Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, Xinmei, Yeung, Dennis C.Y., Karpisek, Michal, Stejskal, David, Zhou, Zhi-Guang, Liu, Feng, Wong, Rachel L.C., Chow, Wing-Sun +3 more·2008·Diabetes
DOI 10.2337/db07-1476

Cited by (907)

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  2. Exercise-induced myokines in health and metabolic diseases
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  3. FGFs and metabolism
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  4. Regulation of myokine expression: Role of exercise and cellular stress
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  6. Stress-induced FGF21 and GDF15 in obesity and obesity resistance
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  7. Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice
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  12. Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid
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  13. Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
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  14. Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
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  17. The role of adipokines in skeletal muscle inflammation and insulin sensitivity
    Thomas A. Nicholson, Chris Church, David J. Baker, Simon Wyn Jones · 2018 · Journal of Inflammation
  18. Fibroblast Growth Factor 21 Predicts the Metabolic Syndrome and Type 2 Diabetes in Caucasians
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  19. Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
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  20. FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats
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  22. Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
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  23. Fibroblast growth factor 21: a regulator of metabolic disease and health span
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  24. Regulation of longevity by FGF21: interaction between energy metabolism and stress responses
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  27. FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
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  28. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
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  47. The FGF21–adiponectin axis in controlling energy and vascular homeostasis
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  48. Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo
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  49. Fibroblast growth factor 21 night watch: advances and uncertainties in the field
    Alexei Kharitonenkov, Richard D. DiMarchi · 2016 · Journal of Internal Medicine
  50. Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease
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  53. Response to Carbohydrate and Fat Refeeding in the Expression of Genes Involved in Nutrient Partitioning and Metabolism: Striking Effects on Fibroblast Growth Factor-21 Induction
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  63. Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway
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  71. FGF21: a novel prospect for the treatment of metabolic diseases.
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  79. Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus
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  82. Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus
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