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A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses
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“These miRNAs—miR-124-3p, miR-204-5p, miR-328-3p, and miR-181c-5p—regulate processes such as synaptic function [48–50], inflammation, and neuronal survival [51–56], which are similarly impacted by miR-129-5p [57–60] and miR-212-5p [61–66].”
From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [57]
Experimental — accuracy not yet measuredIn the citing paper
“neuronal miR-129-5p has been linked to epileptic plasticity and homeostatic synaptic downscaling in excitatory neurons [57].”
From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [57]
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Citations
Cites
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 1×
“Changes in de novo protein synthesis during PTX treat-ment were quantified by pulsed stable isotope labeling of amino acids in culture (pSILAC) (Selbach et al , 2008) followed by mass spectrometry.”
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786
Self-citationLong pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Polymenidou, M., Lagier-Tourenne, C., Hutt, K. R., Huelga, S. C., Moran, J., Liang, T. Y., Ling, S.-C., Sun, E., Wancewicz, E., Mazur, C., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2779 · Cited by 1,335
Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · cited 4×
“, reductions in the membrane ATPases Atp2b1-4; Fig 4 and Tables EV4 and EV7), in agreement with an important function of calcium homeostasis in synaptic scaling (Turrigiano, 2012).”
InfluentialCritical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
Diering, G. H., Nirujogi, R. S., Roth, R. H., Worley, P. F., Pandey, A., & Huganir, R. L. (2017) · Science · doi:10.1126/science.aai8355 · Cited by 516
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges
Lovci, M. T., Ghanem, D., Marr, H., Arnold, J., Gee, S., Parra, M., Liang, T. Y., Stark, T. J., Gehman, L. T., Hoon, S., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2699 · Cited by 385
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain
Gehman, L. T., Stoilov, P., Maguire, J., Damianov, A., Lin, C.-H., Shiue, L., Ares, M., Mody, I., & Black, D. L. (2011) · Nature Genetics · doi:10.1038/ng.841 · Cited by 331
Altrock, W. D., tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T. M., Potschka, H., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00088-6 · Cited by 258
Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes
Lee, J.-A., Damianov, A., Lin, C.-H., Fontes, M., Parikshak, N. N., Anderson, E. S., Geschwind, D. H., Black, D. L., & Martin, K. C. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.025 · Cited by 232
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Cited by
Sorted by citations
Non-coding RNAs: the gatekeepers of neural network activity
Zampa, F., Hartzell, A. L., Zolboot, N., & Lippi, G. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.006 · Cited by 13
Pulcrano, S., De Gregorio, R., De Sanctis, C., Volpicelli, F., Piscitelli, R. M., Speranza, L., Perrone-Capano, C., di Porzio, U., Caiazzo, M., Martini, A., et al. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.0431-23.2023 · Cited by 12
A role for astrocytic miR-129-5p in frontotemporal dementia
Kaurani, L., Pradhan, R., Schröder, S., Burkhardt, S., Schuetz, A.-L., Krüger, D. M., Pena, T., Heutink, P., Sananbenesi, F., & Fischer, A. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03338-y · Cited by 10
Metadata
- Authors
- Rajman, M., Metge, F., Fiore, R., Khudayberdiev, S., Aksoy‐Aksel, A., Bicker, S., Ruedell Reschke, C., Raoof, R., Brennan, G. P., Delanty, N., Farrell, M. A., O'Brien, D. F., Bauer, S., Norwood, B., Veno, M. T., Krüger, M., Braun, T., Kjems, J., Rosenow, F., Henshall, D. C., Dieterich, C., & Schratt, G.
- Venue
- The EMBO Journal
- Published
- 2017-05-09
- Volume
- 36
- Issue
- 12
- Pages
- 1770-1787
- ISSN
- 0261-4189
- 1460-2075
- Cited by
- 99
- References
- 12
- Language
- en
- Funders
- Deutsche Forschungsgemeinschaft (SCHR 1136/8‐1, SCHR 1136/3‐1, DI 1501/5‐1, FI 2157/2‐1)
- European Commission (EpiMiRNA 602130)
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