CoChat
Sign Up
Cited by 453

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Inflammaging: disturbed interplay between autophagy and inflammasomes

Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu·2012·Aging
DOI 10.18632/aging.100444PMC PMC3348477
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.18632/aging.100444

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 The interplay between autophagy and inflammasomes in the generation of inflammaging Normally, the autophagic uptake of dysfunctional mitochondria prevents the excessive ROS production and in that way the activation of inflammasomes. However, during aging, the autophagic capacity declines and increased ROS production and aggregated proteins activate inflammasomes which provoke a low-grade inflammation in several tissues and in that way inhibit autophagy and accelerate the aging process. There are several activators of autophagy which can delay the aging process. It is known that mTOR inhibitors and AMPK activators can extend lifespan in certain conditions.
Figure 1 The interplay between autophagy and inflammasomes in the generation of inflammaging Normally, the autophagic uptake of dysfunctional mitochondria prevents the excessive ROS production and in that way the activation of inflammasomes. However, during aging, the autophagic capacity declines and increased ROS production and aggregated proteins activate inflammasomes which provoke a low-grade inflammation in several tissues and in that way inhibit autophagy and accelerate the aging process. There are several activators of autophagy which can delay the aging process. It is known that mTOR inhibitors and AMPK activators can extend lifespan in certain conditions.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 99

  1. De Benedictis, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. NY. Acad. Sci, 90, 244
  2. Pawelec, 2008, Aging of the immune system as a prognostic factor for human longevity, Physiology, 2, 64
  3. Linton, 2009, Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors, Trends Immunol, 3, 319
  4. Kaley, Aging-induced proinflammatory shift in cytokine expression profile in rat coronary arteries, FASEB J, 1, 1183
  5. Church, 2009, Meta-analysis of age-related gene expression profiles identifies common signatures of aging, Bioinformatics, 2, 875
  6. Bruunsgaard, 2004, Inflammatory mediators in the elderly, Exp. Gerontol, 3, 687
  7. Newman, 2010, Inflammatory markers in population studies of aging, Ageing Res. Rev, 1, 319
  8. Salminen, 1996, Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB, Biochem. J, 31, 603
  9. Chang, 2007, Motif module map reveals enforcement of aging by continual NF-κB activity, Genes Dev, 2, 3244
  10. Suuronen, 2008, Activation of innate immunity system during aging: NF-κB signaling is the culprit of inflamm-aging, Ageing Res. Rev, 7, 83, 10.1016/j.arr.2007.09.002 · DOI · Paper page
  11. Vasto, 2010, Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches, Curr. Pharm. Des, 1, 609
  12. Giunta, 2008, Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm-aging, from robustness to frailty, Inflamm. Res, 5, 558
  13. Nunez, 2009, NOD-like receptors: role in innate immunity and inflammatory disease, Annu. Rev. Pathol. Mech. Dis, 4, 365, 10.1146/annurev.pathol.4.110807.092239 · DOI
  14. Tschopp, 2010, The inflammasomes, Cell, 14, 821
  15. Tschopp, 2011, The inflammasome: an integrated view, Immunol. Rev, 24, 136
  16. Vandenabeele, 2011, NOD-like receptors and the innate immune system: coping with danger, damage and death, Cytokine Growth Factor Rev, 2, 257
  17. Tschopp, 2007, Inflammatory caspases and inflammasomes: master switches of inflammation, Cell Death Differ, 1, 10
  18. Drexler, 2010, Inflammatory caspases in innate immunity and inflammation, J. Innate Immun, 2, 228, 10.1159/000283688 · DOI
  19. Hornung, 2011, Inflammasomes: current understanding and open questions, Cell. Mol. Life Sci, 6, 765
  20. Latz, 2009, Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, J. Immunol, 18, 787
  21. Santoro, 2006, NF-κB: a stress-regulated switch for cell survival. Antioxid, Redox Signal, 8, 478, 10.1089/ars.2006.8.478 · DOI
  22. Ojcius, 2007, ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages, J. Biol. Chem, 28, 2871
  23. Eklund, 2011, Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and cathepsin B-sensitive pathway, J. Immunol, 18, 6119
  24. O'Neill, 2011, Disease-associated amyloid and misfolded protein aggregates activate the inflammasome, Trends Mol. Med, 1, 276
  25. Ting, 2011, Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling, Nat. Immunol, 1, 408
  26. Dixit, 2011, The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance, Nat. Med, 1, 179
  27. Kanneganti, 2011, Inflammasome is a central player in the induction of obesity and insulin resistance, Proc. Natl. Acad. Sci. USA, 10, 15324
  28. Tschopp, 2010, The NLRP3 inflammasome: a sensor for metabolic danger?, Science, 32, 296
  29. Schroder, 2010, NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?, Nat. Rev. Immunol, 1, 210
  30. Deretic, 2010, Autophagy in infection. Curr. Opin, Cell Biol, 2, 252
  31. Rubinsztein, 2010, Regulation of mammalian autophagy in physiology and pathophysiology, Physiol. Rev, 9, 1383
  32. Deretic, 2009, Multiple regulatory and effector roles of autophagy in immunity, Curr. Opin. Immunol, 2, 53, 10.1016/j.coi.2009.02.002 · DOI
  33. Cuervo, 2011, Autophagy in the cellular energetic balance, Cell Metab, 1, 495
  34. Czaja, 2011, Regulation of lipid droplets by autophagy. Trends Endocrinol, Metab, 2, 234
  35. Ryter, 2011, Autophagy in inflammatory diseases, Int. J. Cell Biol
  36. Petrovski, 2011, Autophagy shapes inflammation. Antioxid, Redox Signal, 1, 2233
  37. Choi, 2012, Autophagy: cellular defence to excessive inflammation, Microbes Infect, 1, 119
  38. Akira, 2008, Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production, Nature, 45, 264
  39. Maegawa, 2012, Autophagy regulates inflammation in adipocytes, Biochem. Biophys. Res. Commun, 41, 352
  40. Jo, 2011, Autophagy negatively regulates keratinocytes inflammatory responses via scaffolding protein p62/SQSTM1, J. Immunol, 18, 1248
  41. Cai, 2011, Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway, J. Biol. Chem, 28, 32324
  42. Hsieh, 2011, Complete induction of autophagy is essential for cardioprotection in sepsis, Ann. Surg, 25, 1190, 10.1097/SLA.0b013e318214b67e · DOI
  43. Kehrl, 2012, Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction, Nat. Immunol, 1, 255
  44. Girardin, 2011, Mitochondria in innate immunity, EMBO Rep, 1, 901
  45. Choi, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat. Immunol, 8, 222
  46. Fan, 2011, Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells, J. Immunol, 18, 4809
  47. Cuervo, 2007, Autophagy and neurodegeneration: when the cleaning crew goes on strike, Lancet Neurol, 6, 352, 10.1016/S1474-4422(07)70076-5 · DOI
  48. Yang, 2011, Autophagy failure in Alzheimer's disease - locating the primary defect, Neurobiol. Dis, 4, 38
  49. Ting, 2011, The inflammasome NLRs in immunity, inflammation, and associated diseases, Annu. Rev. Immunol, 2, 707
  50. Kanneganti, 2011, Deregulated inflammasome signaling in disease, Immunol. Rev, 24, 163
  51. Terman, 2002, The mitochondrial-lysosomal axis theory of aging. Accumulation of damaged mitochondria as a result of imperfect autophagocytosis, Eur. J. Biochem, 26, 1996
  52. Cuervo, 2008, Autophagy and aging: keeping that old broom working, Trends Genet, 2, 604, 10.1016/j.tig.2008.10.002 · DOI · Paper page
  53. Bossis, 2009, Aging: Central role for autophagy and the lysosomal degradative system, Ageing Res. Rev, 8, 199, 10.1016/j.arr.2009.05.001 · DOI
  54. Kroemer, 2011, Mitochondria and the autophagy-inflammation-cell death axis in organismal aging, Science, 33, 1109
  55. Kroemer, 2011, Autophagy and aging, Cell, 14, 682
  56. Rodella, 2012, Morphological and biochemical studies on aging and autophagy, Ageing Res. Rev, 1, 10
  57. Vellai, 2008, Lonevity pathways converge on autophagy genes to regulate life span in, Autophagy, 4, 330, 10.4161/auto.5618 · DOI
  58. Finkel, 2009, Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy, Aging (Albany NY), 1, 425
  59. Dice, 2000, Age-related decline in chaperone-mediated autophagy, J. Biol. Chem, 27, 31505
  60. Cuervo, 2008, Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function, Nat. Med, 1, 959
  61. Finley, 2008, Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult, Autophagy, 4, 176, 10.4161/auto.5269 · DOI · Paper page
  62. Kroemer, 2010, Can autophagy promote longevity?, Nat. Cell Biol, 9, 842
  63. Guarente, 2007, Genetic links between diet and lifespan: shared mechanisms from yeast to humans, Nat. Rev. Genet, 8, 835, 10.1038/nrg2188 · DOI
  64. Gori, 2007, The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction, Ann. N.Y. Acad. Sci, 111, 69
  65. Weindruch, 2009, Caloric restriction delays disease onset and mortality in rhesus monkeys, Science, 32, 201
  66. Fontana, 2007, Caloric restriction in humans, Exp. Gerontol, 4, 709
  67. Finch, 2007, Anti-inflammatory mechanisms of dietary restriction in slowing aging processes, Interdiscip. Top. Gerontol, 3, 83
  68. Stuart, 2010, Mitochondrial redox metabolism: aging, longevity and dietary effects, Mech. Ageing Dev, 13, 242
  69. Ramsey, 2011, Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver, J. Bioenerg. Biomembr, 4, 227
  70. Reichert, 2010, Impaired quality control of mitochondria: aging from a new perspective, Exp. Gerontol, 4, 503
  71. Piette, 2006, NF-κB activation by reactive oxygen species: fifteen years later, Biochem. Pharmacol, 7, 1493
  72. Janssen-Heininger, 2006, Redox-sensitive kinases of the nuclear factor-κB signaling pathway, Antioxid. Redox Signal, 8, 1791, 10.1089/ars.2006.8.1791 · DOI
  73. Xiao, 2006, Hsp90 inhibition results in autophagy-mediated proteasomes-independent degradation of IκB kinase (IKK), Cell Res, 1, 895
  74. Xiao, 2007, Hsp90 regulates processing of NF-κB2 p100 involving protection of NF-κB-inducing kinase (NIK) from autophagy-mediated degradation, Cell Res, 1, 520
  75. Kamitani, 2010, Downregulation of active IKKβ by Ro52-mediated autophagy, Mol. Immunol, 4, 2378
  76. Lamark, 2011, Selective autophagy mediated by autophagic adapter proteins, Autophagy, 7, 279, 10.4161/auto.7.3.14487 · DOI
  77. Wooten, 2007, Signal integration and diversification through the p62 scaffold protein, Trends Biochem. Sci, 3, 95
  78. Codogno, 2006, NF-κB activation represses tumor necrosis factor-α-induced autophagy, J. Biol. Chem, 28, 30373
  79. Zheng, 2007, Targeting mammalian target of rapamycin (mTOR) for health and diseases, Drug Discov. Today, 1, 112
  80. Hall, 2011, Rapamycin passes the torch: a new generation of mTOR inhibitors, Nat. Rev. Drug Discov, 1, 868
  81. Hardie, 2010, Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer, Biochim. Biophys. Acta, 180, 581
  82. Marambaud, 2011, Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation, FASEB J, 2, 219
  83. Blagosklonny, 2008, Aging. ROS or TOR, Cell Cycle, 7, 3344, 10.4161/cc.7.21.6965 · DOI · Paper page
  84. Thomas, 2010, With TOR, Less is more: a key role for the conserved nutrient-sensing TOR pathway in Aging, Cell Metab, 1, 453
  85. Blagosklonny, Rapamycin and quasi-programmed aging. Four years later, Cell Cycle, 1, 1859
  86. Blagosklonny, 2010, Calorie restriction. Decelerating mTOR-driven aging from cells to organisms (including humans), Cell Cycle, 9, 683, 10.4161/cc.9.4.10766 · DOI
  87. Blagosklonny, 2011, Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice, Cell Cycle, 1, 4230
  88. Blagosklonny, 2010, Rapamycin extends maximal lifespan in cancer-prone mice, Am. J. Pathol, 17, 2092
  89. Collins, 2011, Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells, Sci. Transl. Med, 3, 89ra58
  90. Oddo, 2012, Life-long rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and NMDA signaling, Aging Cell
  91. Bramlett, 2011, Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats, BMC Neurosci, 1, 123
  92. Kemp, 2009, AMPK in health and disease, Physiol. Rev, 8, 1025
  93. Shaw, 2011, Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy, Science, 33, 456
  94. Shulman, 2007, Aging-associated reductions in AMPK-activated protein kinase activity and mitochondrial biogenesis, Cell. Metab, 5, 151, 10.1016/j.cmet.2007.01.008 · DOI · Paper page
  95. McCullough, 2012, Age-related changes in AMP-activated protein kinase after stroke, Age (Dordr), 3, 157
  96. Kaarniranta, 2011, AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan, J. Mol. Med. (Berl.), 8, 667
  97. Candau, 2012, AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1, J. Cell. Biochem, 11, 695
  98. Tsujimoto, 2010, Involvement of JNK in the regulation of autophagic cell death, Oncogene, 2, 2070
  99. Michiels, 2011, Autophagy as a mediator of chemotherapy-induced cell death in cancer, Biochem. Pharmacol, 8, 427

Cited by

Sorted by citations

See all 453

Metadata

Authors
Salminen, A., Kaarniranta, K., & Kauppinen, A.
Affiliations
  • Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, FIN-70211 Kuopio, Finland
  • Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, FIN-70211 Kuopio, Finland
Venue
Aging
Publisher
Impact Journals, LLC
Published
2012-03-07
Volume
4
Issue
3
Pages
166-175
ISSN
1945-4589
DOI
10.18632/aging.100444
PMC
PMC3348477
Cited by
453
References
29
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review