Cited by 453Mitochondrial Function and PathologyMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism

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Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

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Befroy, Douglas E., Petersen, Kitt Falk, Dufour, Sylvie, Mason, Graeme F., de Graaf, Robin A., Rothman, Douglas L., Shulman, Gerald I.·2007·Diabetes

DOI 10.2337/db06-0783PMC PMC2995532

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Abstract

Insulin resistance is the best predictor for the development of diabetes in offspring of type 2 diabetic patients, but the mechanism responsible for it remains unknown. Recent studies have demonstrated increased intramyocellular lipid, decreased mitochondrial ATP synthesis, and decreased mitochondrial density in the muscle of lean, insulin-resistant offspring of type 2 diabetic patients. These data suggest an important role for mitochondrial dysfunction in the pathogenesis of type 2 diabetes. To further explore this hypothesis, we assessed rates of substrate oxidation in the muscle of these same individuals using 13C magnetic resonance spectroscopy (MRS). Young, lean, insulin-resistant offspring of type 2 diabetic patients and insulin-sensitive control subjects underwent 13C MRS studies to noninvasively assess rates of substrate oxidation in muscle by monitoring the incorporation of 13C label into C4 glutamate during a [2-13C]acetate infusion. Using this approach, we found that rates of muscle mitochondrial substrate oxidation were decreased by 30% in lean, insulin-resistant offspring (59.8 ± 5.1 nmol · g−1 · min−1, P = 0.02) compared with insulin-sensitive control subjects (96.1 ± 16.3 nmol · g−1 · min−1). These data support the hypothesis that insulin resistance in skeletal muscle of insulin-resistant offspring is associated with dysregulation of intramyocellular fatty acid metabolism, possibly because of an inherited defect in the activity of mitochondrial oxidative phosphorylation.

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Authors: Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., de Graaf, R. A., Rothman, D. L., & Shulman, G. I.
Affiliations: Yale University (US)
Howard Hughes Medical Institute (US)
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut
ORCID: Petersen, Kitt Falk
Dufour, Sylvie
Mason, Graeme F.
Rothman, Douglas L.
Shulman, Gerald I.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2007-05-01
Volume: 56
Issue: 5
Pages: 1376-1381
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/db06-0783
PMC: PMC2995532
OpenAlex: W2152386173
Cited by: 453
References: 34
Citations by year: 2026: 5 · 2025: 15 · 2024: 13 · 2023: 17 · 2022: 14 · 2021: 21 · 2020: 22 · 2019: 14 · 2018: 18 · 2017: 19 · 2016: 24 · 2015: 19 · 2014: 28 · 2013: 34 · 2012: 36
FWCI: 15.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R56AG023686, R01AG023686)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK049230, P30DK045735, P01DK068229)
National Center for Research Resources (M01RR000125)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: insulin resistance, type 2 diabetes, offspring of diabetic patients, skeletal muscle, fatty acid oxidation, intramyocellular lipid, oxidative phosphorylation, 13C NMR, glutamate, mitochondrial dysfunction
MeSH terms: Adult, Carbon Isotopes, Citric Acid Cycle, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Kinetics, Life Style, Male, Mitochondria, Muscle, Models, Biological, Nuclear Family, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Body Mass Index

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Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

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