4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases

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Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

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Reactions of 4-hydroxynonenal with proteins and cellular targets

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Basic aspects of the biochemical reactivity of 4-hydroxynonenal

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Biological interactions of α,β-unsaturated aldehydes

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Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate

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4-Hydroxynonenal and neurodegenerative diseases

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4‐Hydroxynonenal in the Pathomechanisms of Oxidative Stress

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Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide

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Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

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Lipid peroxidation and antioxidant status in colorectal cancer

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The Lipid Peroxidation Product, 4‐Hydroxy‐2‐<i>trans</i>‐Nonenal, Alters the Conformation of Cortical Synaptosomal Membrane Proteins

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Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation

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4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications

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Proteins Modified by Malondialdehyde, 4-Hydroxynonenal, or Advanced Glycation End Products in Lipofuscin of Human Retinal Pigment Epithelium

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(E)-4-Hydroxy-2-Nonenal May be Involved in the Pathogenesis of Parkinson’s Disease

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Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

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Aldehydic lipid peroxidation products derived from linoleic acid

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Effect of 4-Hydroxy-2-nonenal Modification on α-Synuclein Aggregation

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Aldose reductase: A novel therapeutic target for inflammatory pathologies

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Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress

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Activation of Rat Alveolar Macrophage-Derived Latent Transforming Growth Factor β-1 by Plasmin Requires Interaction with Thrombospondin-1 and its Cell Surface Receptor, CD36

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Mass spectrometry for detection of 4‐hydroxy‐trans‐2‐nonenal (HNE) adducts with peptides and proteins

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4-Hydroxynonenal inhibits Na+-K+-ATPase

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4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases

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Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease

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Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes

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Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid

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4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis

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Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse

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Aldose Reductase Mediates the Lipopolysaccharide-induced Release of Inflammatory Mediators in RAW264.7 Murine Macrophages

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Mitogenic Responses of Vascular Smooth Muscle Cells to Lipid Peroxidation-derived Aldehyde 4-Hydroxy-trans-2-nonenal (HNE)

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Ebselen prevents early alcohol-induced liver injury in rats

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Aldose Reductase Regulates Growth Factor-Induced Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Colon Cancer Cells

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Mass spectrometric characterization of covalent modification of human serum albumin by 4‐hydroxy‐trans‐2‐nonenal

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Covalent modifications of aminophospholipids by 4-hydroxynonenal

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Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death

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Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury

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Age-Related Macular Degeneration and Retinal Protein Modification by 4-Hydroxy-2-nonenal

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Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway

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Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-β peptide

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Resolvin D1 controls inflammation initiated by glutathione‐lipid conjugates formed during oxidative stress

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Alpha lipoic acid protects heart against myocardial ischemia–reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation

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Role of Aldehyde Dehydrogenase Isozymes in the Defense of Rat Lens and Human Lens Epithelial Cells against Oxidative Stress

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4-Hydroxy-2-Nonenal Induces Mitochondrial Dysfunction and Aberrant Axonal Outgrowth in Adult Sensory Neurons that Mimics Features of Diabetic Neuropathy

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Comparison of the Inactivation of Microsomal Glucose-6-Phosphatase by in Situ Lipid Peroxidation-Derived 4-Hydroxynonenal and Exogenous 4-Hydroxynonenal

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Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

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Inhibition of aldose reductase prevents colon cancer metastasis

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Localization of hydroxynonenal protein adducts in normal human kidney and selected human kidney cancers

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Antioxidant Therapy Alleviates Oxidative Stress by Androgen Deprivation and Prevents Conversion From Androgen Dependent to Castration Resistant Prostate Cancer

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Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase Activity

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Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells

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Inhibition of Aldose Reductase Prevents Growth Factor–Induced G1-S Phase Transition through the AKT/Phosphoinositide 3-Kinase/E2F-1 Pathway in Human Colon Cancer Cells

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Cytotoxicity of linoleic acid peroxide, malondialdehyde and 4-hydroxynonenal towards human fibroblasts

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Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells

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Crotonaldehyde accumulates in glial cells of Alzheimer’s disease brain

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4-Hydroxynonenal and transforming growth factor-β1 expression in colon cancer

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A synthesis of 4‐hydroxy‐2‐trans‐nonenal and 4‐(3H) 4‐hydroxy‐2‐trans‐nonenal

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Immunohistochemical Detection of 4‐Hydroxy‐2‐nonenal‐Modified‐Protein Adducts in Human Alcoholic Liver Diseases

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Stereochemical Configuration of 4-Hydroxy-2-nonenal-Cysteine Adducts and Their Stereoselective Formation in a Redox-regulated Protein

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Genetic Background Influences Cataractogenesis, but Not Lens Growth Deficiency, in Cx50-Knockout Mice

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4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways

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Phospholipids, Sphingolipids, and Cholesterol-Derived Lipid Mediators and Their Role in Neurological Disorders

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The Dual Role of Oxidative Stress in Atherosclerosis and Coronary Artery Disease: Pathological Mechanisms and Diagnostic Potential

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Association Between Human Blood Metabolome and the Risk of Psychiatric Disorders

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Combination of Lutein and Zeaxanthin, and DHA Regulated Polyunsaturated Fatty Acid Oxidation in H2O2-Stressed Retinal Cells

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Novel molecular approaches for improving enzymatic and nonenzymatic detoxification of 4-hydroxynonenal: toward the discovery of a novel class of bioactive compounds

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Pro-apoptotic effects of lipid oxidation products: HNE at the crossroads of NF-κB pathway and anti-apoptotic Bcl-2

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Sympathetic Nervous System and Atherosclerosis

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Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

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Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH -to- F13B

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Oxidative Stress-mediated Lipid Peroxidation-derived Lipid Aldehydes in the Pathophysiology of Neurodegenerative Diseases

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Role of Flavonoids in Protecting Against Neurodegenerative Diseases—Possible Mechanisms of Action

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Lipoxidation and cancer immunity

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Suicidal Erythrocyte Death in Metabolic Syndrome

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Amyloid Proteins and Peripheral Neuropathy

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Mitochondrial aldehyde dehydrogenase 2 protects gastric mucosa cells against DNA damage caused by oxidative stress

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Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

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Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

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Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine

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Gestational age-dependent development of the neonatal metabolome

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The Dual Role of Dietary Phytochemicals in Oxidative Stress: Implications for Oncogenesis, Cancer Chemoprevention, and ncRNA Regulation

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Increase in omega-6 and decrease in omega-3 polyunsaturated fatty acid oxidation elevates the risk of exudative AMD development in adults with Chinese diet

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Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer

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The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells

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New Evidence Implicating 4‐Hydroxynonenal in the Pathogenesis of Osteoarthritis In Vivo

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Lipid mediated brain disorders: A perspective

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Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity

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Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

Liou, C. J., Tong, M., Vonsattel, J. P., & de la Monte, S. M. (2019) · ASN NEURO · doi:10.1177/1759091419839515 · Cited by 26 · see citing works

Changes in Concentration of Selected Biomarkers of Exposure in Users of Classic Cigarettes, E-Cigarettes, and Heated Tobacco Products—A Narrative Review

Śniadach, J., Kicman, A., Michalska‐Falkowska, A., Jończyk, K., & Waszkiewicz, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051796 · Cited by 25 · see citing works

Proeryptotic Activity of 4-Hydroxynonenal: A New Potential Physiopathological Role for Lipid Peroxidation Products

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Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice

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Critical Review on Fatty Acid-Based Food and Nutraceuticals as Supporting Therapy in Cancer

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Functional consequence of Iron dyshomeostasis and ferroptosis in systemic lupus erythematosus and lupus nephritis

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Rapid liquid chromatography–tandem mass spectrometry analysis of 4-hydroxynonenal for the assessment of oxidative degradation and safety of vegetable oils

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Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice

Kim, J., Lim, D.-K., Suh, Y., & Chang, K. (2021) · Antioxidants · doi:10.3390/antiox10081321 · Cited by 21 · see citing works

Mitochondria-Directing Fluorogenic Probe: An Efficient Amyloid Marker for Imaging Lipid Metabolite-Induced Protein Aggregation in Live Cells and Caenorhabditis elegans

Pandey, S. P., Kavyashree, P., Dutta, T., Chakraborty, B., Koner, A. L., & Singh, P. K. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c05466 · Cited by 21 · see citing works

Age-related alteration in HNE elimination enzymes

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4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

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Huanglian Jiedu Decoction in the Treatment of the Traditional Chinese Medicine Syndrome “Shanghuo”–An Intervention Study

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The novel c-Met inhibitor capmatinib mitigates diethylnitrosamine acute liver injury in mice

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Antinociception by the anti‐oxidized phospholipid antibody E06

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Determinants of short- and long-term survival from colorectal cancer in very elderly patients

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Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunityPreprint

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Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury

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Aldehyde dehydrogenase 2 activation ameliorates cyclophosphamide-induced acute cardiotoxicity via detoxification of toxic aldehydes and suppression of cardiac cell death

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Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

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Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer

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Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis

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4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

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4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways

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