Cited by 1,378Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.

The role of corticotropin-releasing factor in depression and anxiety disorders

Open access

Arborelius, L, Owens, MJ, Plotsky, PM, Nemeroff, CB·1999·Journal of Endocrinology

Open this paper in CoChat — free account Open PDF

Abstract

Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the evidence suggesting that CRF is hypersecreted from hypothalamic as well as from extrahypothalamic neurons in depression, resulting in hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and elevations of cerebrospinal fluid (CSF) concentrations of CRF. This increase in CRF neuronal activity is also believed to mediate certain of the behavioral symptoms of depression involving sleep and appetite disturbances, reduced libido, and psychomotor changes. The hyperactivity of CRF neuronal systems appears to be a state marker for depression because HPA axis hyperactivity normalizes following successful antidepressant treatment. Similar biochemical and behavioral findings have been observed in adult rats and monkeys that have been subjected to early-life stress. In contrast, clinical studies have not revealed any consistent changes in CSF CRF concentrations in patients with anxiety disorders; however, preclinical findings strongly implicate a role for CRF in the pathophysiology of certain anxiety disorders, probably through its effects on central noradrenergic systems. The findings reviewed here support the hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1677/joe.0.1600001

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,889
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Hoskins, R. G. (1953) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-13-4-473 · Cited by 3,780
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(1911) · JAMA · doi:10.1001/jama.1911.04260070032017 · Cited by 3,355
Proceedings of the National Academy of Sciences, USA.
Ochoa, S. (1996) · Current Biology · doi:10.1016/s0960-9822(09)00431-x · Cited by 2,783
Alcoholism: Clinical and Experimental Research
(2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/(issn)1530-0277 · Cited by 1,830
The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Self-citation
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Self-citation
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
Vaughan, J. M., Donaldson, C. J., Bittencourt, J. C., Perrin, M. H., Lewis, K., Sutton, S. W., Chan, R. K. W., Turnbull, A. V., Lovejoy, D. A., RIVIER, C. L., et al. (1995) · Nature · doi:10.1038/378287a0 · Cited by 1,479

Show all 105 references

Research works printed but not linked: 14

Amsterdam JD, Maislin G, Winokur A, Berwish N, Kling M & Gold P 1988 The oCRH test before and after clinical recovery from depression. Journal of Affective Disorders 14 213-222.
Ba ´nki CM, Bissette G, Arato ´M, O'Connor L & Nemeroff CB 1987 Cerebrospinal fluid corticotropin-releasing factor-like immuno- reactivity in depression and schizophrenia. American Journal of Psychiatry 144 873-877.
Ba ´nki CM, Karmacsi L, Bissette G & Nemeroff CB 1992a Cerebro- spinal fluid neuropeptides in mood disorders and dementia. Journal of Affective Disorders 25 39-46.
Brown GW, Bifulco A & Harris TO 1987 Life events, vulnerability and onset of depression. British Journal of Psychiatry 150 30-42.
Charney DS, Bremner JD & Redmond DE 1995 Noradrenergic neural substrates for anxiety and fear: clinical associations based on preclinical research. In Psychopharmacology: The Fourth Generation of Progress, pp 387-395. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
De Bellis MD, Gold PW, Geracioti TD, Listwak S & Kling MA 1993 Fluoxetine significantly reduces CSF CRH and AVP concentrations in patients with major depression. American Journal of Psychiatry 150 656-657.
De Souza EB & Grigoriadis DE 1995 Corticotropin-releasing factor: physiology, pharmacology, and role in central neurvous system and immune disorders. In Psychopharmacology: The Fourth Generation of Progress, pp 505-517. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
Kalin NH 1990 Behavioral and endocrine studies of corticotropin- releasing hormone in primates. In Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide, pp 275-289. Eds EB De Souza & CB Nemeroff. Boca Raton, FL: CRC Press, Inc.
Maes M & Meltzer HY 1995 The serotonin hypothesis of major depression. In Psychopharmacology: The Fourth Generation of Progress, pp 933-944. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
Plotsky P, Owens MJ & Nemeroff CB 1995a Neuropeptide alterations in affective disorders. In Psychopharmacology: The Fourth Generation of Progress, pp 971-981. Eds FE Bloom & DJ Kupfer. New York: Raven Press.
Plotsky PM, Thrivikraman KV, Su Y, Caldji C, Sharma S & Meaney MJ 1998 The effects on neonatal rearing environment on CRF mRNA and CRF receptor levels in adult rat brain. Journal of Neuroscience. (In Press).
Ed SC Risch. Washington DC: American Psychiatric Press.
Van Bockstaele EJ, Colago EEO & Valentino RJ 1996 Corticotropin- releasing factor-containing axon terminals synapse onto catechol- amine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain. Journal of Comparative Neurology 364 523-534.
Weiss JM, Stout J, Aaron M, Owens MJ & Nemeroff CB 1994 Experimental studies of depression and anxiety: role of locus coeruleus and corticotropin-releasing factor. Brain Research Bulletin 35 561-572.

Sorted by citations

Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Self-citation
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Self-citation
Relationship between stress, eating behavior, and obesity
Torres, S. J., & Nowson, C. A. (2007) · Nutrition · doi:10.1016/j.nut.2007.08.008 · Cited by 1,622
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984
Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity
Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
Neuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914
Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation
Rodgers, A. B., Morgan, C. P., Bronson, S. L., Revello, S., & Bale, T. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-13.2013 · Cited by 814
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751
Post-traumatic stress disorder: the neurobiological impact of psychological trauma
Sherin, J. E., & Nemeroff, C. B. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.2/jsherin · Cited by 750
Self-citation
Traumatic stress: effects on the brain
Bremner, J. D. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jbremner · Cited by 738
Prenatal stress, glucocorticoids and the programming of the brain
Welberg, L. A. M., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00601.x · Cited by 928
Research Review: The neurobiology and genetics of maltreatment and adversity
McCrory, E., De Brito, S. A., & Viding, E. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02271.x · Cited by 598
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593
Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats
Crumeyrolle-Arias, M., Jaglin, M., Bruneau, A., Vancassel, S., Cardona, A., Daugé, V., Naudon, L., & Rabot, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.014 · Cited by 581
Long term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring
Plotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., & Meaney, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300769 · Cited by 522
Self-citation
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
Importance of studying the contributions of early adverse experience to neurobiological findings in depression
Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300397 · Cited by 514
Self-citation
Effects of early adverse experiences on brain structure and function: clinical implications
Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00998-7 · Cited by 508
Self-citation
Stress Hormone Regulation: Biological Role and Translation into Therapy
Holsboer, F., & Ising, M. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100321 · Cited by 473
Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels
Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00687-6 · Cited by 457
Chapter 21 Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity
Champagne, F., & Meaney, M. J. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33022-4 · Cited by 455
Neuroendocrine aspects of hypercortisolism in major depression
Parker, K. J., Schatzberg, A. F., & Lyons, D. M. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00016-8 · Cited by 455
Fear memory
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453
Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis
Handa, R. J., & Weiser, M. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.001 · Cited by 408
The Role of the Central Nucleus of the Amygdala in Mediating Fear and Anxiety in the Primate
Kalin, N. H., Shelton, S. E., & Davidson, R. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0292-04.2004 · Cited by 406
Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study
Guo, Q., Zheng, Y., Shi, J., Wang, J., Li, G., Li, C., Fromson, J. A., Xu, Y., Liu, X., Xu, H., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.05.038 · Cited by 406
Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
Balbo, M., Leproult, R., & Van Cauter, E. (2010) · International Journal of Endocrinology · doi:10.1155/2010/759234 · Cited by 408
“Responsiveness of ACTH to CRH administration has been shown to be higher in obese patients without OSA compared with lean subjects and to be even higher in obese patients with OSA [145], probably as the result of an alteration in the central control of ACTH secretion, as well as of an impaired sensitivity to the negat…”
BackgroundInfluential
Adverse childhood experiences are associated with adult sleep disorders: a systematic review
Kajeepeta, S., Gelaye, B., Jackson, C. L., & Williams, M. A. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.013 · Cited by 385
A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder
O'Doherty, D. C. M., Chitty, K. M., Saddiqui, S., Bennett, M. R., & Lagopoulos, J. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.01.002 · Cited by 375
Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation
Shanks, N., Windle, R. J., Perks, P. A., Harbuz, M. S., Jessop, D. S., Ingram, C. D., & Lightman, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090571897 · Cited by 374
Hypercortisolemia and depression
Gillespie, C. F., & Nemeroff, C. B. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000163456.22154.d2 · Cited by 361
Self-citation
Prenatal Depression, Prenatal Anxiety, and Spontaneous Preterm Birth: A Prospective Cohort Study Among Women With Early and Regular Care
Dayan, J., Creveuil, C., Marks, M. N., Conroy, S., Herlicoviez, M., Dreyfus, M., & Tordjman, S. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000244025.20549.bd · Cited by 356
Origins of depression in later life
BLAZER, D. G., & HYBELS, C. F. (2005) · Psychological Medicine · doi:10.1017/s0033291705004411 · Cited by 347
Voices from within: gut microbes and the CNS
Forsythe, P., & Kunze, W. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1028-z · Cited by 336
Decreased Regional Brain Metabolism After ECT
Nobler, M. S., Oquendo, M. A., Kegeles, L. S., Malone, K. M., Campbell, C., Sackeim, H. A., & Mann, J. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.305 · Cited by 330
The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors
McCrory, E., De Brito, S. A., & Viding, E. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00048 · Cited by 329
The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity
Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324
The role of DNA methylation in stress-related psychiatric disorders
Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309
Salivary Cortisol Levels in Persons With and Without Different Anxiety Disorders
Vreeburg, S. A., Zitman, F. G., van Pelt, J., DeRijk, R. H., Verhagen, J. C. M., van Dyck, R., Hoogendijk, W. J. G., Smit, J. H., & Penninx, B. W. J. H. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d2f0c8 · Cited by 312
Role of norepinephrine in the pathophysiology and treatment of mood disorders
Ressler, K. J., & Nemeroff, C. B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00127-4 · Cited by 307
Self-citation
Cortisol and depression: three questions for psychiatry
Herbert, J. (2013) · Psychological Medicine · doi:10.1017/s0033291712000955 · Cited by 301
What's wrong with my mouse model?
Kalueff, A. V., Wheaton, M., & Murphy, D. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.023 · Cited by 285
Hormonal Treatments for Major Depressive Disorder: State of the Art
Dwyer, J. B., Aftab, A., Radhakrishnan, R., Widge, A., Rodriguez, C. I., Carpenter, L. L., Nemeroff, C. B., McDonald, W. M., Kalin, N. H., & APA Council of Research Task Force on Novel Biomarkers and Treatments (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19080848 · Cited by 252
Self-citation
A 6-Week Randomized, Placebo-Controlled Trial of CP-316,311 (a Selective CRH 1 Antagonist) in the Treatment of Major Depression
Binneman, B., Feltner, D., Kolluri, S., Shi, Y., Qiu, R., & Stiger, T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07071199 · Cited by 254
microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34
Haramati, S., Navon, I., Issler, O., Ezra-Nevo, G., Gil, S., Zwang, R., Hornstein, E., & Chen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1673-11.2011 · Cited by 252
Childhood parental loss and adult hypothalamic-pituitary-adrenal function
Tyrka, A. R., Wier, L., Price, L. H., Ross, N., Anderson, G. M., Wilkinson, C. W., & Carpenter, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.011 · Cited by 250
Long-term effects of childhood abuse on brain and neurobiology
Bremner, J. D. (2003) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(02)00098-6 · Cited by 243
Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress
Söderholm, J. D., Yates, D. A., Gareau, M. G., Yang, P.-C., MacQueen, G., & Perdue, M. H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00314.2002 · Cited by 243
Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety
Shekhar, A., Truitt, W., Rainnie, D., & Sajdyk, T. (2005) · Stress · doi:10.1080/10253890500504557 · Cited by 237
The role of the gut microbiota in dietary interventions for depression and anxiety
Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229
Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems
Gądek-Michalska, A., Tadeusz, J., Rachwalska, P., & Bugajski, J. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71527-5 · Cited by 225
Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
Urigüen, L., Pérez-Rial, S., Ledent, C., Palomo, T., & Manzanares, J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.01.003 · Cited by 218
Behavioral effects of neuropeptides in rodent models of depression and anxiety
Rotzinger, S., Lovejoy, D. A., & Tan, L. A. (2010) · Peptides · doi:10.1016/j.peptides.2009.12.015 · Cited by 211
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
Smith, R. J., & Aston-Jones, G. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0191-3 · Cited by 206
Requirement of Cannabinoid Receptor Type 1 for the Basal Modulation of Hypothalamic-Pituitary-Adrenal Axis Function
Cota, D., Steiner, M.-A., Marsicano, G., Cervino, C., Herman, J. P., Grübler, Y., Stalla, J., Pasquali, R., Lutz, B., Stalla, G. K., et al. (2007) · Endocrinology · doi:10.1210/en.2005-1649 · Cited by 205
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.002 · Cited by 204
Childhood stressful events, HPA axis and anxiety disorders
Faravelli, C. (2012) · World Journal of Psychiatry · doi:10.5498/wjp.v2.i1.13 · Cited by 198
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197
The timing of maternal depressive symptoms and child cognitive development: a longitudinal study
Evans, J., Melotti, R., Heron, J., Ramchandani, P., Wiles, N., Murray, L., & Stein, A. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02513.x · Cited by 184
Chapter 1 Brain preparations for maternity — adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview
Russell, J. A., Douglas, A. J., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33002-9 · Cited by 187
Metyrapone as Additive Treatment in Major Depression: A Double-blind and Placebo-Controlled Trial
Jahn, H., Schick, M., Kiefer, F., Kellner, M., Yassouridis, A., & Wiedemann, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.12.1235 · Cited by 184
Impact of early adversity on glucocorticoid regulation and later mental disorders
Strüber, N., Strüber, D., & Roth, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.015 · Cited by 173
Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis
Murphy, F., Nasa, A., Cullinane, D., Raajakesary, K., Gazzaz, A., Sooknarine, V., Haines, M., Roman, E., Kelly, L., O'Neill, A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.748372 · Cited by 181
HPA and Immune Axes in Stress: Involvement of the Serotonergic System
Leonard, B. E. (2006) · Neuroimmunomodulation · doi:10.1159/000104854 · Cited by 169
Escalated or Suppressed Cocaine Reward, Tegmental BDNF, and Accumbal Dopamine Caused by Episodic versus Continuous Social Stress in Rats
Miczek, K. A., Nikulina, E. M., Shimamoto, A., & Covington, H. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0637-11.2011 · Cited by 162
Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts
Okusaga, O., Yolken, R. H., Langenberg, P., Lapidus, M., Arling, T. A., Dickerson, F. B., Scrandis, D. A., Severance, E., Cabassa, J. A., Balis, T., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.029 · Cited by 163
The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis
Videbech, P., Ravnkilde, B., Pedersen, T. H., Hartvig, H., Egander, A., Clemmensen, K., Rasmussen, N. A., Andersen, F., Gjedde, A., & Rosenberg, R. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.02245.x · Cited by 161
Sex Differences in Social Interaction Behavior Following Social Defeat Stress in the Monogamous California Mouse (Peromyscus californicus)
Trainor, B. C., Pride, M. C., Villalon Landeros, R., Knoblauch, N. W., Takahashi, E. Y., Silva, A. L., & Crean, K. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017405 · Cited by 157
HPA axis response to a psychological stressor in generalised social phobia
Condren, R. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00070-1 · Cited by 155
Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
García-Gutiérrez, M. S., & Manzanares, J. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110379507 · Cited by 153
Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat
Sterrenburg, L., Gaszner, B., Boerrigter, J., Santbergen, L., Bramini, M., Elliott, E., Chen, A., Peeters, B. W. M. M., Roubos, E. W., & Kozicz, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028128 · Cited by 149
Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling-maternal separation as neonates
Ladd, C. O., Thrivikraman, K. V., Huot, R. L., & Plotsky, P. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.12.004 · Cited by 145
Self-citation
Limbic and HPA axis function in an animal model of chronic neuropathic pain
Ulrich-Lai, Y. M., Xie, W., Meij, J. T. A., Dolgas, C. M., Yu, L., & Herman, J. P. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.03.012 · Cited by 146
The Neuroendocrinology of Posttraumatic Stress Disorder: New Directions
Rasmusson, A. M., Vythilingam, M., & Morgan, C. A. (2003) · CNS Spectrums · doi:10.1017/s1092852900008841 · Cited by 144
Early adverse events, HPA activity and rostral anterior cingulate volume in MDD
Treadway, M. T., Grant, M. M., Ding, Z., Hollon, S. D., Gore, J. C., & Shelton, R. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004887 · Cited by 142
Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders
Hammack, S. E., Cooper, M. A., & Lezak, K. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.024 · Cited by 142
Polymorphisms in CRHR1 and the serotonin transporter loci: Gene × Gene × Environment interactions on depressive symptoms
Ressler, K. J., Bradley, B., Mercer, K. B., Deveau, T. C., Smith, A. K., Gillespie, C. F., Nemeroff, C. B., Cubells, J. F., & Binder, E. B. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31052 · Cited by 140
“In rodents,maternal separation in the early postnatal period also leads to persistent alterations in serotonergic systems, including changes in cell firing of serotonergic raphe neurons, frontal cortical 5-HT concentration, and expression levels of certain serotonin receptors in cortex and hippocampus [Arborelius et a…”
BackgroundInfluentialSelf-citation
Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: a total population study
Engberg, H., Butwicka, A., Nordenström, A., Hirschberg, A. L., Falhammar, H., Lichtenstein, P., Nordenskjöld, A., Frisén, L., & Landén, M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.017 · Cited by 132
Salivary Cortisol and Psychopathology in Children Bereaved by the September 11, 2001 Terror Attacks
Pfeffer, C. R., Altemus, M., Heo, M., & Jiang, H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.037 · Cited by 128
Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress
Green, M. K., Rani, C. S. S., Joshi, A., Soto-Piña, A. E., Martinez, P. A., Frazer, A., Strong, R., & Morilak, D. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.041 · Cited by 124
Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders
Nousen, E. K., Franco, J. G., & Sullivan, E. L. (2013) · Neuroendocrinology · doi:10.1159/000355632 · Cited by 123
Born to be anxious: neuroendocrine and genetic correlates of trait anxiety in HAB rats
Landgraf, R., & Wigger, A. (2003) · Stress · doi:10.1080/1025389031000104193 · Cited by 122
Enhanced Th17 phenotype in individuals with generalized anxiety disorder
Vieira, M. M. M., Ferreira, T. B., Pacheco, P. A. F., Barros, P. O., Almeida, C. R. M., Araújo-Lima, C. F., Silva-Filho, R. G., Hygino, J., Andrade, R. M., Linhares, U. C., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.07.018 · Cited by 118
Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment
Stout, S. C., Owens, M. J., & Nemeroff, C. B. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.1085 · Cited by 117
Self-citation
Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation
Regev, L., Neufeld-Cohen, A., Tsoory, M., Kuperman, Y., Getselter, D., Gil, S., & Chen, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.64 · Cited by 110
Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat
Meloni, E. G., Gerety, L. P., Knoll, A. T., Cohen, B. M., & Carlezon, W. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4957-05.2006 · Cited by 109
Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders
Feder, A., Coplan, J. D., Goetz, R. R., Mathew, S. J., Pine, D. S., Dahl, R. E., Ryan, N. D., Greenwald†, S., & Weissman, M. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.05.005 · Cited by 103
The central corticotropin releasing factor system during development and adulthood
Korosi, A., & Baram, T. Z. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.066 · Cited by 102
Exposure to novelty and forced swimming evoke stressor-dependent changes in extracellular GABA in the rat hippocampus
de Groote, L., & Linthorst, A. C. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.030 · Cited by 100
Midline and intralaminar thalamic connections with the orbital and medial prefrontal networks in macaque monkeys
Hsu, D. T., & Price, J. L. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21440 · Cited by 97
Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent
Chen, Y., Fenoglio, K. A., Dubé, C. M., Grigoriadis, D. E., & Baram, T. Z. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001863 · Cited by 98
Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge
Regev, L., Tsoory, M., Gil, S., & Chen, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.036 · Cited by 93
Paraventricular nucleus of the human hypothalamus in primary hypertension: Activation of corticotropin-releasing hormone neurons
Goncharuk, V. D., Van Heerikhuize, J., Swaab, D. F., & Buijs, R. M. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10124 · Cited by 97
Reduced Glucocorticoid Receptor α Expression in Mood Disorder Patients and First-Degree Relatives
Matsubara, T., Funato, H., Kobayashi, A., Nobumoto, M., & Watanabe, Y. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.026 · Cited by 94

Authors: Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C.
Affiliations: Emory University (US)
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 1999-01-01
Volume: 160
Issue: 1
Pages: 1-12
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1677/joe.0.1600001
OpenAlex: W2143629083
Cited by: 1,378
References: 105
Citations by year: 2026: 8 · 2025: 20 · 2024: 29 · 2023: 24 · 2022: 35 · 2021: 34 · 2020: 34 · 2019: 44 · 2018: 31 · 2017: 48 · 2016: 36 · 2015: 49 · 2014: 63 · 2013: 58 · 2012: 59
FWCI: 4.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Swedish Institute
National Institutes of Health (DS-08705, MH-42088)
Medical Research Council
National Institute of Mental Health (R01MH042088, MH-50113, MH42088, R01MH050113)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: corticotropin-releasing factor, depression, anxiety disorders, hypothalamic-pituitary-adrenal axis, early life stress, childhood abuse and neglect, CRF receptor antagonists, antidepressants, anxiolytics, noradrenergic system, psychomotor changes
MeSH terms: Adult, Animals, Anxiety Disorders, Child, Preschool, Corticotropin-Releasing Hormone, Depression, Disease Models, Animal, Humans, Hypothalamo-Hypophyseal System, Infant, Maternal Deprivation, Neurons, Pituitary-Adrenal System, Stress, Psychological, Receptors, Corticotropin-Releasing Hormone, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of corticotropin-releasing factor in depression and anxiety disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks