Sleep restriction increases white blood cells, mainly neutrophil count, in young healthy men: A pilot study
Open accessAbstract
OBJECTIVES: This study examines the effects of sleep restricted to four hours for three consecutive nights on blood parameters, known to be associated with cardiovascular risk, in young healthy men. MATERIAL AND METHODS: Eight young healthy men (age 24.5 +/- 3.3 years) were studied in the sleep restricted group. Nine young healthy men (age 24 +/- 2 years) were included in the control group and spent the days and nights in the sleep lab, while sleeping eight hours/night. One baseline night was followed by three nights of sleep restriction to four hours and by one recovery night of eight hours. Blood samplings were performed after the baseline night and after the third night of sleep restriction or without restriction for the control group. RESULTS: A significant increase in white blood cells (WBC) (5.79 +/- 1.05 vs. 6.89 +/- 1.31 10(3) cell/microl, p = 0.03), and neutrophils (3.17 +/- 0.69 vs 4.24 +/- 0.97 10(3) cell/microl, p = 0.01) was observed after the third night of sleep restriction. Other blood parameters were not affected. No significant variation was observed in the control group. CONCLUSION: Sleep restriction affected WBC count, mainly neutrophils, considered as risk factor for cardiovascular disease. Stress induced by the short term sleep restriction could be involved in this observation.
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Neurons, glia cells, and nerve fibers themselves can synthesize cytokines and chemokines, demonstrating a further pathway of brain-to-immune signaling.
“Neurons, glia cells, and nerve fibers themselves can synthesize cytokines and chemokines, demonstrating a further pathway of brain-to-immune signaling (70, 592).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [70]
Alternative routes of immune-to-brain signaling include activation of vagal and other neural afferents, cerebral endothelial and perivascular cells, and directed traffic of leukocytes to the brain.
“Alternative routes of immune-to-brain signaling are immunomediators that can activate vagal and other neural afferents, as well as cerebral endothelial and perivascular cells or the directed traffic of leukocytes to the brain (70, 503, 523, 586).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [70]
An increase in WBC count (p=0.03) and neutrophils (p=0.01) was observed the morning after 3 nights of partial sleep deprivation to 4 hours in bed per night, with no changes in monocytes, lymphocytes and CRP.
“An increase in WBC count (p=0.03) and neutrophils (p=0.01) was observed the morning after 3 nights of PSD to 4 hours in bed per night [100]. No changes in monocytes, lymphocytes and CRP were reported.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [100]
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- Authors
- Zouaoui-Boudjeltia, K.
- Venue
- Vascular Health and Risk Management
- Publisher
- Informa UK Limited
- Published
- 2008-12
- Volume
- Volume 4
- Issue
- 6
- Pages
- 1467-1470
- ISSN
- 1176-6344 (ISSN-L)
- 1178-2048
- PMC
- PMC2663438
- OpenAlex
- W94317274
- Cited by
- 86
- References
- 28
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 3 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 1 · 2012: 5
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Vascular Health and Risk Management (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep restriction, white blood cell count, neutrophils, cardiovascular risk, stress, blood parameters, healthy young men
- MeSH terms
- Adult, Cardiovascular Diseases, Humans, Leukocyte Count, Male, Neutrophils, Pilot Projects, Risk Factors, Sleep Deprivation, Stress, Physiological, Biomarkers, Case-Control Studies, Young Adult
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