Cited by 198Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchDevelopmental Biology and Gene Regulation

The fraction of cortical GABAergic neurons is constant from near the start of cortical neurogenesis to adulthood

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Sahara, Setsuko, Yanagawa, Yuchio, O'Leary, Dennis D. M., Stevens, Charles F.·2012·The Journal of Neuroscience

Abstract

Approximately one in five neurons is GABAergic in many neocortical areas and species, forming a critical balance between inhibition and excitation in adult circuits. During development, cortical GABAergic neurons are generated in ventral telencephalon and migrate up to developing cortex where the excitatory glutamatergic neurons are born. We ask here: when during development is the adult GABAergic/glutamatergic neuron ratio first established? To answer this question, we have determined the fraction of all neocortical GABAergic neurons that will become inhibitory (GAD67(+)) in mice from embryonic day 10.5 (E10.5) to postnatal day 28 (P28). We find that this fraction is close to 1/5, the adult value, starting from early in corticogenesis (E14.5, when GAD67(+) neurons are still migrating tangentially to the cortex) and continuing at the same 1/5 value throughout the remainder of brain development. Thus our data indicate the one-in-five fraction of GABAergic neurons is already established during their neuronal migration and well before significant synapse formation.

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Crossref · 10.1523/jneurosci.6412-11.2012

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  • The sampled neuron population is roughly half GABAergic (47%) and half glutamatergic (53%) due to enrichment by design.

    “This enrichment procedure resulted, by design, in a disproportionate representation of GABAergic neurons, canonically ~20% of neurons (Sahara et al., 2012), such that the sampled neuron population is roughly half GABAergic (47%) and half glutamatergic (53%).”

    From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Sahara et al., 2012

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Authors
Sahara, S., Yanagawa, Y., O'Leary, D. D. M., & Stevens, C. F.
Affiliations
  • Salk Institute for Biological Studies (US)
  • Gunma University (JP)
Venue
The Journal of Neuroscience
Published
2012-04-04
Volume
32
Issue
14
Pages
4755-4761
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2073248815
Cited by
198
References
43
Citations by year
2026: 8 · 2025: 21 · 2024: 24 · 2023: 19 · 2022: 14 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 19 · 2017: 15 · 2016: 3 · 2015: 6 · 2014: 9 · 2013: 8 · 2012: 5
FWCI
2.99
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH086147)
  • National Institute of Neurological Disorders and Stroke (R01NS031558, R37NS031558)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
GABAergic neurons, cortical neurogenesis, GAD67, neuronal migration, tangential migration, ventral telencephalon, neocortex development, inhibitory interneurons, synaptogenesis
MeSH terms
Aging, Animals, Animals, Newborn, Cell Movement, Cerebral Cortex, Female, Glutamate Decarboxylase, Male, Mice, Inbred ICR, Pregnancy, Random Allocation, Mice, Neurogenesis, Gene Knock-In Techniques, GABAergic Neurons

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