Garlic (Allium sativum L.): Adverse effects and drug interactions in humans
Abstract
Garlic (Alllium sativum L., Fam Liliaceae) is used medicinally mainly for the treatment of hypercholesterolemia and prevention of arteriosclerosis. Clinical trials have consistently shown that “garlic breath” and body odor are the most common (and well‐documented) complaints associated to garlic intake. Case reports have highlighted the possibility that garlic use may cause allergic reactions (allergic contact dermatitis, generalized urticaria, angiedema, pemphigus, anaphylaxis and photoallergy), alteration of platelet function and coagulation (with a possible risk of bleeding), and burns (when fresh garlic is applied on the skin, particularly under occlusive dressings). Consumption of garlic by nursing mothers modifies their infant's behavior during breast‐feeding. Finally, garlic may enhance the pharmacological effect of anticoagulants (e. g. warfarin, fluindione) and reduce the efficacy of anti‐AIDS drugs (i. e. saquinavir).
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Previous reports have reported the cardiovascular effects of garlic including potentially irreversible antiplatelet activity, anticoagulant, fibrinolytic activity, a remarkable decrease in platelet accumulation and mixed activity on fibrinolytic effectiveness.
“Previous reports have reported the cardiovascular effects of garlic including potentially irreversible antiplatelet activity, anticoagulant, fibrinolytic activity, a remarkable decrease in platelet accumulation and mixed activity on fibrinolytic effectiveness [130].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [130]
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works
Interactions Between Herbal Medicines and Prescribed Drugs: An Updated Systematic Review
Izzo, A. A., & Ernst, E. (2009) · Drugs · doi:10.2165/11317010-000000000-00000 · Cited by 801 · see citing works
Self-citationRied, K., & Fakler, P. (2014) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s51434 · Cited by 198 · see citing works
Allium ursinum: Botanical, phytochemical and pharmacological overview
Sobolewska, D., Podolak, I., & Makowska-Wąs, J. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-013-9334-0 · Cited by 145 · see citing works
Shaik Mohamed Sayed, U. F., Moshawih, S., Goh, H. P., Kifli, N., Gupta, G., Singh, S. K., Chellappan, D. K., Dua, K., Hermansyah, A., Ser, H. L., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1182937 · Cited by 136 · see citing works
Varshney, R., & Budoff, M. J. (2016) · The Journal of Nutrition · doi:10.3945/jn.114.202333 · Cited by 108 · see citing works
Sahebkar, A., Serban, C., Ursoniu, S., & Banach, M. (2016) · Nutrition · doi:10.1016/j.nut.2015.06.009 · Cited by 52 · see citing works
You, B. R., Yoo, J.-M., Baek, S. Y., & Kim, M. R. (2019) · Nutrition Research and Practice · doi:10.4162/nrp.2019.13.3.189 · Cited by 35 · see citing works
Ong, C. E., & Pan, Y. (2014) · TANG [HUMANITAS MEDICINE] · doi:10.5667/tang.2014.0008 · Cited by 1 · see citing works
- Authors
- Borrelli, F., Capasso, R., & Izzo, A. A.
- Affiliations
- University of Naples Federico II (IT)
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2007-10-26
- Volume
- 51
- Issue
- 11
- Pages
- 1386-1397
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2051509036
- Cited by
- 223
- References
- 115
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 9 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 5 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 24 · 2013: 12 · 2012: 18
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- garlic, adverse effects, drug interactions, body odor, allergic contact dermatitis, urticaria, anaphylaxis, platelet function, coagulation, bleeding risk, burns, breastfeeding, anticoagulants, warfarin, fluindione, saquinavir, HIV protease inhibitors, hypercholesterolemia, arteriosclerosis
- MeSH terms
- Anticoagulants, Arteriosclerosis, Blood Coagulation Disorders, Drug Interactions, Female, Garlic, Gastrointestinal Diseases, Halitosis, Humans, Hypercholesterolemia, Lactation, Phytotherapy, Occupational Diseases, Odorants, Pregnancy, Dermatitis, Allergic Contact
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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