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Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
Open accessAbstract
The subjective experience of one's environment is constructed by interactions among sensory, cognitive, and affective processes. For centuries, meditation has been thought to influence such processes by enabling a nonevaluative representation of sensory events. To better understand how meditation influences the sensory experience, we used arterial spin labeling functional magnetic resonance imaging to assess the neural mechanisms by which mindfulness meditation influences pain in healthy human participants. After 4 d of mindfulness meditation training, meditating in the presence of noxious stimulation significantly reduced pain unpleasantness by 57% and pain intensity ratings by 40% when compared to rest. A two-factor repeated-measures ANOVA was used to identify interactions between meditation and pain-related brain activation. Meditation reduced pain-related activation of the contralateral primary somatosensory cortex. Multiple regression analysis was used to identify brain regions associated with individual differences in the magnitude of meditation-related pain reductions. Meditation-induced reductions in pain intensity ratings were associated with increased activity in the anterior cingulate cortex and anterior insula, areas involved in the cognitive regulation of nociceptive processing. Reductions in pain unpleasantness ratings were associated with orbitofrontal cortex activation, an area implicated in reframing the contextual evaluation of sensory events. Moreover, reductions in pain unpleasantness also were associated with thalamic deactivation, which may reflect a limbic gating mechanism involved in modifying interactions between afferent input and executive-order brain areas. Together, these data indicate that meditation engages multiple brain mechanisms that alter the construction of the subjectively available pain experience from afferent information.
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In the citing paper
“The neural mechanisms of mindfulness-based pain relief have demonstrated that reductions of pain intensity are associated with heightened activity of the anterior cingulate cortex, the anterior insula, and the orbitofrontal cortex, while reductions in pain unpleasantness are associated with attenuated activity of the thalamus.32”
From Mechanisms of mindfulness in patients with migraine: Results of a qualitative study. (2023) · cites this paper as [32]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Brain imaging has shown that mindfulnessmeditation-related pain reductions are associated with activation of the perigenual ACC, OFC, and anterior insula (Zeidan et al., 2011;Zeidan et al., 2015).”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Based on our previous studies (Zeidan et al., 2010a;Zeidan et al., 2011;Zeidan et al., 2015) and sample size determination software (G*power, 3.1), 16 subjects per group were considered sufficient to detect a signifi-cant difference (large effect size ϭ p 2 ϭ.14) between groups on a twosided, 0.05 test of proportions [repeated-measures (RM)”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Specifically, mindfulness meditation significantly deactivates the thalamus (Zeidan et al., 2011;Zeidan et al., 2015), potentially reflecting cognitive gating of the transmission of sensory information to the cortex (Zeidan et al., 2011;Zeidan et al., 2012).”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“While mindfulness meditation has been shown to attenuate the subjective pain experience in healthy controls,31, 32”
From Mechanisms of mindfulness in patients with migraine: Results of a qualitative study. (2023) · cites this paper as [32]
The cited source says what the claim attributes to it.
In the citing paper
“Though these mindfulness interventions are too truncated to expect any long-term effects, studies indicate that they can have immediate effects on psychological and neuroendocrine responses to social stress,60 and perceived pain severity in response to noxious heat stimulation.61”
From Mindfulness-Based Interventions for Anxiety and Depression (2017) · cites this paper as [61]
The cited source says what the claim attributes to it.
In the citing paper
“some impact on pain intensity may be reached because mindfulness skills have been found to influence brain mechanisms that may alter the pain experience (Zeidan et al., 2011).”
From Acceptance- and mindfulness-based interventions for the treatment of chronic pain: a meta-analytic review (2016) · cites this paper as Zeidan et al., 2011
The cited source says what the claim attributes to it.
In the citing paper
“Importantly, mindfulness-meditation-induced pain relief is also associated with reduced thalamic activity, which may be related to significantly attenuated low-level sensory processing (Zeidan et al., 2011).”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Zeidan et al., 2011
The cited source says what the claim attributes to it.
In the citing paper
“Brief mindfulness interventions have been reported to reduce experimentally-induced pain in the laboratory, 15, 16”
From Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. (2017) · cites this paper as [15]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“So, decreased functional connectivity in these regions may contribute to enhanced quality of life that is reported post-ACT [21,40].”
From Graph theory analysis of induced neural plasticity post-Acceptance and Commitment Therapy for chronic pain (2020) · cites this paper as [40]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Activation of these regions has been linked to thoughts of helplessness, pessimism, and rumination in the instance of CMP [40].”
From Graph theory analysis of induced neural plasticity post-Acceptance and Commitment Therapy for chronic pain (2020) · cites this paper as [40]
Experimental — accuracy not yet measuredIn the citing paper
“A number of studies have found that meditation-related activation or volume increases are lateralized to the right hemisphere and correspond to tonic alertness–related brain areas (lateral PFC, inferior parietal, and anterior insula).65–70”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Buddhist meditation practices have been found to be associated with increases in activation in the dACC both during meditation45,65,76,78,86 and during tasks.70,80,81,87–89”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Converging evidence suggests that meditation training may be associated with decreased DMN activity,67, 70, 87, 94, 97–99”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Buddhist meditation practices have been found to be associated with increased activity in the DLPFC, both during meditation45,65,76–79 and during tasks,67,70,80,81 as well as larger frontal gray matter volumes.66,82,83”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [70]
In the citing paper
“Vipassana meditation has been described as a state of nonappraisal and/or a nonelaborative mental stance.45,137”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [137]
In the citing paper
“Regression analyses revealed that greater pain relief was directly associated with greater activation of the pgACC, right anterior insula, and bilateral OFC.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Focusing on the breath before the intervention reduced pain unpleasantness ratings but not pain intensity ratings when compared with rest.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“To this extent, it is now well established that mindfulness meditation significantly reduces pain after brief mental training (4 days > 4 weeks).62,134–136,141”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“In the presence of noxious heat, mindfulness significantly reduced SI activation corresponding to the stimulation site (right leg), suggesting that mindfulness reduces ascending nociceptive inputs to somatosensory cortical regions.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“In the presence of noxious heat, mindfulness significantly reduced SI activation corresponding to the stimulation site (right leg), suggesting that mindfulness reduces ascending nociceptive inputs to somatosensory cortical regions.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“After training, mindful attention to the breath significantly reduced pain intensity (↓40%) and pain unpleasantness (↓57%) ratings when compared with rest.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Mindfulness meditation produced widespread activation of the (1) ACC extending from the dACC to the perigenual ACC (pgACC), (2) bilateral orbitofrontal cortex (OFC), (3) the primary somatosensory cortices (SI) corresponding to the face region, (4) bilateral ventral striatum, and (5) deactivation of the default mode network.141”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Greater mindfulness-based pain relief was also associated with significant extensive, bilateral deactivation of the thalamus, a critical node of ascending nociceptive information from the spinal cord (Fig. 1).49”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“There was also significant deactivation of the PAG and thalamus, replicating and extending on the findings described in the previous ASL study.141”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“Furthermore, when compared with BOLD, ASL fMRI can reliably assess rostral neural regions, such as the OFC,126 a brain area repeatedly implicated in mindfulness meditation,135,141 but suffering from substantial susceptibility artifacts.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [141]
In the citing paper
“For instance, we found that mindfulness significantly increases on average by 13% after only three to four, 20 minutes sessions of mindfulness–based mental training [83; 84; 86–88].”
From Neural mechanisms supporting the relationship between dispositional mindfulness and pain (2018) · cites this paper as [88]
In the citing paper
“demonstrating that mindfulness meditation significantly attenuates pain through multiple, unique mechanisms”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“We postulated that mindfulness meditation attenuates pain through engagement of top-down (OFC to thalamus) inhibition of ascending nociceptive information.15, 20, 21, 23”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Meditation, after the four-session intervention, during noxious heat produced a mean 40% reduction in pain intensity and 57% reduction in pain unpleasantness ratings.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Greater activation of the subgenual ACC (sgACC), OFC, and right anterior insula (Fig. 1) was associated with mindfulness meditation–based analgesia.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“We also found that mindfulness meditation–based pain relief was associated with greater bilateral thalamic deactivation (Fig. 1) 21.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Activation of the OFC may facilitate inhibitory connections of the thalamic reticular nuclei (TRN) to further reduce the elaboration of nociceptive information throughout the cortex (evidenced by reductions in thalamic, PAG, and SI activation).21, 23”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“While meditation after brief training (less than 1 week) produces significant reductions in pain intensity and unpleasantness ratings,20, 21, 23, 122, 142”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Novice meditators recruit higher-order brain regions (OFC, sgACC, anterior insula) to downregulate ascending nociceptive input at the level of the thalamus through shifts in executive attention.21,23”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Mindfulness meditation–based pain relief was associated with similar brain activation as in our previous neuroimaging study,21 including greater activation of the OFC, pregenual ACC (pgACC), and right anterior insula.”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Furthermore, across almost all mindfulness/pain–focused experiments, the unpleasantness dimension of pain was significantly more attenuated with respect to pain intensity,16–21, 23, 121, 122”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [21]
In the citing paper
“Mindfulness training decreases the suffering that accompanies painful stimuli,48,50 an effect that seems in part to be orthogonal to opioid-dependent pain processing.47”
From Randomized, wait-list–controlled pilot study of app-delivered mindfulness for patients reporting chronic pain (2021) · cites this paper as [50]
In the citing paper
“These promising results at the end of the proposed mindfulness program may indicate reduced subjective pain and changes in the brain [25-27].”
From A Cloud-Based Virtual Reality App for a Novel Telemindfulness Service: Rationale, Design and Feasibility Evaluation (2017) · cites this paper as [27]
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Citations
Cites
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
PENFIELD, W., & BOLDREY, E. (1937) · Brain · doi:10.1093/brain/60.4.389 · Cited by 4,188
Mindfulness-based stress reduction and health benefits
Grossman, P., Niemann, L., Schmidt, S., & Walach, H. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00573-7 · Cited by 3,958
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 2×
“, 2010), and interoceptive awareness (right AI) (Critchley et al., 2004) (Fig.”
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859
Attention regulation and monitoring in meditation
Lutz, A., Slagter, H. A., Dunne, J. D., & Davidson, R. J. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.01.005 · Cited by 2,659
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Research works printed but not linked: 1
- Allison PD (2002) Missing data (Sage Publications, Thousand Oaks, CA).
Cited by
Sorted by citations
The Neuroscience of Mindfulness Meditation
Tang, Y.-Y., Hölzel, B. K., & Posner, M. I. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3916 · Cited by 2,889
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076
Creswell, J. D. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-042716-051139 · Cited by 1,702
Van Dam, N. T., van Vugt, M. K., Vago, D. R., Schmalzl, L., Saron, C. D., Olendzki, A., Meissner, T., Lazar, S. W., Kerr, C. E., Gorchov, J., et al. (2018) · Perspectives on Psychological Science · doi:10.1177/1745691617709589 · Cited by 1,506
Vago, D. R., & Silbersweig, D. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00296 · Cited by 1,310
Fox, K. C. R., Nijeboer, S., Dixon, M. L., Floman, J. L., Ellamil, M., Rumak, S. P., Sedlmeier, P., & Christoff, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.016 · Cited by 804
Mindfulness-Based Interventions for Anxiety and Depression
Hofmann, S. G., & Gómez, A. F. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.08.008 · Cited by 756
“61 These significant effects after only a few days of mindfulness training are exciting, and future research should explore whether such brief interventions can have similar effects on symptoms of anxiety or depression.”
Veehof, M. M., Trompetter, H. R., Bohlmeijer, E. T., & Schreurs, K. M. G. (2016) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2015.1098724 · Cited by 737
“Pain control and reduction are not the primary aims of acceptance- and mindfulness-based interventions, but some impact on pain intensity may be reached because mindfulness skills have been found to influence brain mechanisms that may alter the pain experience (Zeidan et al., 2011).”
BackgroundGuendelman, S., Medeiros, S., & Rampes, H. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00220 · Cited by 577
“It is worthy of note that participants reported a significant decrease in pain intensity and unpleasantness (Zeidan et al., 2011).”
BackgroundCraske, M. G., Stein, M. B., Eley, T. C., Milad, M. R., Holmes, A., Rapee, R. M., & Wittchen, H.-U. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.24 · Cited by 652
Mindfulness: Top–down or bottom–up emotion regulation strategy?
Chiesa, A., Serretti, A., & Jakobsen, J. C. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.10.006 · Cited by 470
Garland, E. L., Manusov, E. G., Froeliger, B., Kelly, A., Williams, J. M., & Howard, M. O. (2014) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0035798 · Cited by 431
Central mechanisms of pain revealed through functional and structural MRI
Davis, K. D., & Moayedi, M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9386-8 · Cited by 376
Creswell, J. D., Pacilio, L. E., Lindsay, E. K., & Brown, K. W. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.007 · Cited by 376
Zeidan, F., Emerson, N. M., Farris, S. R., Ray, J. N., Jung, Y., McHaffie, J. G., & Coghill, R. C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2542-15.2015 · Cited by 369
Self-citationThe Mindful Brain and Emotion Regulation in Mood Disorders
Farb, N. A. S., Anderson, A. K., & Segal, Z. V. (2012) · The Canadian Journal of Psychiatry · doi:10.1177/070674371205700203 · Cited by 366
Psychological processing in chronic pain: a neural systems approach
Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359
Default mode network connectivity encodes clinical pain: An arterial spin labeling study
Loggia, M. L., Kim, J., Gollub, R. L., Vangel, M. G., Kirsch, I., Kong, J., Wasan, A. D., & Napadow, V. (2012) · Pain · doi:10.1016/j.pain.2012.07.029 · Cited by 323
Creswell, J. D., Taren, A. A., Lindsay, E. K., Greco, C. M., Gianaros, P. J., Fairgrieve, A., Marsland, A. L., Brown, K. W., Way, B. M., Rosen, R. K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.008 · Cited by 299
“Some neuroimaging evidence indicates that acute meditation practice activates the anterior cingulate cortex (56,57), and it may be that anterior cingulate cortex activity during these 4.”
BackgroundMARCHAND, W. R. (2012) · Journal of Psychiatric Practice® · doi:10.1097/01.pra.0000416014.53215.86 · Cited by 305
A mind you can count on: validating breath counting as a behavioral measure of mindfulness
Levinson, D. B., Stoll, E. L., Kindy, S. D., Merry, H. L., & Davidson, R. J. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01202 · Cited by 287
Mindfulness meditation-based pain relief: a mechanistic account
Zeidan, F., & Vago, D. R. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13153 · Cited by 300
Self-citationNeural Primacy of the Salience Processing System in Schizophrenia
Palaniyappan, L. K., Simmonite, M., White, T. P., Liddle, E. B., & Liddle, P. F. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.027 · Cited by 306
Interoception and drug addiction
Paulus, M. P., & Stewart, J. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.002 · Cited by 281
Zeidan, F., Grant, J. A., Brown, C. A., McHaffie, J. G., & Coghill, R. C. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.082 · Cited by 284
Self-citationMindful attention reduces neural and self-reported cue-induced craving in smokers
Westbrook, C., Creswell, J. D., Tabibnia, G., Julson, E., Kober, H., & Tindle, H. A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr076 · Cited by 278
Mindfulness, Interoception, and the Body: A Contemporary Perspective
Gibson, J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02012 · Cited by 278
Gard, T., Holzel, B. K., Sack, A. T., Hempel, H., Lazar, S. W., Vaitl, D., & Ott, U. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr352 · Cited by 276
Garland, E. L., Froeliger, B., Zeidan, F., Partin, K., & Howard, M. O. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.006 · Cited by 277
Self-citationThe anatomy of pain and suffering in the brain and its clinical implications
Ridder, D. D., Adhia, D. B., & Vanneste, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.013 · Cited by 298
Garland, E. L., Froeliger, B., & Howard, M. O. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00173 · Cited by 268
“In that regard, mindfulness training has been shown to increase activity in the anterior insula during provocations by emotionally salient stimuli (113, 114).”
BackgroundJensen, K. B., Loitoile, R., Kosek, E., Petzke, F. W., Carville, S. F., Fransson, P., Marcus, H. E., Williams, S., Choy, E., Mainguy, Y., et al. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-32 · Cited by 276
Waters, L. E., Barsky, A. P., Ridd, A., & Allen, K. (2014) · Educational Psychology Review · doi:10.1007/s10648-014-9258-2 · Cited by 298
Economides, M., Martman, J., Bell, M. J., & Sanderson, B. (2018) · Mindfulness · doi:10.1007/s12671-018-0905-4 · Cited by 250
Taren, A. A., Gianaros, P. J., Greco, C. M., Lindsay, E. K., Fairgrieve, A., Brown, K. W., Rosen, R. K., Ferris, J. L., Julson, E., Marsland, A. L., et al. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv066 · Cited by 236
Jensen, K. B., Kosek, E., Wicksell, R., Kemani, M., Olsson, G., Merle, J. V., Kadetoff, D., & Ingvar, M. (2012) · PAIN · doi:10.1016/j.pain.2012.04.010 · Cited by 230
Lutz, A., McFarlin, D. R., Perlman, D. M., Salomons, T. V., & Davidson, R. J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.030 · Cited by 233
Effects of Brief Mindfulness-Based Interventions on Health-Related Outcomes: a Systematic Review
Howarth, A., Smith, J. G., Perkins-Porras, L., & Ussher, M. (2019) · Mindfulness · doi:10.1007/s12671-019-01163-1 · Cited by 219
Mindful attention to breath regulates emotions via increased amygdala–prefrontal cortex connectivity
Doll, A., Hölzel, B. K., Bratec, S. M., Boucard, C. C., Xie, X., Wohlschläger, A. M., & Sorg, C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.041 · Cited by 245
Women’s sexual dysfunction associated with psychiatric disorders and their treatment
Basson, R., & Gilks, T. (2018) · Women's Health · doi:10.1177/1745506518762664 · Cited by 225
Disrupted functional connectivity of the periaqueductal gray in chronic low back pain
Yu, R., Gollub, R. L., Spaeth, R. B., Napadow, V., Wasan, A. D., & Kong, J. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.08.019 · Cited by 224
Garland, E. L., Gaylord, S. A., Palsson, O., Faurot, K., Douglas Mann, J., & Whitehead, W. E. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-011-9391-z · Cited by 210
Neural mechanisms of mindfulness and meditation: Evidence from neuroimaging studies
Marchand, W. R. (2014) · World Journal of Radiology · doi:10.4329/wjr.v6.i7.471 · Cited by 207
Current status of acceptance and commitment therapy for chronic pain: A narrative review
Feliu Soler, A., Montesinos, F., Gutiérrez-Martínez, O., Scott, W., McCracken, L., & Luciano, J. (2018) · Journal of Pain Research · doi:10.2147/jpr.s144631 · Cited by 198
Pelletier, R., Higgins, J., & Bourbonnais, D. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0480-y · Cited by 215
Martucci, K. T., & Mackey, S. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002137 · Cited by 243
Self-citationMindfulness-Based Mobile Applications: Literature Review and Analysis of Current Features
Plaza, I., Demarzo, M., Herrera‐Mercadal, P., & García‐Campayo, J. (2013) · JMIR mhealth and uhealth · doi:10.2196/mhealth.2733 · Cited by 224
Taren, A. A., Gianaros, P. J., Greco, C. M., Lindsay, E. K., Fairgrieve, A., Brown, K. W., Rosen, R. K., Ferris, J. L., Julson, E., Marsland, A. L., et al. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000466 · Cited by 214
Neural correlates of mindfulness meditation-related anxiety relief
Zeidan, F., Martucci, K. T., Kraft, R. A., McHaffie, J. G., & Coghill, R. C. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst041 · Cited by 196
Self-citationPsychological and neural mechanisms of trait mindfulness in reducing depression vulnerability
Paul, N. A., Stanton, S. J., Greeson, J. M., Smoski, M. J., & Wang, L. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss070 · Cited by 193
“Using different cognitive and affective paradigms, increased and decreased insular activation has also found to be associated with dispositional mindfulness or post-intervention mindfulness (Kumar et al., 2008; Ives-Deliperi et al., 2010; Slagter et al., 2011; Zeidan et al., 2011).”
BackgroundMind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis
Garland, E. L., Brintz, C. E., Hanley, A. W., Roseen, E. J., Atchley, R. M., Gaylord, S. A., Faurot, K. R., Yaffe, J., Fiander, M., & Keefe, F. J. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.4917 · Cited by 190
Wells, R. E., O’Connell, N., Pierce, C. R., Estave, P., Penzien, D. B., Loder, E., Zeidan, F., & Houle, T. T. (2021) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.7090 · Cited by 183
Self-citationWells, R. E., Yeh, G. Y., Kerr, C. E., Wolkin, J. R., Davis, R. B., Tan, Y. H. V., Spaeth, R. B., Wall, R. B., Walsh, J. N., Kaptchuk, T. J., et al. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.10.001 · Cited by 179
Carlson, L. E. (2012) · ISRN Psychiatry · doi:10.5402/2012/651583 · Cited by 182
Neuromodulatory treatments for chronic pain: efficacy and mechanisms
Jensen, M. P., Day, M. A., & Miró, J. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.12 · Cited by 172
Meditation for Migraines: A Pilot Randomized Controlled Trial
Wells, R. E., Burch, R., Paulsen, R. H., Wayne, P. M., Houle, T. T., & Loder, E. (2014) · Headache: The Journal of Head and Face Pain · doi:10.1111/head.12420 · Cited by 161
Neuroprotective effects of yoga practice: age-, experience-, and frequency-dependent plasticity
Villemure, C., ÄŒeko, M., Cotton, V. A., & Bushnell, M. C. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00281 · Cited by 159
Mindfulness-Oriented Recovery Enhancement Reduces Pain Attentional Bias in Chronic Pain Patients
Garland, E. L., & Howard, M. O. (2013) · Psychotherapy and Psychosomatics · doi:10.1159/000348868 · Cited by 141
Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness
Britton, W. B., Lindahl, J. R., Cahn, B. R., Davis, J. H., & Goldman, R. E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12279 · Cited by 134
Self-reported interoceptive awareness in primary care patients with past or current low back pain
Mehling, Daubenmier, J., Price, Acree, Bartmess, & Stewart (2013) · Journal of Pain Research · doi:10.2147/jpr.s42418 · Cited by 137
Froeliger, B., Garland, E. L., Modlin, L. A., & McClernon, F. J. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00048 · Cited by 136
Zgierska, A. E., Burzinski, C. A., Cox, J., Kloke, J. D., Stegner, A. J., Cook, D. B., Singles, J. M., Mirgain, S. A., Coe, C. L., & Bačkonja, M. (2016) · Pain Medicine · doi:10.1093/pm/pnw006 · Cited by 144
Kong, F., Hu, S., Wang, X., Song, Y., & Liu, J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.11.033 · Cited by 139
Mindfulness-meditation-based pain relief is not mediated by endogenous opioids
Zeidan, F., Adler-Neal, A. L., Wells, R. E., Stagnaro, E., May, L. M., Eisenach, J. C., McHaffie, J. G., & Coghill, R. C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.4328-15.2016 · Cited by 132
“Specifically, mindfulness meditation significantly deactivates the thalamus (Zeidan et al., 2011; Zeidan et al., 2015), potentially reflecting cognitive gating of the transmission of sensory information to the cortex (Zeidan et al.”
BackgroundMethodInfluentialSelf-citationSpiking Neural Networks applied to the classification of motor tasks in EEG signals
Gonzalez, C. D. V., Sossa, H., Antelis, J. M., & Falcón-Morales, L. E. (2019) · Neural Networks · doi:10.1016/j.neunet.2019.09.037 · Cited by 132
Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information
Nahman‐Averbuch, H., Martucci, K. T., Granovsky, Y., Weissman‐Fogel, I., Yarnitsky, D., & Coghill, R. C. (2014) · Pain · doi:10.1016/j.pain.2014.07.008 · Cited by 128
Self-citationMindfulness-based training attenuates insula response to an aversive interoceptive challenge.
Haase, L., Thom, N. J., Shukla, A., Davenport, P. W., Simmons, A. N., Stanley, E. A., Paulus, M. P., & Johnson, D. C. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu042 · Cited by 124
“…al., 2010; Kang et al., 2013) and functional (Cahn and Polich, 2006; Brefczynski-Lewis et al., 2007; Farb et al., 2007; IvesDeliperi et al., 2011; Zeidan et al., 2011; Tang et al., 2012; Dickenson et al., 2013) brain changes are associated with MT, particularly in the insula, ACC and prefrontal…”
BackgroundCahn, B. R., Arnaud Delorme, A., & Polich, J. M. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss060 · Cited by 142
Pain sensitivity is inversely related to regional grey matter density in the brain
Emerson, N. M., Zeidan, F., Lobanov, O. V., Hadsel, M. S., Martucci, K. T., Quevedo, A. S., Starr, C. J., Nahman-Averbuch, H., Weissman-Fogel, I., Granovsky, Y., et al. (2014) · Pain · doi:10.1016/j.pain.2013.12.004 · Cited by 121
Self-citationZeidan, F., Baumgartner, J. N., & Coghill, R. C. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000759 · Cited by 115
Self-citationUsing Integrative Medicine in Pain Management: An Evaluation of Current Evidence
Lin, Y., Wan, L., & Jamison, R. N. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002579 · Cited by 124
Let it be: mindful acceptance down-regulates pain and negative emotion
Hedy Kober, A., Buhle, J. T., Weber, J., Ochsner, K. N., & Wager, T. D. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz104 · Cited by 127
The Distributed Nociceptive System: A Framework for Understanding Pain
Coghill, R. C. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.07.004 · Cited by 135
Self-citationTrindade, I. A., Guiomar, R., Carvalho, S. A., Duarte, J., Lapa, T., Menezes, P., Nogueira, M. R., Patrão, B., Pinto-Gouveia, J., & Castilho, P. (2021) · The Journal of Pain · doi:10.1016/j.jpain.2021.04.003 · Cited by 117
Wren, A., Ross, A., D’Souza, G., Almgren, C., Feinstein, A., Marshall, A., & Golianu, B. (2019) · Children · doi:10.3390/children6020033 · Cited by 115
Effects of stress on the corticolimbic system: implications for chronic pain
Vachon‐Presseau, É. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.014 · Cited by 123
Seminowicz, D. A., Burrowes, S. A. B., Kearson, A., Zhang, J., Krimmel, S. R., Samawi, L., Furman, A. J., Keaser, M. L., Gould, N. F., Magyari, T., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000001860 · Cited by 110
Brief mindfulness meditation improves emotion processing
Wu, R., Liu, L.-L., Zhu, H., Su, W.-J., Cao, Z.-Y., Zhong, S.-Y., Liu, X.-H., & Jiang, C.-L. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01074 · Cited by 110
The role of stress in the mosaic of autoimmunity: An overlooked association
Sharif, Κ., Watad, ., Coplan, L., Lichtbroun, B., Krosser, A., Lichtbroun, M., Bragazzi, N. L., Amital, H., Afek, A. B., & Shoenfeld, Y. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.04.005 · Cited by 118
Brief Mindfulness-Based Interventions for Acute and Chronic Pain: A Systematic Review
McClintock, A. S., McCarrick, S. M., Garland, E. L., Zeidan, F., & Zgierska, A. E. (2019) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0351 · Cited by 107
Self-citationGarland, E. L., Baker, A. K., Larsen, P., Riquino, M. R., Priddy, S. E., Thomas, E., Hanley, A. W., Galbraith, P., Wanner, N., & Nakamura, Y. (2017) · Journal of General Internal Medicine · doi:10.1007/s11606-017-4116-9 · Cited by 109
A systematic review: mindfulness intervention for cancer-related pain
Ngamkham, S., Holden, J. E., & Smith, E. L. (2019) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/apjon.apjon_67_18 · Cited by 103
“Practicing mindfulness meditation has been shown to be associated with increased activity in the anterior cingulate and anterior insular cortices, both of which are involved in cognitive regulation of nociceptive processes, and in the orbitofrontal cortex that is implicated in reframing the contextual evaluation of se…”
BackgroundCognitive processing of a common stimulus synchronizes brains, hearts, and eyes
Madsen, J., & Parra, L. C. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac020 · Cited by 91
Bakhshani, N. M., Amirani, A., Amirifard, H., & Shahrakipoor, M. (2015) · Global Journal of Health Science · doi:10.5539/gjhs.v8n4p142 · Cited by 101
Liu, X., Wang, S., Chang, S., Chen, W., & Si, M. (2013) · Stress and Health · doi:10.1002/smi.2446 · Cited by 100
Using suggestion to modulate automatic processes: From Stroop to McGurk and beyond
Lifshitz, M., Bonn, N. A., Fischer, A., Kashem, I. F., & Raz, A. (2012) · Cortex · doi:10.1016/j.cortex.2012.08.007 · Cited by 105
Brown, C. A., & Jones, A. K. P. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31824c5d9f · Cited by 106
Interaction between Neuroanatomical and Psychological Changes after Mindfulness-Based Training
Santarnecchi, E., D’Arista, S., Egiziano, E., Gardi, C., Petrosino, R., Vatti, G., Reda, M. A., & Rossi, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108359 · Cited by 110
Long-term mindfulness training is associated with reliable differences in resting respiration rate
Wielgosz, J., Schuyler, B. S., Lutz, A., & Davidson, R. J. (2016) · Scientific Reports · doi:10.1038/srep27533 · Cited by 114
Neuroimaging chronic pain: what have we learned and where are we going?
Martucci, K. T., Ng, P., & Mackey, S. (2014) · Future Neurology · doi:10.2217/fnl.14.57 · Cited by 92
Self-citationVago, D. R., & Nakamura, Y. (2011) · Cognitive Therapy and Research · doi:10.1007/s10608-011-9391-x · Cited by 93
Zabaniotou, A. A. (2020) · Global Transitions · doi:10.1016/j.glt.2020.06.002 · Cited by 104
Orbitofrontal cortex mediates pain inhibition by monetary reward
Becker, S., Gandhi, W., Pomares, F. B., Wager, T. D., & Schweinhardt, P. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw173 · Cited by 95
Gierthmühlen, J., Enax‐Krumova, E., Attal, N., Bouhassira, D., Cruccu, G., Finnerup, N. B., Haanpää, M., Hansson, P. T., Jensen, T. S., Freynhagen, R., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000227 · Cited by 89
The effects of Beta-Endorphin: state change modification
Veening, J. G., & Barendregt, H. P. (2015) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-12-3 · Cited by 89
Kong, F., Wang, X., Song, Y., & Liu, J. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1092469 · Cited by 92
Palaniyappan, L. K., White, T. P., & Liddle, P. F. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612805289881 · Cited by 91
Mindfulness Meditation for Fibromyalgia: Mechanistic and Clinical Considerations
Adler-Neal, A. L., & Zeidan, F. Z. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0686-0 · Cited by 101
Self-citationRivest-Gadbois, E., & Boudrias, M. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.03.021 · Cited by 91
Neural mechanisms supporting the relationship between dispositional mindfulness and pain
Zeidan, F., Salomons, T., Farris, S. R., Emerson, N. M., Adler-Neal, A., Jung, Y., & Coghill, R. C. (2018) · Pain · doi:10.1097/j.pain.0000000000001344 · Cited by 77
“The present evidence suggest that highly mindful individuals may be more resilient to pain-related ruminations(43,44,60,81) and potentially less likely to magnify evaluations that normally impart significance to salient sensory events, mechanisms also associated with mindfulness meditation–induced anxiety(89) and pain…”
Self-citation
Metadata
- Authors
- Zeidan, F., Martucci, K. T., Kraft, R. A., Gordon, N. S., McHaffie, J. G., & Coghill, R. C.
- Affiliations
- Marquette University (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Zeidan, Fadel
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-04-06
- Volume
- 31
- Issue
- 14
- Pages
- 5540-5548
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3090218
- OpenAlex
- W2151568754
- Cited by
- 640
- References
- 64
- Citations by year
- 2026: 31 · 2025: 27 · 2024: 42 · 2023: 40 · 2022: 42 · 2021: 49 · 2020: 42 · 2019: 46 · 2018: 47 · 2017: 44 · 2016: 41 · 2015: 50 · 2014: 55 · 2013: 35 · 2012: 37
- FWCI
- 47.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Funders
- Wake Forest University
- Mind and Life Institute
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS-39426, R01NS039426)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- mindfulness meditation, pain modulation, pain unpleasantness, pain intensity, primary somatosensory cortex, anterior cingulate cortex, anterior insula, orbitofrontal cortex, thalamus, arterial spin labeling, individual differences, meditation training
- MeSH terms
- Adult, Analysis of Variance, Attention, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Individuality, Functional Laterality, Magnetic Resonance Imaging, Male, Oxygen, Pain, Pain Measurement, Physical Stimulation, Psychophysics, Regression Analysis, Pain Threshold, Meditation, Young Adult, Pain Management
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