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Cited by 190Probiotics and Fermented FoodsGestational Diabetes Research and ManagementGut microbiota and health

Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial

Callaway, Leonie K., McIntyre, H. David, Barrett, Helen L., Foxcroft, Katie, Tremellen, Anne, Lingwood, Barbara E., Tobin, Jacinta M., Wilkinson, Shelley +5 more·2019·Diabetes Care
DOI 10.2337/dc18-2248
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Abstract

OBJECTIVE: Given the role of gut microbiota in regulating metabolism, probiotics administered during pregnancy might prevent gestational diabetes mellitus (GDM). This question has not previously been studied in high-risk overweight and obese pregnant women. We aimed to determine whether probiotics (Lactobacillus rhamnosus and Bifidobacterium animalis subspecies lactis) administered from the second trimester in overweight and obese women prevent GDM as assessed by an oral glucose tolerance test (OGTT) at 28 weeks’ gestation. Secondary outcomes included maternal and neonatal complications, maternal blood pressure and BMI, and infant body composition. RESEARCH DESIGN AND METHODS: This was a double-blind randomized controlled trial of probiotic versus placebo in overweight and obese pregnant women in Brisbane, Australia. RESULTS: The study was completed in 411 women. GDM occurred in 12.3% (25 of 204) in the placebo arm and 18.4% (38 of 207) in the probiotics arm (P = 0.10). At OGTT, mean fasting glucose was higher in women randomized to probiotics (79.3 mg/dL) compared with placebo (77.5 mg/dL) (P = 0.049). One- and two-hour glucose measures were similar. Preeclampsia occurred in 9.2% of women randomized to probiotics compared with 4.9% in the placebo arm (P = 0.09). Excessive weight gain occurred in 32.5% of women in the probiotics arm (55 of 169) compared with 46% in the placebo arm (81 of 176) (P = 0.01). Rates of small for gestational age (<10th percentile) were 2.4% in the probiotics arm (5 of 205) and 6.5% in the placebo arm (13 of 199) (P = 0.042). There were no differences in other secondary outcomes. CONCLUSIONS: The probiotics used in this study did not prevent GDM in overweight and obese pregnant women.

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  • Studies on the beneficial effects of probiotics in the prevention or treatment of GDM have inconclusive results.

    “However, in the conducted studies on the beneficial effects of probiotics in the prevention or treatment of GDM, the results are still inconclusive [88,89,90,91].”

    From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [89]

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Authors
Callaway, L. K., McIntyre, H. D., Barrett, H. L., Foxcroft, K., Tremellen, A., Lingwood, B. E., Tobin, J. M., Wilkinson, S., Kothari, A., Morrison, M., O’Rourke, P., Pelecanos, A., & Dekker Nitert, M.
Affiliations
  • The University of Queensland (AU)
  • Faculty of Medicine, The University of Queensland, Herston, Australia
  • Royal Brisbane and Women's Hospital (AU)
  • Mater Research (AU)
  • James Cook University (AU)
  • Redcliffe Hospital (AU)
  • Translational Research Institute (AU)
  • QIMR Berghofer Medical Research Institute, Herston, Australia
  • QIMR Berghofer Medical Research Institute (AU)
  • School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia
Corresponding author
Callaway, Leonie K.
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2019-01-18
Volume
42
Issue
3
Pages
364-371
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc18-2248
OpenAlex
W2911130073
Cited by
187
References
47
Citations by year
2026: 19 · 2025: 18 · 2024: 29 · 2023: 23 · 2022: 37 · 2021: 27 · 2020: 19 · 2019: 15
FWCI
18.91
Type
journal article
Language
en
Open access
closed
Licence
www.diabetesjournals.org/content/license (vor, 33 d)
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchOnline - JCU (James Cook University) (submittedVersion)
Funders
  • National Health and Medical Research Council (APP1028575)
  • Royal Brisbane and Women’s Hospital Foundation
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, gestational diabetes mellitus, overweight in pregnancy, maternal obesity, Lactobacillus rhamnosus, Bifidobacterium animalis subsp. lactis, gut microbiota, preeclampsia, fetal growth restriction, gestational weight gain, maternal blood pressure, infant body composition
MeSH terms
Gastrointestinal Microbiome, Adult, Australia, Double-Blind Method, Female, Glucose Tolerance Test, Humans, Obesity, Pregnancy, Pregnancy Complications, Weight Gain, Diabetes, Gestational, Probiotics, Overweight

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