The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms
Abstract
Fruits and vegetables are rich in flavonoids, and ample epidemiological data show that diets rich in fruits and vegetables confer protection against cardiovascular, neurodegenerative and inflammatory diseases, and cancer. However, flavonoid bioavailability is reportedly very low in mammals and the molecular mechanisms of their action are still poorly known. This review focuses on membrane transport of flavonoids, a critical determinant of their bioavailability. Cellular influx and efflux transporters are reviewed for their involvement in the absorption of flavonoids from the gastro-intestinal tract and their subsequent tissue distribution. A focus on the mammalian bilirubin transporter bilitranslocase (TCDB 2.A.65.1.1) provides further insight into flavonoid bioavailability and its relationship with plasma bilirubin (an endogenous antioxidant). The general function of bilitranslocase as a flavonoid membrane transporter is further demonstrated by the occurrence of a plant homologue in organs (petals, berries) where flavonoid biosynthesis is most active. Bilitranslocase appears associated with sub-cellular membrane compartments and operates as a flavonoid membrane transporter.
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A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
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Cited by
Chemistry, Pharmacology and Health Benefits of Anthocyanins
Smeriglio, A., Barreca, D., Bellocco, E., & Trombetta, D. (2016) · Phytotherapy Research · doi:10.1002/ptr.5642 · Cited by 447
Unraveling Anthocyanin Bioavailability for Human Health
Lila, M. A., Burton-Freeman, B., Grace, M., & Kalt, W. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033346 · Cited by 309
Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects
Olivas-Aguirre, F., Rodrigo-García, J., Martínez-Ruiz, N., Cárdenas-Robles, A., Mendoza-Díaz, S., Álvarez-Parrilla, E., González-Aguilar, G., De la Rosa, L., Ramos-Jiménez, A., & Wall-Medrano, A. (2016) · Molecules · doi:10.3390/molecules21091264 · Cited by 308
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Metadata
- Authors
- Passamonti, S., Terdoslavich, M., Franca, R., Vanzo, A., Tramer, F., Braidot, E., Petrussa, E., & Vianello, A.
- Venue
- Current Drug Metabolism
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-05-01
- Volume
- 10
- Issue
- 4
- Pages
- 369-394
- ISSN
- 1389-2002 (ISSN-L)
- OpenAlex
- W2143165274
- Cited by
- 191
- References
- 10
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms. https://app.cochat.ai/papers/10.2174/138920009788498950
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- Passamonti, S., Terdoslavich, M., Franca, R., Vanzo, A., Tramer, F., Braidot, E., Petrussa, E., & Vianello, A. (2009). Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms. Current Drug Metabolism. https://doi.org/10.2174/138920009788498950
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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