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Cited by 572

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The Immunogenicity of Human Adipose‐Derived Cells: Temporal Changes In Vitro

Open access
McIntosh, Kevin, Zvonic, Sanjin, Garrett, Sara, Mitchell, James B., Floyd, Z. Elizabeth, Hammill, Lora, Kloster, Amy, Di Halvorsen, Yuan, Ting, Jenny P., Storms, Robert W., Goh, Brian, Kilroy, Gail, Wu, Xiying, Gimble, Jeffrey M.·2006·STEM CELLS
DOI 10.1634/stemcells.2005-0235
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Abstract

Regenerative medical techniques will require an abundant source of human adult stem cells that can be readily available at the point of care. The ability to use unmatched allogeneic stem cells will help achieve this goal. Since adipose tissue represents an untapped reservoir of human cells, we have compared the immunogenic properties of freshly isolated, collagenase-digested human adipose tissue-derived stromal vascular fraction cells (SVFs) relative to passaged, plastic-adherent adipose-derived stem cells (ASCs). Parallel studies have shown that adherence to plastic and subsequent expansion of human adipose-derived cells selects for a relatively homogeneous cell population based on immunophenotype. Consistent with these findings, the presence of hematopoietic-associated markers (CD11a, CD14, CD45, CD86, and histocompatible locus antigen-DR [HLA-DR]) detected on the heterogeneous SVF cell population decreased upon subsequent passage of the ASCs. In mixed lymphocyte reactions (MLRs), SVFs, and early passage ASCs stimulated proliferation by allogeneic responder T cells. In contrast, the ASCs beyond passage P1 failed to elicit a response from T cells. Indeed, late passage ASCs actually suppressed the MLR response. Although these results support the feasibility of allogeneic human ASC transplantation, confirmatory in vivo animal studies will be required.

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Research works printed but not linked: 32

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Metadata

Authors
McIntosh, K., Zvonic, S., Garrett, S., Mitchell, J. B., Floyd, Z. E., Hammill, L., Kloster, A., Di Halvorsen, Y., Ting, J. P., Storms, R. W., Goh, B., Kilroy, G., Wu, X., & Gimble, J. M.
Venue
STEM CELLS
Publisher
Oxford University Press (OUP)
Published
2006-05
Volume
24
Issue
5
Pages
1246-1253
ISSN
  • 1066-5099 (ISSN-L)
  • 1549-4918
DOI
10.1634/stemcells.2005-0235
OpenAlex
W2054134729
Cited by
572
References
4
FWCI
9.91
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: The Immunogenicity of Human Adipose‐Derived Cells: Temporal Changes In Vitro. https://app.cochat.ai/papers/10.1634/stemcells.2005-0235
The paper
McIntosh, K., Zvonic, S., Garrett, S., Mitchell, J. B., Floyd, Z. E., Hammill, L., Kloster, A., Di Halvorsen, Y., Ting, J. P., Storms, R. W., Goh, B., Kilroy, G., Wu, X., & Gimble, J. M. (2006). The Immunogenicity of Human Adipose‐Derived Cells: Temporal Changes In Vitro. STEM CELLS. https://doi.org/10.1634/stemcells.2005-0235

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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