The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
Abstract
During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is a progenitor region that is distinct from both the MGE and LGE. Notably, CGE cells showed a unique in vivo pattern of migration, and the CGE contributed cells to nuclei distinct from those populated by the MGE and LGE. Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE.
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The CGE produces all VIP+ and CCK+ cortical interneurons along with several less abundant types such as single bouquet cells.
“the CGE produces all VIP+ and CCK+ cortical interneurons along with several other less abundant types of interneurons such as single bouquet cells”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Nery et al., 2002
The CGE is a source of cortical interneurons that assume mature fates distinct from MGE-derived interneurons.
“in vitro culture and in vivo transplant studies implicated the CGE as a source of cortical interneurons that assumed mature fates distinct from MGE-derived interneurons”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [829]
MGE- and CGE-derived interneurons reach the dorsal telencephalon via separate pathways: MGE-derived cells travel via dorsolateral routes, while CGE-derived cells follow three distinct routes laterally, medially, and caudally.
“MGE- and CGE-derived interneurons reach the dorsal telencephalon via separate pathways: those from the MGE travel via dorsolateral routes while those from the CGE follow three distinct routes laterally, medially, and caudally.”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [829]
Interneurons from both GEs converge and disperse via two streams running in parallel, separated by the cortical plate or hippocampal primordium: a deep stream in the IZ/SVZ and a superficial one in the MZ.
“interneurons from both GEs converge and then disperse widely via two streams running in parallel, separated by the cortical plate (CPl) or hippocampal primordium: a deep stream in the intermediate/subventricular zones (IZ/SVZ) and a superficial one in the marginal zone (MZ)”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [829]
MGE progenitors preferentially express Nkx2.1, which must be downregulated in migrating postmitotic cells for them to avoid the striatum and reach the cortex.
“MGE progenitors preferentially express the transcription factor Nkx2.1 (147, 148, 829, 1233), which must be downregulated in migrating postmitotic cells in order for them to avoid the striatum and reach the cortex”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [829]
The choice of migratory path appears to be an intrinsic property of cells dependent on their region of origin and ultimate destination, and governed by different transcription factors.
“The choice of migratory path appears to be an intrinsic property of cells dependent on their region of origin and ultimate destination, and governed by different transcription factors”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [829]
The medial and caudal ganglionic eminences generate different groups of cortical interneurons.
“The MGE and CGE generate different groups of cortical interneurons (17–19).”
From Early emergence of cortical interneuron diversity in the mouse embryo (2018) · cites this paper as [18]
Part of the BNST originates embryonically from the CGE.
“Part of the BNST has embryonic origins in the CGE (Nery et al., 2002), suggesting that this structure may harbor such cell types.”
From Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity (2019) · cites this paper as Nery et al., 2002
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Self-citation
- Authors
- Nery, S., Fishell, G., & Corbin, J. G.
- Affiliations
- NYU Langone Health (US)
- Venue
- Nature Neuroscience
- Published
- 2002-11-04
- Volume
- 5
- Issue
- 12
- Pages
- 1279-1287
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2084114120
- Cited by
- 558
- References
- 48
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 15 · 2023: 23 · 2022: 16 · 2021: 18 · 2020: 26 · 2019: 19 · 2018: 16 · 2017: 23 · 2016: 20 · 2015: 19 · 2014: 23 · 2013: 39 · 2012: 29
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Funders
- National Institutes of Health (5f32ns010962-02)
- National Institute of Neurological Disorders and Stroke (R01 NS39007-03, R01NS039007, NS10962-03)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- caudal ganglionic eminence, ganglionic eminence, ventral telencephalon, cortical development, neuronal migration, progenitor cells, medial ganglionic eminence, lateral ganglionic eminence, cell fate determination, fate mapping, mouse embryo
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Corpus Striatum, Genetic Markers, Immunohistochemistry, Interneurons, Limbic System, Mice, Transgenic, Mutation, Neurons, Stem Cells, Telencephalon, Transcription Factors, Homeodomain Proteins, Gene Expression Regulation, Developmental, Cell Lineage, Stem Cell Transplantation, Mice
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