Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1

Flames, Nuria; Long, Jason E.; Garratt, Alistair N.; Fischer, Tobias M.; Gassmann, Martin; Birchmeier, Carmen; Lai, Cary; Rubenstein, John L.R.; Marı́n, Oscar

doi:10.1016/j.neuron.2004.09.028

Cited by 431Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal SignalingDevelopmental Biology and Gene Regulation

Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1

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Flames, Nuria, Long, Jason E., Garratt, Alistair N., Fischer, Tobias M., Gassmann, Martin, Birchmeier, Carmen, Lai, Cary, Rubenstein, John L.R. +1 more·2004·Neuron

DOI 10.1016/j.neuron.2004.09.028

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Abstract

Most cortical interneurons arise from the subcortical telencephalon, but the molecules that control their migration remain largely unidentified. Here, we show that different isoforms of Neuregulin-1 are expressed in the developing cortex and in the route that migrating interneurons follow toward the cortex, whereas a population of the migrating interneurons express ErbB4, a receptor for Neuregulin-1. The different isoforms of Neuregulin-1 act as short- and long-range attractants for migrating interneurons, and perturbing ErbB4 function in vitro decreases the number of interneurons that tangentially migrate to the cortex. In vivo, loss of Neuregulin-1/ErbB4 signaling causes an alteration in the tangential migration of cortical interneurons and a reduction in the number of GABAergic interneurons in the postnatal cortex. These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system.

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When ErbB4 is absent, many interneurons do not reach the cerebral cortex.
“In the absence of ErbB4, many interneurons fail to reach the cerebral cortex (Flames et al., 2004).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Flames et al., 2004
Nrg1 acts through ErbB4, the main neuregulin receptor expressed by interneurons.
“The function of Nrg1 is mediated by the tyrosine kinase receptor ErbB4, the main neuregulin receptor expressed by interneurons (Flames et al., 2004; Yau et al., 2003).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Flames et al., 2004

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Authors: Flames, N., Long, J. E., Garratt, A. N., Fischer, T. M., Gassmann, M., Birchmeier, C., Lai, C., Rubenstein, J. L. R., & Marı́n, O.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
University of California, San Francisco (US)
Max Delbrück Center (DE)
Scripps Research Institute (US)
University of Basel (CH)
ORCID: Flames, Nuria
Garratt, Alistair N.
Gassmann, Martin
Birchmeier, Carmen
Lai, Cary
Rubenstein, John L.R.
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-10
Volume: 44
Issue: 2
Pages: 251-261
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2004.09.028
OpenAlex: W1994124220
Cited by: 431
References: 58
Citations by year: 2026: 3 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 15 · 2021: 25 · 2020: 21 · 2019: 17 · 2018: 20 · 2017: 15 · 2016: 16 · 2015: 16 · 2014: 17 · 2013: 37 · 2012: 22
FWCI: 5.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3211 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: National Institutes of Health (2k02mh001046-06, 2r01mh051561-04a1)
National Institute of Mental Health (R01MH49428, R01MH51561, K02MH01046, R01MH049428)
National Institute on Drug Abuse (R01DA012462, R01 DA12462)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: neuregulin-1, ErbB4, GABAergic interneurons, cortical interneuron migration, tangential migration, neuronal migration, telencephalon
MeSH terms: Animals, Cell Movement, Chlorocebus aethiops, Cerebral Cortex, Interneurons, Mice, Transgenic, Signal Transduction, In Situ Hybridization, COS Cells, Protein Isoforms, Neuregulin-1, Mice, ErbB Receptors, Receptor, ErbB-4

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Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1

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