Cited by 223Garlic and Onion StudiesComplementary and Alternative Medicine StudiesPharmacovigilance and Adverse Drug Reactions

Garlic (Allium sativum L.): Adverse effects and drug interactions in humans

Borrelli, Francesca, Capasso, Raffaele, Izzo, Angelo A.·2007·Molecular Nutrition & Food Research

Abstract

Garlic (Alllium sativum L., Fam Liliaceae) is used medicinally mainly for the treatment of hypercholesterolemia and prevention of arteriosclerosis. Clinical trials have consistently shown that “garlic breath” and body odor are the most common (and well‐documented) complaints associated to garlic intake. Case reports have highlighted the possibility that garlic use may cause allergic reactions (allergic contact dermatitis, generalized urticaria, angiedema, pemphigus, anaphylaxis and photoallergy), alteration of platelet function and coagulation (with a possible risk of bleeding), and burns (when fresh garlic is applied on the skin, particularly under occlusive dressings). Consumption of garlic by nursing mothers modifies their infant's behavior during breast‐feeding. Finally, garlic may enhance the pharmacological effect of anticoagulants (e. g. warfarin, fluindione) and reduce the efficacy of anti‐AIDS drugs (i. e. saquinavir).

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Registry

Crossref · 10.1002/mnfr.200700072

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115 of 115 references verified0 citation errors · 0 not checkable

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  • Previous reports have reported the cardiovascular effects of garlic including potentially irreversible antiplatelet activity, anticoagulant, fibrinolytic activity, a remarkable decrease in platelet accumulation and mixed activity on fibrinolytic effectiveness.

    “Previous reports have reported the cardiovascular effects of garlic including potentially irreversible antiplatelet activity, anticoagulant, fibrinolytic activity, a remarkable decrease in platelet accumulation and mixed activity on fibrinolytic effectiveness [130].”

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Authors
Borrelli, F., Capasso, R., & Izzo, A. A.
Affiliations
University of Naples Federico II (IT)
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2007-10-26
Volume
51
Issue
11
Pages
1386-1397
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2051509036
Cited by
223
References
115
Citations by year
2026: 13 · 2025: 9 · 2024: 9 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 5 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 24 · 2013: 12 · 2012: 18
FWCI
0.47
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Keywords
garlic, adverse effects, drug interactions, body odor, allergic contact dermatitis, urticaria, anaphylaxis, platelet function, coagulation, bleeding risk, burns, breastfeeding, anticoagulants, warfarin, fluindione, saquinavir, HIV protease inhibitors, hypercholesterolemia, arteriosclerosis
MeSH terms
Anticoagulants, Arteriosclerosis, Blood Coagulation Disorders, Drug Interactions, Female, Garlic, Gastrointestinal Diseases, Halitosis, Humans, Hypercholesterolemia, Lactation, Phytotherapy, Occupational Diseases, Odorants, Pregnancy, Dermatitis, Allergic Contact

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