The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Effectiveness of a Novel Integrative Online Treatment for Depression (Deprexis): Randomized Controlled Trial
Open accessAbstract
BACKGROUND: Depression is associated with immense suffering and costs, and many patients receive inadequate care, often because of the limited availability of treatment. Web-based treatments may play an increasingly important role in closing this gap between demand and supply. We developed the integrative, Web-based program Deprexis, which covers therapeutic approaches such as behavioral activation, cognitive restructuring, mindfulness/acceptance exercises, and social skills training. OBJECTIVE: To evaluate the effectiveness of the Web-based intervention in a randomized controlled trial. METHODS: There were 396 adults recruited via Internet depression forums in Germany, and they were randomly assigned in an 80:20 weighted randomization sequence to either 9 weeks of immediate-program-access as an add-on to treatment-as-usual (N = 320), or to a 9-week delayed-access plus treatment-as-usual condition (N = 76). At pre- and post-treatment and 6-month follow-up, we measured depression (Beck Depression Inventory) as the primary outcome measure and social functioning (Work and Social Adjustment Scale) as the secondary outcome measure. Complete analyses and intention-to-treat analyses were performed. RESULTS: Of 396 participants, 216 (55%) completed the post-measurement 9 weeks later. Available case analyses revealed a significant reduction in depression severity (BDI), Cohen's d = .64 (CI 95% = 0.33 - 0.94), and significant improvement in social functioning (WSA), Cohen's d = .64, 95% (CI 95% = 0.33 - 0.95). These improvements were maintained at 6-month follow-up. Intention-to-treat analyses confirmed significant effects on depression and social functioning improvements (BDI: Cohen's d = .30, CI 95% = 0.05 - 0.55; WSA: Cohen's d = .36, CI 95% = 0.10 - 0.61). Moreover, a much higher percentage of patients in the intervention group experienced a significant reduction of depression symptoms (BDI: odds ratio [OR] = 6.8, CI 95% = 2.90 - 18.19) and recovered more often (OR = 17.3, 95% CI 2.3 - 130). More than 80% of the users felt subjectively that the program had been helpful. CONCLUSIONS: This integrative, Web-based intervention was effective in reducing symptoms of depression and in improving social functioning. Findings suggest that the program could serve as an adjunctive or stand-alone treatment tool for patients suffering from symptoms of depression.
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In the citing paper
“online treatment is clearly better than nothing, according to recent studies. [17-19,32]”
From The more it is needed, the less it is wanted: Attitudes toward face-to-face intervention among depressed patients undergoing online treatment (2013) · cites this paper as [17]
In the citing paper
“The number of modules completed was found to correlate with outcomes in interventions that targeted cigarette smoking [42,46,47], depression [45,48-51], and anxiety disorders [52-57].”
From A Systematic Review of the Impact of Adherence on the Effectiveness of e-Therapies (2011) · cites this paper as [50]
In the citing paper
“While recent studies have shown that adding online sessions or modules to regular face-to-face psychotherapy can increase the adherence and effectiveness of a patients’ treatment, it also increases costs and workload among professionals [17-19].”
In the citing paper
“Deprexis, the treatment tested by Meyer et al. [23] and Berger et al. [16], is an example of such a blend as it includes positive psychology interventions, dreamwork and emotion-focused interventions above more traditional cognitive and behavioral techniques.”
From Internet-based psychological treatments for depression (2012) · cites this paper as [23]
In the citing paper
“The WSAS has been shown to have sound psychometric properties when administered on the Internet [20]”
From Breaking open the black box: isolating the most potent features of a web and mobile phone-based intervention for depression, anxiety, and stress (2015) · cites this paper as [20]
In the citing paper
“An analysis of a number of previous studies of an online intervention for depression in the community and that have used a CBT protocol similar to the intervention in the current study have reported post-treatment effect sizes averaging 1.29, and follow-up effects averaging 1.42, based on samples ranging from 45 – 300 [39,42-48].”
In the citing paper
“Some online programs, such as Deprexis, use patient feedback to select specific content presented to patients [35].”
In the citing paper
“It has been reported that a free-choice program in European countries had a higher completion rate and was more effective than a fixed order program24.”
From Effect of smartphone-based stress management programs on depression and anxiety of hospital nurses in Vietnam: a three-arm randomized controlled trial (2021) · cites this paper as [24]
In the citing paper
“In addition, Program A (free-choice) showed non-significant effects on depression and anxiety symptoms at any follow-up, which were smaller than Program B (fixed-order), which is also contrast to previous finding in Europe24.”
From Effect of smartphone-based stress management programs on depression and anxiety of hospital nurses in Vietnam: a three-arm randomized controlled trial (2021) · cites this paper as [24]
In the citing paper
“This is contradicted previous findings that a free-choice program showed a higher completion rate than a fixed order program in European countries24.”
From Effect of smartphone-based stress management programs on depression and anxiety of hospital nurses in Vietnam: a three-arm randomized controlled trial (2021) · cites this paper as [24]
In the citing paper
“A possible reason is a difference in ways of tailoring between the previous study and the present study. While the previous study used a navigation program to direct users to the most appropriate program based on pre-determined responses concerning their needs and preferences, the present study simply asked users to select one of the free-choice modules.”
From Effect of smartphone-based stress management programs on depression and anxiety of hospital nurses in Vietnam: a three-arm randomized controlled trial (2021) · cites this paper as [24]
In the citing paper
“The completion rates, satisfaction, and usefulness of the two programs were similar. The finding is inconsistent with a previous finding reporting a more favorable adherence to a free-choice program than a fixed-order program in European countries24.”
From Effect of smartphone-based stress management programs on depression and anxiety of hospital nurses in Vietnam: a three-arm randomized controlled trial (2021) · cites this paper as [24]
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Items 101–200 of 362
Moritz, S., Schröder, J., Meyer, B., & Hauschildt, M. (2013) · Depression and Anxiety · doi:10.1002/da.21988 · Cited by 53
“For a detailed description of Deprexis the reader is referred to Meyer et al.[17] and Moritz et al.[19] In brief, Deprexis encompasses 10 content modules with a strong focus on evidencebased cognitive-behavioral techniques, either from its so-called first (behavior-oriented), second (cognitive-oriented), or third wave…”
BackgroundInfluentialSelf-citationRichards, D., Timulak, L., & Hevey, D. (2013) · Counselling and Psychotherapy Research · doi:10.1080/14733145.2012.733715 · Cited by 55
“The results for the cCBT group are larger than those in other unsupported online studies (de Graaf et al., 2009; Meyer et al., 2009).”
MethodResultInfluentialSchure, M. B., Lindow, J. C., Greist, J. H., Nakonezny, P. A., Bailey, S. J., Bryan, W. L., & Byerly, M. (2019) · Journal of Medical Internet Research · doi:10.2196/14754 · Cited by 50
“Of the seven studies described in Karyotaki et al [21] and Lorenzo-Luaces et al [22], only one that delivered a fully automated, stand-alone iCBT intervention like the Thrive intervention had similarly broad eligibility criteria [29].”
InfluentialTimakum, T., Xie, Q. S., & Song, M. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03713-9 · Cited by 55
“They can improve the health care of patients, provide professional education through e-learning, and contribute to electronic research in mental health care [9], cognitive behavioral therapy (CBT) [10], mental health diagnosis, and treat illness-related mental health conditions [11, 12].”
BackgroundPalacios, J. E., Richards, D., Palmer, R., Coudray, C., Hofmann, S. G., Palmieri, P. A., & Frazier, P. (2018) · JMIR Mental Health · doi:10.2196/11467 · Cited by 58
“For instance, clinical recovery rates between 25% and 49% have been reported [33,34,12].”
BackgroundAcceptability of Digital Mental Health Interventions for Depression and Anxiety: Systematic Review
Lau, C. K. Y., Saad, A., Camara, B., Rahman, D., & Bolea-Alamanac, B. (2024) · Journal of Medical Internet Research · doi:10.2196/52609 · Cited by 51
Paul, C. L., Carey, M. L., Sanson-Fisher, R. W., Houlcroft, L. E., & Turon, H. E. (2013) · Health Education Research · doi:10.1093/her/cyt053 · Cited by 51
Klein, J. P., Berger, T., Schröder, J., Späth, C., Meyer, B., Caspar, F., Lutz, W., Greiner, W., Hautzinger, M., Rose, M., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-239 · Cited by 52
“Drop-out rates in previous studies of the intervention used in this study range from 9% [33] to 45% [32], thus this estimate is rather conservative.”
BackgroundMethodSelf-citationBücker, L., Bierbrodt, J., Hand, I., Wittekind, C., & Moritz, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198859 · Cited by 50
Unsolved, Forgotten, and Ignored Features of the Placebo Response in Medicine
Enck, P., Klosterhalfen, S., & Weimer, K. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.11.016 · Cited by 51
Mäder, M., Timpel, P., Schönfelder, T., Militzer-Horstmann, C., Scheibe, S., Heinrich, R., & Häckl, D. (2023) · BMC Health Services Research · doi:10.1186/s12913-023-09287-w · Cited by 57
“Deprexis [17, 18] mental health 0 6 0 Elevida [19] nervous system 1 0 0 Hello Better Diabetes and Depression [20, 21] hormones and metabolism 2 0 0 Hello Better Panik [22, 23] mental health 0 1 1 Hello Better Stress and Burnout [24, 25] mental health 1 0 0 Hello Better Vaginismus Plus [26, 27]…”
BackgroundWahle, F., Bollhalder, L., Kowatsch, T., & Fleisch, E. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.7381 · Cited by 48
“…Ly [48] Adults without older adults (18-75 years) Moderately severe to severe Deprexis 163 Germany Meyer [49] Adults (≥16 years) NR Deprexis 396 Germany Meyer [50] Adults (≥16 years) Mild to severe Mood Memos 1736 UK Australia Canada Ireland New Zealand USA Morgan [51] Adults without older adults”
BackgroundSchulze, N., Reuter, S. C., Kuchler, I., Reinke, B., Hinkelmann, L., Stöckigt, S., Siemoneit, H., & Tonn, P. (2019) · Telemedicine and e-Health · doi:10.1089/tmj.2018.0225 · Cited by 48
“8 10–13 Internet interventions in mental health are almost always based on CBT and a large number of programs for different mental illnesses have already been developed.”
Kivi, M., Eriksson, M. C. M., Hange, D., Petersson, E., Björkelund, C., & Johansson, B. E. A. (2015) · Internet Interventions · doi:10.1016/j.invent.2015.06.001 · Cited by 53
Hunkeler, E. M., Hargreaves, W. A., FIREMAN, B. H., Terdiman, J. F., Meresman, J. F., Porterfield, Y., Lee, J., Dea, R., Simon, G. E., Bauer, M. S., et al. (2012) · Psychiatric Services · doi:10.1176/appi.ps.005332011 · Cited by 46
Griffiths, K. M., Crisp, D. A., Christensen, H. M., Mackinnon, A. J., & Bennett, K. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-20 · Cited by 49
“In particular, a number of studies have reported a reduction in depressive symptoms associated with the use of automated online programs in the absence of clinical input (e.g., [8-14]).”
BackgroundHill, C., Martin, J. L., Thomson, S., Scott-Ram, N., Penfold, H. A., & Creswell, C. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.115.180372 · Cited by 48
Burger, F., Neerincx, M. A., & Brinkman, W. (2019) · Journal of Medical Internet Research · doi:10.2196/12599 · Cited by 49
“The top two systems in both rankings are Help4Mood [29] and Deprexis [30].”
BackgroundDifferential Treatment Mechanisms in Mindfulness Meditation and Progressive Muscle Relaxation
Gao, L., Curtiss, J., Liu, X., & Hofmann, S. G. (2018) · Mindfulness · doi:10.1007/s12671-017-0869-9 · Cited by 46
Urech, A., Krieger, T., Möseneder, L., Biaggi, A., Vincent, A., Poppe, C., Meyer, B., Riper, H., & Berger, T. (2019) · Psychotherapy Research · doi:10.1080/10503307.2018.1430910 · Cited by 43
Self-citationBeyond words: Sensory properties of depressive thoughts
Moritz, S., Hörmann, C. C., Schröder, J., Berger, T., Jacob, G. A., Meyer, B., Holmes, E. A., Späth, C., Hautzinger, M., Lutz, W., et al. (2014) · Cognition and Emotion · doi:10.1080/02699931.2013.868342 · Cited by 51
“The present study examined to what extent depressive thoughts are accompanied by sensory experiences and how this is associated with symptom severity, insight of illness and quality of life.”
BackgroundMethodSelf-citationInternet‐Based Psychotherapy for Adult Depression: What About the Mechanisms of Change?
Mogoaşe, C., Cobeanu, O., David, D., Giosan, C., & Szentágotai, A. (2016) · Journal of Clinical Psychology · doi:10.1002/jclp.22326 · Cited by 48
Schröder, J., Berger, T., Meyer, B., Lutz, W., Späth, C., Michel, P., Rose, M., Hautzinger, M., Hohagen, F., Klein, J. P., et al. (2018) · Depression and Anxiety · doi:10.1002/da.22727 · Cited by 43
“It also contains audio recordings, worksheets, and brief automatic daily messages, delivered either by SMSor e-mail (Meyer et al., 2009).”
MethodSelf-citationDavid, N., Schlenker, P., Prudlo, U., & Larbig, W. (2013) · Psycho-Oncology · doi:10.1002/pon.3104 · Cited by 42
Internet-Based Depression Prevention over the Life Course: A Call for Behavioral Vaccines
Voorhees, B. W. V., Mahoney, N., Mazo, R., Barrera, A. Z., Siemer, C. P., Gladstone, T. R. G., & Muñoz, R. F. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.11.002 · Cited by 44
“26 for Meyer and colleagues.(44) Two adult face-to-face studies, focused on postpartum depression, produced a mean between-group effect size of 0.”
Zwerenz, R., Baumgarten, C., Becker, J., Tibubos, A. N., Siepmann, M., Knickenberg, R. J., & Beutel, M. E. (2019) · Journal of Medical Internet Research · doi:10.2196/13655 · Cited by 43
“Deprexis is an interactive Web-based self-help program [9] with proven effectiveness in several randomized controlled studies (RCTs).”
Gold, S. M., Friede, T., Meyer, B., Moss-Morris, R. E., Hudson, J. L., Asseyer, S., Bellmann–Strobl, J., Leisdon, A., Ißels, L., Ritter, K., et al. (2023) · The Lancet Digital Health · doi:10.1016/s2589-7500(23)00109-7 · Cited by 48
Self-citationThukral, A., Sasi, A., Chawla, D., Datta, P., Wahid, S., Rao, S. P., Kannan, V., Veeragandam, A., Murki, S., & Deorari, A. K. (2012) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fms029 · Cited by 41
“Previous studies on online training have mainly focussed on undergraduate teaching in medicine [12], clinical care [13–17] and proposals of online learning for nursing education [18].”
BackgroundMcCall, H. C., Hadjistavropoulos, H. D., & Sundström, C. (2021) · Journal of Medical Internet Research · doi:10.2196/26939 · Cited by 52
“✓ Waitlist 9 396 Deprexis Meyer et al, 2009 [60]”
BackgroundRichards, D., & Timulak, L. (2013) · British Journal of Guidance & Counselling · doi:10.1080/03069885.2012.726347 · Cited by 40
“…used quantitative methodology asking participants to rate their level of satisfaction (Cavanagh, Seccombe, & Lidbetter, 2011; Learmonth & Rai, 2008; Meyer et al., 2009; Whitfield, Hinshelwood, Pashely, Campsie, & Williams, 2006) or qualitative methodology soliciting participants’ opinions on what…”
BackgroundMethodInfluentialZhao, C., Wampold, B. E., Ren, Z., Zhang, L., & Guangrong, J. (2022) · Journal of Clinical Psychology · doi:10.1002/jclp.23329 · Cited by 39
Toward Data-Driven Digital Therapeutics Analytics: Literature Review and Research Directions
Lee, U., Jung, G., Ma, E.-Y., Kim, J. S., Kim, H., Alikhanov, J., Noh, Y., & Kim, H. (2023) · IEEE/CAA Journal of Automatica Sinica · doi:10.1109/jas.2023.123015 · Cited by 42
“A report published in 2017 showed that there are more than 318,000 digital health apps publicly available to consumers through Apple Store and Google Play, with more than 200 apps added each day [39].”
Biskupiak, Z., Ha, V. V., Rohaj, A., & Bulaj, G. W. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020403 · Cited by 45
“Examples of DTx for depression include Deprexis ® [217–219], SparkRx ® [220], HelloBetter [221,222], and Daylight for anxiety [223].”
BackgroundSampling bias in an internet treatment trial for depression
Donkin, L., Hickie, I. B., Christensen, H., Naismith, S. L., Neal, B., Cockayne, N. L., & Glozier, N. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.100 · Cited by 38
“Of the 35 health survey variables explored, only 4 were independently associated with higher likelihood of consenting—female sex (odds ratio (OR) 1.11, 95% confidence interval (CI) 1.05–1.19), speaking English at home (OR 1.48, 95% CI 1.15–1.90) higher education (OR 1.67, 95% CI 1.46–1.92) and a prior diagnosis of dep…”
BackgroundInfluentialGómez Penedo, J. M., Babl, A. M., grosse Holtforth, M., Hohagen, F., Krieger, T., Lutz, W., Meyer, B., Moritz, S., Klein, J. P., & Berger, T. (2020) · Journal of Medical Internet Research · doi:10.2196/15824 · Cited by 33
“Furthermore, the analyses of the study were conducted using a subsample of the EVIDENT randomized controlled trial (ie, patients with moderate depression who received Deprexis with email support).”
MethodInfluentialSelf-citationLin, A., & Espay, A. J. (2021) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2021.100469 · Cited by 38
Imamura, K., Tran, T. T. T., Nguyen, H. T., Sasaki, N., Kuribayashi, K., Sakuraya, A., Bui, T. M., Nguyen, A. Q., Nguyen, Q. T., Nguyen, N. T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90320-5 · Cited by 31
Richards, D., Timulak, L., Doherty, G., Sharry, J., Colla, A., Joyce, C., & Hayes, C. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-147 · Cited by 35
“42, based on samples ranging from 45 – 300 [39,42-48].”
BackgroundPfirrmann, D., Huber, Y., Schattenberg, J. M., & Simon, P. D. (2018) · Journal of Medical Internet Research · doi:10.2196/11250 · Cited by 34
“Web-based interventions are essential to bridge the treatment gap between demand and supply [83,84].”
BackgroundBoschloo, L., Cuijpers, P. J., Karyotaki, E., Berger, T., Moritz, S., Meyer, B., & Klein, J. P. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103440 · Cited by 33
Self-citationResults from a trial of an unsupported internet intervention for depressive symptoms
Leykin, Y., Muñoz, R. F., Contreras, O., & Latham, M. D. (2014) · Internet Interventions · doi:10.1016/j.invent.2014.09.002 · Cited by 34
“The few truly unsupported studies (Christensen et al., 2002; Christensen et al., 2004b; Donker et al., 2013; Meyer et al., 2009) used randomization, which may have turned away participants who were reluctant to receive a control condition or their non-preferred condition.”
BackgroundResultWatzke, B., Heddaeus, D., Steinmann, M., König, H., Wegscheider, K., Schulz, H., & Härter, M. C. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0230-y · Cited by 34
“The program deprexis® is a certified medical product based on a cognitive-behavioral approach that allows patients to work independently and at their own pace [28].”
BackgroundInternet trials: participant experiences and perspectives
Mathieu, E., Barratt, A. L., Carter, S. M., & Jamtvedt, G. (2012) · BMC Medical Research Methodology · doi:10.1186/1471-2288-12-162 · Cited by 35
“In Internetbased trials, the Internet is used for recruitment of trial participants, delivery of the health intervention, and/or data collection [3-5].”
MethodAdaptive Elements in Internet-Delivered Psychological Treatment Systems: Systematic Review
Mukhiya, S. K., Wake, J. D., İnal, Y., Pun, K. I., & Lamo, Y. (2020) · Journal of Medical Internet Research · doi:10.2196/21066 · Cited by 33
“Analogously, other variations include creation of technical platforms such as Interapy [30], Deprexis [31], ULTEMAT [32], digital behavior change interventions [33], and smartphone-based apps with specific brand names [34].”
ALAVI, N., & HIRJI, A. (2020) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000455 · Cited by 33
Yang, R., Vigod, S. N., & Hensel, J. M. (2019) · Journal of Medical Internet Research · doi:10.2196/13172 · Cited by 33
“However, childcare responsibilities and physical recovery, particularly after a surgical birth, create barriers for regular therapy attendance [6-8].”
Victorson, D. E., Sauer, C. M., Wolters, L., Maletich, C., Lukoff, K., & Sufrin, N. (2020) · Mindfulness · doi:10.1007/s12671-020-01373-y · Cited by 33
“When adherence was defined as completing at least 75% of the intervention, adherence ranged from 20 to 82.5% (Aikens et al. 2014; Allexandre et al. 2016; Bhayee et al. 2016; Meyer et al. 2009; Morledge et al. 2013).”
BackgroundInfluentialDavidson, T. M., Soltis, K. E., Albia, C. M., de Arellano, M. A., & Ruggiero, K. J. (2014) · Psychological Services · doi:10.1037/a0037686 · Cited by 32
“This addition was a necessary component as authors have found that tailoring web-based interventions according to patient characteristics may improve motivation and treatment adherence (Carlbring et al., 2011; Meyer et al., 2009).”
BackgroundKrieger, T., Meyer, B., Sude, K., Urech, A., Maercker, A., & Berger, T. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0285-9 · Cited by 31
“A more comprehensive description of the program can be found in Meyer and colleagues [23].”
BackgroundMethodSelf-citationPositive imagery training increases positive self-referent cognition in depression
Dainer‐Best, J., Shumake, J., & Beevers, C. G. (2018) · Behaviour Research and Therapy · doi:10.1016/j.brat.2018.09.010 · Cited by 31
“) Such rare communication limits the ability to generalize the results to in-person therapy, although it is analogous to internet interventions that often have relatively little levels of in-person support (Meyer et al., 2009).”
BackgroundSelf-citationHøifødt, R. S., Mittner, M., Lillevoll, K. R., Katla, S. K., Kolstrup, N., Eisemann, M. R., Friborg, O., & Waterloo, K. K. (2015) · Journal of Medical Internet Research · doi:10.2196/jmir.4351 · Cited by 35
“One may presume that greater adherence leads to better outcomes, but even on this point there are inconsistencies with some studies finding an association [5,60,62-65] and others not [12,54,57,66-68].”
Program Use and Outcome Change in a Web-Based Trauma Intervention: Individual and Social Factors
Wang, Z., Wang, J., & Maercker, A. R. A. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5839 · Cited by 32
“While PTSD symptoms, depression, and social functioning impairment correlated positively with each other, social support correlated negatively with depression and social functioning and positively with coping self-efficacy.”
BackgroundInfluentialSchneider, B. C., Schröder, J., Berger, T., Hohagen, F., Meyer, B., Späth, C., Greiner, W., Hautzinger, M., Lutz, W., Rose, M., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.101 · Cited by 32
Self-citationMoritz, S., Stepulovs, O., Schröder, J., Hottenrott, B., Meyer, B., & Hauschildt, M. (2016) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2016.04.001 · Cited by 32
Self-citationElkjær, M. (2012) · PubMed · Cited by 32
Leong, Q. Y., Sridhar, S., Blasiak, A., Tadeo, X., Yeo, G., Remus, A., & Ho, D. (2021) · Journal of Medical Internet Research · doi:10.2196/27388 · Cited by 39
“7% (145/8362) of articles (Multimedia Appendix 2 [22-166]).”
Brandt, L. R., Hidalgo, L., Diez-Canseco, F., Araya, R., Mohr, D. C., Menezes, P. R., & Miranda, J. J. (2019) · JMIR Mental Health · doi:10.2196/11701 · Cited by 32
“Other strategies to overcome health system barriers and make mental health care more accessible to the community [35,36] are mobile health (mHealth) [35,37-41] and other digital self-help interventions [42-45], which have been shown to improve mental health–related outcomes.”
BackgroundSandoval, L. R., Buckey, J. C., Ainslie, R. C., Tombari, M. L., Stone, W. S., & Hegel, M. T. (2016) · Behavior Therapy · doi:10.1016/j.beth.2016.04.001 · Cited by 32
“A similar study conducted by Meyer et al. (2009) observed lasting therapeutic effects for patients receiving a fewer number of sessions.”
BackgroundMesser, D., Horan, J. J., Turner, W., & Weber, W. (2016) · AERA Open · doi:10.1177/2332858415625188 · Cited by 30
“Meyer et al. (2009), for example, used it in conjunction with cognitive restructuring and social skills training and found statistically and clinically significant reductions in depression.”
MethodHaaf, R., Vock, P., Wächtershäuser, N., Correll, C. U., Köhler, S., & Klein, J. P. (2024) · Der Nervenarzt · doi:10.1007/s00115-023-01587-0 · Cited by 30
Mullarkey, M. C., Stein, A. T., Pearson, R., & Beevers, C. G. (2019) · Depression and Anxiety · doi:10.1002/da.22972 · Cited by 35
“Deprexis is an Internet‐based intervention designed for adults with symptoms of unipolar depression (Meyer et al., 2009).”
BackgroundInfluentialSelf-citationComputer-delivered cognitive behavioural therapy: effective and getting ready for dissemination
Titov, N., Andrews, G., & Sachdev, P. (2010) · F1000 Medicine Reports · doi:10.3410/m2-49 · Cited by 30
“In comparison, smaller but significant effect sizes were recently reported for selfguided programs [11].”
BackgroundSasaki, N., Imamura, K., Tran, T. T. T., Nguyen, H. T., Kuribayashi, K., Sakuraya, A., Bui, T. M., Nguyen, Q. T., Nguyen, N. T., Nguyen, G. T. H., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/20445 · Cited by 30
“One study in a Western country reported that tailored (ie, partially personalized) options provided a better outcome of eHealth programs because free choice was culturally preferred [49].”
Understanding adherence to web-based interventions
Kelders, S. M. (2012) · doi:10.3990/1.9789036534178 · Cited by 29
Kushlev, K., Heintzelman, S. J., Lutes, L. D., Wirtz, D., Oishi, S., & Diener, E. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.11.003 · Cited by 33
Effects of Internet Training in Mindfulness Meditation on Variables Related to Cancer Recovery
Messer, D. W., Horan, J. J., Larkey, L., & Shanholtz, C. E. (2019) · Mindfulness · doi:10.1007/s12671-019-01182-y · Cited by 31
“Online mindfulness training, combined with other elements, has led to symptom improvement in heart disease (Younge et al., 2015), irritable bowel syndrome (Ljottson et. al., 2010, 2011), epilepsy (Thompson et al., 2010), depression (Meyer et al., 2009) and chronic pain (Dowd et al., 2015).”
Adaptive Systems for Internet-Delivered Psychological Treatments
Mukhiya, S. K., Wake, J. D., İnal, Y., & Lamo, Y. (2020) · IEEE Access · doi:10.1109/access.2020.3002793 · Cited by 31
“In addition to this, researchers use different technical terms to represent the IDPT systems, for example Interapy [13], Deprexis [14],”
MethodClarke, J., Proudfoot, J., & Ma, H. (2016) · JMIR Mental Health · doi:10.2196/mental.5131 · Cited by 26
“The Work and Social Adjustment Scale (WSAS; [33]) measured the impact of mental health problems on daily functioning in 5 domains: work, social leisure activities, private leisure activities, home management, and personal relationships [33,34].”
Fuhr, K., Fahse, B., Hautzinger, M., & Gulewitsch, M. D. (2018) · PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie · doi:10.1055/s-0043-122241 · Cited by 26
“In der verwendeten Programmversion von Deprexis können tägliche SMS an die Nutzer verschickt werden, in denen auf die Grundideen des Programms hingewiesen sowie an die tägliche Einbindung dieser in den Alltag erinnert wird [28].”
BackgroundInfluentialA Narrative Review of Empirical Literature of Behavioral Activation Treatment for Depression
Wang, X., & Feng, Z. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.845138 · Cited by 26
Psychenet.de: development and process evaluation of an e-mental health portal
Dirmaier, J., Liebherz, S., Sänger, S., Härter, M. C., & Tlach, L. (2015) · Informatics for Health and Social Care · doi:10.3109/17538157.2015.1008486 · Cited by 27
“Deprexis has been created and evaluated within 6 years of development (44,45).”
Paul, C. L., Carey, M. L., Hall, A. E., Lynagh, M., Sanson‐Fisher, R., & Henskens, F. A. (2011) · Journal of Medical Internet Research · doi:10.2196/jmir.1894 · Cited by 25
García-Robles, A., Yáñez, A. M., Bennasar‐Veny, M., Navarro, C., Salvá, J., Ibarra, O., Gómez-Juanes, R., Serrano-Ripoll, M. J., Oliván‐Blázquez, B., Gili, M., et al. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114975 · Cited by 26
“First, because of the COVID-19 pandemic, our sample size was smaller than originally planned (Navarro, 2020) and was also smaller than that used in similar previous studies (Meyer et al., 2009).”
Ramirez, M., Wu, S., Jin, H., Ell, K., Gross-Schulman, S. G., Sklaroff, L. M., & Guterman, J. J. (2016) · JMIR Mental Health · doi:10.2196/mental.4823 · Cited by 25
“Related studies of connected health technologies [42], including those focused on depression care [37,43-54], uncritically regard acceptance as patient satisfaction with care, which tells us little about why patients accept or reject the technology or how system design features affect patient acceptance.”
Klein, J. P., Späth, C., Schröder, J., Meyer, B., Greiner, W., Hautzinger, M., Lutz, W., Rose, M., Vettorazzi, E., Andersson, G., et al. (2017) · Behaviour Research and Therapy · doi:10.1016/j.brat.2017.07.013 · Cited by 25
Self-citationZill, J. M., Dirmaier, J., Augustin, M., Dwinger, S., Christalle, E., Härter, M. C., & Mrowietz, U. (2018) · JMIR Research Protocols · doi:10.2196/resprot.8490 · Cited by 25
“Existing Internet-based programs (eg, for depression, alcohol consumption, or stress reduction) could be adapted for these patients or certain modules could be tailored [43,44].”
BackgroundImamura, K., Tran, T. T. T., Nguyen, H. T., Kuribayashi, K., Sakuraya, A., Nguyen, A. Q., Bui, T. M., Nguyen, Q. T., Nguyen, K. T., Nguyen, G. T. H., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025138 · Cited by 26
“For instance, a previous RCT showed that the attrition and adherence rate of an individually tailored iCBT programme appeared favourable compared with studies that applied non-tailored iCBT programmes.(29) Even programmes that are not fully tailored but that allow participants to choose a module from multiple options…”
ResultPersonality change after Internet-delivered cognitive behavior therapy for depression
Johansson, R., Lyssarides, C., Andersson, G., & Rousseau, A. (2013) · PeerJ · doi:10.7717/peerj.39 · Cited by 25
“, 2011) and MDD (Andersson et al., 2005; Johansson & Andersson, 2012; Meyer et al., 2009; Perini, Titov & Andrews, 2009).”
Self-citationZhao, D., Lustria, M. L. A., & Hendrickse, J. (2017) · Patient Education and Counseling · doi:10.1016/j.pec.2017.01.004 · Cited by 27
Klein, J. P., Gamon, C., Späth, C., Berger, T., Meyer, B., Hohagen, F., Hautzinger, M., Lutz, W., Vettorazzi, E., Moritz, S., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015391 · Cited by 25
“Briefly, this programme consists of modules covering content that is broadly consistent with CBT (eg, cognitive restructuring, behavioural activation, acceptance and mindfulness, problem-solving).(21) The intervention can be used with or without guidance by a clinician.”
MethodSelf-citationInternet-Delivered Cognitive Behaviour Therapy
Richards, D., Enrique, Á., Palacios, J. E., & Duffy, D. J. (2018) · InTech eBooks · doi:10.5772/intechopen.71412 · Cited by 24
“Some of the developments in the field have used brand names such as Interapy for PTSD [3], Deprexis for depression [4], and SilverCloud for depression, anxiety, and long-term conditions management [5].”
MethodSchuster, R., Laireiter, A., Berger, T., Moritz, S., Meyer, B., Hohagen, F., & Klein, J. P. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.122 · Cited by 23
Self-citationMorgan, A., Jorm, A. F., & Mackinnon, A. (2011) · Trials · doi:10.1186/1745-6215-12-11 · Cited by 25
“It has also been used in online studies of depression treatment [62,63].”
MethodGräfe, V., Moritz, S., & Greiner, W. (2020) · Health Economics Review · doi:10.1186/s13561-020-00273-0 · Cited by 22
Heißel, A., Bollmann, J., Kangas, M., Abdulla, K. B., Rapp, M. A., & Sanchez, A. (2021) · BMC Health Services Research · doi:10.1186/s12913-021-06622-x · Cited by 23
Religious versus Conventional Internet-based Cognitive Behavioral Therapy for Depression
Tulbure, B. T., Andersson, G., Sălăgean, N., Pearce, M., & Koenig, H. G. (2017) · Journal of Religion and Health · doi:10.1007/s10943-017-0503-0 · Cited by 28
Self-citationDigital health applications in the area of mental health
Schreiter, S., Mascarell-Maricic, L., Rakitzis, O., Volkmann, C., Kaminski, J. A., & Daniels, M. A. (2023) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2023.0208 · Cited by 24
Lau, Y., Ang, W. H. D., Ang, W. W., Pang, P. C., Wong, S. H., & Chan, K. S. (2025) · Depression and Anxiety · doi:10.1155/da/8930012 · Cited by 31
Meyer, B., Utter, G.-L., & Hillman, C. (2021) · JMIR Mental Health · doi:10.2196/31173 · Cited by 22
Self-citationCollaborative und Stepped Care bei depressiven Erkrankungen
Härter, M. C., Heddaeus, D., Steinmann, M., Schreiber, R., Brettschneider, C., König, H., & Watzke, B. (2015) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-015-2124-7 · Cited by 22
“Internetbasierte Selbsthilfe: Das internetgestützte Selbstmanagementprogramm „deprexis®“ ist ein zertifiziertes Medizinprodukt, das aus 12 interaktiven simulierten Konversationen besteht [38].”
BackgroundInternetbasierte psychologische Behandlung bei Depressionen
Klein, J. P., & Berger, T. (2013) · Verhaltenstherapie · doi:10.1159/000354046 · Cited by 23
“Diese individuelle Anpassung kann auch erfolgen, indem auf individuelle Vorlieben der Nutzer für die Länge oder das Präsentationsformat der Inhalte im Rahmen eines simulierten Dialogs eingegangen wird [Meyer et al., 2009].”
BackgroundInfluentialSelf-citationWeymann, N., Härter, M. C., Petrak, & Dirmaier, J. (2013) · Patient Preference and Adherence · doi:10.2147/ppa.s46924 · Cited by 22
“This dialogue format has been found to be effective in depression and acute low back pain, 55–58 but has not been applied to diabetes websites so far.”
Messerli‐Bürgy, N., Barth, J., & Berger, T. (2012) · Trials · doi:10.1186/1745-6215-13-245 · Cited by 22
“To our knowledge, this is the only psychological treatment for German-speaking patients with depression, and in contrast to other web-based tools, it integrates different psychotherapeutic approaches [36].”
BackgroundResultSelf-citationLüdtke, T., Westermann, S., Pult, L. K., Schneider, B. C., Pfuhl, G., & Moritz, S. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.06.004 · Cited by 18
“, 2007), or 10 (Meyer et al., 2009) modules/sessions addressing multiple depression-related topics.”
Mira, A., Bretón-López, J., Enrique, Á., Castilla, D., García-Palacios, A., Baños, R., & Botella, C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02360 · Cited by 21
Hensel, J. M., Yang, R., Vigod, S. N., & Desveaux, L. (2020) · Counselling and Psychotherapy Research · doi:10.1002/capr.12372 · Cited by 22
Jakobsen, H., Andersson, G., Havik, O. E., & Nordgreen, T. (2016) · Internet Interventions · doi:10.1016/j.invent.2016.11.002 · Cited by 25
“…list or treatment as usual control groups have varied from strong (Andersson et al., 2005, 2013b; Christensen et al., 2004; Kessler et al., 2009; Meyer et al., 2009; Perini et al., 2009; Spek et al., 2007b; Vernmark et al., 2010), to moderate (Christensen et al., 2004) to no effect (Clarke et…”
BackgroundSelf-citationKrause, N., Riemann-Lorenz, K., Rahn, A. C., Pöttgen, J., Köpke, S., Meyer, B., Thale, F., Temmes, H., van de Loo, M., Gold, S. M., et al. (2022) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864221118729 · Cited by 20
Self-citationGhosh, A., Cherian, R. J., Wagle, S., Sharma, P., Kannan, K. R., Bajpai, A., & Gupta, N. (2023) · Journal of Medical Internet Research · doi:10.2196/41005 · Cited by 25
“Deprexis, a well-evaluated intervention, reported a full adherence rate of 7.5% in a fully unguided evaluation [50].”
InfluentialRodriguez-Pulido, F., Castillo-Sánchez, G., Hamrioui, S., Martin, L. D., Vazquez-Beltrán, P., Díez, I. D. L. T., & Franco, M. (2020) · Journal of Medical Systems · doi:10.1007/s10916-020-1543-7 · Cited by 21
“Apart from studies previously mentioned, they found those of Meyer 2009 [43], Titov 2010 [41], and Vernmark 2010 [44].”
Result
Metadata
- Authors
- Meyer, B., Berger, T., Caspar, F., Beevers, C. G., Andersson, G., & Weiss, M.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- University of Bern (CH)
- The University of Texas at Austin (US)
- Linköping University (SE)
- GAIA (Germany) (DE)
- Corresponding author
- Meyer, Björn
- Venue
- Journal of Medical Internet Research
- Publisher
- JMIR Publications Inc.
- Published
- 2009-05-11
- Volume
- 11
- Issue
- 2
- Pages
- e15
- ISSN
- 1438-8871 (ISSN-L)
- PMC
- PMC2762808
- OpenAlex
- W2115531241
- Semantic Scholar
- 37b1f1ccf725c315bb299af7bb17a1f37a3fe471
- Cited by
- 363
- References
- 96
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 13 · 2021: 28 · 2020: 24 · 2019: 25 · 2018: 25 · 2017: 28 · 2016: 30 · 2015: 25 · 2014: 33 · 2013: 32 · 2012: 24
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- other-oa
- Locations
- Journal of Medical Internet Research (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- depression, online therapy, online intervention, Deprexis, behavioral activation, cognitive restructuring, mindfulness, acceptance and commitment therapy, social skills training, integrative psychotherapy, social functioning, online forums, medication adherence, recovery from depression, digital mental health, treatment gap, user satisfaction
- MeSH terms
- Adult, Behavior, Behavior Therapy, Cognition, Depression, Depressive Disorder, Emotions, Female, Follow-Up Studies, Humans, Life Style, Male, Online Systems, Patient Education as Topic, Personality Inventory, Problem Solving, Psychiatric Status Rating Scales, Social Adjustment, Social Behavior, Social Support, Exercise, Internet
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