The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
The role of corticotropin-releasing factor in depression and anxiety disorders
Open accessAbstract
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the evidence suggesting that CRF is hypersecreted from hypothalamic as well as from extrahypothalamic neurons in depression, resulting in hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and elevations of cerebrospinal fluid (CSF) concentrations of CRF. This increase in CRF neuronal activity is also believed to mediate certain of the behavioral symptoms of depression involving sleep and appetite disturbances, reduced libido, and psychomotor changes. The hyperactivity of CRF neuronal systems appears to be a state marker for depression because HPA axis hyperactivity normalizes following successful antidepressant treatment. Similar biochemical and behavioral findings have been observed in adult rats and monkeys that have been subjected to early-life stress. In contrast, clinical studies have not revealed any consistent changes in CSF CRF concentrations in patients with anxiety disorders; however, preclinical findings strongly implicate a role for CRF in the pathophysiology of certain anxiety disorders, probably through its effects on central noradrenergic systems. The findings reviewed here support the hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Alterations of the hypothalamic–pituitary–adrenal (HPA) axis is one of the most notable neurobiological findings in psychiatry (1, 2).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [1]
Experimental — accuracy not yet measuredIn the citing paper
“An important interplay is also the excitatory reciprocal interaction between the HPA axis and the brainstem sympathetic locus coeruleus (LC)-norepinephrine (NE) system: CRH activates the LC; in turn, NE, a known wake-promoting neurotransmitter, activates hypothalamic CRH [9, 10].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,889
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Hoskins, R. G. (1953) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-13-4-473 · Cited by 3,780
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(1911) · JAMA · doi:10.1001/jama.1911.04260070032017 · Cited by 3,355
Proceedings of the National Academy of Sciences, USA.
Ochoa, S. (1996) · Current Biology · doi:10.1016/s0960-9822(09)00431-x · Cited by 2,783
Alcoholism: Clinical and Experimental Research
(2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/(issn)1530-0277 · Cited by 1,830
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Self-citationNemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Self-citationVaughan, J. M., Donaldson, C. J., Bittencourt, J. C., Perrin, M. H., Lewis, K., Sutton, S. W., Chan, R. K. W., Turnbull, A. V., Lovejoy, D. A., RIVIER, C. L., et al. (1995) · Nature · doi:10.1038/378287a0 · Cited by 1,479
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
DAOUD, G. (1965) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1965.02090030355030 · Cited by 1,170
Physiology and pharmacology of corticotropin-releasing factor.
Owens, M. J., & Nemeroff, C. B. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06673-6 · Cited by 1,147
Self-citationRole of serotonin in the pathophysiology of depression: focus on the serotonin transporter
Owens, M. J., & Nemeroff, C. B. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.2.288 · Cited by 932
Self-citationTimpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics · doi:10.1038/520 · Cited by 919
Clinical Characteristics of Women With a History of Childhood Abuse: Unhealed Wounds
McCauley, J. (1997) · JAMA · doi:10.1001/jama.1997.03540410040028 · Cited by 904
Smith, G. W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80491-2 · Cited by 892
Antoni, F. A. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-4-351 · Cited by 888
Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation
HOLSBOER, F., & Barden, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 860
Brain corticosteroid receptor balance and homeostatic control
de Kloet, E. R. (1991) · Frontiers in Neuroendocrinology · Cited by 842
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.624 · Cited by 721
Self-citationRaadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000126778 · Cited by 667
Maternal Glucocorticoid Secretion Mediates Long-Term Effects of Prenatal Stress
Barbazanges, A., Piazza, P., le Moal, M., & Maccari, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03943.1996 · Cited by 655
Coplan, J. D., Andrews, M. W., Rosenblum, L. A., Owens, M. J., Friedman, S., Gorman, J. M., & Nemeroff, C. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1619 · Cited by 649
Self-citationCorticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus
Valentino, R. J., Foote, S. L., & Aston‐Jones, G. (1983) · Brain Research · doi:10.1016/0006-8993(83)90615-7 · Cited by 603
Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims
Nemeroff, C. B. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800300075009 · Cited by 555
Self-citationLadd, C. O., Owens, M. J., & Nemeroff, C. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625891 · Cited by 536
Self-citationPrenatal Stress Increases the Hypothalamo‐Pituitary‐Adrenal Axis Response in Young and Adult Rats
Henry, C., Kabbaj, M., Simon, H., Moal, M. L., & Maccari, S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00591.x · Cited by 528
Stenzel‐Poore, M. P., Heinrichs, S. C., Rivest, S., Koob, G. F., & Vale, W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02579.1994 · Cited by 468
Chappell, P., Smith, M., Kilts, C., Bissette, G., Ritchie, J., Anderson, C., & Nemeroff, C. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02908.1986 · Cited by 464
Self-citationLiu, Caldji, Sharma, Plotsky, & Meaney (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00422.x · Cited by 456
Life Events, Vulnerability and Onset of Depression: Some Refinements
Brown, G. W., Bifulco, A., & Harris, T. O. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.1.30 · Cited by 428
Raadsheer, F. C., van Heerikhuize, J. J., Lucassen, P. J., Hoogendijk, W. J. G., Tilders, F. J. H., & Swaab, D. F. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1372 · Cited by 417
Butler, P., Weiss, J., Stout, J., & Nemeroff, C. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00176.1990 · Cited by 402
Self-citationCorticotrophin-releasing factor receptors: from molecular biology to drug design
Chalmers, D. T., Lovenberg, T. W., Grigoriadis, D. E., Behan, D. P., & Souza, E. B. D. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)81594-x · Cited by 398
Childhood Parental Loss and Adult Psychopathology in Women
Kendler, K. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820020029004 · Cited by 394
Joëls, M., & de Kloet, E. R. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90014-0 · Cited by 394
Cloning and characterization of human urocortin.
Donaldson, C. J., Sutton, S. W., Perrin, M. H., CORRIGAN, A. Z., Lewis, K. A., Rivier, J., Vaughan, J. M., & Vale, W. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612563 · Cited by 371
Holsboer, F., Lauer, C. J., Schreiber, W., & Krieg, J.-C. (2008) · Neuroendocrinology · doi:10.1159/000127023 · Cited by 369
The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factorsa
Levine, S. D. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39245.x · Cited by 343
CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia
Bánki, C. M., Bissette, G., Arató, M., O'Connor, L., & Nemeroff, C. B. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.7.873 · Cited by 336
Self-citationOntogeny of the Stress Response in the Rat: Role of the Pituitary and the Hypothalamus*
Walker, C., Perrin, M. H., Vale, W., & RIVIER, C. L. (1986) · Endocrinology · doi:10.1210/endo-118-4-1445 · Cited by 309
Adrenal Gland Enlargement in Major Depression: A Computed Tomographic Study
Nemeroff, C. B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820050048008 · Cited by 283
Self-citationPathways to the Secretion of Adrenocorticotropin: A View from the Portal*
Plotsky, P. M. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00231.x · Cited by 259
Self-citationNemeroff, C. B., Bissette, G., Akil, H., & Fink, M. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.1.59 · Cited by 251
Self-citationSensitization of the Hypothalamic‐Pituitary‐Adrenal Axis in Posttraumatic Stress Disordera
Yehuda, R. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48269.x · Cited by 250
The Effects of Varying Environmental Demands on Maternal and Infant Behavior
Rosenblum, L. A., & Paully, G. S. (1984) · Child Development · doi:10.1111/j.1467-8624.1984.tb00293.x · Cited by 242
Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior
Heinrichs, S. C., Lapsansky, J., Lovenberg, T. W., Souza, E. B. D., & Chalmers, D. T. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(97)01005-7 · Cited by 235
The corticotropin-releasing hormone test in patients with posttraumatic stress disorder
Smith, M. A., Davidson, J. R. T., Ritchie, J., Kudler, H. S., Lipper, S., Chappell, P. B., & Nemeroff, C. B. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90050-4 · Cited by 234
Self-citationKRISHNAN, K. R. R., DORAISWAMY, P. M., LURIE, S. N., FIGIEL, G. S., HUSAIN, M. M., BOYKO, O. B., ELLINWOOD, E. H., & NEMEROFF, C. B. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-256 · Cited by 232
Self-citationThe Amygdala: Corticotropin-Releasing Factor, Steroids, and Stress
Gray, T. S., & Bingaman, E. W. (1996) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v10.i2.10 · Cited by 230
Adrenal Gland Volume in Major Depression
Rubín, R. T. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950150045009 · Cited by 208
Elevated CSF CRF in suicide victims
Arató, M., Bánki, C. M., Bissette, G., & Nemeroff, C. B. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90183-2 · Cited by 205
Self-citationThe corticotropin-releasing hormone stimulation test in patients with panic disorder
Roy‐Byrne, P., Uhde, T. W., Post, R. M., Gallucci, W. T., Chrousos, G. P., & Gold, P. W. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.896 · Cited by 204
Clinical characteristics of women with a history of childhood abuse: unhealed wounds
McCauley, J. (1997) · JAMA · doi:10.1001/jama.277.17.1362 · Cited by 199
The Effects of Varying Environmental Demands on Maternal and Infant Behavior
Rosenblum, L. A., & Paully, G. S. (1984) · Child Development · doi:10.2307/1129854 · Cited by 198
Heim, C. C., Owens, M. J., Plotsky, P. M., & Nemeroff, C. B. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48279.x · Cited by 197
Self-citationAltemus, M. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820010009002 · Cited by 187
CSF corticotropin-releasing hormone in depressed patients and normal control subjects
Roy, A., Pickar, D., Paul, S. M., Doran, A., Chrousos, G. P., & Gold, P. W. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.5.641 · Cited by 183
Chronic Administration of Corticotropin-Releasing Factor Increases Pituitary Corticotroph Number*
Gertz, B. J., Contreras, L. N., McComb, D. J., Kovács, K., Tyrrell, J., & Dallman, M. F. (1987) · Endocrinology · doi:10.1210/endo-120-1-381 · Cited by 174
Melia, K., & Duman, R. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8382 · Cited by 170
Early Stress and Adult Emotional Reactivity in Rhesus Monkeys
Suomi, S. J. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514047.ch11 · Cited by 167
Hypercortisolism and its possible neural bases
Sapolsky, R. M., & Plotsky, P. M. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90032-w · Cited by 161
Self-citationThe Role of CRF in Behavioral Aspects of Stress
Heinrichs, S. C., Menzaghi, F., Pich, E. M., Britton, K. T., & Koob, G. F. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44673.x · Cited by 160
Psychiatric history and stress: Predictors of severity of unipolar depression.
Hammen, C. L., Davila, J., Brown, G. P., Ellicott, A., & al, E. (1992) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.101.1.45 · Cited by 152
Banki, C. M., Karmacsi, L., Bissette, G., & Nemeroff, C. B. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90019-5 · Cited by 149
Self-citationAxelson, D., Doraiswamy, P. M., Boyko, O. B., Escalona, P. R., McDonald, W. M., Ritchie, J., Patterson, L. J., Ellinwood, E. H., Nemeroff, C. B., & Krishnan, K. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90070-j · Cited by 147
Self-citationPsychological Stress and Endocrine Functions
FRANCIS BOARD, Persky, H., & Hamburg, D. A. (1956) · Psychosomatic Medicine · doi:10.1097/00006842-195607000-00006 · Cited by 147
Kling, M. A., Roy, A., Doran, R. J., Calabrese, J. R., Rubinow, D. R., DAVID, H. J., May, C., Post, R. M., Chrousos, G. P., & Gold, P. W. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-260 · Cited by 145
Catalani, A., Marinelli, M., Scaccianoce, S., Nicolai, R., Muscolo, L. A. A., Porcu, A., Kora´nyi, L., Piazza, P. V., & Angelucci, L. (1993) · Brain Research · doi:10.1016/0006-8993(93)90079-3 · Cited by 133
Pihoker, C. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90042-j · Cited by 129
Holsboer, F., Gerken, A., von Bardeleben, U., Grimm, W., Beyer, H., Müller, O. A., & Stalla, G. K. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90121-6 · Cited by 126
Smagin, G., Świergiel, A., & Dunn, A. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(94)00166-x · Cited by 110
Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression
Geracioti, T. D., Loosen, P. T., & Orth, D. N. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00312-5 · Cited by 105
Lee, S., Imaki, T., Vale, W., & RIVIER, C. L. (1990) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(90)90022-v · Cited by 104
Post, R. M., Gold, P. W., Rubinow, D. R., Ballenger, J. C., Bunney, W. E., & Goodwin, F. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90394-0 · Cited by 99
Life Events at the Onset of Bipolar Affective Illness
Dünner, D. L., Patrick, V., & Fieve, R. R. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.1979.136.4b.508 · Cited by 99
Owens, M. J., Vargas, M. A., Knight, D. L., & Nemeroff, C. B. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20232-4 · Cited by 94
Self-citationGrigoriadis, D. E., Liu, X. J., Vaughn, J. R., Palmer, S. F., True, C., Vale, W. W., LING, N. C., & Souza, E. B. D. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09341-1 · Cited by 93
Fossey, M. D., Lydiard, R. B., Ballenger, J. C., Laraia, M. T., Bissette, G., & Nemeroff, C. B. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00197-2 · Cited by 90
Self-citationLocalization of urocortin messenger RNA in rat brain and pituitary.
Wong, M., Alshekhlee, A., Bongiorno, P. B., Esposito, A., Khatri, P., Sternberg, E. M., Pw, G., & Licinio, J. (1996) · PubMed · Cited by 90
Owens, M. J., Bissette, G., & Nemeroff, C. B. (1989) · Synapse · doi:10.1002/syn.890040304 · Cited by 86
Self-citationAltemus, M. M. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950100042004 · Cited by 86
The Role of Limbic and Hypothalamic Corticotropin‐Releasing Factor in Behavioral Responses to Stress
Menzaghi, F., Heinrichs, S. C., Pich, E. M., Weiss, F., & Koob, G. F. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49929.x · Cited by 86
Chappell, P. B., Leckman, J. F., Goodman, W. K., Bissette, G., Pauls, D. L., Anderson, G. M., Riddle, M. A., Scahill, L. D., McDougle, C. J., & Cohen, D. J. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00221-9 · Cited by 85
Urocortin Expression in Human Pituitary Gland and Pituitary Adenoma
Iino, K., Sasano, H., Oki, Y., Andoh, N., Shin, R., Kitamoto, T., Totsune, K., Takahashi, K., Suzuki, H., Nagura, H., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4371 · Cited by 84
Pitts, A. F., Samuelson, S. D., Meller, W. H., Bissette, G., Nemeroff, C. B., & Kathol, R. G. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(95)00229-a · Cited by 79
Self-citationWiderlöv, E., Bissette, G., & Nemeroff, C. B. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90051-1 · Cited by 77
Self-citationNeurochemical Correlates of Sympathetic Activation during Severe Alcohol Withdrawal
Hawley, R. J., Nemeroff, C. B., Bissette, G., Guidotti, A., Rawlings, R. R., & Linnoila, M. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb01429.x · Cited by 73
Self-citationHypothalamic‐Pituitary‐Adrenal Axis and Suicide
Arató, M., Bánki, C. M., Nemeroff, C. B., & Bissette, G. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb27905.x · Cited by 70
Self-citationSkutella, T., Criswell, H. E., Moy, S. S., Probst, J. C., Breese, G. R., Jirikowski, G. F., & Holsboer, F. (1994) · Neuroreport · doi:10.1097/00001756-199410270-00048 · Cited by 62
Antidepressants and hypothalamic-pituitary-adrenocortical regulation
Holsboer, F. (1996) · Endocrine Reviews · doi:10.1210/er.17.2.187 · Cited by 62
Adinoff, B. H. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00212-v · Cited by 60
Molchan, S. E. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90044-l · Cited by 60
Kling, M. A., Geracioti, T. D., Licinio, J., Michelson, D., Oldfield, E. H., & Gold, P. W. (1994) · PubMed · Cited by 53
Psychobiological Consequences of Social Relationshipsa
Levine, S., Lyons, D. M., & Schatzberg, A. F. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51922.x · Cited by 50
CSF corticotropin-releasing factor is not affected in panic disorder
Jolkkonen, J., Lepola, U., Bissette, G., Nemeroff, C., & Riekkinen, P. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90315-5 · Cited by 49
Self-citationKling, M. A., DeBellis, M. D., O'Rourke, D. K., Listwak, S. J., Geracioti, T. D., McCutcheon, I. E., Kalogeras, K. T., Oldfield, E. H., & Gold, P. W. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.1.8027234 · Cited by 45
Kling, M. A., Rubinow, D. R., Doran, A. R., Roy, A., Davis, C. L., Calabrese, J. R., Nieman, L. K., Post, R. M., Chrousos, G. P., & Gold, P. W. (2008) · Neuroendocrinology · doi:10.1159/000126345 · Cited by 30
Conchlear inner hair cells exist transiently in the fetal Bronx waltzer (bv/bv) mouse
Whitlon, D. S., Gabel, C., & Zhang, X. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960115)364:3 · Cited by 30
Urocortin Expression in Human Pituitary Gland and Pituitary Adenoma
Iino, K. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.11.3842 · Cited by 27
Krishnan, K., Rayasam, K., Reed, D. A., SMITH, M. J., Chapell, P., Saunders, W. B., Ritchie, J., Carroll, B. J., & Nemeroff, C. B. (1993) · Depression · doi:10.1002/depr.3050010303 · Cited by 23
Self-citationLee, S., & RIVIER, C. L. (1992) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(92)90015-t · Cited by 23
Childhood parental loss and adult psychopathology in women.
Kendler, K. S., Neale, M. C., Kessler, R. C., et al. (1992) · PsycEXTRA Dataset · doi:10.1037/e324162004-010 · Cited by 5
Flagged first, then by citations
Research works printed but not linked: 14
- Amsterdam JD, Maislin G, Winokur A, Berwish N, Kling M & Gold P 1988 The oCRH test before and after clinical recovery from depression. Journal of Affective Disorders 14 213-222.
- Ba ´nki CM, Bissette G, Arato ´M, O'Connor L & Nemeroff CB 1987 Cerebrospinal fluid corticotropin-releasing factor-like immuno- reactivity in depression and schizophrenia. American Journal of Psychiatry 144 873-877.
- Ba ´nki CM, Karmacsi L, Bissette G & Nemeroff CB 1992a Cerebro- spinal fluid neuropeptides in mood disorders and dementia. Journal of Affective Disorders 25 39-46.
- Brown GW, Bifulco A & Harris TO 1987 Life events, vulnerability and onset of depression. British Journal of Psychiatry 150 30-42.
- Charney DS, Bremner JD & Redmond DE 1995 Noradrenergic neural substrates for anxiety and fear: clinical associations based on preclinical research. In Psychopharmacology: The Fourth Generation of Progress, pp 387-395. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
- De Bellis MD, Gold PW, Geracioti TD, Listwak S & Kling MA 1993 Fluoxetine significantly reduces CSF CRH and AVP concentrations in patients with major depression. American Journal of Psychiatry 150 656-657.
- De Souza EB & Grigoriadis DE 1995 Corticotropin-releasing factor: physiology, pharmacology, and role in central neurvous system and immune disorders. In Psychopharmacology: The Fourth Generation of Progress, pp 505-517. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
- Kalin NH 1990 Behavioral and endocrine studies of corticotropin- releasing hormone in primates. In Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide, pp 275-289. Eds EB De Souza & CB Nemeroff. Boca Raton, FL: CRC Press, Inc.
- Maes M & Meltzer HY 1995 The serotonin hypothesis of major depression. In Psychopharmacology: The Fourth Generation of Progress, pp 933-944. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
- Plotsky P, Owens MJ & Nemeroff CB 1995a Neuropeptide alterations in affective disorders. In Psychopharmacology: The Fourth Generation of Progress, pp 971-981. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
- Plotsky PM, Thrivikraman KV, Su Y, Caldji C, Sharma S & Meaney MJ 1998 The effects on neonatal rearing environment on CRF mRNA and CRF receptor levels in adult rat brain. Journal of Neuroscience. (In Press).
- Ed SC Risch. Washington DC: American Psychiatric Press.
- Van Bockstaele EJ, Colago EEO & Valentino RJ 1996 Corticotropin- releasing factor-containing axon terminals synapse onto catechol- amine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain. Journal of Comparative Neurology 364 523-534.
- Weiss JM, Stout J, Aaron M, Owens MJ & Nemeroff CB 1994 Experimental studies of depression and anxiety: role of locus coeruleus and corticotropin-releasing factor. Brain Research Bulletin 35 561-572.
Cited by
Sorted by citations
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Self-citationThe link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Self-citationRelationship between stress, eating behavior, and obesity
Torres, S. J., & Nowson, C. A. (2007) · Nutrition · doi:10.1016/j.nut.2007.08.008 · Cited by 1,622
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590
Metadata
- Authors
- Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C.
- Affiliations
- Emory University (US)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1999-01-01
- Volume
- 160
- Issue
- 1
- Pages
- 1-12
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2143629083
- Cited by
- 1,378
- References
- 105
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 29 · 2023: 24 · 2022: 35 · 2021: 34 · 2020: 34 · 2019: 44 · 2018: 31 · 2017: 48 · 2016: 36 · 2015: 49 · 2014: 63 · 2013: 58 · 2012: 59
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Institute
- National Institutes of Health (DS-08705, MH-42088)
- Medical Research Council
- National Institute of Mental Health (R01MH042088, MH-50113, MH42088, R01MH050113)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- corticotropin-releasing factor, depression, anxiety disorders, hypothalamic-pituitary-adrenal axis, early life stress, childhood abuse and neglect, CRF receptor antagonists, antidepressants, anxiolytics, noradrenergic system, psychomotor changes
- MeSH terms
- Adult, Animals, Anxiety Disorders, Child, Preschool, Corticotropin-Releasing Hormone, Depression, Disease Models, Animal, Humans, Hypothalamo-Hypophyseal System, Infant, Maternal Deprivation, Neurons, Pituitary-Adrenal System, Stress, Psychological, Receptors, Corticotropin-Releasing Hormone, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
