Mesenchymal stem cell-derived exosomes affect macrophage phenotype: a cell-free strategy for the treatment of skeletal muscle disorders
Abstract
The process of tissue damage, repair, and regeneration in the skeletal muscle system involves complex inflammatory processes. Factors released in the inflammatory microenvironment can affect the phenotypic changes of macrophages, thereby changing the inflammatory process, making macrophages an important target for tissue repair treatment. Mesenchymal stem cells exert anti-inflammatory effects by regulating immune cells. In particular, exosomes secreted by mesenchymal stem cells have become a new cell-free treatment strategy due to their low tumorigenicity and immunogenicity. This article focuses on the mechanism of the effect of exosomes derived from mesenchymal stem cells on the phenotype of macrophages after skeletal muscle system injury and explores the possible mechanism of macrophages as potential therapeutic targets after tissue injury.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tissue injury, healing, and regeneration within the musculoskeletal system involve intricate inflammatory processes, and MSCs and their exosomes exert anti-inflammatory effects by modulating the inflammatory microenvironment.
“Tissue injury, healing, and regeneration within the musculoskeletal system involve intricate inflammatory processes, and MSCs and their exosomes are able to exert anti-inflammatory effects by modulating the inflammatory microenvironment [27].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [27]
Cites
1 retracted
Xiong, Y., Chen, L., Yan, C., Zhou, W., Tao, Y., Sun, Y. T., Cao, F., Xue, H., Hu, Y., Chen, D., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00622-5 · Cited by 164 · see citing works
RetractedThéry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works
The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works
Macrophage plasticity, polarization, and function in health and disease
Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930 · see citing works
Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,776 · see citing works
Mesenchymal stem cells in health and disease
Uccelli, A., Moretta, L., & Pistoia, V. (2008) · Nature reviews. Immunology · doi:10.1038/nri2395 · Cited by 3,750 · see citing works
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160 · see citing works
Osteoporosis: now and the future
Rachner, T. D., Khosla, S., & Hofbauer, L. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62349-5 · Cited by 2,696 · see citing works
Yunna, C., Mengru, H., Lei, W., & Weidong, C. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173090 · Cited by 2,454 · see citing works
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096 · see citing works
Microglial <scp>M1/M2</scp> polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works
The metabolic signature of macrophage responses
Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021 · see citing works
Concise review: MSC-derived exosomes for cell-free therapy
Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834 · see citing works
Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730 · see citing works
Macrophages: master regulators of inflammation and fibrosis
Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392 · see citing works
Inflammatory processes in muscle injury and repair.
Tidball, J. (2005) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00454.2004 · Cited by 1,392 · see citing works
Macrophage Polarization in Bacterial Infections
Benoit, M. E., Desnues, B., & Mège, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3733 · Cited by 1,317 · see citing works
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
Wang, T., & He, C. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.002 · Cited by 1,034 · see citing works
The role of macrophages in the resolution of inflammation
Watanabe, S., Alexander, M., Misharin, A. V., & Budinger, G. R. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124615 · Cited by 925 · see citing works
Zhang, S., Chuah, S. J., Lai, R. C., Hui, J. H. P., Lim, S. K., & Toh, W. S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.028 · Cited by 919 · see citing works
Exosomes in tumor microenvironment influence cancer progression and metastasis
Kahlert, C., & Kalluri, R. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1020-6 · Cited by 869 · see citing works
Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles
Pathan, M., Fonseka, P., Chitti, S. V., Kang, T., Sanwlani, R., Deun, J. V., Hendrix, A., & Mathivanan, S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1029 · Cited by 769 · see citing works
Cosenza, S., Ruiz, M., Toupet, K., Jørgensen, C., & Noël, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-15376-8 · Cited by 651 · see citing works
Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro
Chen, C. C., Liu, L., Ma, F., Wong, C. W., Guo, X. E., Chacko, J. V., Farhoodi, H. P., Zhang, S. X., Zimak, J., Ségaliny, A., et al. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0458-3 · Cited by 537 · see citing works
Microenvironment Imbalance of Spinal Cord Injury
Fan, B., Wei, Z., Yao, X. X., Shi, G., Cheng, X., Zhou, X., Zhou, H., Ning, G., Kong, X., & Feng, S. (2018) · Cell Transplantation · doi:10.1177/0963689718755778 · Cited by 535 · see citing works
Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration
Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., Akimoto, T., Higashi, Y., & Ochi, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.031 · Cited by 511 · see citing works
Mesenchymal stem cell-derived exosomes for clinical use
Mendt, M. C., Rezvani, K., & Shpall, E. J. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0616-z · Cited by 472 · see citing works
Chen, P., Zheng, L., Wang, Y., Tao, M., Xie, Z., Xia, C., Gu, C., Chen, J., Qiu, P., Mei, S., et al. (2019) · Theranostics · doi:10.7150/thno.31017 · Cited by 464 · see citing works
Mechanisms of Muscle Injury, Repair, and Regeneration
Tidball, J. G. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100092 · Cited by 439 · see citing works
He, Y., Li, Z. A., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 400 · see citing works
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage
Uderhardt, S., Martins, A. J., Tsang, J. S., Lämmermann, T., & Germain, R. N. (2019) · Cell · doi:10.1016/j.cell.2019.02.028 · Cited by 383 · see citing works
Trafficking and differentiation of mesenchymal stem cells
Liu, Z., Zhuge, Y., & Velazquez, O. C. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22091 · Cited by 370 · see citing works
Ratajczak, M. Z., Kucia, M., Jadczyk, T., Greco, N. J., Wojakowski, W., Tendera, M., & Ratajczak, J. (2011) · Leukemia · doi:10.1038/leu.2011.389 · Cited by 324 · see citing works
Sun, G., Li, G., Li, D., Huang, W., Zhang, R., Zhang, H., Duan, Y., & Wang, B. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.04.006 · Cited by 314 · see citing works
MSC-exosome: A novel cell-free therapy for cutaneous regeneration
Wu, P., Zhang, B., Shi, H., Qian, H., & Xu, W. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2017.11.002 · Cited by 292 · see citing works
Luo, Z.-W., Li, F.-X.-Z., Liu, Y.-W., Rao, S.-S., Yin, H., Huang, J., Chen, C.-Y., Hu, Y., Zhang, Y., Tan, Y.-J., et al. (2019) · Nanoscale · doi:10.1039/c9nr02791b · Cited by 281 · see citing works
Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue
Arthur, A., & Gronthos, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249759 · Cited by 277 · see citing works
Varderidou‐Minasian, S., & Lorenowicz, M. J. (2020) · Theranostics · doi:10.7150/thno.40122 · Cited by 274 · see citing works
Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies
Iyer, S. S., & Rojas, M. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.5.569 · Cited by 269 · see citing works
Liu, W.-Z., Ma, Z.-J., Li, J.-R., & Kang, X.-W. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02153-8 · Cited by 252 · see citing works
Huang, Y., He, B., Wang, L., Yuan, B., Shu, H., Zhang, F., & Sun, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02005-x · Cited by 234 · see citing works
Monocyte Exosomes Stimulate the Osteogenic Gene Expression of Mesenchymal Stem Cells
Ekström, K. M., Omar, O., Granéli, C., Wang, X., Vazirisani, F., & Thomsen, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075227 · Cited by 219 · see citing works
Lankford, K. L., Arroyo, E. J., Nazimek, K., Bryniarski, K., Askenase, P. W., & Kocsis, J. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190358 · Cited by 213 · see citing works
Xu, R., Shen, X., Si, Y., Fu, Y., Zhu, W., Xiao, T., Fu, Z., Zhang, P., Cheng, J., & Jiang, H. (2018) · Aging Cell · doi:10.1111/acel.12794 · Cited by 213 · see citing works
Exosome-eluting stents for vascular healing after ischaemic injury
Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., Dinh, P., Cores, J., & Cheng, K. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00705-0 · Cited by 213 · see citing works
Zhang, J., Rong, Y., Luo, C., & Cui, W. (2020) · Aging · doi:10.18632/aging.104110 · Cited by 204 · see citing works
Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing
Chamberlain, C. S., Clements, A. E. B., Kink, J. A., Choi, U., Baer, G. S., Halanski, M. A., Hematti, P., & Vanderby, R. (2019) · Stem Cells · doi:10.1002/stem.2988 · Cited by 189 · see citing works
Mesenchymal Stem Cell-Derived Exosomes: New Opportunity in Cell-Free Therapy
Sarvar, D. P., Shamsasenjan, K., & Akbarzadehlaleh, P. (2016) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2016.041 · Cited by 161 · see citing works
Emerging Role of Extracellular Vesicles in Bone Remodeling
Liu, M., Sun, Y., & Zhang, Q. (2018) · Journal of Dental Research · doi:10.1177/0022034518764411 · Cited by 142 · see citing works
Shi, Y., Kang, X., Wang, Y., Bian, X., He, G., Zhou, M., & Tang, K. (2020) · Medical Science Monitor · doi:10.12659/msm.923328 · Cited by 128 · see citing works
Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis
Zhao, X., Zhao, Y., Sun, X., Xing, Y., Wang, X., & Yang, Q. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.575057 · Cited by 127 · see citing works
Gomzikova, M. O., James, V. H., & Rizvanov, A. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02663 · Cited by 124 · see citing works
Wang, R., & Xu, B. (2021) · Cell and Tissue Research · doi:10.1007/s00441-020-03319-1 · Cited by 123 · see citing works
Zhao, C., Chen, J., Peng, W., Yuan, B., Bi, Q., & Xu, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.10982 · Cited by 119 · see citing works
Fatima, F., Ekström, K. M., Nazarenko, I. A., Maugeri, M., Valadi, H., Hill, A. F., Camussi, G., & Nawaz, M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00161 · Cited by 114 · see citing works
Temporal changes in macrophage phenotype after peripheral nerve injury
Tomlinson, J. E., Žygelytė, E., Grenier, J. K., Edwards, M. G., & Cheetham, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1219-0 · Cited by 110 · see citing works
Chang, Q., Hao, Y., Wang, Y., Zhou, Y., Zhuo, H., & Zhao, G. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.02.015 · Cited by 110 · see citing works
Zhang, L., Wang, Q., Su, H., & Cheng, J. (2021) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2021.02.007 · Cited by 110 · see citing works
Chronology of age-related disease definitions: Osteoporosis and sarcopenia
Bijlsma, A. Y., Meskers, C. G. M., Westendorp, R. G. J., & Maier, A. B. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.001 · Cited by 101 · see citing works
Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential
Zhao, A. G., Shah, K., Cromer, B. A., & Sümer, H. (2020) · Stem Cells International · doi:10.1155/2020/8825771 · Cited by 95 · see citing works
Bosurgi, L., Manfredi, A., & Rovere-Querini, P. (2011) · Front. Immun. · doi:10.3389/fimmu.2011.00062 · Cited by 80 · see citing works
Adatia, A., Rainsford, K., & Kean, W. (2012) · The Journal of pharmacy and pharmacology · doi:10.1111/j.2042-7158.2012.01458.x · Cited by 77 · see citing works
Hu, Y., Xu, R., Chen, C., Rao, S., Xia, K., Huang, J., Yin, H., Wang, Z., Cao, J., Liu, Z., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2019.01.009 · Cited by 75 · see citing works
Mesenchymal Stem Cells-Derived Exosomes: A Possible Therapeutic Strategy for Osteoporosis
Li, Y., Jin, D., Xie, W., Wen, L., Chen, W., Xu, J., Ding, J., Ren, D., & Xiao, Z. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x13666180403163456 · Cited by 69 · see citing works
Luo, Z., Lin, J., Sun, Y.-Y., Wang, C.-H., & Chen, J.-W. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0167 · Cited by 69 · see citing works
Stem cell therapy for the spinal cord
Donnelly, E. M., Lamanna, J. J., & Boulis, N. M. (2012) · Stem Cell Research & Therapy · doi:10.1186/scrt115 · Cited by 65 · see citing works
Targeted Delivery of Mesenchymal Stem Cell-Derived Nanovesicles for Spinal Cord Injury Treatment
Lee, J., Kyung, J. W., Kumar, H., Kwon, S. P., Song, S. Y., Han, I.-B., & Kim, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114185 · Cited by 64 · see citing works
Wang, C., Zhang, Y., Zhang, G., Yu, W., & He, Y. (2021) · The American Journal of Sports Medicine · doi:10.1177/03635465211020010 · Cited by 64 · see citing works
Exosome-educated macrophages and exosomes differentially improve ligament healing
Chamberlain, C. S., Kink, J. A., Wildenauer, L. A., McCaughey, M., Henry, K., Spiker, A. M., Halanski, M. A., Hematti, P., & Vanderby, R. (2020) · Stem Cells · doi:10.1002/stem.3291 · Cited by 61 · see citing works
Gebraad, A., Kornilov, R., Kaur, S., Miettinen, S., Haimi, S. P., Peltoniemi, H. H., Mannerström, B., & Seppänen‐Kaijansinkko, R. (2018) · FEBS Journal · doi:10.1111/febs.14485 · Cited by 56 · see citing works
Blázquez, R., Sanchez-Margallo, F. M., Álvarez, V., Usón, A., Marinaro, F., & Casado, J. G. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.02.014 · Cited by 53 · see citing works
Taheri, B., Soleimani, M., Aval, S. F., Esmaeili, E., Bazi, Z., & Zarghami, N. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27775 · Cited by 48 · see citing works
Wang, X., Ao, J., Lu, H., Zhao, Q., Ma, Y., Zhang, J., Ren, H., & Zhang, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s248741 · Cited by 37 · see citing works
Xing, J., Hou, T., Jin, H., Luo, F., Change, Z., Li, Z., Xie, Z., & Xu, J. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358663 · Cited by 22 · see citing works
Qiao, K., Chen, Q., Cao, Y., Li, J., Xu, G., Liu, J., Cui, X., Tian, K., & Zhang, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.698614 · Cited by 20 · see citing works
Wound Healing Properties of Exosomes — A Review and Modelling of Combinatorial Analysis Strategies
Liew, F. F., Chew, B. C., & Ooi, D. J. (2021) · Current Molecular Medicine · doi:10.2174/1566524021666210405131238 · Cited by 14 · see citing works
Soft tissue injuries are still a challenge in musculoskeletal sports and exercise medicine
Malliaropoulos, N., Ghrairi, M., Zerguini, Y., & Padhiar, N. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-097171 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Jiang, X., Yang, J., Lin, Y., Liu, F., Tao, J., Zhang, W., Xu, J., & Zhang, M. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03530-1 · Cited by 39 · see citing works
Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage
Zhou, Z., Wang, R., Wang, J., Hao, Y., Xie, Q., Wang, L., & Wang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.933736 · Cited by 21 · see citing works
Longo, V., Aloi, N., Presti, E. L., Fiannaca, A., Longo, A., Adamo, G., Urso, A. M., Meraviglia, S., Bongiovanni, A., Cibella, F., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1069207 · Cited by 19 · see citing works
Si, Y., Li, X., Dong, S., Gao, X., Zhu, Y., Mo, L., Wang, Z., Wang, S., & Zhang, C. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.026 · Cited by 17 · see citing works
“Tissue injury, healing, and regeneration within the musculoskeletal system involve intricate inflammatory processes, and MSCs and their exosomes are able to exert anti-inflammatory effects by modulating the inflammatory microenvironment [27].”
Mondal, K., Ghanty, R., Mahadevan, A., Waghmare, G., Santhoshkumar, R., Nandeesh, B. N., & Datta, I. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04573-2 · Cited by 10 · see citing works
Development of stem cell therapy for atherosclerosis
Ma, Y., Gu, T., He, S., He, S., & Jiang, Z. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04762-8 · Cited by 9 · see citing works
Mesenchymal stem cells: A new strategy for the treatment of femoral head necrosis
Tian, F., Peng, J., Xu, Y., & Li, C. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.07.008 · Cited by 3 · see citing works
Unveiling research hotspots: a bibliometric study on macrophages in musculoskeletal diseases
Yue, Y., Cao, S., Cao, F., Wei, Y., Li, A., Wang, D., Liu, P., Zeng, H., & Lin, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1519321 · Cited by 2 · see citing works
Jiang, X., Yang, J., Lin, Y., Liu, F., Tao, J., Zhang, W., Xu, J., & Zhang, M. (2024) · Figshare · doi:10.6084/m9.figshare.26639956
Jiang, X., Yang, J., Lin, Y., Liu, F., Tao, J., Zhang, W., Xu, J., & Zhang, M. (2024) · Figshare · doi:10.6084/m9.figshare.26639953
Jiang, X., Yang, J., Lin, Y., Liu, F., Tao, J., Zhang, W., Xu, J., & Zhang, M. (2024) · Figshare · doi:10.6084/m9.figshare.26639959
Jiang, X., Yang, J., Lin, Y., Liu, F., Tao, J., Zhang, W., Xu, J., & Zhang, M. (2024) · Figshare · doi:10.6084/m9.figshare.26639950
- Authors
- Su, G., Lei, X., Wang, Z., Xie, W., Wen, D., & Wu, Y.
- Affiliations
- Lanzhou University (CN)
- Department of Orthopedics, The First People's Hospital of Tianshui City, Tianshui, China
- Corresponding author
- Wu, Yucheng
- ORCID
- Venue
- Current Molecular Medicine
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2023-05
- Volume
- 23
- Issue
- 4
- Pages
- 350-357
- ISSN
- 1566-5240 (ISSN-L)
- OpenAlex
- W4280492644
- Cited by
- 10
- References
- 79
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- KNC Key Laboratory of Gastrointestinal Tumors Diagnosis and Treatment Open Project (NLDTG2020005)
- Natural Science Foundation of Science and Technology Department of Gansu Province (20JR5RA344)
- Lanzhou University Second Hospital Cuiying Technology Innovation Program Project (CY2019-MS18)
- National Natural Science Foundation of China (31870335)
- Lanzhou University Second Hospital (201802)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- mesenchymal stem cell-derived exosomes, macrophage phenotype, skeletal muscle disorders, skeletal muscle injury, cell-free therapy, anti-inflammatory activity, tissue repair, inflammatory microenvironment, macrophage polarization
- MeSH terms
- Humans, Macrophages, Muscular Diseases, Phenotype, Exosomes, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
