Evolution of prime editing systems: move forward to the treatment of hereditary diseases

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Recent advances with liposomes as pharmaceutical carriers

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Search-and-replace genome editing without double-strand breaks or donor DNA

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Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

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Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

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Double-Strand Break End Resection and Repair Pathway Choice

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Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

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DNA MISMATCH REPAIR

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CRISPR RNA–guided activation of endogenous human genes

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Delivering CRISPR: a review of the challenges and approaches

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Genetic engineering of human pluripotent cells using TALE nucleases

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Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

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Effect of genome size on AAV vector packaging

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Digenome-seq: Genome-wide profiling of CRISPR-cas9 off-target effects in human cells

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Gene therapy using adeno-associated virus vectors

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

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Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

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Engineered pegRNAs improve prime editing efficiency

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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

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Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

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Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

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Advanced transfection with Lipofectamine 2000 reagent: Primary neurons, siRNA, and high-throughput applications

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Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

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Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

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Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

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Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

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Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

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CRISPR-Cas9 DNA Base-Editing and Prime-Editing

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Regulation of Single-Strand Annealing and its Role in Genome Maintenance

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DNA mismatch repair: Molecular mechanism, cancer, and ageing

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Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

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The characterization of a mammalian DNA structure‐specific endonuclease.

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Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing

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A Review on the Mechanism and Applications of CRISPR/Cas9/Cas12/Cas13/Cas14 Proteins Utilized for Genome Engineering

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Universal strategies in research and drug discovery based on protein-fragment complementation assays

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Phage-assisted evolution and protein engineering yield compact, efficient prime editors

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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

An, M., Raguram, A., Du, S. W., Banskota, S., Davis, J. R., Newby, G. A., Chen, P., Palczewski, K., & Liu, D. R. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-02078-y · Cited by 275 · see citing works

Meganucleases and DNA Double-Strand Break-Induced Recombination: Perspectives for Gene Therapy

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TALEN-based Gene Correction for Epidermolysis Bullosa

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Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing

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Mismatch Repair

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Prime editing for functional repair in patient-derived disease models

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Functional regulation of FEN1 nuclease and its link to cancer

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In vivo prime editing of a metabolic liver disease in mice

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Adenoviral Vector Immunity: Its Implications and Circumvention Strategies

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CRISPR/Cas9 Immune System as a Tool for Genome Engineering

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Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases

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Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

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Robust ZFN-mediated genome editing in adult hemophilic mice

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Dual-AAV delivering split prime editor system for in vivo genome editing

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Saturation variant interpretation using CRISPR prime editing

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Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination.

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Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives

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Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

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Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure

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Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor

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Adenine base editors catalyze cytosine conversions in human cells

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Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1

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Nature's recipe for splitting inteins

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Enhancement of prime editing via xrRNA motif-joined pegRNA

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Targeted Gene Therapy of Xeroderma Pigmentosum Cells Using Meganuclease and TALEN™

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Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain

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AP Endonuclease 1 Coordinates Flap Endonuclease 1 and DNA Ligase I Activity in Long Patch Base Excision Repair

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First-in-human in vivo genome editing via AAV-zinc-finger nucleases for mucopolysaccharidosis I/II and hemophilia B

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In vivo HSC prime editing rescues Sickle Cell Disease in a mouse model

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FEN1 Ensures Telomere Stability by Facilitating Replication Fork Re-initiation

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High-throughput PRIME-editing screens identify functional DNA variants in the human genome

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Plasmid DNA Size Does Affect Nonviral Gene Delivery Efficiency in Stem Cells

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Exonuclease 1 and its versatile roles in DNA repair

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Peptide fusion improves prime editing efficiency

Velimirovic, M., Zanetti, L. C., Shen, M. W., Fife, J. D., Lin, L., Cha, M., Akıncı, E., Barnum, D., Yu, T., & Sherwood, R. I. (2022) · Nature Communications · doi:10.1038/s41467-022-31270-y · Cited by 63 · see citing works

The road less traveled: strategies to enhance the frequency of homology-directed repair (HDR) for increased efficiency of CRISPR/Cas-mediated transgenesis

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EXO1: A tightly regulated nuclease

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Integration and exchange of split dCas9 domains for transcriptional controls in mammalian cells

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Development of Highly Efficient Dual‐AAV Split Adenosine Base Editor for In Vivo Gene Therapy

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Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

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Human exonuclease 1 (EXO1) activity characterization and its function on flap structures

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Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system

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Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery

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Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases

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M-MuLV reverse transcriptase: Selected properties and improved mutants

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TALEN-Mediated Gene Targeting for Cystic Fibrosis-Gene Therapy

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