Endogenous opioid actions and effects of environmental disturbance on parturition and oxytocin secretion in rats
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Blood samples were taken from conscious, chronically-catheterized rats during parturition for measurement of oxytocin by specific radioimmunoassay. After the birth of the 3rd pup, rats were allowed to remain in their nesting cage (undisturbed rats) or were transferred for 45 min to a glass bowl (disturbed rats); at the time of transfer, rats were given an i.v. injection of the opioid antagonist naloxone or saline vehicle. Subsequent parturition was prolonged in saline-treated disturbed rats, but not in naloxone-treated disturbed rats. Parturition was significantly hastened in naloxone-treated undisturbed rats. Naloxone injections were followed by a large rise in plasma oxytocin concentrations in disturbed and undisturbed rats. We conclude, from a statistical analysis of the relationship within experimental groups between plasma oxytocin concentration and speed of parturition, that the effects of disturbance and of naloxone upon parturition may be accounted for, at least in part, by their effects upon oxytocin release. However, the effects of disturbance on parturition may not be mediated entirely by activation of opioid pathways. Naloxone did not potentiate oxytocin release in non-pregnant rats, or on Day 1 post partum, but did potentiate oxytocin release on Day 22 of pregnancy even in rats before the onset of parturition. Endogenous opioid pathways regulating oxytocin release therefore appear to be active during late pregnancy and during parturition itself.
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Enhancing opioidergic tone with morphine severely delays the course of parturition, accompanied by a reduced level of circulating oxytocin, whereas attenuating opioidergic tone with naloxone acutely increases the speed of parturition by greatly elevating oxytocin levels, reversing this delay.
“Enhancing opioidergic tone with morphine severely delays the course of parturition, accompanied by a reduced level of circulating OT, whereas attenuating opioidergic tone with NAL acutely increases the speed of parturition by greatly elevating OT levels, reversing this delay (27–29).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [28]
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The importance of increased levels of oxytocin induced by naloxone to milk removal in dairy cows
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Oxytocin and opioid antagonists: A dual approach to improving social behavior
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Effects of Stress on Pregnancy and Parturition
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Stress influencing production and welfare in farmed mink
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Stress influencing production and welfare in farmed mink
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REVIEW Sex, parturition and motherhood without oxytocin?
Russell, J. A., & Leng, G. (2015)
Changes in pain threshold during pregnancy and parturition in the sow and the involvement of opioids
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- Authors
- Leng, G., Mansfield, S., Bicknell, R. J., Blackburn, R. E., Brown, D., Chapman, C., Dyer, R. G., Hollingsworth, S., Shibuki, K., Yates, J. O., & Way, S.
- Affiliations
- Babraham Institute (GB)
- ORCID
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-09-01
- Volume
- 84
- Issue
- 1
- Pages
- 345-356
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2064789467
- Cited by
- 88
- References
- 19
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- endogenous opioids, childbirth, oxytocin secretion, naloxone, environmental disturbance, nesting behavior, parturition duration, late pregnancy, opioid antagonists, plasma oxytocin
- MeSH terms
- Animals, Endorphins, Female, Labor, Obstetric, Naloxone, Oxytocin, Pregnancy, Rats, Inbred Strains, Stress, Physiological, Rats
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