Religiosity, depression, and quality of life in bipolar disorder: a two-year prospective study
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OBJECTIVE: Few quantitative studies have examined the effect of religious involvement on the course of bipolar disorder (BD). We investigated the effects of religious activity and coping behaviors on the course of depression, mania, and quality of life (QoL) in patients with BD. METHODS: Two-year longitudinal study of 168 outpatients with BD. Linear regression was used to examine associations between religious predictors and outcome variables (manic symptoms, depression, QoL), controlling for sociodemographic variables. RESULTS: Among the 158 patients reassessed after 2 years, positive religious coping at T1 predicted better QoL across all four domains: physical (β = 10.2, 95%CI 4.2 to 16.1), mental (β = 13.4, 95%CI 7.1 to 19.7), social (β = 10.5, 95%CI 3.6 to 17.33), and environmental (β = 11.1, 95%CI 6.2 to 16.1) at T2. Negative religious coping at T1 predicted worse mental (β = -28.1, 95%CI -52.06 to -4.2) and environmental (β = -20.4, 95%CI -39.3 to -1.6) QoL. Intrinsic religiosity at T1 predicted better environmental QoL (β = 9.56, 95%CI 2.76 to 16.36) at T2. Negative religious coping at T1 predicted manic symptoms (β = 4.1) at T2. CONCLUSION: Religiosity/spirituality (R/S) may influence the QoL of patients with BD over time, even among euthymic patients. Targeting R/S (especially positive and negative religious coping) in psychosocial interventions may enhance the quality of recovery in patients with BD.
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Prospective high-quality studies have confirmed the predominantly positive effect of R/S across different psychiatric conditions, including depressive disorders and bipolar disorders.
“Prospective high-quality studies have confirmed the predominantly positive effect of R/S across different psychiatric conditions, including depressive disorders8 and bipolar disorders,9”
From Brazilian Psychiatric Association guidelines on the integration of spirituality into mental health clinical practice: Part 1. Spiritual history and differential diagnosis (2023) · cites this paper as [9]
The Discussion reports that positive religious coping predicted better quality of life over two years in patients with bipolar disorder. But negative religious coping predicted worse quality of life, R/S did not predict later depression levels, and the authors caution against causal inference from this observational study. Thus the study supports a beneficial association for one aspect of R/S, not a confirmed, predominantly positive effect of R/S overall in bipolar disorder. (LLM, conf=0.88)
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A influência da espiritualidade na terapêutica e prognóstico dos pacientes com transtornos mentais
Gomes, L. N., Rodrigues, I. C. D. F., Rocha, S. M. A., Alves, W. G., Botelho, L. L., Franco, A. C. S. D. M., Santana, D. S., Labuda, S. F., Gonçalves, L. S. F., & Soares, G. F. G. (2021) · Revista Eletrônica Acervo Científico · doi:10.25248/reac.e7729.2021
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Abdel‐Khalek, A. M. (2021) · Springer eBooks · doi:10.1007/978-3-319-69909-7_3832-2
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0034
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0021
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0007
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0005
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0029
Self-citationLevin, J. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.002.0007
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0033
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.002.0009
Self-citationAlzheimer’s Disease and Other Dementias
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0023
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0024
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0020
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0026
Self-citationDisease Prevention, Detection, and Treatment
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0030
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0019
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.002.0004
Self-citationPersonality Traits and Disorders
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0011
Self-citationSchizophrenia and Other Psychoses
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0009
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0004
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0018
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0003 · Cited by 1 · see citing works
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0013
Self-citationKoh, H. K. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.002.0006
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0028
Self-citationKoenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0022
Self-citationStudies on Religion and Health
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.005.0001
Self-citationQuality of Life and Religiosity in Arab College Students and Elderly
Abdel‐Khalek, A. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-17299-1_3832
Religion and Mental Health in South Asia
Rajkumar, R. P. (2025) · Springer eBooks · doi:10.1007/978-981-96-8078-8_14
Menegatti-Chequini, M. C., Loch, A. A., Leão, F. C., Peres, M. F. P., & Vallada, H. (2020) · Figshare · doi:10.6084/m9.figshare.13279173
A Abordagem da Espiritualidade/Religiosidade no Contexto Clínico da Psicologia
Fernandes, L. F. B., Barros, L. T., Ibanhez, R. J., & Pereira, F. D. M. (2026) · Psicologia Ciência e Profissão · doi:10.1590/1982-3703003288107
Osman, A. A., Elnoor, M., Bokhari, S. A., Malik, M. A., Javaid, S. F., Osman, A. H. M., & Alnor, M. A. (2026) · BJPsych Open · doi:10.1192/bjo.2026.12115
- Authors
- Stroppa, A., Colugnati, F. A., Koenig, H. G., & Moreira-Almeida, A.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Duke University (US)
- Universidade Federal de Juiz de Fora, Brazil
- Venue
- Revista Brasileira de Psiquiatria
- Publisher
- EDITORA SCIENTIFIC
- Published
- 2018-02-15
- Volume
- 40
- Issue
- 3
- Pages
- 238-243
- ISSN
- 1516-4446 (ISSN-L)
- 1809-452X
- PMC
- PMC6899393
- OpenAlex
- W2790462092
- Cited by
- 89
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 49 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 2
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Psychiatry (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- bipolar disorder, religiosity, spirituality, religious coping, quality of life, depression, manic symptoms, intrinsic religiosity, clinical course, psychosocial interventions
- MeSH terms
- Adaptation, Psychological, Adult, Bipolar Disorder, Depression, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Quality of Life, Surveys and Questionnaires, Religion and Psychology, Socioeconomic Factors, Spirituality
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