited by 22
Zangrando, F., Piccinini, G., Tagliolini, C., Marsilli, G., Iosa, M., Vulpiani, M. C., & Paolucci, T. (2017) · Journal of Pain Research · doi:10.2147/jpr.s129313 · Cited by 20
Sexual Dysfunction in Men and Women
Bhasin, S., & Basson, R. J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00020-1 · Cited by 20
Consedine, N. S., & Butler, H. F. (2014) · Psychology, Health & Medicine · doi:10.1080/13548506.2013.824596 · Cited by 19
Grazzi, L., Grignani, E., Raggi, A., Rizzoli, P., & Guastafierro, E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182211739 · Cited by 19
Meints, S. M., Garcia, R. G., Schuman‐Olivier, Z., Datko, M., Desbordes, G., Cornelius, M. C., Edwards, R. R., & Napadow, V. (2022) · Pain Medicine · doi:10.1093/pm/pnac025 · Cited by 20
Krane, N. A., Simmons, J. K., Sykes, K. J., Kriet, J. D., & Humphrey, C. D. (2021) · Facial Plastic Surgery & Aesthetic Medicine · doi:10.1089/fpsam.2021.0184 · Cited by 19
Varieties of attention in hypnosis and meditation
Lifshitz, M., Campbell, N. K. J., & Raz, A. (2012) · Consciousness and Cognition · doi:10.1016/j.concog.2012.05.008 · Cited by 19
Applications cliniques en psychologie de la santé
Gauchet, A., Shankland, R., Dantzer, C., Pelissier, S., & Aguerre, C. (2012) · Psychologie Francaise · doi:10.1016/j.psfr.2012.03.005 · Cited by 18
Davies, J. N., Sharpe, L., Day, M. A., & Colagiuri, B. (2022) · Pain · doi:10.1097/j.pain.0000000000002593 · Cited by 18
The meditation app revolution.
Creswell, J. D., & Goldberg, S. B. (2025) · American Psychologist · doi:10.1037/amp0001576 · Cited by 18
Psychophysiologic symptom relief therapy for chronic back pain: a pilot randomized controlled trial
Donnino, M. W., Thompson, G. S., Mehta, S. M., Paschali, M., Howard, P., Antonsen, S. B., Balaji, L., Bertisch, S. M., Edwards, R. R., Ngo, L. H., et al. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000959 · Cited by 18
Tong, H., Maloney, T., Payne, M. F., Suñol, M., Dudley, J. A., King, C. D., Ting, T. V., Kashikar‐Zuck, S., Coghill, R. C., & López‐Solà, M. (2023) · Pain · doi:10.1097/j.pain.0000000000002933 · Cited by 20
Self-citationMindfulness Meditation and Placebo Modulate Distinct Multivariate Neural Signatures to Reduce Pain
Riegner, G., Dean, J., Wager, T. D., & Zeidan, F. Z. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.08.023 · Cited by 22
Self-citationYoga as a therapeutic tool in autism: A detailed review
Bhavanani, A. B., Artchoudane, S., Ramanathan, M., & Mariangela, A. (2019) · Yoga Mimamsa · doi:10.4103/ym.ym_3_19 · Cited by 18
Hirayama, M. S., Milani, D., Rodrigues, R. C. M., de Barros, N. F., & Alexandre, N. M. C. (2014) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232014199.12272013 · Cited by 19
Ramasawmy, P., Khalid, S., Petzke, F. W., & Antal, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.908133 · Cited by 20
Fedeli, D., Ciullo, G., Demichelis, G., Medina, J. P., Bruzzone, M. G., Ciusani, E., Erbetta, A., Ferraro, S., Grisoli, M., Guastafierro, E., et al. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01803-5 · Cited by 17
Lange, K., Gorbunova, A. V., & Christ, O. (2012) · Mindfulness · doi:10.1007/s12671-012-0113-6 · Cited by 17
Predictive mechanisms linking brain opioids to chronic pain vulnerability and resilience
Jones, A. K. P., & Brown, C. A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13840 · Cited by 17
Miller-Matero, L. R., Coleman, J. P., Smith-Mason, C. E., Moore, D. A., Marszalek, D., & Ahmedani, B. K. (2019) · Pain Medicine · doi:10.1093/pm/pnz082 · Cited by 20
Brain Processing of Itch and Scratching
Mochizuki, H. (2014) · CRC Press eBooks · doi:10.1201/b16573-27 · Cited by 17
Mascaro, J. S., Singh, V., Wehrmeyer, K., Scott, B., Juan, J., McKenzie-Brown, A. M., Lane, O. P., & Haack, C. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000924 · Cited by 14
Emotionsregulation und Schmerzen
Konietzny, K., Boris Suchan, A., Kreddig, N., Hasenbring, M. I., & Chehadi, O. (2016) · Der Schmerz · doi:10.1007/s00482-016-0162-1 · Cited by 16
Noble, D. J., Goolsby, W. N., Garraway, S. M., Martin, K. K., & Hochman, S. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00854 · Cited by 16
Agarwal, V. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082842 · Cited by 18
Meditation and the Brain in Health and Disease
Fox, K. C. R., & Cahn, B. R. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780198808640.013.23 · Cited by 16
Hanley, A. W., Hinich, J., Kennedy, A., Newman, C., Martorella, G., Anderson, L. A., Pelt, C. E., Gililland, J. M., & Garland, E. L. (2023) · Mindfulness · doi:10.1007/s12671-023-02112-9 · Cited by 20
Garland, E. L. (2014) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2014.911791 · Cited by 21
Ding, H., Zhang, L., Ma, C., Wen, H., & Zhao, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-97179-w · Cited by 20
Spinal fMRI of Interoceptive Attention/Awareness in Experts and Novices
Nejad, K. K., Sugiura, M., Thyreau, B., Nozawa, T., Kotozaki, Y., Furusawa, Y., Nishino, K., Nukiwa, T., & Kawashima, R. (2014) · Neural Plasticity · doi:10.1155/2014/679509 · Cited by 18
Effects of Meditation on Symptoms of Knee Osteoarthritis: A Pilot Study
Selfe, T. K., & Innes, K. E. (2013) · Alternative and Complementary Therapies · doi:10.1089/act.2013.19302 · Cited by 15
Mindfulness-Based Stress Reduction for Chronic Pain
Greeson, J. M., & Eisenlohr-Moul, T. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416031-6.00012-8 · Cited by 15
Hassett, A. L., Williams, D. A., Harris, R. E., Harte, S. E., Kaplan, C. M., Schrepf, A., Kratz, A. L., Brummett, C. M., Kidwell, K., Tsodikov, A. D., et al. (2023) · Pain Medicine · doi:10.1093/pm/pnad005 · Cited by 15
Imaging the neural substrate of trigeminal neuralgia pain using deep learning
Liang, Y., Zhao, Q., Hu, Z., Bo, K., Meyyappan, S., Neubert, J. K., & Ding, M. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1144159 · Cited by 13
Dynamic processes of mindfulness-based alterations in pain perception
Chen, L., Moliadze, V., & Nees, F. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1253559 · Cited by 13
Mindfulness and Trauma: Some Striking Similarities
Ataria, Y. (2018) · Anthropology of Consciousness · doi:10.1111/anoc.12086 · Cited by 14
Case, L. K., Adler-Neal, A. L., Wells, R. E., & Zeidan, F. Z. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000908 · Cited by 16
Self-citationKhazraee, H., Omidi, A., Kakhaki, R. D., Zanjani, Z., & Sehat, M. (2018) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.57151 · Cited by 14
Roberts, R. L., Hanley, A. W., & Garland, E. L. (2022) · The American Surgeon · doi:10.1177/00031348221114019 · Cited by 19
Liu, W., Li, H., Lin, X., Li, P., Zhu, X., Su, S., Shi, J., Lü, L., Deng, J., & Sun, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1001447 · Cited by 14
Garland, E. L., Roberts, R. L., Hanley, A. W., Zeidan, F. Z., & Keefe, F. J. (2022) · Mindfulness · doi:10.1007/s12671-022-02034-y · Cited by 15
Self-citationKhazraee, H., Bakhtiari, M., Kianimoghadam, A. S., & Hajmanouchehri, R. (2023) · Life · doi:10.3390/life13010131 · Cited by 13
“Also, nonjudgmental awareness of bodily sensation with acceptance increases body awareness, and parasympathetic activity leads to improved body mechanisms and reduces pain [54,55].”
Background
Metadata
- Authors
- Zeidan, F., Martucci, K. T., Kraft, R. A., Gordon, N. S., McHaffie, J. G., & Coghill, R. C.
- Affiliations
- Marquette University (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Zeidan, Fadel
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-04-06
- Volume
- 31
- Issue
- 14
- Pages
- 5540-5548
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3090218
- OpenAlex
- W2151568754
- Cited by
- 640
- References
- 64
- Citations by year
- 2026: 31 · 2025: 27 · 2024: 42 · 2023: 40 · 2022: 42 · 2021: 49 · 2020: 42 · 2019: 46 · 2018: 47 · 2017: 44 · 2016: 41 · 2015: 50 · 2014: 55 · 2013: 35 · 2012: 37
- FWCI
- 47.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Funders
- Wake Forest University
- Mind and Life Institute
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS-39426, R01NS039426)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- mindfulness meditation, pain modulation, pain unpleasantness, pain intensity, primary somatosensory cortex, anterior cingulate cortex, anterior insula, orbitofrontal cortex, thalamus, arterial spin labeling, individual differences, meditation training
- MeSH terms
- Adult, Analysis of Variance, Attention, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Individuality, Functional Laterality, Magnetic Resonance Imaging, Male, Oxygen, Pain, Pain Measurement, Physical Stimulation, Psychophysics, Regression Analysis, Pain Threshold, Meditation, Young Adult, Pain Management
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