The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
In Vivo Biodistribution of Nanoparticles
Abstract
Nanoparticles have potential applications in diagnostics, imaging, gene and drug delivery and other types of therapy. Iron oxide nanoparticles, gold nanoparticles and quantum dots have all generated substantial interest and their properties and applications have been thoroughly studied. Yet, metal-containing particles raise biodistribution and toxicity concerns because they can be quickly cleared from the blood by the reticuloendothelial system and can remain in organs, such as the liver and spleen, for prolonged periods of time. Design considerations, such as size, shape, surface coating and dosing, can be manipulated to prolong blood circulation and enhance treatment efficacy, but nonspecific distribution has thus far been unavoidable. Renal excretion of nanoparticles is possible and is size dependent, but the need to incorporate coatings to particles for increased circulation can hinder such excretion. Further long-term studies are needed because recent work has shown varying degrees of in vivo toxicity as well as varying levels of nanoparticle excretion over time. The interaction of these particles with immune cells and their effect on the innate and adaptive immune response also needs further characterization. Finally, more systematic in vitro approaches are needed to both guide in vivo work and better correlate nanoparticle properties to their biological effects.
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Cites
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Cited by
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570
Gold nanoparticles for cancer radiotherapy: a review
Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., Solov’yov, A. V., Prise, K. M., Golding, J., & Mason, N. J. (2016) · Cancer Nanotechnology · doi:10.1186/s12645-016-0021-x · Cited by 445
Animal Models of Heart Failure: A Scientific Statement From the American Heart Association
Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research · doi:10.1161/res.0b013e3182582523 · Cited by 435
Metadata
- Authors
- Almeida, J. P. M., Chen, A. L., Foster, A., & Drezek, R.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2011-07
- Volume
- 6
- Issue
- 5
- Pages
- 815-835
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2146704352
- Cited by
- 583
- References
- 8
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Almeida, J. P. M., Chen, A. L., Foster, A., & Drezek, R. (2011). In Vivo Biodistribution of Nanoparticles. Nanomedicine. https://doi.org/10.2217/nnm.11.79
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
