Interaction between COMT Val158Met polymorphism and childhood adversity affects reward processing in adulthood
Abstract
Background Accumulating evidence suggests that altered dopamine transmission may increase the risk of mental disorders such as ADHD, schizophrenia or depression, possibly mediated by reward system dysfunction. This study aimed to clarify the impact of the COMT Val(158)Met polymorphism in interaction with environmental variation (G×E) on neuronal activity during reward processing.Methods 168 healthy young adults from a prospective study conducted over 25years participated in a monetary incentive delay task measured with simultaneous EEG-fMRI. DNA was genotyped for COMT, and childhood family adversity (CFA) up to age 11 was assessed by a standardized parent interview.Results At reward delivery, a G×E revealed that fMRI activation for win vs. no-win trials in reward-related regions increased with the level of CFA in Met homozygotes as compared to Val/Met heterozygotes and Val homozygotes, who showed no significant effect. During the anticipation of monetary vs. verbal rewards, activation decreased with the level of CFA, which was also observed for EEG, in which the CNV declined with the level of CFA.Conclusions These results identify convergent genetic and environmental effects on reward processing in a prospective study. Moreover, G×E effects during reward delivery suggest that stress during childhood is associated with higher reward sensitivity and reduced efficiency in processing rewarding stimuli in genetically at-risk individuals. Together with previous evidence, these results begin to define a specific system mediating interacting effects of early environmental and genetic risk factors, which may be targeted by early intervention and prevention.
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Four monetary incentive delay studies reported lower basal ganglia activity during reward anticipation in people exposed to institutionalization or early adversity before adolescence.
“Using the monetary incentive delay task, four studies demonstrated decreased activity in regions of basal ganglia during the anticipation phase, suggesting reduced approach motivation in individuals who were exposed to institutionalization or early life adversity prior to adolescence (Boecker et al., 2014; Boecker-Schlier et al., 2016; Dillon et al., 2009; Mehta et al., 2010).”
From The effects of early life stress on reward processing (2018) · cites this paper as Boecker-Schlier et al., 2016
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Early environmental influences on the development of children's brain structure and function
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The effects of early life stress on reward processing
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“Using the monetary incentive delay task, four studies demonstrated decreased activity in regions of basal ganglia during the anticipation phase, suggesting reduced approach motivation in individuals who were exposed to institutionalization or early life adversity prior to adolescence (Boecker et al., 2014; Boecker-Sch…”
BackgroundResilience and the brain: a key role for regulatory circuits linked to social stress and support
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Self-citationLower cortisol level in response to a psychosocial stressor in young females with self-harm
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Self-citation
- Authors
- Boecker-Schlier, R., Holz, N. E., Buchmann, A. F., Blomeyer, D., Plichta, M. M., Jennen-Steinmetz, C., Wolf, I., Baumeister, S., Treutlein, J., Rietschel, M., Meyer-Lindenberg, A., Banaschewski, T., Brandeis, D., & Laucht, M.
- Affiliations
- Heidelberg University (DE)
- University of Zurich (CH)
- University of Potsdam (DE)
- Corresponding author
- Brandeis, Daniel
- Laucht, Manfred
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 132
- Pages
- 556-570
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2271009504
- Cited by
- 42
- References
- 138
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 1 · 2016: 3
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- publish.UP (University of Potsdam) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (FKZ 01GS08152, LA 733/1–2)
- Bundesministerium für Bildung und Forschung (01ZX1311A)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- COMT Val158Met polymorphism, childhood adversity, reward processing, gene-environment interaction, dopamine signaling, monetary incentive delay task, contingent negative variation, reward anticipation, childhood stress, genetic risk factors, early intervention
- MeSH terms
- Adult, Brain Mapping, Catechol O-Methyltransferase, Choice Behavior, Electroencephalography, Female, Genotype, Humans, Life Change Events, Magnetic Resonance Imaging, Male, Prospective Studies, Reward, Risk Factors, Stress, Psychological, Polymorphism, Single Nucleotide, Young Adult, Gene-Environment Interaction
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