Cited by 88Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyMaternal and Perinatal Health Interventions

Endogenous opioid actions and effects of environmental disturbance on parturition and oxytocin secretion in rats

Open access
Leng, G., Mansfield, S., Bicknell, R. J., Blackburn, R. E., Brown, D., Chapman, C., Dyer, R. G., Hollingsworth, S. +3 more·1988·Reproduction

Abstract

Blood samples were taken from conscious, chronically-catheterized rats during parturition for measurement of oxytocin by specific radioimmunoassay. After the birth of the 3rd pup, rats were allowed to remain in their nesting cage (undisturbed rats) or were transferred for 45 min to a glass bowl (disturbed rats); at the time of transfer, rats were given an i.v. injection of the opioid antagonist naloxone or saline vehicle. Subsequent parturition was prolonged in saline-treated disturbed rats, but not in naloxone-treated disturbed rats. Parturition was significantly hastened in naloxone-treated undisturbed rats. Naloxone injections were followed by a large rise in plasma oxytocin concentrations in disturbed and undisturbed rats. We conclude, from a statistical analysis of the relationship within experimental groups between plasma oxytocin concentration and speed of parturition, that the effects of disturbance and of naloxone upon parturition may be accounted for, at least in part, by their effects upon oxytocin release. However, the effects of disturbance on parturition may not be mediated entirely by activation of opioid pathways. Naloxone did not potentiate oxytocin release in non-pregnant rats, or on Day 1 post partum, but did potentiate oxytocin release on Day 22 of pregnancy even in rats before the onset of parturition. Endogenous opioid pathways regulating oxytocin release therefore appear to be active during late pregnancy and during parturition itself.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1530/jrf.0.0840345

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Enhancing opioidergic tone with morphine severely delays the course of parturition, accompanied by a reduced level of circulating oxytocin, whereas attenuating opioidergic tone with naloxone acutely increases the speed of parturition by greatly elevating oxytocin levels, reversing this delay.

    “Enhancing opioidergic tone with morphine severely delays the course of parturition, accompanied by a reduced level of circulating OT, whereas attenuating opioidergic tone with NAL acutely increases the speed of parturition by greatly elevating OT levels, reversing this delay (27–29).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. Leng, G. & Bicknell, R.J. (1984) Patterns of electrical activity and hormone release from neurosecretory cells. In Endocrinology, pp. 1020-1023.
  2. Eds F. Labrie & L. Proulx. Elsevier, North Holland.
  3. Lindheimer, M.D., Barren, W.M. & Davison, J.M. (1985) Water metabolism and vasopressin secretion in preg¬ nancy. In Vasopressin, pp. 229-240.
  4. Ed. R. W. Schrier. Raven Press, New York.

Cited by

Sorted by citations

Authors
Leng, G., Mansfield, S., Bicknell, R. J., Blackburn, R. E., Brown, D., Chapman, C., Dyer, R. G., Hollingsworth, S., Shibuki, K., Yates, J. O., & Way, S.
Affiliations
Babraham Institute (GB)
Venue
Reproduction
Published
1988-09-01
Volume
84
Issue
1
Pages
345-356
ISSN
  • 1470-1626 (ISSN-L)
  • 1741-7899
OpenAlex
W2064789467
Cited by
88
References
19
Citations by year
2025: 1 · 2024: 2 · 2022: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
1.96
Type
journal article
Language
en
Open access
Locations
  • Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords
endogenous opioids, childbirth, oxytocin secretion, naloxone, environmental disturbance, nesting behavior, parturition duration, late pregnancy, opioid antagonists, plasma oxytocin
MeSH terms
Animals, Endorphins, Female, Labor, Obstetric, Naloxone, Oxytocin, Pregnancy, Rats, Inbred Strains, Stress, Physiological, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review