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Role of microRNAs in glioblastoma
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“MicroRNA-based strategies have gained attention as effective methods for sensitizing cancer cells because many microRNAs contribute to the increased resistance of cancer cells to standard treatments.206,207”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [206]
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MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
Gabriely, G., Wurdinger, T., Kesari, S., Esau, C. C., Burchard, J., Linsley, P. S., & Krichevsky, A. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00479-08 · Cited by 888 · cited 2×
“By targeting MMPs, Ras/Raf, and ERK, miR-21 increases the invasive potential of GBM cells [77, 85, 87].”
BackgroundMicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
Papagiannakopoulos, T., Shapiro, A., & Kosik, K. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1305 · Cited by 705 · cited 1×
“Additional targets include P53, TGF-β, and the mitochondrial apoptotic pathways [78, 89, 90].”
BackgroundDenzler, R., McGeary, S. E., Title, A. C., Agarwal, V., Bartel, D. P., & Stoffel, M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.027 · Cited by 340
Brain Extracellular Space: The Final Frontier of Neuroscience
Nicholson, C., & Hrabětová, S. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2017.06.052 · Cited by 321
Abels, E. R., Maas, S. L. N., Nieland, L., Wei, Z., Cheah, P. S., Tai, E., Kolsteeg, C.-J., Dusoswa, S. A., Ting, D. T., Hickman, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.036 · Cited by 199
Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo
Gaur, A. B., Holbeck, S. L., Colburn, N. H., & Israel, M. A. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor033 · Cited by 180 · cited 2×
“Other oncogenic effects of miR-21, such as proliferation, invasiveness, and chemoresistance in a variety of GBM cell lines have also been reported [79, 81, 84].”
BackgroundSkalsky, R. L., & Cullen, B. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024248 · Cited by 170
Malhotra, M., Sekar, T. V., Ananta, J. S., Devulapally, R., Afjei, R., Babikir, H. A., Paulmurugan, R., & Massoud, T. F. (2018) · Oncotarget · doi:10.18632/oncotarget.25135 · Cited by 71
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Cited by
Sorted by citations
MiR-128-3p – a gray eminence of the human central nervous system
Kiel, K., Król, S. K., Bronisz, A., & Godlewski, J. (2024) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2024.102141 · Cited by 15
Metadata
- Authors
- Chen, M., Medarova, Z., & Moore, A.
- Affiliations
- Precision Health Program, Michigan State University, East Lansing, MI 48824, USA
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2021-08-17
- Volume
- 12
- Issue
- 17
- Pages
- 1707-1723
- ISSN
- 1949-2553
- PMC
- PMC8378762
- Cited by
- 84
- References
- 8
- Language
- en
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