Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, Xinmei, Yeung, Dennis C.Y., Karpisek, Michal, Stejskal, David, Zhou, Zhi-Guang, Liu, Feng, Wong, Rachel L.C., Chow, Wing-Sun, Tso, Annette W.K., Lam, Karen S.L., Xu, Aimin·2008·Diabetes

DOI 10.2337/db07-1476

Cited by (907)

Items 301–400 of 907

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Zhifeng Huang, Huiyan Wang, Meifei Lu, Chuanchuan Sun, Xiaoping Wu, Yi Tan, Chaohui Ye, Guanghui Zhu, Xiaojie Wang, Lu Cai et al. · 2011 · PLoS ONE
Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients
Xiaoyan Zhang, Yanyun Hu, Hui Zeng, Lianxi Li, Jungong Zhao, Jun Zhao, Fang Liu, Yuqian Bao, Weiping Jia · 2015 · Cardiovascular Diabetology
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Daniela Zanetti, Abhiram S. Rao, Stefan Gustafsson, Themistocles L. Assimes, Stephen B. Montgomery, Erik Ingelsson · 2019 · Kidney International
Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals
Slusher, A.L., Whitehurst, M., Zoeller, R.F., Mock, J.T., Maharaj, M., Huang, C.-J. · 2015 · Nutrition Metabolism and Cardiovascular Diseases
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Type VIII Collagen Modulates TGF-β1-induced Proliferation of Mesangial Cells
Ivonne Loeffler, Ulrike Hopfer, Dirk Koczan, Günter Wolf · 2011 · Journal of the American Society of Nephrology
The regulation of FGF21 gene expression by metabolic factors and nutrients
Anjeza Erickson, Régis F. Moreau · 2016 · Hormone Molecular Biology and Clinical Investigation
Diabetes and dyslipidemia: characterizing lipoprotein metabolism
GERALD H. TOMKIN, Daphne Owens · 2017 · Diabetes Metabolic Syndrome and Obesity
Liver Plays a Major Role in FGF-21 Mediated Glucose Homeostasis
Mingyao Liu, Hongwei Cao, Yuting Hou, Guopeng Sun, Deshan Li, Wenfei Wang · 2018 · Cellular Physiology and Biochemistry
Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research
Thomas Ho-yin Lee, Douglas Affonso Formolo, Tammie Kong, Samantha Wing-Yan Lau, Charlotte Sze-Lok Ho, Rachel Yan Hei Leung, Felix Hin-Yan Hung, Suk‐Yu Yau · 2019 · International review of neurobiology
Regulation of Energy Metabolism by Receptor Tyrosine Kinase Ligands
Meng Zhao, Yunshin Jung, Zewen Jiang, Katrin J. Svensson · 2020 · Frontiers in Physiology
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
Nadejda Bozadjieva-Kramer, Jae Hoon Shin, Yikai Shao, Ruth Gutiérrez‐Aguilar, Ziru Li, Kristy M. Heppner, Samuel Chiang, Sara G. Vargo, Katrina Granger, Darleen A. Sandoval et al. · 2021 · Nature Communications
Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism
Tae Hyun Kim, Dong-Gyun Hong, Yoon Mee Yang · 2021 · Biomedicines
Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children
Ko Bj, Seon Mee Kim, Park Kh, Park Hs, Christos Socrates Mantzoros · 2014 · International Journal of Obesity
Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa
Pouneh K. Fazeli, Alexander T. Faje, Ela J. Cross, Hang Lee, Clifford james Rosen, Mary Bouxsein, Anne Klibanski · 2015 · Bone
Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism
Kook Hwan Kim, Myung‐Shik Lee · 2013 · Reviews in Endocrine and Metabolic Disorders
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Masato Furuhashi, Megumi Matsumoto, Takayo Murase, Takashi Nakamura, Yukimura Higashiura, Masayuki Koyama, Marenao Tanaka, Norihito Moniwa, Hirofumi Ohnishi, Shigeyuki Saitoh et al. · 2018 · Journal of Diabetes Investigation
Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease
Mohammad Zarei, David Aguilar-Recarte, Xavier Palomer, Manuel Vázquez‐Carrera · 2020 · Metabolism
Fibroblast growth factor 21: an overview from a clinical perspective
Mikael Rydén · 2009 · Cellular and Molecular Life Sciences
Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight
Stefano Ballestri, Fabio Nascimbeni, Dante Romagnoli, Enrica Baldelli, Giovanni Targher, Amedeo Lonardo · 2016 · International Journal of Molecular Sciences
Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
Vienberg, Sara G, Brøns, Charlotte, Nilsson, Emma, Astrup, Arne, Vaag, Allan, Andersen, Birgitte · 2012 · European Journal of Endocrinology
Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet
Liang Xu, Dandan Li, Haoran Li, Ouyang Zhang, Yaxin Huang, Hengrong Shao, Yajiao Wang, Suili Cai, Yuqin Zhu, Shengnan Jin et al. · 2022 · Nutrition and Diabetes
Effects of the Intragastric Balloon MedSil® on Weight Loss, Fat Tissue, Lipid Metabolism, and Hormones Involved in Energy Balance
Marek Bužga, Evžen Machytka, Pavel Klvaňa, Tomáš Kupka, Vladislava Zavadilová, Pavel Zonča, Zdeněk Švagera · 2014 · Obesity Surgery
Anorexia nervosa and bone metabolism
Pouneh K. Fazeli, Anne Klibanski · 2014 · Bone
Organokines in disease
2020 · Advances in clinical chemistry
The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases
Katsunori Nonogaki · 2022 · International Journal of Molecular Sciences
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, Tiantian, Zhou, Dong, Hong, Zhen · 2025 · MedComm
Heart Failure and Obesity: Translational Approaches and Therapeutic Perspectives. A Scientific Statement of the Heart Failure Association of the ESC
Gianluigi Savarese, Gabriele G. Schiattarella, Felix Lindberg, Markus S. Anker, Antoni Bayés‐Genís, Magnus Bäck, Frieder Braunschweig, Chiara Bucciarelli‐Ducci, Javed Butler, Antonio Nicola Cannata et al. · 2025 · European Journal of Heart Failure
Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes
Kazuhiro Eto, Bayasgalan Tumenbayar, Shuichi Nagashima, Fumiko Tazoe, Michiaki Miyamoto, Manabu Takahashi, Akihiko Ando, Kenta Okada, Hiroaki Yagyu, Shun Ishibashi · 2010 · Diabetes Research and Clinical Practice
Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding
Christine Loyd, I. Jack Magrisso, Michael Haas, Sowmya Balusu, Radha Krishna, Nobuyuki Itoh, Darleen A. Sandoval, Diego Pérez–Tilve, Silvana Obici, Kirk M. Habegger · 2016 · Journal of Applied Physiology
Effect of bariatric surgery on plasma GDF15 in humans
Maximilian Kleinert, Kirstine Nyvold Bojsen-Møller, Nils B. Jørgensen, Maria S. Svane, Christoffer Martinussen, Bente Kiens, Jørgen F. P. Wojtaszewski, Sten Madsbad, Erik Arne Richter, Christoffer Clemmensen · 2019 · American Journal of Physiology-Endocrinology and Metabolism
Lyophilized Maqui (Aristotelia chilensis) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice
Viviana Sandoval, Antoni Femenias, Úrsula Martínez‐Garza, Hèctor Sanz‐Lamora, Juan Manuel Castagnini, Paola Quifer‐Rada, Rosa Maria Lamuela-Raventós, Pedro F. Marrero, Diego Haro, Joana Relat · 2019 · Antioxidants
Old Paradoxes and New Opportunities for Appetite Control in Obesity
Léa Montégut, Carlos López-Otı́n, Chr̀istophe Magnan, Guido Kroemer · 2021 · Trends in Endocrinology and Metabolism
Metabolic actions of fibroblast growth factor 21
Daniel Cuevas Ramos, Carlos Alberto Aguilar-Salinas, Francisco Javier Gomez-Perez · 2012 · Current Opinion in Pediatrics
Association between circulating oxidized OxLDL/LDL-C ratio and the severity of coronary atherosclerosis, along with other emerging biomarkers of cardiovascular disease in patients with type 2 diabetes
Lei Xu, Xinfeng Yan, Zhaosheng Tang, Bo Feng · 2022 · Diabetes Research and Clinical Practice
Serum Fibroblast Growth Factor 19 Levels Are Decreased in Chinese Subjects With Impaired Fasting Glucose and Inversely Associated With Fasting Plasma Glucose Levels
Qichen Fang, Huating Li, Qianqian Song, Wen Jing Yang, Xuhong Hou, Xiaojing Ma, Junxi Lu, Aimin Xu, Weiping Jia · 2013 · Diabetes Care
Fibroblast growth factor 21 in heart failure
William Tucker, Bradley Tucker, Kerry‐Anne Rye, Kwok Leung Ong · 2022 · Heart Failure Reviews
Serum fibroblast growth factor 21 is predictive of combined cardiovascular morbidity and mortality in patients with type 2 diabetes at a relatively short-term follow-up
Monika Lenart-Lipińska, Beata Matyjaszek‐Matuszek, Wojciech Gernand, Andrzej Marcin Nowakowski, Janusz Solski · 2013 · Diabetes Research and Clinical Practice
Serum Fibroblast Growth Factor 21 Levels Are Positively Associated with Metabolic Syndrome in Patients with Type 2 Diabetes
Ruo-Yao Gao, B. Hsu, Du-An Wu, Jia-Sian Hou, Ming-Chun Chen · 2019 · International Journal of Endocrinology
Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome
Sherma Zibadi, Randy Vazquez, Derek Moore, Douglas F. Larson, RONALD ROSS WATSON · 2009 · American Journal of Physiology-Heart and Circulatory Physiology
Maternal chocolate and sucrose soft drink intake induces hepatic steatosis in rat offspring associated with altered lipid gene expression profile
M. Kjaergaard, Cecilia Nilsson, Åsa Rosendal, Mette Olaf Nielsen, Kirsten Raun · 2013 · Acta Physiologica
Curcumin and dietary polyphenol research: beyond drug discovery
Tianru Jin · 2018 · Acta Pharmacologica Sinica
The influence of skeletal muscle on appetite regulation
Andrew Grannell, Giuseppe DE VITO, John Conleth Murphy, Carel Wynand le Roux · 2019 · Expert Review of Endocrinology & Metabolism
Serum fibroblast growth factor 21 levels in polycystic ovary syndrome
Süheyla Görar, Cavit Çulha, Ziynet Alphan Üç, Fatma Dilek Dellal, Rüştü Serter, Sema Aral, Yalçın Aral · 2010 · Gynecological Endocrinology
Plasma levels of myonectin but not myostatin or fibroblast-derived growth factor 21 are associated with insulin resistance in adult humans without diabetes mellitus
Toloza, Freddy J. K., Mantilla-Rivas, Jose O., Pérez-Matos, Maria C., Ricardo-Silgado, Maria L., Morales-Alvarez, Martha C., Pinzón-Cortés, Jairo A., Pérez-Mayorga, Maritza, Arévalo-Garcia, Martha L., Tolosa-González, Giovanni, Mendivil, Carlos O. · 2018 · Frontiers in Endocrinology
Effects of aerobic exercise on fibroblast growth factor 21 in overweight and obesity. A systematic review
María Porflitt-Rodríguez, Valentina Guzmán-Arriagada, Romina Sandoval-Valderrama, Charmaine S. Tam, Francisca Pavicic, Pamela Ehrenfeld, Sergio Martínez-Huenchullán · 2022 · Metabolism
Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes
Thomas Reinehr, Beate Karges, Thomas Meißner, Susanna Wiegand, Maria Fritsch, Reinhard Walter Holl, Joachim Woelfle · 2015 · The Journal of Clinical Endocrinology & Metabolism
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Javier Donate‐Correa, Ernesto Martín‐Núñez, Nayra Pérez‐Delgado, Mercedes Muros de Fuentes, Alberto Ortíz, Carmen Mora Fernández, Juan F. Navarro‐González · 2015 · Cytokine & Growth Factor Reviews
Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency
Mohammad Zarei, Emma Barroso, Rosana Leiva, Marta Barniol‐Xicota, Eugènia Pujol, Carmen Escolano, Santiago Vázquez, Xavier Palomer, Virginia Pardo, Águeda González‐Rodríguez et al. · 2016 · Diabetes
Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention
Sylwia Marta Figarska, Joseph Rigdon, Andrea Ganna, Sölve Elmståhl, Lars Lind, Christopher D. Gardner, Erik Ingelsson · 2020 · Scientific Reports
Recruitment of Histone Methyltransferase G9a Mediates Transcriptional Repression of Fgf21 Gene by E4BP4 Protein*
Xin Tong, Deqiang Zhang, Katie L. Buelow, Anirvan Guha, Blake Arthurs, Hugh J.M. Brady, Lei Yin · 2013 · Journal of Biological Chemistry
The roles of FGF21 in atherosclerosis pathogenesis
Farzane Shanehbandpour-Tabari, Ansar Karimian, Hadi Parsian, Vahid Rameshknia, Ata Mahmoodpoor, Maryam Majidinia, Mahmood Maniati, Bahman Yousefi · 2019 · Reviews in Endocrine and Metabolic Disorders
Increased Expression of FGF-21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice
Hongshuai Li, Hui Sun, Baoli Qian, Wei Hong Feng, Dwayne Carney, Jennifer P. Miller, MaCalus Vinson Hogan, Ling Wang · 2019 · Journal of Bone and Mineral Research
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Bamidele A. Adesunloye · 2021 · International Journal of Molecular Sciences
Fibroblast Growth Factor 21 and Thyroid Hormone Show Mutual Regulatory Dependency but Have Independent Actions In Vivo
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Hirokazu Taniguchi, Kumpei Tanisawa, Xiaomin Sun, Zhen‐Bo Cao, Satomi Oshima, Ryuken Ise, Shizuo Sakamoto, Mitsuru Higuchi · 2014 · The Journal of Clinical Endocrinology & Metabolism
FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats
Jianli He, Miao Zhao, Jing-Jun Xia, Jian Guan, Yang Liu, Lu-Qi Wang, Dong-Xue Song, Mei-Yu Qu, Meng Zuo, Xin Wen et al. · 2016 · Scientific Reports
Fibroblast growth factor 21 in chronic kidney disease
Sahapab Anuwatmatee, Shudi Tang, Ben J. Wu, Kerry‐Anne Rye, Kwok Leung Ong · 2017 · Clinica Chimica Acta
Aerobic exercise regulates FGF21 and NLRP3 inflammasome-mediated pyroptosis and inhibits atherosclerosis in mice
Xiao-Hong Li, Liangzhong Liu, Lin Chen, Qini Pan, Ziyao Ouyang, Dejing Fan, Xiao Pan, Su-Yu Lu, Qiu-Hu Luo, Pinyue Tao et al. · 2022 · PLoS ONE
Evaluation of Total Adiponectin, Adipocyte Fatty Acid Binding Protein and Fibroblast Growth Factor 21 Levels in Individuals With Metabolic Syndrome
Dalibor Novotný, H Vaverková, David Karásek, Jiří Lukeš, Luděk Slavík, Pavel Malina, J. Orság · 2014 · Physiological Research
Decrease in circulating fibroblast growth factor 21 after an oral fat load is related to postprandial triglyceride-rich lipoproteins and liver fat
Niina Matikainen, Marja‐Riitta Taskinen, Sanna Stennabb, Nina M I Lundbom, Antti Hakkarainen, Kirsi Vaaralahti, Taneli Raivio · 2011 · European Journal of Endocrinology
Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta1–42-Induced Toxicity in SH-SY5Y Cells
Mona Amiri, Nady Braidy, Malihe Aminzadeh · 2018 · Neurotoxicity Research
Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
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The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes
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Metabolically Protective Cytokines Adiponectin and Fibroblast Growth Factor-21 Are Increased by Acute Overfeeding in Healthy Humans
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Transcriptional Regulation of Fibroblast Growth Factor 21 Expression
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Increased Circulating and Epicardial Adipose Tissue mRNA Expression of Fibroblast Growth Factor-21 After Cardiac Surgery: Possible Role in Postoperative Inflammatory Response and Insulin Resistance
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Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity
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Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents
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Modulation of energy balance by fibroblast growth factor 21
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Plasma FGF21 levels are increased in patients with hypothyroidism independently of lipid profile
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