Tapering opioids: a comprehensive qualitative review

Davis, Mellar P.; Digwood, Glen; Mehta, Zankhana; McPherson, Mary Lynn

doi:10.21037/apm.2019.12.10

Cited by 33Opioid Use Disorder TreatmentPain Management and Opioid UseAnesthesia and Pain Management

Tapering opioids: a comprehensive qualitative review

Open access

Davis, Mellar P., Digwood, Glen, Mehta, Zankhana, McPherson, Mary Lynn·2020·Annals of Palliative Medicine

DOI 10.21037/apm.2019.12.10

Open this paper in CoChat — free account

Abstract

This state-of-the-art review comprehensive covers the benefits and risks of tapering opioids. The review discusses opioid strategies and pitfalls that may occur during tapering. The purpose of this review is to expand the knowledge of clinicians regarding tapering opioids and equip them to be able to successfully reduce and stop opioid therapy when appropriate.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.21037/apm.2019.12.10

Cites

237 of 237 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The patients most likely to have a reduction in pain severity are those with mild to moderate pain.
“The patients most likely to have a reduction in pain severity are those with mild to moderate pain. 58”
From Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms (2025) · cites this paper as [58]
For patients prescribed opioids for pain, tapering off opioids does not increase pain and may lead to a reduction in pain intensity over time.
“For patients prescribed opioids for pain, it is important to inform them that generally speaking tapering off opioids does not increase pain and, in fact, may lead to a reduction in pain intensity over time: 80% of such patients show a reduction in pain, 15% have no change to their pain and only 3% have an increase in pain intensity. 58”
From Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms (2025) · cites this paper as [58]
Among patients prescribed opioids for pain who taper, 80% show a reduction in pain, 15% have no change, and only 3% have an increase in pain intensity.
“For patients prescribed opioids for pain, it is important to inform them that generally speaking tapering off opioids does not increase pain and, in fact, may lead to a reduction in pain intensity over time: 80% of such patients show a reduction in pain, 15% have no change to their pain and only 3% have an increase in pain intensity. 58”
From Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms (2025) · cites this paper as [58]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016
Dowell, D., Haegerich, T. M., & Chou, R. (2016) · JAMA · doi:10.1001/jama.2016.1464 · Cited by 5,161 · see citing works
Neurobiology of addiction: a neurocircuitry analysis
Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698 · cited 1× · see citing works
“The “liking” affect is mediated through the nucleus accumbens and “wanting” affect mediated by phasic release of dopamine in the nucleus accumbens (31,32).”
Background
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457 · see citing works
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works
The glutamate homeostasis hypothesis of addiction
Kalivas, P. W. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2515 · Cited by 1,350 · see citing works
Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women: An Epidemiological and Cotwin Control Analysis
Kendler, K. S., Bulik, C. M., Silberg, J., Hettema, J. M., Myers, J., & Prescott, C. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.953 · Cited by 1,259 · see citing works
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216 · see citing works
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105 · see citing works
Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial
Krebs, E. E., Gravely, A., Nugent, S., Jensen, A. C., DeRonne, B., Goldsmith, E. S., Kroenke, K., Bair, M. J., & Noorbaloochi, S. (2018) · JAMA · doi:10.1001/jama.2018.0899 · Cited by 983 · see citing works
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
Izzo, A. A., Borrelli, F., Capasso, R., Marzo, V. D., & Mechoulam, R. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.07.006 · Cited by 851 · see citing works
Familial Transmission of Substance Use Disorders
Merikangas, K. R., Stolar, M., Stevens, D. E., Goulet, J., Preisig, M. A., Fenton, B., Zhang, H., O'Malley, S. S., & Rounsaville, B. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.973 · Cited by 783 · see citing works
Cannabidiol displays unexpectedly high potency as an antagonist of CB 1 and CB 2 receptor agonists in vitro
Thomas, A., Baillie, G. L., Phillips, A. M., Razdan, R. K., Ross, R. A., & Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707133 · Cited by 763 · see citing works
Alcoholism: Allostasis and Beyond
Koob, G. F. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000057122.36127.c2 · Cited by 737 · see citing works
Guideline for opioid therapy and chronic noncancer pain
Busse, J. W., Craigie, S., Juurlink, D. N., Buckley, D. N., Wang, L., Couban, R. J., Agoritsas, T., Akl, E. A., Carrasco-Labra, A., Cooper, L., et al. (2017) · Canadian Medical Association Journal · doi:10.1503/cmaj.170363 · Cited by 707 · cited 1× · see citing works
“For slow tapers, the general rule is that the duration of the taper should be proportional to the duration of the opioid therapy (163).”
Background
Neurobiological mechanisms for opponent motivational processes in addiction
Koob, G. F., & Moal, M. L. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0094 · Cited by 702 · see citing works
American Society of Addiction Medicine (ASAM) National Practice Guideline for the Use of Medications in the Treatment of Addiction Involving Opioid Use
Kampman, K. M., & Jarvis, M. A. E. (2015) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000166 · Cited by 680 · see citing works
An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies
Iffland, K., & Grotenhermen, F. (2017) · Cannabis & Cannabinoid Research · doi:10.1089/can.2016.0034 · Cited by 645 · see citing works
Opioid pseudoaddiction — an iatrogenic syndrome
Weissman, D. E., & Haddox, J. D. (1989) · Pain · doi:10.1016/0304-3959(89)90097-3 · Cited by 644 · see citing works
Opioid Dose and Drug-Related Mortality in Patients With Nonmalignant Pain
Gomes, T., Mamdani, M., Dhalla, I. A., Paterson, J. M., & Juurlink, D. N. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.117 · Cited by 637 · see citing works
Breast Cancer Follow-Up and Management After Primary Treatment: American Society of Clinical Oncology Clinical Practice Guideline Update
Khatcheressian, J. L., Hurley, P., Bantug, E., Esserman, L. J., Grunfeld, E., Halberg, F., Hantel, A., Henry, N. L., Muss, H. B., Smith, T. J., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.9859 · Cited by 626 · see citing works
Neural Mechanisms of Drug Reinforcementa
Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25966.x · Cited by 607 · see citing works
Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline
Paice, J. A., Portenoy, R. K., Lacchetti, C., Campbell, T. C., Cheville, A. L., Citron, M. L., Constine, L. S., Cooper, A., Glare, P. A., Keefe, F., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.68.5206 · Cited by 604 · see citing works
Adjunctive Counseling During Brief and Extended Buprenorphine-Naloxone Treatment for Prescription Opioid Dependence: A 2-Phase Randomized Controlled Trial
Weiss, R. D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.121 · Cited by 540 · see citing works
Neurobiological substrates for the dark side of compulsivity in addiction
Koob, G. F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.043 · Cited by 458 · see citing works
Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain
Boehnke, K. F., Litinas, E., & Clauw, D. J. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.03.002 · Cited by 412 · see citing works
No Shortcuts to Safer Opioid Prescribing
Dowell, D., Haegerich, T., & Chou, R. (2019) · New England Journal of Medicine · doi:10.1056/nejmp1904190 · Cited by 408 · see citing works
Opioid Consumption Following Outpatient Upper Extremity Surgery
Rodgers, J. A., Cunningham, K., Fitzgerald, K., & Finnerty, E. P. (2012) · The Journal Of Hand Surgery · doi:10.1016/j.jhsa.2012.01.035 · Cited by 400 · see citing works
The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
Wee, S., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1825-8 · Cited by 398 · see citing works
Group cognitive behavioural treatment for low-back pain in primary care: a randomised controlled trial and cost-effectiveness analysis
Lamb, S. E., Hansen, Z., Lall, R., Castelnuovo, E., Withers, E. J., Nichols, V., Potter, R., & Underwood, M. R. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62164-4 · Cited by 393 · see citing works
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389 · see citing works
The IASP classification of chronic pain for ICD-11: chronic cancer-related pain
Bennett, M., Kaasa, S., Barke, A., Korwisi, B., Rief, W., Treede, R., & Pain, T. I. T. F. T. C. O. C. (2018) · Pain · doi:10.1097/j.pain.0000000000001363 · Cited by 388 · see citing works
Association of Opioid Prescribing With Opioid Consumption After Surgery in Michigan
Howard, R., Fry, B. T., Gunaseelan, V., et al. (2018) · JAMA Surgery · doi:10.1001/jamasurg.2018.4234 · Cited by 379 · see citing works
Follow-Up Care, Surveillance Protocol, and Secondary Prevention Measures for Survivors of Colorectal Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement
Meyerhardt, J. A., Mangu, P. B., Flynn, P. J., Korde, L. A., Loprinzi, C. L., Minsky, B. D., Petrelli, N. J., Ryan, K., Schrag, D., Wong, S. L., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.50.7442 · Cited by 369 · see citing works
Opioid Use and Storage Patterns by Patients after Hospital Discharge following Surgery
Bartels, K., Mayes, L. M., Dingmann, C., Bullard, K. J., Hopfer, C. J., & Binswanger, I. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147972 · Cited by 363 · see citing works
A review of opioid dependence treatment: Pharmacological and psychosocial interventions to treat opioid addiction
Veilleux, J. C., Colvin, P. J., Anderson, J., York, C., & Heinz, A. J. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.10.006 · Cited by 336 · see citing works
Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review
Frank, J. W., Lovejoy, T. I., Becker, W. C., Morasco, B. J., Koenig, C. J., Hoffecker, L., Dischinger, H. R., Dobscha, S. K., & Krebs, E. E. (2017) · Annals of Internal Medicine · doi:10.7326/m17-0598 · Cited by 318 · see citing works
Risk of death during and after opiate substitution treatment in primary care: prospective observational study in UK General Practice Research Database
Cornish, R., Macleod, J., Strang, J., Vickerman, P., & Hickman, M. (2010) · BMJ · doi:10.1136/bmj.c5475 · Cited by 307 · see citing works
Pharmacokinetics of Opioids in Liver Disease
Tegeder, I., L??tsch, J., & Geißlinger, G. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199937010-00002 · Cited by 307 · see citing works
Opioids block long-term potentiation of inhibitory synapses
Nugent, F. S., Penick, E. C., & Kauer, J. A. (2007) · Nature · doi:10.1038/nature05726 · Cited by 297 · see citing works
The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways
Garland, E. L., Froeliger, B., Zeidan, F., Partin, K., & Howard, M. O. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.006 · Cited by 277 · see citing works
Is cannabis a gateway drug? Testing hypotheses about the relationship between cannabis use and the use of other illicit drugs
Hall, W., & Lynskey, M. T. (2005) · Drug and Alcohol Review · doi:10.1080/09595230500126698 · Cited by 265 · see citing works
Medical cannabis and mental health: A guided systematic review
Walsh, Z., González, R., Crosby, K., Thiessen, M. S., Carroll, C., & Bonn‐Miller, M. O. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.10.002 · Cited by 247 · see citing works
Review article: Effective management of opioid withdrawal symptoms: A gateway to opioid dependence treatment
Kosten, T. R., & Baxter, L. E. (2019) · American Journal on Addictions · doi:10.1111/ajad.12862 · Cited by 236 · see citing works
Association of Medical and Adult-Use Marijuana Laws With Opioid Prescribing for Medicaid Enrollees
Wen, H., & Hockenberry, J. M. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.1007 · Cited by 229 · see citing works
Tapering Long-term Opioid Therapy in Chronic Noncancer Pain
Berna, C., Kulich, R. J., & Rathmell, J. P. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.04.003 · Cited by 217 · see citing works
Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain
Shurman, J., Koob, G. F., & Gutstein, H. B. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00881.x · Cited by 215 · see citing works
Opioid prescribing trends and geographical variation in England, 1998–2018: a retrospective database study
Curtis, H. J., Croker, R., Walker, A. J., Richards, G. C., Quinlan, J., & Goldacre, B. M. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30471-1 · Cited by 209 · see citing works
Higher Opioid Doses Predict Poorer Functional Outcome in Patients with Chronic Disabling Occupational Musculoskeletal Disorders
Kidner, C. L., Mayer, T. G., & Gatchel, R. J. (2009) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.h.00286 · Cited by 208 · see citing works
Persistent pain is associated with substance use after detoxification: a prospective cohort analysis
Larson, M. J., Paasche‐Orlow, M., Cheng, D. M., Lloyd‐Travaglini, C., Saitz, R., & Samet, J. H. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01759.x · Cited by 204 · see citing works
Are detoxification programmes effective?
Mattick, R. P., & Hall, W. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90215-9 · Cited by 196 · see citing works
Safety, Tolerability, and Clinical Effect of Low-Dose Buprenorphine for Treatment-Resistant Depression in Midlife and Older Adults
Karp, J. F., Butters, M. A., Begley, A. E., Miller, M. D., Lenze, E. J., Blumberger, D. M., Mulsant, B. H., & Reynolds, C. F. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08725 · Cited by 191 · see citing works
Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep
Piper, B. J., DeKeuster, R. M., Beals, M. L., Cobb, C. M., Burchman, C. A., Perkinson, L., Lynn, S. T., Nichols, S. D., & Abess, A. T. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117699616 · Cited by 190 · see citing works
Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems
George, O., Le Moal, M., & Koob, G. F. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.004 · Cited by 184 · see citing works
Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence
Fiellin, D. A., Schottenfeld, R. S., Cutter, C. J., Moore, B. A., Barry, D. T., & O’Connor, P. G. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.5302 · Cited by 183 · see citing works
Opioid medication discontinuation and risk of adverse opioid-related health care events
Mark, T. L., & Parish, W. J. (2019) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2019.05.001 · Cited by 180 · see citing works
Patients’ Perspectives on Tapering of Chronic Opioid Therapy: A Qualitative Study
Frank, J. W., Levy, C. R., Matlock, D. D., Calcaterra, S. L., Mueller, S. R., Koester, S. K., & Binswanger, I. A. (2016) · Pain Medicine · doi:10.1093/pm/pnw078 · Cited by 173 · see citing works
Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids
Campos, A. C., & Guimarães, F. S. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.08.017 · Cited by 172 · see citing works
Clonidine in Morphine Withdrawal
Jasinski, D. R. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790340041006 · Cited by 164 · see citing works
Incident opioid drug use and adverse respiratory outcomes among older adults with COPD
Vozoris, N. T., Wang, X., Fischer, H. D., Bell, C. M., O’Donnell, D. E., Austin, P. C., Stephenson, A. L., Gill, S. S., & Rochon, P. A. (2016) · European Respiratory Journal · doi:10.1183/13993003.01967-2015 · Cited by 156 · see citing works
Issues in Long-term Opioid Therapy: Unmet Needs, Risks, and Solutions
Passik, S. D. (2009) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60748-9 · Cited by 148 · see citing works
Childhood trauma as a correlate of lifetime opiate use in psychiatric patients
Heffernan, K., Cloître, M., Tardiff, K. J., Marzuk, P. M., S, L. P. M., & Leon, A. C. (2000) · Addictive Behaviors · doi:10.1016/s0306-4603(00)00066-6 · Cited by 147 · see citing works
Prescription Opioid Taper Support for Outpatients With Chronic Pain: A Randomized Controlled Trial
Sullivan, M. D., Turner, J. A., DiLodovico, C., D'Appollonio, A., Stephens, K. A., & Chan, Y.-F. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.11.003 · Cited by 146 · see citing works
2009 Clinical Guidelines from the American Pain Society and the American Academy of Pain Medicine on the use of chronic opioid therapy in chronic noncancer pain: what are the key messages for clinical practice?
Chou, R. (2009) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.741 · Cited by 140 · see citing works
Development of a Risk Index for Serious Prescription Opioid-Induced Respiratory Depression or Overdose in Veterans' Health Administration Patients
Zedler, B., Xie, L., Wang, L., Joyce, A., Vick, C., Brigham, J., Kariburyo, F., Baser, O., & Murrelle, L. (2015) · Pain Medicine · doi:10.1111/pme.12777 · Cited by 138 · cited 1× · see citing works
“There is an increasing risk of opioid induced respiratory depression in those with organ failure if ignored by rote use of equianalgesic tables (170).”
Background
Clinical pharmacology of methadone for pain
Fredheim, O. M. S., Moksnes, K., Borchgrevink, P. C., Kaasa, S., & Dale, O. (2008) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2008.01597.x · Cited by 135 · see citing works
Cannabis as an Adjunct to or Substitute for Opiates in the Treatment of Chronic Pain
Lucas, P. (2012) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2012.684624 · Cited by 131 · see citing works
A longitudinal study of the efficacy of a comprehensive pain rehabilitation program with opioid withdrawal: Comparison of treatment outcomes based on opioid use status at admission
Townsend, C. O., Kerkvliet, J. L., Bruce, B. K., Rome, J. D., Hooten, M. W., Luedtke, C. A., & Hodgson, J. E. (2008) · Pain · doi:10.1016/j.pain.2008.08.005 · Cited by 128 · see citing works
Opioid Detoxification and Naltrexone Induction Strategies: Recommendations for Clinical Practice
Sigmon, S. C., Bisaga, A. M., Nunes, E. V., O’Connor, P. G., Kosten, T. R., & WOODY, G. E. (2012) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2011.653426 · Cited by 126 · see citing works
Patient-Centered Prescription Opioid Tapering in Community Outpatients With Chronic Pain
Darnall, B. D., Ziadni, M. S., Stieg, R. L., Mackey, I. G., Kao, M. J., & Flood, P. D. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.8709 · Cited by 121 · see citing works
Early Onset Cannabis Use and Progression to other Drug Use in a Sample of Dutch Twins
Lynskey, M. T., Vink, J. M., & Boomsma, D. I. (2006) · Behavior Genetics · doi:10.1007/s10519-005-9023-x · Cited by 120 · see citing works
Identifying and assessing the risk of opioid abuse in patients with cancer: an integrative review
Fabbro, E. D., Carmichael, A.-N., & Morgan, L. A. (2016) · Substance Abuse and Rehabilitation · doi:10.2147/sar.s85409 · Cited by 118 · see citing works
Withdrawal From Methadone Maintenance: Rate of Withdrawal and Expectation
Senay, E. C. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770150119014 · Cited by 117 · see citing works
Practical management of opioid rotation and equianalgesia
Treillet, E., LAURENT, S., & Hadjiat, Y. (2018) · Journal of Pain Research · doi:10.2147/jpr.s170269 · Cited by 117 · see citing works
Screening for substance abuse risk in cancer patients using the Opioid Risk Tool and urine drug screen
Barclay, J. S., Owens, J. E., & Blackhall, L. J. (2014) · Supportive Care in Cancer · doi:10.1007/s00520-014-2167-6 · Cited by 111 · see citing works
Treatment Outcomes after Multidisciplinary Pain Rehabilitation with Analgesic Medication Withdrawal for Patients with Fibromyalgia
Hooten, W. M., Townsend, C. O., Sletten, C. D., Bruce, B. K., & Rome, J. D. (2007) · Pain Medicine · doi:10.1111/j.1526-4637.2007.00253.x · Cited by 111 · see citing works
“Those Conversations in My Experience Don’t Go Well”: A Qualitative Study of Primary Care Provider Experiences Tapering Long-term Opioid Medications
Kennedy, L. C., Binswanger, I. A., Mueller, S. R., Levy, C. R., Matlock, D. D., Calcaterra, S. L., Koester, S. K., & Frank, J. W. (2017) · Pain Medicine · doi:10.1093/pm/pnx276 · Cited by 108 · see citing works
Suicidal ideation and suicidal self-directed violence following clinician-initiated prescription opioid discontinuation among long-term opioid users
Demidenko, M. I., Dobscha, S. K., Morasco, B. J., Meath, T. H. A., Ilgen, M. A., & Lovejoy, T. I. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.04.011 · Cited by 106 · see citing works
Prolonged rewarding stimulation of the rat medial forebrain bundle: Neurochemical and behavioral consequences.
Hernández, G., Hamdani, S., Rajabi, H., Conover, K. L., Stewart, J., Arvanitogiannis, A., & Shizgal, P. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.4.888 · Cited by 105 · see citing works
Significant pain reduction in chronic pain patients after detoxification from high-dose opioids
Michael J. Baron, M., & McDonald, P. (2006) · Journal of Opioid Management · doi:10.5055/jom.2006.0041 · Cited by 105 · see citing works
Switching from Methadone to a Different Opioid: What Is the Equianalgesic Dose Ratio?
Walker, P. W., Palla, S. L., Pei, B.-L., et al. (2008) · Journal of Palliative Medicine · doi:10.1089/jpm.2007.0285 · Cited by 102 · see citing works
“Like being put on an ice floe and shoved away”: A qualitative study of the impacts of opioid-related policy changes on people who take opioids
Antoniou, T., Ala‐Leppilampi, K., Shearer, D., Parsons, J. A., Tadrous, M., & Gomes, T. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.01.015 · Cited by 102 · see citing works
The Conundrum of Opioid Tapering in Long-Term Opioid Therapy for Chronic Pain: A Commentary
Manhapra, A., Arias, A. J., & Ballantyne, J. C. (2018) · Substance Abuse · doi:10.1080/08897077.2017.1381663 · Cited by 98 · see citing works
Provider and patient perspectives on opioids and alternative treatments for managing chronic pain: a qualitative study
Penney, L., Ritenbaugh, C., DeBar, L., Elder, C. R., & Deyo, R. A. (2016) · BMC Family Practice · doi:10.1186/s12875-016-0566-0 · Cited by 97 · see citing works
Pharmacokinetics and ventilatory effects of oxycodone before and after liver transplantation*
Tallgren, M. K., Olkkola, K. T., Seppαlä, T., et al. (1997) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(97)90100-4 · Cited by 96 · see citing works
Factors associated with lapses to heroin use during methadone maintenance
Wasserman, D. A., WEINSTEIN, M. G., Havassy, B. E., & Hall, S. M. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00092-1 · Cited by 94 · see citing works
Patients’ Experience With Opioid Tapering: A Conceptual Model With Recommendations for Clinicians
Henry, S. G., Paterniti, D. A., Feng, B., Iosif, A., Kravitz, R. L., Weinberg, G., Cowan, P., & Verba, S. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.09.001 · Cited by 94 · see citing works
Does cannabis use predict poor outcome for heroin-dependent patients on maintenance treatment? Past findings and more evidence against.
Epstein, D. H., & Preston, K. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00310.x · Cited by 93 · see citing works
Electrophysiological evidence that drug cues have greater salience than other affective stimuli in opiate addiction
Lubman, D. I., Allen, N. B., PETERS, L. A., & Deakin, J. F. W. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107083846 · Cited by 93 · see citing works
Hypogonadism and sexual dysfunction in male cancer survivors receiving chronic opioid therapy
Rajagopal, A., Vassilopoulou‐Sellin, R., Palmer, J. L., Kaur, G., & Bruera, E. D. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(03)00331-2 · Cited by 92 · see citing works
Chronic Pain and Risk Factors for Opioid Misuse in a Palliative Care Clinic
Childers, J. W., King, L. A., & Arnold, R. M. (2014) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909114531445 · Cited by 92 · see citing works
Cannabis use stages as predictors of subsequent initiation with other illicit drugs among French adolescents: Use of a multi-state model
Mayet, A., Legleye, S., Falissard, B., & Chau, N. (2011) · Addictive Behaviors · doi:10.1016/j.addbeh.2011.09.012 · Cited by 92 · see citing works
Chronic Noncancer Pain Rehabilitation With Opioid Withdrawal: Comparison of Treatment Outcomes Based on Opioid Use Status at Admission
Rome, J. D., Townsend, C. O., Bruce, B. K., Sletten, C. D., Luedtke, C. A., & Hodgson, J. E. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.6.759 · Cited by 91 · see citing works
Cannabidiol disrupts the reconsolidation of contextual drug‐associated memories in Wistar rats
de Carvalho, C. R., & Takahashi, R. N. (2016) · Addiction Biology · doi:10.1111/adb.12366 · Cited by 91 · see citing works
A Randomized, Double-blind Evaluation of Buprenorphine Taper Duration in Primary Prescription Opioid Abusers
Sigmon, S., Dunn, K., Saulsgiver, K., Patrick, M. E., Badger, G., Heil, S., Brooklyn, J., & Higgins, S. (2013) · JAMA psychiatry · doi:10.1001/jamapsychiatry.2013.2216 · Cited by 89 · see citing works
Exploring beliefs and practice of opioid prescribing for persistent non‐cancer pain by general practitioners
Hutchinson, K., Moreland, A. M. E., Williams, A. C. D. C., et al. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2006.01.003 · Cited by 85 · see citing works
Therapeutic Interactive Voice Response (TIVR) to Reduce Analgesic Medication Use for Chronic Pain Management
Naylor, M. R., Naud, S. J., Keefe, F. J., & Helzer, J. E. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.03.019 · Cited by 82 · see citing works
Refractory dependence on opioid analgesics
Ballantyne, J. C., Sullivan, M. D., & Koob, G. F. (2019) · Pain · doi:10.1097/j.pain.0000000000001680 · Cited by 81 · see citing works
Update on pharmacotherapy for treatment of opioid use disorder
Ayanga, D., Shorter, D. I., & Kosten, T. R. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1244529 · Cited by 79 · see citing works
Comorbid Posttraumatic Stress Disorder and Opiate Addiction: A Literature Review
Fareed, A., Eilender, P., Haber, M. J., Bremner, J. D., Whitfield, N., & Drexler, K. P. G. (2013) · Journal of Addictive Diseases · doi:10.1080/10550887.2013.795467 · Cited by 78 · see citing works
Association of Primary Care Clinic Appointment Time With Opioid Prescribing
Neprash, H. T., & Barnett, M. L. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.10373 · Cited by 78 · see citing works
A phase III, randomized, multi-center, double blind, placebo controlled study of safety and efficacy of lofexidine for relief of symptoms in individuals undergoing inpatient opioid withdrawal
Gorodetzky, C. W., WALSH, S. L., Martin, P., et al. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.02.020 · Cited by 72 · see citing works
Opioid–galanin receptor heteromers mediate the dopaminergic effects of opioids
Cai, N.-S., Quiroz, C., Bonaventura, J., Bonifazi, A., Cole, T. O., Purks, J., Billing, A. S., Massey, E. C., Wagner, M., Wish, E. D., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126912 · Cited by 71 · see citing works
Opiate reduction in chronic pain patients: A comparison of patient-controlled reduction and staff controlled cocktail methods
Ralphs, J. A., de C Williams, A. C., Richardson, P. H., Pither, C. E., & Nicholas, M. K. (1994) · Pain · doi:10.1016/0304-3959(94)90166-x · Cited by 70 · see citing works
Opioid withdrawal suppression efficacy of oral dronabinol in opioid dependent humans
Lofwall, M. R., Babalonis, S. L., Nuzzo, P. A., Elayi, C. S., & WALSH, S. L. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.05.002 · Cited by 70 · see citing works
Opioid Taper Is Associated with Subsequent Termination of Care: a Retrospective Cohort Study
Perez, H. R., Buonora, M. J., Cunningham, C. O., Heo, M., & Starrels, J. L. (2019) · Journal of General Internal Medicine · doi:10.1007/s11606-019-05227-9 · Cited by 70 · see citing works
Managing Chronic Pain in Cancer Survivors Prescribed Long-Term Opioid Therapy: A National Survey of Ambulatory Palliative Care Providers
Merlin, J. S., Patel, K., Thompson, N., Kapo, J. M., Keefe, F., Liebschutz, J. M., Paice, J. A., Somers, T. J., Starrels, J. L., Childers, J. W., et al. (2018) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2018.10.493 · Cited by 69 · see citing works
Attentional bias for prescription opioid cues among opioid dependent chronic pain patients
Garland, E. L., Froeliger, B., Passik, S. D., & Howard, M. O. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9455-8 · Cited by 65 · see citing works
Associations between Heat Pain Perception and Opioid Dose among Patients with Chronic Pain Undergoing Opioid Tapering
Hooten, W. M., Mantilla, C. B., Sandroni, P., & Townsend, C. O. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00962.x · Cited by 64 · see citing works
Malpractice Claims Associated with Medication Management for Chronic Pain
Fitzgibbon, D. R., Rathmell, J. P., Michna, E., Stephens, L. S., Posner, K. L., & Domino, K. B. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181cdef98 · Cited by 64 · see citing works
Tobacco Smoking, Nicotine Dependence, and Patterns of Prescription Opioid Misuse: Results From a Nationally Representative Sample
Zale, E. L., Dorfman, M. L., Hooten, W. M., Warner, D. O., Zvolensky, M. J., & Ditre, J. W. (2014) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntu227 · Cited by 63 · see citing works
Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons
Cao, J., Vialou, V., Lobo, M. K., Robison, A. J., Neve, R. L., Cooper, D., Nestler, E. J., & Han, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010077107 · Cited by 60 · see citing works
Inter- and Intraindividual Variabilities in Pharmacokinetics of Fentanyl After Repeated 72-Hour Transdermal Applications in Cancer Pain Patients
Solassol, I., Bressolle, F. O., Caumette, L., et al. (2005) · Therapeutic Drug Monitoring · doi:10.1097/01.ftd.0000160717.50704.42 · Cited by 59 · see citing works
A Clinical Trial Comparing Tapering Doses of Buprenorphine With Steady Doses for Chronic Pain and Coexistent Opioid Addiction
Blondell, R. D., Ashrafioun, L., Dambra, C. M., Foschio, E. M., Zielinski, A. L., & Salcedo, D. M. (2010) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e3181ba895d · Cited by 59 · see citing works
Why Don’t Physicians (and Patients) Consistently Follow Clinical Practice Guidelines?
Casey, D. E. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.7672 · Cited by 58 · see citing works
Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: A discrete survival and growth mixture model
Northrup, T. F., Stotts, A. L., Green, C., Potter, J. S., Marino, E. N., Walker, R., Weiss, R. D., & Trivedi, M. H. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.09.021 · Cited by 57 · see citing works
Who gets high-dose opioid therapy for chronic non-cancer pain?
Sullivan, M. D. (2010) · Pain · doi:10.1016/j.pain.2010.08.036 · Cited by 57 · see citing works
What Are We Treating With Long-term Opioid Therapy?
Sullivan, M. D. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.2156 · Cited by 57 · see citing works
Electrophysiological evidence of the motivational salience of drug cues in opiate addiction
Lubman, D. I., Allen, N. B., Peters, L., & Deakin, J. F. W. (2007) · Psychological Medicine · doi:10.1017/s0033291707009932 · Cited by 56 · see citing works
Do Palliative Care Clinics Screen for Substance Abuse and Diversion? Results of a National Survey
Tan, P., Barclay, J. S., & Blackhall, L. J. (2015) · Journal of Palliative Medicine · doi:10.1089/jpm.2015.0098 · Cited by 55 · see citing works
Outpatient Treatment of Prescription Opioid Dependence: Comparison of Two Methods
Tennant, F. S. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340230087016 · Cited by 53 · see citing works
Opiate Detoxification Protocols: A Clinical Manual
Fishbain, D. A., Rosomoff, H. L., Cutler, R., et al. (1993) · Annals of Clinical Psychiatry · doi:10.3109/10401239309148924 · Cited by 53 · see citing works
Intermittent Marijuana Use Is Associated with Improved Retention in Naltrexone Treatment for Opiate‐Dependence
Raby, W. N., Carpenter, K. M., Rothenberg, J. L., Brooks, A. C., Jiang, H., Sullivan, M. A., Bisaga, A. M., Comer, S. D., & Nunes, E. V. (2009) · American Journal on Addictions · doi:10.1080/10550490902927785 · Cited by 53 · see citing works
An Ethical Exploration of Barriers to Research on Controlled Drugs
Andreae, M. H., Rhodes, E., Bourgoise, T., Carter, G. M., White, R. S., Indyk, D., Sacks, H. S., & Rhodes, R. (2016) · The American Journal of Bioethics · doi:10.1080/15265161.2016.1145282 · Cited by 53 · see citing works
Longitudinal Observation of Changes in Pain Sensitivity during Opioid Tapering in Patients with Chronic Low-Back Pain
Wang, H., el Akbar, M., Weinsheimer, N., Gantz, S., & Schiltenwolf, M. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01276.x · Cited by 52 · see citing works
Chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer survivors: a comparison of patient-reported outcomes and quantitative sensory testing
Zhi, W. I., Chen, P. A., Kwon, A., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05416-4 · Cited by 52 · see citing works
Prolonged Preoperative Opioid Therapy Associated With Poor Return to Work Rates After Single-Level Cervical Fusion for Radiculopathy for Patients Receiving Workers’ Compensation Benefits
Faour, M., Anderson, J. T., Haas, A. R., Percy, R., Woods, S. T., Ahn, U. M., & Ahn, N. U. (2016) · Spine · doi:10.1097/brs.0000000000001715 · Cited by 50 · see citing works
Urine drug screen findings among ambulatory oncology patients in a supportive care clinic
Rauenzahn, S. L., Sima, A. P., Cassel, B. J., Noreika, D. M., Gomez, T. H., Ryan, L., Wolf, C. E., Legakis, L. P., & Fabbro, E. D. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-017-3575-1 · Cited by 50 · see citing works
Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress
Polter, A. M., Barcomb, K., Chen, R. W., Dingess, P. M., Graziane, N., Brown, T. E., & Kauer, J. A. (2017) · eLife · doi:10.7554/elife.23785 · Cited by 50 · see citing works
Cannabis Use is Associated with Lower Odds of Prescription Opioid Analgesic Use Among HIV-Infected Individuals with Chronic Pain
Sohler, N., Starrels, J. L., Khalid, L., Bachhuber, M. A., Arnsten, J. H., Nahvi, S., Jost, J. T., & Cunningham, C. O. (2018) · Substance Use & Misuse · doi:10.1080/10826084.2017.1416408 · Cited by 50 · see citing works
Does Opioid Tapering in Chronic Pain Patients Result in Improved Pain or Same Pain vs Increased Pain at Taper Completion? A Structured Evidence-Based Systematic Review
Fishbain, D. A., & Pulikal, A. (2018) · Pain Medicine · doi:10.1093/pm/pny231 · Cited by 49 · see citing works
Potential risk factors associated with risk for drop‐out and relapse during and following withdrawal of opioid prescription medication
Heiwel, S., Lönnquistl, I., & Källménl, H. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.03.006 · Cited by 48 · see citing works
Changes in pain intensity after discontinuation of long-term opioid therapy for chronic noncancer pain
McPherson, S., Smith, C. L., Dobscha, S. K., Morasco, B. J., Demidenko, M. I., Meath, T. H. A., & Lovejoy, T. I. (2018) · Pain · doi:10.1097/j.pain.0000000000001315 · Cited by 48 · see citing works
Thought suppression as a mediator of the association between depressed mood and prescription opioid craving among chronic pain patients
Garland, E. L., Brown, S. M., & Howard, M. O. (2016) · Journal of Behavioral Medicine · doi:10.1007/s10865-015-9675-9 · Cited by 47 · see citing works
Inter- and intra-individual variability in transdermal fentanyl absorption in cancer pain patients
Solassol, I., Caumette, L., Bressolle, F., Garcia, F., Thézenas, S., Astre, C., Culine, S., Coulouma, R., & Pinguet, F. (2005) · Oncology Reports · doi:10.3892/or.14.4.1029 · Cited by 47 · see citing works
Reduction of Opioid-Withdrawal Symptoms With Quetiapine
Pinkofsky, H. B., Hahn, A. M., Campbell, F. A., Rueda, J., Daley, D. C., & Douaihy, A. B. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1011 · Cited by 47 · see citing works
Buprenorphine—Clinically useful but often misunderstood
Butler, S. (2013) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2013.05.004 · Cited by 47 · see citing works
Predicting Time on Prolonged Benefits for Injured Workers with Acute Back Pain
Steenstra, I. A., Busse, J. W., Tolusso, D., Davilmar, A., Lee, H., Furlan, A. D., Amick, B., & Hogg‐Johnson, S. (2014) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-014-9534-5 · Cited by 47 · see citing works
Conditioned facilitation of brain reward function after repeated cocaine administration.
Kenny, P. J., Koob, G. F., & Markou, A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.5.1103 · Cited by 45 · see citing works
Recurrence patterns and surveillance for patients with early stage endometrial cancer
Salani, R., Nagel, C. I., Drennen, E., et al. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.07.014 · Cited by 45 · see citing works
Strategies to prevent opioid misuse, abuse, and diversion that may also reduce the associated costs.
Hahn, K. L. (2011) · PubMed · Cited by 44 · see citing works
Is There a Potential of Misuse for Quetiapine?: Literature Review and Analysis of the European Medicines Agency/European Medicines Agency Adverse Drug Reactions' Database
Chiappini, S., & Schifano, F. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000814 · Cited by 44 · see citing works
The brain on opioids
Ballantyne, J. C. (2018) · Pain · doi:10.1097/j.pain.0000000000001270 · Cited by 44 · see citing works
States Move to Substitute Opioids With Medical Marijuana to Quell Epidemic
Voelker, R. (2018) · JAMA · doi:10.1001/jama.2018.17329 · Cited by 43 · see citing works
“Broken Heart Syndrome” After Separation (From OxyContin)
Rivera, J., Locketz, A. J., Fritz, K. D., et al. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.6.825 · Cited by 41 · see citing works
Low Pain Intensity After Opioid Withdrawal as a First Step of a Comprehensive Pain Rehabilitation Program Predicts Long-term Nonuse of Opioids in Chronic Noncancer Pain
Krumova, E. K., Bennemann, P., Kindler, D., Schwarzer, A., Zenz, M. W., & Maier, C. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31827c7cf6 · Cited by 41 · see citing works
Stopping or Decreasing Opioid Therapy in Patients on Chronic Opioid Therapy
Pergolizzi, J. V., Varrassi, G., Paladini, A., & LeQuang, J. A. (2019) · Pain and Therapy · doi:10.1007/s40122-019-00135-6 · Cited by 41 · see citing works
Opioid Prescriptions for Acute and Chronic Pain Management Among Medicaid Beneficiaries
Janakiram, C., Fontelo, P. A., Huser, V., Chalmers, N. I., Mitnik, G. L., Brow, A. R., Iafolla, T., & Dye, B. A. (2019) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.04.022 · Cited by 41 · see citing works
A non‐rewarding, non‐aversive buprenorphine/naltrexone combination attenuates drug‐primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
Cordery, S. F., Taverner, A., Ridzwan, I. E., Guy, R. H., Delgado-Charro, M. B., Husbands, S. M., & Bailey, C. P. (2012) · Addiction Biology · doi:10.1111/adb.12020 · Cited by 40 · see citing works
Measurement of opioid problems among chronic pain patients in a general medical population
Banta‐Green, C. J., Merrill, J. O., Doyle, S. R., Boudreau, D. M., & Calsyn, D. A. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.03.022 · Cited by 40 · see citing works
Heart failure due to ‘stress cardiomyopathy’: a severe manifestation of the opioid withdrawal syndrome
Spadotto, V., Zorzi, A., ElMaghawry, M., Meggiolaro, M., & Pittoni, G. M. (2013) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872612474923 · Cited by 40 · see citing works
A Novel Observational Method for Assessing Acute Responses to Cannabis: Preliminary Validation Using Legal Market Strains
Bidwell, L. C., Mueller, R. L., YorkWilliams, S. L., Hagerty, S. L., Bryan, A. D., & Hutchison, K. E. (2018) · Cannabis and Cannabinoid Research · doi:10.1089/can.2017.0038 · Cited by 40 · see citing works
The Failing Cascade: Comorbid Post Traumatic- and Opioid Use Disorders.
Elman, I., & Borsook, D. (2019) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.023 · Cited by 40 · see citing works
A pilot study assessing acceptability and feasibility of hatha yoga for chronic pain in people receiving opioid agonist therapy for opioid use disorder
Uebelacker, L. A., Van Noppen, D., Tremont, G., Bailey, G., Abrantes, A., & Stein, M. (2019) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2019.07.015 · Cited by 38 · see citing works
Patients with problematic opioid use can be weaned from codeine without pain escalation
Nilsen, H. K., Stiles, T. C., Landrø, N., Fors, E. A., Kaasa, S., & Borchgrevink, P. C. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.02164.x · Cited by 37 · see citing works
ACOEM Practice Guidelines
Hegmann, K. T., Weiss, M., Bowden, K., Branco, F., DuBrueler, K., Els, C., Mandel, S., McKinney, D. W., Miguel, R. V., Mueller, K. L., et al. (2014) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000237 · Cited by 36 · see citing works
Determining Pharmacological Selectivity of the Kappa Opioid Receptor Antagonist LY2456302 Using Pupillometry as a Translational Biomarker in Rat and Human
Rorick‐Kehn, L. M., Witcher, J., Lowe, S. L., et al. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu036 · Cited by 36 · see citing works
Illicit Substance Use in US Adults With Chronic Low Back Pain
Shmagel, A., Krebs, E. E., Ensrud, K. E., & Foley, R. N. (2016) · Spine · doi:10.1097/brs.0000000000001702 · Cited by 36 · see citing works
Reasons for discontinuation of long-term opioid therapy in patients with and without substance use disorders
Lovejoy, T. I., Morasco, B. J., Demidenko, M. I., Meath, T. H. A., Frank, J. W., & Dobscha, S. K. (2016) · Pain · doi:10.1097/j.pain.0000000000000796 · Cited by 36 · see citing works
Opioid agonist treatment dosage and patient-perceived dosage adequacy, and risk of hepatitis C infection among people who inject drugs
Artenie, A. A., Minoyan, N., Jacka, B. P., et al. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.181506 · Cited by 36 · see citing works
Long‐Term Opioid Therapy in Older Cancer Survivors: A Retrospective Cohort Study
Shah, R., Chou, L., Kuo, Y., & Raji, M. A. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15945 · Cited by 36 · see citing works
No evidence for reduction of opioid-withdrawal symptoms by cannabis smoking during a methadone dose taper
Epstein, D. H., & Preston, K. L. (2015) · American Journal on Addictions · doi:10.1111/ajad.12183 · Cited by 35 · see citing works
Resolution of Acute Pain Following Discharge From the Emergency Department: The Acute Pain Trajectory
Chapman, C. R., Fosnocht, D. E., & Donaldson, G. W. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.11.007 · Cited by 34 · see citing works
Opioid Use 12 Months Following Interdisciplinary Pain Rehabilitation with Weaning
Huffman, K. L., Sweis, G. W., Gase, A. H., Scheman, J., & Covington, E. C. (2013) · Pain Medicine · doi:10.1111/pme.12201 · Cited by 33 · see citing works
Does familiarity with CDC guidelines, continuing education, and provider characteristics influence adherence to chronic pain management practices and opioid prescribing?
McCalmont, J. C., Jones, K. D., Bennett, R. M., et al. (2018) · Journal of Opioid Management · doi:10.5055/jom.2018.0437 · Cited by 33 · see citing works
Gabapentin‐related Deaths: Patterns of Abuse and Postmortem Levels
Tharp, A. M., Hobron, K., & Wright, T. H. (2019) · Journal of Forensic Sciences · doi:10.1111/1556-4029.14021 · Cited by 33 · see citing works
Pain in Cancer Survivors: How to Manage
Paice, J. A. (2019) · Current Treatment Options in Oncology · doi:10.1007/s11864-019-0647-0 · Cited by 33 · see citing works
Managing Cancer Pain, Monitoring for Cancer Recurrence, and Mitigating Risk of Opioid Use Disorders: A Team-Based, Interdisciplinary Approach to Cancer Survivorship
Goodlev, E. R., DiScala, S., Darnall, B. D., Hanson, M., Petok, A., & Silverman, M. A. (2019) · Journal of Palliative Medicine · doi:10.1089/jpm.2019.0171 · Cited by 33 · see citing works
Abuse potential of intranasal buprenorphine versus buprenorphine/naloxone in buprenorphine‐maintained heroin users
Jones, J. D., Sullivan, M. A., Vosburg, S. K., Manubay, J. M., Mogali, S., Metz, V. E., & Comer, S. D. (2014) · Addiction Biology · doi:10.1111/adb.12163 · Cited by 32 · see citing works
The MEDD myth: the impact of pseudoscience on pain research and prescribing-guideline development
Schatman, M. E., Fudin, J., & Cleary, J. P. (2016) · Journal of Pain Research · doi:10.2147/jpr.s107794 · Cited by 32 · see citing works
Evaluation of the Tolerability of Switching Patients on Chronic Full μ-Opioid Agonist Therapy to Buccal Buprenorphine
Webster, L. R., Gruener, D., Kirby, T., Xiang, Q., Tzanis, E. L., & Finn, A. L. (2016) · Pain Medicine · doi:10.1093/pm/pnv110 · Cited by 32 · see citing works
Comparison of Quetiapine Abuse and Misuse Reports to the FDA Adverse Event Reporting System With Other Second-Generation Antipsychotics
Evoy, K. E., Teng, C., Encarnacion, V., et al. (2019) · Substance Abuse Research and Treatment · doi:10.1177/1178221819844205 · Cited by 32 · see citing works
The Marginalization of Chronic Pain Patients on Chronic Opioid Therapy
Peppin, J. F. (2009) · Pain Physician · doi:10.36076/ppj.2009/12/493 · Cited by 31 · see citing works
Impact of adherence to antidepressants on long-term prescription opioid use cessation
Scherrer, J. F., Salas, J., Sullivan, M. D., Ahmedani, B. K., Copeland, L. A., Bucholz, K. K., Burroughs, T. E., Schneider, D., & Lustman, P. J. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2017.25 · Cited by 31 · see citing works
CONCURRENT SUBSTANCE USE AND OUTCOME IN COMBINED BEHAVIORAL AND NALTREXONE THERAPY FOR OPIATE DEPENDENCE
Church, S. H., Rothenberg, J. L., Sullivan, M. A., et al. (2001) · The American Journal of Drug and Alcohol Abuse · doi:10.1081/ada-100104511 · Cited by 30 · see citing works
Neurobiological mechanisms in cocaine and opiate dependence.
Koob, G. F. (1992) · PubMed · Cited by 30 · see citing works
When Opioids Fail in Chronic Pain Management
Berland, D., Malinoff, H. L., Weiner, M. A., & Przybylski, R. (2013) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31827ab599 · Cited by 29 · see citing works
Reduced Cold Pain Tolerance in Chronic Pain Patients Following Opioid Detoxification
Younger, J., Barelka, P. L., Carroll, I. R., Kaplan, K., Chu, L. F., Prasad, R., Gaeta, R. R., & Mackey, S. (2008) · Pain Medicine · doi:10.1111/j.1526-4637.2008.00475.x · Cited by 29 · see citing works
Type and Frequency of Opioid Pain Medications Returned for Disposal
Welham, G., Mount, J. K., & Gilson, A. M. (2015) · Drugs - Real World Outcomes · doi:10.1007/s40801-015-0019-4 · Cited by 29 · see citing works
Reminders of cancer risk and pain catastrophizing: relationships with cancer worry and perceived risk in women with a first-degree relative with breast cancer
Whitney, C. A., Dorfman, C. S., Shelby, R. A., Keefe, F. J., Gandhi, V., & Somers, T. J. (2018) · Familial Cancer · doi:10.1007/s10689-018-0082-6 · Cited by 28 · see citing works
The Role of Lofexidine in Management of Opioid Withdrawal
Pergolizzi, J. V., Annabi, H., Gharibo, C. G., et al. (2018) · Pain and Therapy · doi:10.1007/s40122-018-0108-7 · Cited by 27 · see citing works
Managing Pain in Patients and Survivors: Challenges Within the United States Opioid Crisis.
Paice, J. A. (2019) · PubMed · doi:10.6004/jnccn.2019.5010 · Cited by 27 · see citing works
The risk for problematic opioid use in chronic pain: What can we learn from studies of pain and reward?
Finan, P. H., Remeniuk, B., & Dunn, K. E. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.029 · Cited by 26 · see citing works
Guidance on opioid tapering in the context of chronic pain: Evidence, practical advice and frequently asked questions
Murphy, L. L., Babaei-Rad, R., Buna, D., Isaac, P., Murphy, A. L., Ng, K., Regier, L. D., Steenhof, N., Zhang, M., & Sproule, B. A. (2018) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.1177/1715163518754918 · Cited by 26 · see citing works
Doctor-Patient Trust Among Chronic Pain Patients on Chronic Opioid Therapy after Opioid Risk Reduction Initiatives: A Survey
Sherman, K. J., Walker, R. L., Saunders, K. W., et al. (2018) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2018.04.180021 · Cited by 26 · see citing works
Does brief chronic pain management education change opioid prescribing rates? A pragmatic trial in Australian early-career general practitioners
Holliday, S., Hayes, C., Dunlop, A. J., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000755 · Cited by 25 · see citing works
A Pilot Crossover Trial of Sleep Medications for Sleep-disturbed Methadone Maintenance Patients
Stein, M. D., Kurth, M. E., Anderson, B. J., & Blevins, C. E. (2019) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000531 · Cited by 25 · see citing works
Association of new opioid continuation with surgical specialty and type in the United States
Bicket, M. C., Murimi, I. B., Mansour, O., Wu, C. L., & Alexander, G. C. (2019) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2019.04.010 · Cited by 25 · see citing works
Good clinical practice guide for opioids in pain management: the three Ts – titration (trial), tweaking (tailoring), transition (tapering)
Coluzzi, F., Taylor, R., Pergolizzi, J. V., Mattia, C., & Raffa, R. B. (2014) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2014.09.005 · Cited by 24 · see citing works
Characteristics of physicians who prescribe opioids for chronic pain: a meta-narrative systematic review
Hooten, W. M., Dvorkin, J., Warner, N. S., Pearson, A. C. S., Murad, M. H., & Warner, D. O. (2019) · Journal of Pain Research · doi:10.2147/jpr.s202376 · Cited by 24 · see citing works
Ultra-rapid opioid detoxification: current status and controversies.
Singh, J., & Basu, D. (2004) · PubMed · Cited by 22 · see citing works
Use of Ultra Rapid Opioid Detoxification in the Treatment of US Military Burn Casualties
Maani, C. V., DeSocio, P. A., Jansen, R. K., Merrell, J. D., McGhee, L. L., Young, A. W., Williams, J., Tyrell, K., Jackson, B. A., Serio-Melvin, M. L., et al. (2011) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3182219209 · Cited by 21 · see citing works
A double‐blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow‐release oral morphine versus methadone in opioid‐dependent in‐patients willing to undergo detoxification
Madlung, E., Spitzer, B., Brosch, R., Dunkel, D., & Häring, C. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02653.x · Cited by 21 · see citing works
Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment
Kristensen, Ø., Lølandsmo, T., Isaksen, Å., et al. (2006) · BMC Psychiatry · doi:10.1186/1471-244x-6-54 · Cited by 20 · see citing works
Risk Assessment and Monitoring of Patients with Cancer Receiving Opioid Therapy
Paice, J. A. (2019) · The Oncologist · doi:10.1634/theoncologist.2019-0301 · Cited by 20 · see citing works
Addressing the opioid crisis: An assessment of clinicians’ training experience, practices, and attitudes within a large healthcare organization
Kirane, H., Drits, E., Ahn, S., et al. (2019) · Journal of Opioid Management · doi:10.5055/jom.2019.0503 · Cited by 20 · see citing works
Chronic cannabis use does not affect the normalization of hypothalamic–pituitary–adrenal (HPA) axis induced by methadone in heroin addicts
Nava, F. A., Manzato, E., & Lucchini, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.013 · Cited by 19 · see citing works
Gabapentin prescribed during substance abuse treatment: The perspective of treatment providers
Buttram, M. E., Kurtz, S. P., Ellis, M. S., & Cicero, T. J. (2019) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2019.07.011 · Cited by 19 · see citing works
Abuse liability of intravenous buprenorphine vs. buprenorphine/naloxone: Importance of absolute naloxone amount
Jones, J. D., Manubay, J. M., Mogali, S., Metz, V. E., Madera, G., Martinez, S., Mumtaz, M., & Comer, S. D. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.06.033 · Cited by 18 · see citing works
Opioid tapering in patients with prescription opioid use disorder: A retrospective study
Zhou, K., Jia, P., Bhargava, S., Zhang, Y., Reza, T., Peng, Y. B., & Wang, G. G. (2017) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2017.09.005 · Cited by 18 · see citing works

Flagged first, then by citations

Research works printed but not linked: 51

Monitto CL, Hsu A, Gao S, et al. Opioid Prescribing for the Treatment of Acute Pain in Children on Hospital Discharge. Anesth Analg 2017;125:2113-22. [Crossref] [PubMed]
Levy B, Paulozzi L, Mack KA, et al. Trends in Opioid Analgesic-Prescribing Rates by Specialty, U.S., 2007-2012. Am J Prev Med 2015;49:409-13. [Crossref] [PubMed]
Boudreau D, Von Korff M, Rutter CM, et al. Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf 2009;18:1166-75. [Crossref] [PubMed]
Koob GF. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug Discov Today Dis Models 2008;5:207-15. [Crossref] [PubMed]
Moreno E, Quiroz C, Rea W, et al. Functional mu-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area. J Neurosci 2017;37:1176-86. [Crossref] [PubMed]
Pierce RC, Wolf ME. Psychostimulant-induced neuroadaptations in nucleus accumbens AMPA receptor transmission. Cold Spring Harb Perspect Med 2013;3:a012021. [Crossref] [PubMed]
Rorick-Kehn LM, Witkin JM, Statnick MA, et al. LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders. Neuropharmacology 2014;77:131-44. [Crossref] [PubMed]
Schreier AM, Johnson LA, Vohra NA, et al. Post-Treatment Symptoms of Pain, Anxiety, Sleep Disturbance, and Fatigue in Breast Cancer Survivors. Pain Manag Nurs 2019;20:146-51. [Crossref] [PubMed]
Leysen L, Adriaenssens N, Nijs J, et al. Chronic Pain in Breast Cancer Survivors: Nociceptive, Neuropathic, or Central Sensitization Pain? Pain Pract 2019;19:183-95. [Crossref] [PubMed]
Kanzawa-Lee GA, Knoerl R, Donohoe C, et al. Mechanisms, Predictors, and Challenges in Assessing and Managing Painful Chemotherapy-Induced Peripheral Neuropathy. Semin Oncol Nurs 2019;35:253-60. [Crossref] [PubMed]
Davis MP, Mehta Z. Opioids and Chronic Pain: Where Is the Balance? Curr Oncol Rep 2016;18:71. [Crossref] [PubMed]
Paice JA. Cancer Pain Management: Strategies for Safe and Effective Opioid Prescribing. J Natl Compr Canc Netw 2016;14:695-7. [Crossref] [PubMed]
Campbell G, Bruno R, Darke S, et al. Associations of borderline personality with pain, problems with medications and suicidality in a community sample of chronic non-cancer pain patients prescribed opioids for pain. Gen Hosp Psychiatry 2015;37:434-40. [Crossref] [PubMed]
Austin AE, Shanahan ME, Zvara BJ. Association of childhood abuse and prescription opioid use in early adulthood. Addict Behav 2018;76:265-9. [Crossref] [PubMed]
Kiepek N, Hancock L, Toppozini D, et al. Facilitating medical withdrawal from opiates in rural Ontario. Rural Remote Health 2012;12:2193. [PubMed]
Matthias MS, Johnson NL, Shields CG, et al. "I'm Not Gonna Pull the Rug out From Under You": Patient-Provider Communication About Opioid Tapering. J Pain 2017;18:1365-73. [Crossref] [PubMed]
García MC, Heilig CM, Lee SH, et al. Opioid Prescribing Rates in Nonmetropolitan and Metropolitan Counties Among Primary Care Providers Using an Electronic Health Record System - United States, 2014-2017. MMWR Morb Mortal Wkly Rep 2019;68:25-30. [Crossref] [PubMed]
White R, Hayes C, Boyes AW, et al. General practitioners and management of chronic noncancer pain: a cross-sectional survey of influences on opioid deprescribing. J Pain Res 2019;12:467-75. [Crossref] [PubMed]
Collins ED, Kleber HD, Whittington RA, et al. Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. JAMA 2005;294:903-13. [Crossref] [PubMed]
Gowing L, Farrell M, Ali R, et al. Alpha(2)-adrenergic agonists for the management of opioid withdrawal. Cochrane Database Syst Rev 2016.CD002024. [PubMed]
Sakamoto A, Takayama H, Mamiya K, et al. Opioid withdrawal presenting only nausea during tapering of oxycodone after celiac plexus block: a case report. Ann Palliat Med. 2016;5:67-70. [PubMed]
Holliday S, Hayes C, Dunlop A. Opioid use in chronic non-cancer pain--part 2: prescribing issues and alternatives. Aust Fam Physician 2013;42:104-11. [PubMed]
Mattick RP, Breen C, Kimber J, et al. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev 2014.CD002207. [PubMed]
Rennick A, Atkinson T, Cimino NM, et al. Variability in Opioid Equivalence Calculations. Pain Med 2016;17:892-8. [PubMed]
Gowing L, Ali R, White JM. Buprenorphine for the management of opioid withdrawal. Cochrane Database Syst Rev 2009.CD002025. [PubMed]
Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001;24:97-129. [Crossref] [PubMed]
Foster B, Twycross R, Mihalyo M, et al. Buprenorphine. J Pain Symptom Manage 2013;45:939-49. [Crossref] [PubMed]
Farrell M. Opiate withdrawal. Addiction 1994;89:1471-5. [Crossref] [PubMed]
Cowan DT, Wilson-Barnett J, Griffiths P, et al. A randomized, double-blind, placebo-controlled, cross-over pilot study to assess the effects of long-term opioid drug consumption and subsequent abstinence in chronic noncancer pain patients receiving controlled-release morphine. Pain Med 2005;6:113-21. [Crossref] [PubMed]
Sandhu H, Underwood M, Furlan AD, et al. What interventions are effective to taper opioids in patients with chronic pain? BMJ 2018;362:k2990. [Crossref] [PubMed]
Gowing L, Ali R, White JM, et al. Buprenorphine for managing opioid withdrawal. Cochrane Database Syst Rev 2017;2:CD002025. [PubMed]
Akhurst JS. Lofexidine in opiate withdrawal: a safety and usage survey. Pharmacoepidemiol Drug Saf 2000;9:43-7. [Crossref] [PubMed]
Lofexidine (Lucemyra) for opioid withdrawal. Med Lett Drugs Ther 2018;60:115-7. [PubMed]
Zarghami M, Sheikhmoonesi F, Ala S, et al. A comparative study of beneficial effects of Olanzapine and sodium valproate on aggressive behavior of patients who are on methadone maintenance therapy: a randomized triple blind clinical trial. Eur Rev Med Pharmacol Sci 2013;17:1073-81. [PubMed]
Stein MD, Kurth ME, Sharkey KM, et al. Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. Drug Alcohol Depend 2012;120:65-73. [Crossref] [PubMed]
Vento AE, Kotzalidis GD, Cacciotti M, et al. Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review. Subst Use Misuse 2020;55:304-13. [Crossref] [PubMed]
Walley AY, Bernson D, Larochelle MR, et al. The Contribution of Prescribed and Illicit Opioids to Fatal Overdoses in Massachusetts, 2013-2015. Public Health Rep 2019;134:667-74. [Crossref] [PubMed]
Raffa RB, Pergolizzi JV Jr, LeQuang JA, et al. The fentanyl family: A distinguished medical history tainted by abuse. J Clin Pharm Ther 2018;43:154-8. [Crossref] [PubMed]
Vigil JM, Stith SS, Adams IM, et al. Associations between medical cannabis and prescription opioid use in chronic pain patients: A preliminary cohort study. PLoS One 2017;12:e0187795. [Crossref] [PubMed]
Bradford AC, Bradford WD, Abraham A, et al. Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population. JAMA Intern Med 2018;178:667-72. [Crossref] [PubMed]
Seeman P. Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose. Transl Psychiatry 2016;6:e920. [Crossref] [PubMed]
Choo EK, Feldstein Ewing SW, Lovejoy TI. Opioids Out, Cannabis In: Negotiating the Unknowns in Patient Care for Chronic Pain. JAMA 2016;316:1763-4. [Crossref] [PubMed]
Casarett DJ, Beliveau JN, Arbus MS. Benefit of Tetrahydrocannabinol versus Cannabidiol for Common Palliative Care Symptoms. J Palliat Med 2019;22:1180-4. [Crossref] [PubMed]
Ren Y, Whittard J, Higuera-Matas A, et al. Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances. J Neurosci 2009;29:14764-9. [Crossref] [PubMed]
Nugent SM, Kansagara D. The Effects of Cannabis Among Adults With Chronic Pain. Ann Intern Med 2018;168:525. [Crossref] [PubMed]
Banister SD, Arnold JC, Connor M, et al. Dark Classics in Chemical Neuroscience: Delta(9)-Tetrahydrocannabinol. ACS Chem Neurosci 2019;10:2160-75. [Crossref] [PubMed]
Amato L, Minozzi S, Davoli M, et al. Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification. Cochrane Database Syst Rev 2011.CD005031. [PubMed]
Windmill J, Fisher E, Eccleston C, et al. Interventions for the reduction of prescribed opioid use in chronic non-cancer pain. Cochrane Database Syst Rev. 2013.CD010323. [PubMed]
Eccleston C, Fisher E, Thomas KH, et al. Interventions for the reduction of prescribed opioid use in chronic non-cancer pain. Cochrane Database Syst Rev 2017;11:CD010323. [PubMed]
Austin RC, Fusco CW, Fagan EB, et al. Teaching Opioid Tapering Through Guided Instruction. Fam Med 2019;51:434-7. [Crossref] [PubMed]
Cite this article as: Davis MP, Digwood G, Mehta Z, McPherson ML. Tapering opioids: a comprehensive qualitative review. Ann Palliat Med 2020;9(2):586-610. doi: 10.21037/apm.2019.12.10

Sorted by citations

Discontinuation of psychotropic medication: a synthesis of evidence across medication classes.
Vinkers, C. H., Kupka, R. W., Penninx, B. W., Ruhé, H. G., van Gaalen, J. M., van Haaren, P. C. F., Schellekens, A. F. A., Jauhar, S., Ramos-Quiroga, J. A., Vieta, E., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02445-4 · Cited by 51 · see citing works
Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms
Abie Horowitz, M., Framer, A., Strang, J., & Taylor, D. (2025) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253251371504
“58 The patients most likely to have a reduction in pain severity are those with mild to moderate pain.”

Authors: Davis, M. P., Digwood, G., Mehta, Z., & McPherson, M. L.
Affiliations: Geisinger Health System (US)
Corresponding author: Davis, Mellar P.
ORCID: Davis, Mellar P.
McPherson, Mary Lynn
Venue: Annals of Palliative Medicine
Publisher: AME Publishing Company
Published: 2020-03
Volume: 9
Issue: 2
Pages: 586-610
ISSN: 2224-5820 (ISSN-L)
2224-5839
DOI: 10.21037/apm.2019.12.10
OpenAlex: W2998948908
Cited by: 33
References: 237
Citations by year: 2026: 2 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 3
FWCI: 3.37
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc-nd
Locations: Annals of Palliative Medicine (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
Keywords: opioid tapering, opioid withdrawal, opioid use disorder, palliative care
MeSH terms: Analgesics, Opioid, Humans, Opioid-Related Disorders, Substance Withdrawal Syndrome, Withholding Treatment, Opiate Substitution Treatment, Chronic Pain, Pain Management

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tapering opioids: a comprehensive qualitative review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks