Cited by 234Autism Spectrum Disorder ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional Development

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Cognitive-Behavioral Therapy for Anxiety in Children With High-Functioning Autism: A Meta-analysis

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Sukhodolsky, Denis G., Bloch, Michael H., Panza, Kaitlyn E., Reichow, Brian·2013·Pediatrics

DOI 10.1542/peds.2013-1193PMC PMC3813396

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Abstract

BACKGROUND: Anxiety is a common and impairing problem in children and adolescents with autism spectrum disorder (ASD). There is emerging evidence that cognitive-behavioral therapy (CBT) could reduce anxiety in children with high-functioning ASD. OBJECTIVE: To systematically review the evidence of using CBT to treat anxiety in children and adolescents with ASD. Methods for this review were registered with PROSPERO (CRD42012002722). METHODS: We included randomized controlled trials published in English in peer-reviewed journals comparing CBT with another treatment, no treatment control, or waitlist control. Two authors independently screened 396 records obtained from database searches and hand searched relevant journals. Two authors independently extracted and reconciled all data used in analyses from study reports. RESULTS: Eight studies involving 469 participants (252 treatment, 217 comparison) met our inclusion criteria and were included in meta-analyses. Overall effect sizes for clinician- and parent-rated outcome measures of anxiety across all studies were d = 1.19 and d = 1.21, respectively. Five studies that included child self-report yielded an average d = 0.68 across self-reported anxiety. CONCLUSIONS: Parent ratings and clinician ratings of anxiety are sensitive to detecting treatment change with CBT for anxiety relative to waitlist and treatment-as-usual control conditions in children with high-functioning ASD. Clinical studies are needed to evaluate CBT for anxiety against attention control conditions in samples of children with ASD that are well characterized with regard to ASD diagnosis and co-occurring anxiety symptoms.

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Background
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Authors: Sukhodolsky, D. G., Bloch, M. H., Panza, K. E., & Reichow, B.
Affiliations: Yale University (US)
ORCID: Sukhodolsky, Denis G.
Bloch, Michael H.
Panza, Kaitlyn E.
Reichow, Brian
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2013-10-28
Volume: 132
Issue: 5
Pages: e1341-e1350
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2013-1193
PMC: PMC3813396
OpenAlex: W2110855627
Cited by: 234
References: 87
Citations by year: 2026: 8 · 2025: 11 · 2024: 16 · 2023: 18 · 2022: 17 · 2021: 27 · 2020: 31 · 2019: 21 · 2018: 22 · 2017: 27 · 2016: 16 · 2015: 14 · 2014: 5 · 2013: 1
FWCI: 6.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: PEDIATRICS (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (K01MH079130, K23MH091240, R25MH077823)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD083881)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: cognitive behavioral therapy, anxiety, high-functioning autism, autism spectrum disorder, children, adolescents, treatment efficacy, child self-report, waitlist control
MeSH terms: Anxiety, Autistic Disorder, Child, Humans, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic

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Cognitive-Behavioral Therapy for Anxiety in Children With High-Functioning Autism: A Meta-analysis

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